{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:45:27Z","timestamp":1790293527573,"version":"4.1.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000927","name":"Prostate Cancer Foundation of Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000927","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001168","name":"Cancer Council Queensland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001168","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001793","name":"Queensland University of Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001655","name":"Deutscher Akademischer Austauschdienst","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001655","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008719","name":"Movember Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008719","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.biomaterials.2018.10.014","type":"journal-article","created":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T05:32:45Z","timestamp":1539667965000},"page":"63-75","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"special_numbering":"C","title":["A 3D tumor microenvironment regulates cell proliferation, peritoneal growth and expression patterns"],"prefix":"10.1016","volume":"190-191","author":[{"given":"Daniela","family":"Loessner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Rockstroh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Shokoohmand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris M.","family":"Holzapfel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinand","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Baldwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Boxberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Schmalfeldt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernst","family":"Lengyel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith A.","family":"Clements","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietmar W.","family":"Hutmacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.biomaterials.2018.10.014_bib1","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/nrc4019","article-title":"Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer","volume":"15","author":"Bowtell","year":"2015","journal-title":"Nat. Rev. Canc."},{"issue":"2","key":"10.1016\/j.biomaterials.2018.10.014_bib2","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/path.4002","article-title":"The peritoneal tumour microenvironment of high-grade serous ovarian cancer","volume":"227","author":"Leinster","year":"2012","journal-title":"J. Pathol."},{"issue":"3","key":"10.1016\/j.biomaterials.2018.10.014_bib3","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.molonc.2014.01.008","article-title":"Molecular correlates of platinum response in human high-grade serous ovarian cancer patient-derived xenografts","volume":"8","author":"Topp","year":"2014","journal-title":"Mol. Oncol."},{"issue":"9","key":"10.1016\/j.biomaterials.2018.10.014_bib4","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1158\/2159-8290.CD-14-0001","article-title":"Patient-derived xenograft models: an emerging platform for translational cancer research","volume":"4","author":"Hidalgo","year":"2014","journal-title":"Cancer Discov."},{"issue":"3","key":"10.1016\/j.biomaterials.2018.10.014_bib5","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/nm.2328","article-title":"Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression","volume":"17","author":"Bissell","year":"2011","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.biomaterials.2018.10.014_bib6","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/nprot.2016.037","article-title":"Functionalization, preparation and use of cell-laden gelatin methacryloyl-based hydrogels as modular tissue culture platforms","volume":"11","author":"Loessner","year":"2016","journal-title":"Nat. Protoc."},{"issue":"28","key":"10.1016\/j.biomaterials.2018.10.014_bib7","doi-asserted-by":"crossref","first-page":"3619","DOI":"10.1038\/onc.2013.321","article-title":"Epithelial ovarian cancer experimental models","volume":"33","author":"Lengyel","year":"2014","journal-title":"Oncogene"},{"key":"10.1016\/j.biomaterials.2018.10.014_bib8","doi-asserted-by":"crossref","first-page":"8989","DOI":"10.1038\/ncomms9989","article-title":"The Notch and Wnt pathways regulate stemness and differentiation in human fallopian tube organoids","volume":"6","author":"Kessler","year":"2015","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/j.biomaterials.2018.10.014_bib9","doi-asserted-by":"crossref","first-page":"4614","DOI":"10.1172\/JCI74778","article-title":"Mesothelial cells promote early ovarian cancer metastasis through fibronectin secretion","volume":"124","author":"Kenny","year":"2014","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.biomaterials.2018.10.014_bib10","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/0014-4827(85)90197-1","article-title":"Interactions of human ovarian tumor cells with human mesothelial cells grown on extracellular matrix. An in vitro model system for studying tumor cell adhesion and invasion","volume":"160","author":"Niedbala","year":"1985","journal-title":"Exp. Cell Res."