{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:12:09Z","timestamp":1792699929873,"version":"4.5.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI17C1238"],"award-info":[{"award-number":["HI17C1238"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["NRF-2017R1A6A1A03015713"],"award-info":[{"award-number":["NRF-2017R1A6A1A03015713"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["2015R1A5A1009701"],"award-info":[{"award-number":["2015R1A5A1009701"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.biomaterials.2019.01.008","type":"journal-article","created":{"date-parts":[[2019,1,6]],"date-time":"2019-01-06T23:31:55Z","timestamp":1546817515000},"page":"1-11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["Intravenous sustained-release nifedipine ameliorates nonalcoholic fatty liver disease by restoring autophagic clearance"],"prefix":"10.1016","volume":"197","author":[{"given":"Solji","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daewon","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Goo","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su Jin","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Eun","family":"Jo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jongdae","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do Kyung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwan-Woo","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biomaterials.2019.01.008_bib1","first-page":"1","volume":"vol. 219","author":"Ogden","year":"2015"},{"issue":"6","key":"10.1016\/j.biomaterials.2019.01.008_bib2","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1002\/hep.25762","article-title":"The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American college of gastroenterology, and the American gastroenterological association","volume":"55","author":"Chalasani","year":"2012","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.biomaterials.2019.01.008_bib3","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/nrd.2015.3","article-title":"Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies","volume":"15","author":"Musso","year":"2016","journal-title":"Nat. Rev. Drug Discov."},{"issue":"8","key":"10.1016\/j.biomaterials.2019.01.008_bib4","doi-asserted-by":"crossref","DOI":"10.1038\/s41575-018-0014-9","article-title":"Noninvasive biomarkers in NAFLD and NASH - current progress and future promise","volume":"15","author":"Wong","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"7245","key":"10.1016\/j.biomaterials.2019.01.008_bib5","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/459340a","article-title":"Obesity: causes and control of excess body fat","volume":"459","author":"Friedman","year":"2009","journal-title":"Nature"},{"issue":"15","key":"10.1016\/j.biomaterials.2019.01.008_bib6","first-page":"1492","article-title":"Mechanisms, pathophysiology, and management of obesity","volume":"376","author":"Heymsfield","year":"2017","journal-title":"N. Engl. J. Med."},{"issue":"9","key":"10.1016\/j.biomaterials.2019.01.008_bib7","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/nrd3739","article-title":"Limitations in anti-obesity drug development: the critical role of hunger-promoting neurons","volume":"11","author":"Dietrich","year":"2012","journal-title":"Nat. Rev. Drug Discov."},{"issue":"5497","key":"10.1016\/j.biomaterials.2019.01.008_bib8","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1126\/science.290.5497.1717","article-title":"Autophagy as a regulated pathway of cellular degradation","volume":"290","author":"Klionsky","year":"2000","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.biomaterials.2019.01.008_bib9","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/s41574-018-0009-1","article-title":"Targeting autophagy in obesity: from pathophysiology to management","volume":"14","author":"Zhang","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"issue":"33","key":"10.1016\/j.biomaterials.2019.01.008_bib10","doi-asserted-by":"crossref","first-page":"24131","DOI":"10.1074\/jbc.M702824200","article-title":"p62\/SQSTM1 binds directly to Atg 8\/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy","volume":"282","author":"Pankiv","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.biomaterials.2019.01.008_bib11","doi-asserted-by":"crossref","first-page":"630","DOI":"10.4161\/onci.20297","article-title":"Insufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease","volume":"1","author":"Fujii","year":"2012","journal-title":"OncoImmunology"},{"issue":"1","key":"10.1016\/j.biomaterials.2019.01.008_bib12","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0002-9440(10)64369-6","article-title":"p62 Is a common component of cytoplasmic inclusions in protein aggregation diseases","volume":"160","author":"Zatloukal","year":"2002","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.biomaterials.2019.01.008_bib13","doi-asserted-by":"crossref","first-page":"4834","DOI":"10.1038\/ncomms5834","article-title":"Pharmacological correction of obesity-induced autophagy arrest using calcium channel blockers","volume":"5","author":"Park","year":"2014","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.biomaterials.2019.01.008_bib14","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.4161\/15548627.2014.984268","article-title":"Calcium channel blockers as potential therapeutics for obesity-associated autophagy defects and fatty liver pathologies","volume":"10","author":"Park","year":"2014","journal-title":"Autophagy"},{"issue":"11","key":"10.1016\/j.biomaterials.2019.01.008_bib15","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.mpmed.2007.08.025","article-title":"Calcium channel blockers","volume":"35","author":"Buckley","year":"2007","journal-title":"Medicine"},{"key":"10.1016\/j.biomaterials.2019.01.008_bib16","series-title":"Assay Guidance Manual","article-title":"Cell viability assays","author":"Riss","year":"2004"},{"issue":"2","key":"10.1016\/j.biomaterials.2019.01.008_bib17","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s10616-012-9481-y","article-title":"Beyond annexin V: fluorescence response of cellular membranes to apoptosis","volume":"65","author":"Demchenko","year":"2013","journal-title":"Cytotechnology"},{"issue":"3","key":"10.1016\/j.biomaterials.2019.01.008_bib18","doi-asserted-by":"crossref","first-page":"181","DOI":"10.4161\/21623945.2014.987580","article-title":"Optimization