{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T15:21:35Z","timestamp":1787671295060,"version":"build-2736575974"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["IK2RX002013"],"award-info":[{"award-number":["IK2RX002013"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS094218"],"award-info":[{"award-number":["R01NS094218"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS092847"],"award-info":[{"award-number":["R01NS092847"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["S10OD021624"],"award-info":[{"award-number":["S10OD021624"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.biomaterials.2018.11.031","type":"journal-article","created":{"date-parts":[[2018,11,25]],"date-time":"2018-11-25T23:24:41Z","timestamp":1543188281000},"page":"510-522","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Engineering advanced neural tissue constructs to mitigate acute cerebral inflammation after brain transplantation in rats"],"prefix":"10.1016","volume":"192","author":[{"given":"Volha","family":"Liaudanskaya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Jgamadze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander N.","family":"Berk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Bischoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben J.","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Hawks-Mayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Whalen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Isaac","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biomaterials.2018.11.031_bib1","series-title":"Brain Injury Medicine","article-title":"Conducting research in Traumatic brain injury: current concepts","author":"Wagner","year":"2013"},{"key":"10.1016\/j.biomaterials.2018.11.031_bib2","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.neulet.2016.04.009","article-title":"Epigenetic changes following traumatic brain injury and their implications for outcome, recovery and therapy","volume":"625","author":"Wong","year":"2016","journal-title":"Neurosci. Lett."},{"issue":"3","key":"10.1016\/j.biomaterials.2018.11.031_bib3","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.neuron.2013.10.037","article-title":"Neural stem cells: generating and regenerating the brain","volume":"80","author":"Gage","year":"2013","journal-title":"Neuron"},{"issue":"9","key":"10.1016\/j.biomaterials.2018.11.031_bib4","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/nm747","article-title":"Neuronal replacement from endogenous precursors in the adult brain after stroke","volume":"8","author":"Arvidsson","year":"2002","journal-title":"Nat. Med."},{"key":"10.1016\/j.biomaterials.2018.11.031_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnsys.2016.00001","article-title":"Neural substrate expansion for the restoration of brain function","volume":"10","author":"Chen","year":"2016","journal-title":"Front. Syst. Neurosci."},{"issue":"7628","key":"10.1016\/j.biomaterials.2018.11.031_bib6","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nature20113","article-title":"Transplanted embryonic neurons integrate into adult neocortical circuits","volume":"539","author":"Falkner","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.biomaterials.2018.11.031_bib7","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.nbd.2015.04.003","article-title":"Reconstruction of brain circuitry by neural transplants generated from pluripotent stem cells","volume":"79","author":"Thompson","year":"2015","journal-title":"Neurobiol. Dis."},{"issue":"1","key":"10.1016\/j.biomaterials.2018.11.031_bib8","doi-asserted-by":"crossref","first-page":"e30293","DOI":"10.1371\/journal.pone.0030293","article-title":"Colloids as mobile substrates for the implantation and integration of differentiated neurons into the mammalian brain","volume":"7","author":"Jgamadze","year":"2012","journal-title":"PloS One"},{"issue":"1","key":"10.1016\/j.biomaterials.2018.11.031_bib9","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/adma.201503916","article-title":"A bio-acoustic levitational (BAL) assembly method for engineering of multilayered, 3D brain-like constructs, using human embryonic stem cell derived neuro-progenitors","volume":"28","author":"Bouyer","year":"2016","journal-title":"Adv. Mater."