},{"issue":"2","key":"10.1016\/j.biomaterials.2018.10.014_bib11","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1158\/2159-8274.CD-11-0010","article-title":"Ovarian cancer spheroids use myosin-generated force to clear the mesothelium","volume":"1","author":"Iwanicki","year":"2011","journal-title":"Cancer Discov."},{"issue":"1\u20132","key":"10.1016\/j.biomaterials.2018.10.014_bib12","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s10555-012-9351-2","article-title":"Cell-cell and cell-matrix dynamics in intraperitoneal cancer metastasis","volume":"31","author":"Sodek","year":"2012","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.biomaterials.2018.10.014_bib13","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.progpolymsci.2016.01.001","article-title":"Melt electrospinning today: an opportune time for an emerging polymer process","volume":"56","author":"Brown","year":"2016","journal-title":"Prog. Polym. Sci."},{"issue":"30","key":"10.1016\/j.biomaterials.2018.10.014_bib14","doi-asserted-by":"crossref","first-page":"7389","DOI":"10.1016\/j.biomaterials.2013.06.009","article-title":"A bioengineered 3D ovarian cancer model for the assessment of peptidase-mediated enhancement of spheroid growth and intraperitoneal spread","volume":"34","author":"Loessner","year":"2013","journal-title":"Biomaterials"},{"issue":"9","key":"10.1016\/j.biomaterials.2018.10.014_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0040217","article-title":"Phenotypic characterization of prostate cancer LNCaP cells cultured within a bioengineered microenvironment","volume":"7","author":"Sieh","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.biomaterials.2018.10.014_bib16","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1471-2105-10-48","article-title":"GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists","volume":"10","author":"Eden","year":"2009","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.biomaterials.2018.10.014_bib17","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.biomaterials.2017.12.017","article-title":"Heterocellular 3D scaffolds as biomimetic to recapitulate the tumor microenvironment of peritoneal metastases in vitro and in vivo","volume":"158","author":"De Jaeghere","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2018.10.014_bib18","doi-asserted-by":"crossref","first-page":"12645","DOI":"10.1038\/ncomms12645","article-title":"Integrative proteomic profiling of ovarian cancer cell lines reveals precursor cell associated proteins and functional status","volume":"7","author":"Coscia","year":"2016","journal-title":"Nat. Commun."},{"issue":"7353","key":"10.1016\/j.biomaterials.2018.10.014_bib19","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/nature10166","article-title":"Integrated genomic analyses of ovarian carcinoma","volume":"474","author":"Cancer Genome Atlas Research Network","year":"2011","journal-title":"Nature"},{"issue":"7553","key":"10.1016\/j.biomaterials.2018.10.014_bib20","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/nature14410","article-title":"Whole-genome characterization of chemoresistant ovarian cancer","volume":"521","author":"Patch","year":"2015","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.biomaterials.2018.10.014_bib21","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1002\/cncr.11650","article-title":"The effect of cyclooxygenase-2 expression on tumor vascularity in advanced stage ovarian serous carcinoma","volume":"98","author":"Ali-Fehmi","year":"2003","journal-title":"Cancer"},{"issue":"25","key":"10.1016\/j.biomaterials.2018.10.014_bib22","doi-asserted-by":"crossref","first-page":"21353","DOI":"10.18632\/oncotarget.3860","article-title":"Aberrant over-expression of COX-1 intersects multiple pro-tumorigenic pathways in high-grade serous ovarian cancer","volume":"6","author":"Wilson","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.biomaterials.2018.10.014_bib23","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s12885-015-1138-8","article-title":"Low levels of IGFBP7 expression in high-grade serous ovarian carcinoma is associated with patient outcome","volume":"15","author":"Gambaro","year":"2015","journal-title":"BMC Canc."},{"issue":"4","key":"10.1016\/j.biomaterials.2018.10.014_bib24","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.ajpath.2013.12.030","article-title":"Vascular endothelial growth factor c promotes ovarian carcinoma progression through paracrine and autocrine mechanisms","volume":"184","author":"Decio","year":"2014","journal-title":"Am. J. Pathol."