{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:41:12Z","timestamp":1791567672002,"version":"4.3.4"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,6,24]],"date-time":"2019-06-24T00:00:00Z","timestamp":1561334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.biomaterials.2019.119264","type":"journal-article","created":{"date-parts":[[2019,6,23]],"date-time":"2019-06-23T13:19:14Z","timestamp":1561295954000},"page":"119264","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":136,"special_numbering":"C","title":["Synergistic triple-combination therapy with hyaluronic acid-shelled PPy\/CPT nanoparticles results in tumor regression and prevents tumor recurrence and metastasis in 4T1 breast cancer"],"prefix":"10.1016","volume":"217","author":[{"given":"Wei","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuyu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinhua","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.biomaterials.2019.119264_bib1","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1080\/15384047.2014.1003004","article-title":"COX-2 dependent regulation of mechanotransduction in human breast cancer cells","volume":"16","author":"Rum","year":"2015","journal-title":"J. Sci. Cancer Biol Ther."},{"key":"10.1016\/j.biomaterials.2019.119264_bib2","doi-asserted-by":"crossref","first-page":"27871","DOI":"10.1038\/srep27871","article-title":"Phototheranostics of CD44-positive cell populations in triple negative breast cancer","volume":"6","author":"Jin","year":"2016","journal-title":"J. Sci Rep."},{"issue":"12","key":"10.1016\/j.biomaterials.2019.119264_bib3","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/nrclinonc.2010.154","article-title":"Triple-negative breast cancer: disease entity or title of convenience?","volume":"7","author":"Carey","year":"2010","journal-title":"J. Sci. Nat Rev Clin Oncol."},{"issue":"51","key":"10.1016\/j.biomaterials.2019.119264_bib4","doi-asserted-by":"crossref","first-page":"7939","DOI":"10.1039\/C6CC02571D","article-title":"NIR light\/H2O2-triggered nanocomposites for a highly efficient and selective synergistic photodynamic and photothermal therapy against hypoxic tumor cells","volume":"52","author":"Zhang","year":"2016","journal-title":"J. Sci. Chem Commun."},{"issue":"21","key":"10.1016\/j.biomaterials.2019.119264_bib5","first-page":"7428","article-title":"Differential induction of topoisomerase I-DNA cleavage complexes by the indenoisoquinoline MJ-III-65 (NSC 706744) and camptothecin: base sequence analysis and activity against camptothecin-resistant topoisomerases I","volume":"63","author":"Antony","year":"2003","journal-title":"Cancer Res."},{"issue":"10","key":"10.1016\/j.biomaterials.2019.119264_bib6","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1021\/ar200022e","article-title":"Cancer theranostics with near-infrared light-activatable multimodal nanoparticles","volume":"44","author":"Melancon","year":"2011","journal-title":"J. Sci. Acc Chem Res."},{"issue":"7","key":"10.1016\/j.biomaterials.2019.119264_bib7","doi-asserted-by":"crossref","first-page":"3391","DOI":"10.1039\/c0cs00180e","article-title":"Beating cancer in multiple ways using nanogold","volume":"40","author":"Dreaden","year":"2011","journal-title":"J. Sci. Chem. Soc. Revi."},{"issue":"5","key":"10.1016\/j.biomaterials.2019.119264_bib8","doi-asserted-by":"crossref","first-page":"3008","DOI":"10.1021\/nl5048972","article-title":"Dendrimer-inspired nanomaterials for the in vivo delivery of sirna to lung vasculature","volume":"15","author":"Khan","year":"2015","journal-title":"J. Sci. Nano Letters ."},{"issue":"1","key":"10.1016\/j.biomaterials.2019.119264_bib9","doi-asserted-by":"crossref","first-page":"87","DOI":"10.7150\/ntno.21942","article-title":"Construction of multifunctional Fe3O4-MTX@HBc nanoparticles for MR imaging and photothermal therapy\/chemotherapy","volume":"2","author":"Zhang","year":"2018","journal-title":"J. Sci. Nanotheranostics."},{"key":"10.1016\/j.biomaterials.2019.119264_bib10","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.canlet.2017.01.040","article-title":"Metronomic chemotherapy and immunotherapy in cancer treatment","volume":"400","author":"Chen","year":"2017","journal-title":"J. Sci. Cancer Lett."