},{"issue":"7467","key":"10.1016\/j.biomaterials.2018.11.031_bib10","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nature12517","article-title":"Cerebral organoids model human brain development and microcephaly","volume":"501","author":"Lancaster","year":"2013","journal-title":"Nature"},{"issue":"38","key":"10.1016\/j.biomaterials.2018.11.031_bib11","doi-asserted-by":"crossref","first-page":"13811","DOI":"10.1073\/pnas.1324214111","article-title":"Bioengineered functional brain-like cortical tissue","volume":"111","author":"Tang-Schomer","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"30","key":"10.1016\/j.biomaterials.2018.11.031_bib12","doi-asserted-by":"crossref","first-page":"7435","DOI":"10.1016\/j.biomaterials.2012.06.085","article-title":"Neo-vascularization of the stroke cavity by implantation of human neural stem cells on VEGF-releasing PLGA microparticles","volume":"33","author":"Bible","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2018.11.031_bib13","doi-asserted-by":"crossref","first-page":"10862","DOI":"10.1038\/ncomms10862","article-title":"Generation and transplantation of reprogrammed human neurons in the brain using 3D microtopographic scaffolds","volume":"7","author":"Carlson","year":"2016","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.biomaterials.2018.11.031_bib14","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1016\/j.biomaterials.2012.11.043","article-title":"Neural stem cells encapsulated in a functionalized self-assembling peptide hydrogel for brain tissue engineering","volume":"34","author":"Cheng","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2018.11.031_bib15","doi-asserted-by":"crossref","first-page":"336","DOI":"10.3171\/2009.2.JNS08495","article-title":"Effect of biodegradable fibrin scaffold on survival, migration, and differentiation of transplanted bone marrow stromal cells after cortical injury in rats","volume":"112","author":"Yasuda","year":"2010","journal-title":"J. Neurosurg."},{"issue":"2","key":"10.1016\/j.biomaterials.2018.11.031_bib16","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.tcb.2013.08.004","article-title":"Neuroinflammation and central nervous system regeneration in vertebrates","volume":"24","author":"Kyritsis","year":"2014","journal-title":"Trends Cell Biol."},{"issue":"5","key":"10.1016\/j.biomaterials.2018.11.031_bib17","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/nrn3722","article-title":"Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease","volume":"15","author":"Prinz","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"issue":"1","key":"10.1016\/j.biomaterials.2018.11.031_bib18","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/nan.12011","article-title":"Review: activation patterns of microglia and their identification in the human brain","volume":"39","author":"Boche","year":"2013","journal-title":"Neuropathol. Appl. Neurobiol."},{"issue":"1","key":"10.1016\/j.biomaterials.2018.11.031_bib19","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nrneurol.2014.207","article-title":"Microglial and macrophage polarization-new prospects for brain repair","volume":"11","author":"Hu","year":"2015","journal-title":"Nat. Rev. Neurol."},{"issue":"11","key":"10.1016\/j.biomaterials.2018.11.031_bib20","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nri3086","article-title":"Microglial cell origin and phenotypes in health and disease","volume":"11","author":"Saijo","year":"2011","journal-title":"Nat. Rev. Immunol."},{"issue":"10","key":"10.1016\/j.biomaterials.2018.11.031_bib21","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.tins.2015.08.002","article-title":"Priming the inflammatory pump of the CNS after traumatic brain injury","volume":"38","author":"Witcher","year":"2015","journal-title":"Trends Neurosci."},{"issue":"7560","key":"10.1016\/j.biomaterials.2018.11.031_bib22","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature14432","article-title":"Structural and functional features of central nervous system lymphatic vessels","volume":"523","author":"Louveau","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.biomaterials.2018.11.031_bib23","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/1742-2094-11-98","article-title":"Neuroinflammation and M2 microglia: the good, the bad, and the inflamed","volume":"11","author":"Cherry","year":"2014","journal-title":"J. Neuroinflammation"},{"issue":"5","key":"10.1016\/j.biomaterials.2018.11.031_bib24","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.cell.2018.05.003","article-title":"Disease-associated microglia: a universal immune sensor of neurodegeneration","volume":"173","author":"Deczkowska","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.biomaterials.2018.11.031_bib25","doi-asserted-by":"crossref","unstructured":"B.A. Friedman, K. Srinivasan, G. Ayalon, W.J. Meilandt, H. Lin, M.A. Huntley, Y. Cao, S.H. Lee, P.C.G. Haddick, H. Ngu, Z. Modrusan, J.L. Larson, J.S. Kaminker, M.P. van der