of in vitro cultivation strategies for human adipocyte derived stem cells","volume":"4","author":"Storck","year":"2015","journal-title":"Adipocyte"},{"key":"10.1016\/j.biomaterials.2019.01.008_bib19","doi-asserted-by":"crossref","first-page":"4233","DOI":"10.1038\/ncomms5233","article-title":"Hepatoprotective role of Sestrin2 against chronic ER stress","volume":"5","author":"Park","year":"2014","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.biomaterials.2019.01.008_bib20","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/15548627.2015.1121360","article-title":"Interplay of endoplasmic reticulum stress and autophagy in neurodegenerative disorders","volume":"12","author":"Cai","year":"2016","journal-title":"Autophagy"},{"issue":"6","key":"10.1016\/j.biomaterials.2019.01.008_bib21","doi-asserted-by":"crossref","first-page":"E1656","DOI":"10.1152\/ajpendo.00318.2007","article-title":"Induction of endoplasmic reticulum stress-induced beta-cell apoptosis and accumulation of polyubiquitinated proteins by human islet amyloid polypeptide","volume":"293","author":"Huang","year":"2007","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.biomaterials.2019.01.008_bib22","doi-asserted-by":"crossref","DOI":"10.1002\/hep.29742","article-title":"Lipotoxicity induces hepatic protein inclusions through TANK binding kinase 1-mediated p62\/sequestosome 1 phosphorylation","volume":"68","author":"Cho","year":"2017","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.biomaterials.2019.01.008_bib23","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.cmet.2010.04.005","article-title":"Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance","volume":"11","author":"Yang","year":"2010","journal-title":"Cell Metabol."},{"issue":"8","key":"10.1016\/j.biomaterials.2019.01.008_bib24","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.2337\/db16-1147","article-title":"Mechanisms of insulin resistance in primary and secondary nonalcoholic fatty liver","volume":"66","author":"Jelenik","year":"2017","journal-title":"Diabetes"},{"issue":"5","key":"10.1016\/j.biomaterials.2019.01.008_bib25","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1053\/jhep.2002.32674","article-title":"Mallory body--a disease-associated type of sequestosome","volume":"35","author":"Stumptner","year":"2002","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.biomaterials.2019.01.008_bib26","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1083\/jcb.201005012","article-title":"Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection","volume":"191","author":"Riley","year":"2010","journal-title":"J. Cell Biol."},{"issue":"1","key":"10.1016\/j.biomaterials.2019.01.008_bib27","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00109-006-0125-6","article-title":"CaMKII, an emerging molecular driver for calcium homeostasis, arrhythmias, and cardiac dysfunction","volume":"85","author":"Grueter","year":"2007","journal-title":"J. Mol. Med. (Berl)"},{"issue":"4","key":"10.1016\/j.biomaterials.2019.01.008_bib28","doi-asserted-by":"crossref","first-page":"848","DOI":"10.2337\/db11-0955","article-title":"Preventing beta-cell loss and diabetes with calcium channel blockers","volume":"61","author":"Xu","year":"2012","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.biomaterials.2019.01.008_bib29","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1021\/acs.chemrev.5b00346","article-title":"Degradable controlled-release polymers and polymeric nanoparticles: mechanisms of controlling drug release","volume":"116","author":"Kamaly","year":"2016","journal-title":"Chem. Rev."},{"issue":"9","key":"10.1016\/j.biomaterials.2019.01.008_bib30","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/nrd4363","article-title":"Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies","volume":"13","author":"Mitragotri","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"issue":"12","key":"10.1016\/j.biomaterials.2019.01.008_bib31","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1164\/rccm.200504-613PP","article-title":"The potential advantages of nanoparticle drug delivery systems in chemotherapy of tuberculosis","volume":"172","author":"Gelperina","year":"2005","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"3","key":"10.1016\/j.biomaterials.2019.01.008_bib32","doi-asserted-by":"crossref","first-page":"474","DOI":"10.2174\/13816128113199990400","article-title":"Nanotechnology versus other techniques in improving drug dissolution","volume":"20","author":"Kwok","year":"2014","journal-title":"Curr. Pharmaceut. Des."},{"issue":"4","key":"10.1016\/j.biomaterials.2019.01.008_bib33","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1208\/s12249-014-0107-x","article-title":"Nanocarrier for poorly water-soluble anticancer drugs--barriers of translation and solutions","volume":"15","author":"Narvekar","year":"2014","journal-title":"AAPS PharmSciTech"},{"issue":"7","key":"10.1016\/j.biomaterials.2019.01.008_bib34","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1097\/01.prs.0000218787.49887.73","article-title":"Maxillary and mandibular osteosyntheses with PLGA and P(L\/DL)LA implants: a 5-year inpatient biocompatibility and degradation experience","volume":"117","author":"Landes","year":"2006","journal-title":"Plast. Reconstr. Surg."},{"key":"10.1016\/j.biomaterials.2019.01.008_bib35","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.2147\/IJN.S64100","article-title":"Safety evaluation of poly(lactic-co-glycolic acid)\/poly(lactic-acid) microspheres through intravitreal injection in rabbits","volume":"9","author":"Rong","year":"2014","journal-title":"Int. J. Nanomed."}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961219300146?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961219300146?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T16:39:16Z","timestamp":1758904756000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961219300146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":35,"alternative-id":["S0142961219300146"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2019.01.008","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intravenous sustained-release nifedipine ameliorates nonalcoholic fatty liver disease by restoring autophagic clearance","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2019.01.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}