},{"issue":"51","key":"10.1016\/j.biomaterials.2019.119264_bib11","doi-asserted-by":"crossref","first-page":"16686","DOI":"10.1021\/jacs.6b09538","article-title":"Photodynamic Therapy mediated by nontoxic core\u2013shell nanoparticles synergizes with immune checkpoint blockade to elicit antitumor immunity and antimetastatic effect on breast cancer","volume":"138","author":"Duan","year":"2016","journal-title":"J. Sci. Am Chem Soc."},{"issue":"5","key":"10.1016\/j.biomaterials.2019.119264_bib12","doi-asserted-by":"crossref","first-page":"627","DOI":"10.7150\/thno.14792","article-title":"Enhanced anti-tumor efficacy through a combination of integrin \u03b1v\u03b26-targeted photodynamic therapy and immune checkpoint inhibition","volume":"6","author":"Gao","year":"2016","journal-title":"J. Sci. Theranostics."},{"key":"10.1016\/j.biomaterials.2019.119264_bib13","first-page":"1","article-title":"Programmed death ligand-1 expression in adrenocortical carcinoma: an exploratory biomarker study","volume":"3","author":"Fay","year":"2015","journal-title":"J. Sci. J Immunother Cancer."},{"issue":"2","key":"10.1016\/j.biomaterials.2019.119264_bib14","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.lungcan.2015.03.003","article-title":"Immunohistochemical status of PD-L1 in thymoma and thymic carcinoma","volume":"88","author":"Katsuya","year":"2015","journal-title":"J. Sci. Lung Cancer."},{"issue":"4","key":"10.1016\/j.biomaterials.2019.119264_bib15","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1158\/2326-6066.CIR-13-0127","article-title":"PD-L1 expression in triple-negative breast cancer","volume":"2","author":"Mittendorf","year":"2014","journal-title":"J. Cancer Immunol Res."},{"issue":"2","key":"10.1016\/j.biomaterials.2019.119264_bib16","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1159\/000445335","article-title":"Checkpoint inhibitors and their application in breast cancer","volume":"11","author":"Bedognetti","year":"2016","journal-title":"J. Sci. Breast Care"},{"issue":"5","key":"10.1016\/j.biomaterials.2019.119264_bib17","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nrc.2016.36","article-title":"Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy","volume":"16","author":"Topalian","year":"2016","journal-title":"J. Sci. Nat Rev Cancer."},{"issue":"5","key":"10.1016\/j.biomaterials.2019.119264_bib18","doi-asserted-by":"crossref","first-page":"4463","DOI":"10.1021\/acsnano.7b00715","article-title":"Near-infrared-triggered photodynamic therapy with multi-tasking upconversion nanoparticles in combination with checkpoint blockade for immunotherapy of colorectal cancer","volume":"11","author":"Xu","year":"2017","journal-title":"J. Sci. Acs Nano."},{"issue":"3","key":"10.1016\/j.biomaterials.2019.119264_bib19","doi-asserted-by":"crossref","first-page":"290","DOI":"10.7150\/thno.7341","article-title":"Radiolabeled nanoparticles for multimodality tumor imaging","volume":"4","author":"Xing","year":"2014","journal-title":"J. Sci. Theranostics."},{"key":"10.1016\/j.biomaterials.2019.119264_bib20","first-page":"711","article-title":"Nanoparticles for multimodal in vivo imaging in nanomedicine","volume":"9","author":"Key","year":"2014","journal-title":"J. Sci. Int J Nanomedicine."},{"key":"10.1016\/j.biomaterials.2019.119264_bib21","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.canlet.2017.03.030","article-title":"A tantalum oxide-based core\/shell nanoparticle for triple-modality image-guided chemo-thermal synergetic therapy of esophageal carcinoma","volume":"397","author":"Jin","year":"2017","journal-title":"J. Sci. Cancer Lett."},{"key":"10.1016\/j.biomaterials.2019.119264_bib22","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/anie.201005075","article-title":"Convertible organic nanoparticles for near-infrared photothermal ablation of cancer cells","volume":"50","author":"Yang","year":"2011","journal-title":"J. Chem. Int. Ed."},{"key":"10.1016\/j.biomaterials.2019.119264_bib23","first-page":"5586","article-title":"In vitro and in vivo near-infrared photothermal therapy of cancer using polypyrrole organic nanoparticles","volume":"25","author":"Yang","year":"2013","journal-title":"J. Sci. Adv Materi."