},{"issue":"5","key":"10.1016\/j.biomaterials.2018.10.014_bib25","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/nm.3848","article-title":"Reciprocal cellular cross-talk within the tumor microenvironment promotes oncolytic virus activity","volume":"21","author":"Ilkow","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.biomaterials.2018.10.014_bib26","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.biochi.2015.09.002","article-title":"The kallikrein-related peptidase family: dysregulation and functions during cancer progression","volume":"122","author":"Kryza","year":"2016","journal-title":"Biochimie"},{"issue":"6","key":"10.1016\/j.biomaterials.2018.10.014_bib27","doi-asserted-by":"crossref","first-page":"e2425","DOI":"10.1371\/journal.pone.0002425","article-title":"Proteomic analysis of ovarian cancer cells reveals dynamic processes of protein secretion and shedding of extra-cellular domains","volume":"3","author":"Faca","year":"2008","journal-title":"PloS One"},{"issue":"4","key":"10.1016\/j.biomaterials.2018.10.014_bib28","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1074\/mcp.M800313-MCP200","article-title":"Mining the ovarian cancer ascites proteome for potential ovarian cancer biomarkers","volume":"8","author":"Kuk","year":"2009","journal-title":"Mol. Cell. Proteomics"},{"issue":"1","key":"10.1016\/j.biomaterials.2018.10.014_bib29","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.molonc.2013.09.003","article-title":"Secretome and degradome profiling shows that Kallikrein-related peptidases 4, 5, 6, and 7 induce TGFbeta-1 signaling in ovarian cancer cells","volume":"8","author":"Shahinian","year":"2014","journal-title":"Mol. Oncol."},{"issue":"3","key":"10.1016\/j.biomaterials.2018.10.014_bib30","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1158\/2159-8290.CD-17-0284","article-title":"Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers","volume":"8","author":"Pearce","year":"2018","journal-title":"Cancer Discov."},{"issue":"7","key":"10.1016\/j.biomaterials.2018.10.014_bib31","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/ng.3573","article-title":"Divergent modes of clonal spread and intraperitoneal mixing in high-grade serous ovarian cancer","volume":"48","author":"McPherson","year":"2016","journal-title":"Nat. Genet."},{"issue":"11","key":"10.1016\/j.biomaterials.2018.10.014_bib32","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1038\/nm.2492","article-title":"Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth","volume":"17","author":"Nieman","year":"2011","journal-title":"Nat. Med."},{"issue":"2","key":"10.1016\/j.biomaterials.2018.10.014_bib33","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.canlet.2014.09.041","article-title":"Peritoneal mesothelium promotes the progression of ovarian cancer cells in vitro and in a mice xenograft model in vivo","volume":"355","author":"Mikula-Pietrasik","year":"2014","journal-title":"Cancer Lett."},{"issue":"3","key":"10.1016\/j.biomaterials.2018.10.014_bib34","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1158\/1078-0432.CCR-13-1256","article-title":"A collagen-remodeling gene signature regulated by TGF-beta signaling is associated with metastasis and poor survival in serous ovarian cancer","volume":"20","author":"Cheon","year":"2014","journal-title":"Clin. Canc. Res."},{"issue":"24","key":"10.1016\/j.biomaterials.2018.10.014_bib35","doi-asserted-by":"crossref","first-page":"7621","DOI":"10.1158\/1078-0432.CCR-17-1159","article-title":"A complex network of tumor microenvironment in human high grade serous ovarian cancer","volume":"23","author":"Kreuzinger","year":"2017","journal-title":"Clin. Canc. Res."},{"issue":"6","key":"10.1016\/j.biomaterials.2018.10.014_bib36","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1172\/JCI69815","article-title":"Mesenchymal gene program-expressing ovarian cancer spheroids exhibit enhanced mesothelial clearance","volume":"124","author":"Davidowitz","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.biomaterials.2018.10.014_bib37","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/1476-4598-5-62","article-title":"Ovarian epithelial cancer: a role for PGE2-synthesis and signalling in malignant transformation and progression","volume":"5","author":"Rask","year":"2006","journal-title":"Mol. Canc."},{"issue":"3","key":"10.1016\/j.biomaterials.2018.10.014_bib38","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S0002-9440(10)64912-7","article-title":"Expression of cyclooxygenase 2 is an independent prognostic factor in human ovarian carcinoma","volume":"160","author":"Denkert","year":"2002","journal-title":"Am. J. Pathol."},{"issue":"5","key":"10.1016\/j.biomaterials.2018.10.014_bib39","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/bjc.2016.172","article-title":"CXCL9 and CXCL10 predict survival and are regulated by cyclooxygenase inhibition in advanced serous ovarian cancer","volume":"115","author":"Bronger","year":"2016","journal-title":"Br. J. Canc."},{"issue":"5","key":"10.1016\/j.biomaterials.2018.10.014_bib40","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nrc3720","article-title":"IGF binding proteins in cancer: mechanistic and clinical insights","volume":"14","author":"Baxter","year":"2014","journal-title":"Nat. Rev. Canc."