Brug, D.V. Hansen, Diverse brain myeloid expression profiles reveal distinct microglial activation states and aspects of Alzheimer's disease not evident in mouse models, Cell Rep. 22 832-847.","DOI":"10.1016\/j.celrep.2017.12.066"},{"issue":"6","key":"10.1016\/j.biomaterials.2018.11.031_bib26","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.neuron.2017.07.010","article-title":"Neuroimmunology of traumatic brain injury: time for a paradigm shift","volume":"95","author":"Jassam","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.biomaterials.2018.11.031_bib27","article-title":"The role of an NF\u03baB-STAT3 signaling Axis in regulating the induction and maintenance of the pluripotent state, pluripotent stem cell biology - advances in mechanics","author":"Agarwal","year":"2014","journal-title":"Meth. Model. INTECH"},{"issue":"6","key":"10.1016\/j.biomaterials.2018.11.031_bib28","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.tins.2011.03.001","article-title":"Regulation of neural process growth, elaboration and structural plasticity by NF-kappaB","volume":"34","author":"Gutierrez","year":"2011","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.biomaterials.2018.11.031_bib29","doi-asserted-by":"crossref","first-page":"38665","DOI":"10.1038\/srep38665","article-title":"Transcriptional regulation of Notch1 expression by Nkx6.1 in neural stem\/progenitor cells during ventral spinal cord development","volume":"6","author":"Li","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biomaterials.2018.11.031_bib31","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12974-015-0463-9","article-title":"Cyclic AMP is a key regulator of M1 to M2a phenotypic conversion of microglia in the presence of Th2 cytokines","volume":"13","author":"Ghosh","year":"2016","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.biomaterials.2018.11.031_bib32","doi-asserted-by":"crossref","first-page":"7750","DOI":"10.1038\/ncomms8750","article-title":"GABA depolarizes immature neurons and inhibits network activity in the neonatal neocortex in vivo","volume":"6","author":"Kirmse","year":"2015","journal-title":"Nat. Commun."},{"issue":"3\u20134","key":"10.1016\/j.biomaterials.2018.11.031_bib33","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1089\/ten.tea.2016.0515","article-title":"In vitro maturation of human iPSC-derived neuroepithelial cells influences transplant survival in the stroke-injured rat brain","volume":"24","author":"Payne","year":"2018","journal-title":"Tissue Eng."},{"issue":"4","key":"10.1016\/j.biomaterials.2018.11.031_bib34","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/ijo.2017.3","article-title":"Intracellular ATP in balance of pro- and anti-inflammatory cytokines in adipose tissue with and without tissue expansion","volume":"41","author":"Lee","year":"2017","journal-title":"Int. J. Obes. (Lond)"},{"issue":"5","key":"10.1016\/j.biomaterials.2018.11.031_bib35","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.tem.2015.02.006","article-title":"Notch signaling as a novel regulator of metabolism","volume":"26","author":"Bi","year":"2015","journal-title":"Trends Endocrinol. Metabol."},{"key":"10.1016\/j.biomaterials.2018.11.031_bib36","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/bph.13139","article-title":"Microglia M1\/M2 polarization and metabolic states","volume":"173","author":"Orihuela","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.biomaterials.2018.11.031_bib37","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3389\/fnmol.2015.00077","article-title":"NF-kappaB signaling pathways in neurological inflammation: a mini review","volume":"8","author":"Shih","year":"2015","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.biomaterials.2018.11.031_bib38","series-title":"NF\u03baB Signaling Directs Neuronal Fate Decision","author":"Zhang","year":"2013"},{"issue":"8","key":"10.1016\/j.biomaterials.2018.11.031_bib39","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1002\/glia.22850","article-title":"Reactive astrocytes as neural stem or progenitor cells: in vivo lineage, in vitro potential, and Genome-wide expression analysis","volume":"63","author":"Gotz","year":"2015","journal-title":"Glia"},{"issue":"4","key":"10.1016\/j.biomaterials.2018.11.031_bib40","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1002\/stem.1959","article-title":"Concise review: reactive astrocytes and stem cells in spinal cord injury: good guys or bad guys?","volume":"33","author":"Lukovic","year":"2015","journal-title":"Stem Cell."