},{"key":"10.1016\/j.biomaterials.2019.119264_bib24","doi-asserted-by":"crossref","first-page":"5605","DOI":"10.1021\/nn301539m","article-title":"Organic stealth nanoparticles for highly effective in vivo near-infrared photothermal therapy of cancer","volume":"6","author":"Cheng","year":"2012","journal-title":"J. Sci. ACS Nano."},{"key":"10.1016\/j.biomaterials.2019.119264_bib25","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jconrel.2016.06.021","article-title":"Dual CD44 and folate receptor-targeted nanoparticles for cancer diagnosis and anticancer drug delivery","volume":"236","author":"Lee","year":"2016","journal-title":"J. Control. Release"},{"issue":"7","key":"10.1016\/j.biomaterials.2019.119264_bib26","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.ejca.2010.02.024","article-title":"CD44, a therapeutic target for metastasising tumours","volume":"46","author":"Orian-Rousseau","year":"2010","journal-title":"J. Sci. Eur J Cancer."},{"issue":"2","key":"10.1016\/j.biomaterials.2019.119264_bib27","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.nano.2017.10.010","article-title":"CD44 targeting hyaluronic acid coated lapatinib nanocrystals foster the efficacy against triple-negative breast cancer","volume":"14","author":"Agrawal","year":"2017","journal-title":"J. Sci. Nanomedicine."},{"issue":"2","key":"10.1016\/j.biomaterials.2019.119264_bib28","first-page":"159","article-title":"Nanoplatform assembled from a CD44-targeted prodrug and smart liposomes for dual targeting of tumor microenvironment and cancer cells","volume":"12","author":"Lv","year":"2018","journal-title":"J. Sci. Acs Nano."},{"issue":"10","key":"10.1016\/j.biomaterials.2019.119264_bib29","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1002\/ijc.31236","article-title":"Fluorescence- and multispectral optoacoustic imaging for an optimized detection of deeply located tumors in an orthotopic mouse model of pancreatic carcinoma","volume":"142","author":"Napp","year":"2018","journal-title":"J. Sci. Int J Cancer."},{"issue":"34","key":"10.1016\/j.biomaterials.2019.119264_bib30","doi-asserted-by":"crossref","first-page":"5049","DOI":"10.1002\/adma.201501942","article-title":"Rational design and synthesis of g-Fe2O3@Au magnetic gold nanoflowers for efficient cancer theranostics","volume":"27","author":"Huang","year":"2015","journal-title":"J. Sci. Adv. Mater."},{"issue":"9","key":"10.1016\/j.biomaterials.2019.119264_bib31","first-page":"E966","article-title":"Therapeutic antitumor immunity by checkpoint blockade is enhanced by ibrutinib, an inhibitor of both BTK and ITK","volume":"112","author":"Sagivbarfi","year":"2015","journal-title":"J. Sci. Proc Natl Acad Sci U S A."},{"key":"10.1016\/j.biomaterials.2019.119264_bib32","doi-asserted-by":"crossref","first-page":"13193","DOI":"10.1038\/ncomms13193","article-title":"Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy","volume":"7","author":"Chen","year":"2016","journal-title":"J. Sci. Nat Commun"},{"issue":"48","key":"10.1016\/j.biomaterials.2019.119264_bib33","doi-asserted-by":"crossref","first-page":"8154","DOI":"10.1002\/adma.201402996","article-title":"Immunological responses triggered by photothermal therapy with carbon nanotubes in combination with anti\u2010CTLA\u20104 therapy to inhibit cancer metastasis","volume":"26","author":"Wang","year":"2014","journal-title":"J. Sci. Adv Mater."},{"issue":"9","key":"10.1016\/j.biomaterials.2019.119264_bib34","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/nnano.2017.113","article-title":"Antigen-capturing nanoparticles improve the abscopal effect and cancer immunotherapy","volume":"12","author":"Min","year":"2017","journal-title":"J. Sci. Nat Nanotechnol."},{"issue":"2","key":"10.1016\/j.biomaterials.2019.119264_bib35","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2015.1074374","article-title":"Hydrogel dual delivered celecoxib and anti-PD-1 synergistically improve antitumor immunity","volume":"5","author":"Li","year":"2015","journal-title":"OncoImmunology"},{"issue":"10","key":"10.1016\/j.biomaterials.2019.119264_bib36","article-title":"Nanoparticle-enhanced radiotherapy to trigger robust cancer immunotherapy","volume":"31","author":"Chen","year":"2019","journal-title":"J. Sci. Adv Mater."