},{"issue":"5","key":"10.1016\/j.biomaterials.2018.10.014_bib41","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/onc.2012.630","article-title":"IGFBP-2 nuclear translocation is mediated by a functional NLS sequence and is essential for its pro-tumorigenic actions in cancer cells","volume":"33","author":"Azar","year":"2014","journal-title":"Oncogene"},{"issue":"2","key":"10.1016\/j.biomaterials.2018.10.014_bib42","doi-asserted-by":"crossref","first-page":"189","DOI":"10.4161\/cbt.5.2.2333","article-title":"Insulin-like growth factor binding protein-2 stimulates proliferation and activates multiple cascades of the mitogen-activated protein kinase pathways in NIH-OVCAR3 human epithelial ovarian cancer cells","volume":"5","author":"Chakrabarty","year":"2006","journal-title":"Cancer Biol. Ther."},{"issue":"5","key":"10.1016\/j.biomaterials.2018.10.014_bib43","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1158\/1078-0432.CCR-0672-2","article-title":"Elevated serum insulin-like growth factor binding protein-2 as a prognostic marker in patients with ovarian cancer","volume":"10","author":"Baron-Hay","year":"2004","journal-title":"Clin. Canc. Res."},{"issue":"9","key":"10.1016\/j.biomaterials.2018.10.014_bib44","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.1158\/1078-0432.CCR-04-1148","article-title":"Vascular endothelial growth factor-C expression and invasive phenotype in ovarian carcinomas","volume":"11","author":"Ueda","year":"2005","journal-title":"Clin. Canc. Res."},{"issue":"26","key":"10.1016\/j.biomaterials.2018.10.014_bib45","doi-asserted-by":"crossref","first-page":"43218","DOI":"10.18632\/oncotarget.17978","article-title":"VEGF-C expression attributes the risk for lymphatic metastases to ovarian cancer patients","volume":"8","author":"Kuerti","year":"2017","journal-title":"Oncotarget"},{"issue":"6","key":"10.1016\/j.biomaterials.2018.10.014_bib46","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1002\/cncr.20449","article-title":"Vascular endothelial growth factor C and vascular endothelial growth factor receptor 2 are related closely to the prognosis of patients with ovarian carcinoma","volume":"101","author":"Nishida","year":"2004","journal-title":"Cancer"},{"issue":"4","key":"10.1016\/j.biomaterials.2018.10.014_bib47","doi-asserted-by":"crossref","first-page":"e4992","DOI":"10.1371\/journal.pone.0004992","article-title":"Mesenchymal stem cell transition to tumor-associated fibroblasts contributes to fibrovascular network expansion and tumor progression","volume":"4","author":"Spaeth","year":"2009","journal-title":"PloS One"},{"issue":"Suppl 1","key":"10.1016\/j.biomaterials.2018.10.014_bib48","doi-asserted-by":"crossref","first-page":"i33","DOI":"10.1093\/annonc\/mdw093","article-title":"Anti-angiogenic agents in ovarian cancer: past, present, and future","volume":"27","author":"Monk","year":"2016","journal-title":"Ann. Oncol."},{"issue":"16","key":"10.1016\/j.biomaterials.2018.10.014_bib49","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1200\/JCO.2006.09.0795","article-title":"Whole genome oligonucleotide-based array comparative genomic hybridization analysis identified fibroblast growth factor 1 as a prognostic marker for advanced-stage serous ovarian adenocarcinomas","volume":"25","author":"Birrer","year":"2007","journal-title":"J. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.biomaterials.2018.10.014_bib50","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.ygyno.2007.03.021","article-title":"Co-expression of angiogenic markers and associations with prognosis in advanced epithelial ovarian cancer: a Gynecologic Oncology Group study","volume":"106","author":"Secord","year":"2007","journal-title":"Gynecol. Oncol."},{"issue":"49","key":"10.1016\/j.biomaterials.2018.10.014_bib51","doi-asserted-by":"crossref","first-page":"8171","DOI":"10.1038\/sj.onc.1207979","article-title":"Gene expression profiling of advanced ovarian cancer: characterization of a molecular signature involving fibroblast growth factor 2","volume":"23","author":"De Cecco","year":"2004","journal-title":"Oncogene"},{"issue":"11 Pt B","key":"10.1016\/j.biomaterials.2018.10.014_bib52","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1016\/j.bbamcr.2017.08.004","article-title":"Overview of transcriptomic analysis of all human proteases, non-proteolytic homologs and inhibitors: organ, tissue and ovarian cancer cell line expression profiling of the human protease degradome by the CLIP-CHIPTM DNA microarray","volume":"1864","author":"Kappelhoff","year":"2017","journal-title":"Biochim. Biophys. Acta"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961218307221?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961218307221?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T16:38:29Z","timestamp":1758904709000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961218307221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":52,"alternative-id":["S0142961218307221"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2018.10.014","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A 3D tumor microenvironment regulates cell proliferation, peritoneal growth and expression patterns","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2018.10.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}