},{"issue":"2","key":"10.1016\/j.biomaterials.2018.11.031_bib41","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/ki.2013.131","article-title":"Long-term follow-up of patients with severe ANCA-associated vasculitis comparing plasma exchange to intravenous methylprednisolone treatment is unclear","volume":"84","author":"Walsh","year":"2013","journal-title":"Kidney Int."},{"issue":"3","key":"10.1016\/j.biomaterials.2018.11.031_bib42","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.cell.2016.03.008","article-title":"Personalized immunomonitoring uncovers molecular networks that stratify lupus patients","volume":"165","author":"Banchereau","year":"2016","journal-title":"Cell"},{"issue":"9997","key":"10.1016\/j.biomaterials.2018.11.031_bib43","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/S0140-6736(15)61137-0","article-title":"Oral versus intravenous high-dose methylprednisolone for treatment of relapses in patients with multiple sclerosis (COPOUSEP): a randomised, controlled, double-blind, non-inferiority trial","volume":"386","author":"Le Page","year":"2015","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.biomaterials.2018.11.031_bib44","first-page":"385","article-title":"Intravenous immunoglobulin accompanied with high-dose methylprednisolone therapy for 17 children with anti-N-methyl-D-aspartate receptor encephalitis: clinic and nursing","volume":"3","author":"Zhao","year":"2016","journal-title":"Int. J. Nurs. Sci."},{"issue":"4","key":"10.1016\/j.biomaterials.2018.11.031_bib45","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1080\/14767050701227992","article-title":"Toxicity of corticosteroids and catecholamines for mice neuronal cell cultures: role of preservatives","volume":"20","author":"Dani","year":"2007","journal-title":"J. Matern. Fetal Neonatal Med."},{"issue":"5","key":"10.1016\/j.biomaterials.2018.11.031_bib46","doi-asserted-by":"crossref","first-page":"823","DOI":"10.4103\/1673-5374.182711","article-title":"Methylprednisolone exerts neuroprotective effects by regulating autophagy and apoptosis","volume":"11","author":"Gao","year":"2016","journal-title":"Neural Regen. Res."},{"issue":"7","key":"10.1016\/j.biomaterials.2018.11.031_bib47","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.ijdevneu.2013.07.004","article-title":"Review of transplantation of neural stem\/progenitor cells for spinal cord injury","volume":"31","author":"Mothe","year":"2013","journal-title":"Int. J. Dev. Neurosci."},{"issue":"5","key":"10.1016\/j.biomaterials.2018.11.031_bib48","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/mp.2009.98","article-title":"Leptin regulates leukocyte recruitment into the brain following systemic LPS-induced inflammation","volume":"15","author":"Rummel","year":"2010","journal-title":"Mol. Psychiatr."},{"issue":"10","key":"10.1016\/j.biomaterials.2018.11.031_bib49","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1038\/nprot.2011.379","article-title":"Materials fabrication from Bombyx mori silk fibroin","volume":"6","author":"Rockwood","year":"2011","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.biomaterials.2018.11.031_bib50","first-page":"e3814","article-title":"Primary microglia isolation from mixed glial cell cultures of neonatal rat brain tissue","volume":"66","author":"Tamashiro","year":"2012","journal-title":"J. Vis. Exp."},{"issue":"12","key":"10.1016\/j.biomaterials.2018.11.031_bib51","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1016\/j.biomaterials.2007.01.008","article-title":"Enhanced neurite growth from mammalian neurons in three-dimensional salmon fibrin gels","volume":"28","author":"Ju","year":"2007","journal-title":"Biomaterials"},{"issue":"9","key":"10.1016\/j.biomaterials.2018.11.031_bib52","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1038\/nprot.2015.091","article-title":"In vitro bioengineered model of cortical brain tissue","volume":"10","author":"Chwalek","year":"2015","journal-title":"Nat. Prostoc."}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961218308160?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961218308160?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T16:42:57Z","timestamp":1758904977000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961218308160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":51,"alternative-id":["S0142961218308160"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2018.11.031","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Engineering advanced neural tissue constructs to mitigate acute cerebral inflammation after brain transplantation in rats","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2018.11.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}