},{"issue":"6","key":"10.1016\/j.biomaterials.2019.119264_bib37","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/nm.4078","article-title":"The EGFR-specific antibody cetuximab combined with chemotherapy triggers immunogenic cell death","volume":"22","author":"Pozzi","year":"2016","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.biomaterials.2019.119264_bib38","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1038\/s41467-019-09401-9","article-title":"IL-4 together with IL-1\u03b2 induces antitumor Th9 cell differentiation in the absence of TGF-\u03b2 signaling","volume":"10","author":"Xue","year":"2019","journal-title":"J. Sci. Nat commun."},{"issue":"8","key":"10.1016\/j.biomaterials.2019.119264_bib39","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1097\/CJI.0b013e3181acec1e","article-title":"IL-4 suppresses very late antigen-4 expression which is required for therapeutic Th1 T-cell trafficking into tumors","volume":"32","author":"Sasaki","year":"2009","journal-title":"J. Sci. J Immunother."},{"issue":"2","key":"10.1016\/j.biomaterials.2019.119264_bib40","first-page":"196","article-title":"Activated T cells express the OX40 ligand: requirements for induction and costimulatory function","volume":"117","author":"Mendel","year":"2006","journal-title":"J. Sci. Immunology"},{"issue":"1","key":"10.1016\/j.biomaterials.2019.119264_bib41","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/j.1600-065X.2009.00766.x","article-title":"The significance of OX40 and OX40L to T-cell biology and immune disease","volume":"229","author":"Croft","year":"2009","journal-title":"J. Sci. Immunol Rev."},{"issue":"1","key":"10.1016\/j.biomaterials.2019.119264_bib42","doi-asserted-by":"crossref","first-page":"844","DOI":"10.3892\/ol.2017.6202","article-title":"The novel immunomodulator IMMUNEPOTENT CRP combined with chemotherapy agent increased the rate of immunogenic cell death and prevented melanoma growth","volume":"14","author":"Rodriguez-Salazar","year":"2017","journal-title":"J. Sci. Oncol Lett."},{"issue":"1","key":"10.1016\/j.biomaterials.2019.119264_bib43","doi-asserted-by":"crossref","first-page":"4644","DOI":"10.1038\/s41467-018-06807-9","article-title":"Macrophages regulate the clearance of living cells by calreticulin","volume":"9","author":"Krysko","year":"2018","journal-title":"J. sci. Nat Commun."},{"issue":"1","key":"10.1016\/j.biomaterials.2019.119264_bib44","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1038\/s41467-018-04703-w","article-title":"Nanoscale metal-organic frameworks enhance radiotherapy to potentiate checkpoint blockade immunotherapy","volume":"9","author":"Ni","year":"2018","journal-title":"J. Sci. Nat Commun."},{"issue":"4","key":"10.1016\/j.biomaterials.2019.119264_bib45","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nm.4287","article-title":"Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice","volume":"23","author":"Beckerman","year":"2017","journal-title":"Nat. Med."},{"issue":"8","key":"10.1016\/j.biomaterials.2019.119264_bib46","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/s41551-018-0262-6","article-title":"Combined local immunostimulatory radioisotope therapy and systemic immune checkpoint blockade imparts potent antitumour responses","volume":"2","author":"Yu","year":"2018","journal-title":"J. Sci. Nat Biomed Eng."}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961219303631?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961219303631?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T16:46:13Z","timestamp":1758905173000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961219303631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":46,"alternative-id":["S0142961219303631"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2019.119264","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synergistic triple-combination therapy with hyaluronic acid-shelled PPy\/CPT nanoparticles results in tumor regression and prevents tumor recurrence and metastasis in 4T1 breast cancer","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2019.119264","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"119264"}}