{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T05:54:37Z","timestamp":1769061277210,"version":"3.49.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Samsung Research Funding Center"},{"DOI":"10.13039\/100004358","name":"Samsung Electronics","doi-asserted-by":"publisher","award":["SRFC-MA1402-05"],"award-info":[{"award-number":["SRFC-MA1402-05"]}],"id":[{"id":"10.13039\/100004358","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.biomaterials.2019.119600","type":"journal-article","created":{"date-parts":[[2019,11,3]],"date-time":"2019-11-03T23:27:33Z","timestamp":1572823653000},"page":"119600","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Differential characterization of hepatic tumors in MR imaging by burst-released Mn2+-ions from hollow manganese-silicate nanoparticles in the liver"],"prefix":"10.1016","volume":"230","author":[{"given":"Jin Goo","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moon-Sun","family":"Jang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nitee","family":"Kumari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Kyu","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geun Ho","family":"Im","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taewan","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Hee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won Jae","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In Su","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biomaterials.2019.119600_bib1","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.1021\/cr100025t","article-title":"Challenges for molecular magnetic resonance imaging","volume":"110","author":"Terreno","year":"2010","journal-title":"Chem. Rev."},{"key":"10.1016\/j.biomaterials.2019.119600_bib2","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1148\/rg.266065014","article-title":"MR contrast agents for liver imaging: what, when, how","volume":"26","author":"Gandhi","year":"2006","journal-title":"RadioGraphics"},{"key":"10.1016\/j.biomaterials.2019.119600_bib3","doi-asserted-by":"crossref","first-page":"W154","DOI":"10.2214\/AJR.05.1421","article-title":"Diagnostic accuracy of rim and segmental MRI enhancement of colorectal hepatic metastasis after administration of mangafodipir trisodium","volume":"188","author":"Koh","year":"2007","journal-title":"AJR Am. J. Roentgenol."},{"key":"10.1016\/j.biomaterials.2019.119600_bib4","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1148\/rg.296095515","article-title":"Hepatobiliary-specific MR contrast agents: role in imaging the liver and biliary tree","volume":"29","author":"Seale","year":"2009","journal-title":"RadioGraphics"},{"key":"10.1016\/j.biomaterials.2019.119600_bib5","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1148\/rg.316115528","article-title":"Diagnostic challenges and pitfalls in MR imaging with hepatocyte-specific contrast agents","volume":"31","author":"Goodwin","year":"2011","journal-title":"RadioGraphics"},{"key":"10.1016\/j.biomaterials.2019.119600_bib6","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1053\/j.sult.2012.11.004","article-title":"The role of hepatocyte-specific contrast agents in hepatobiliary magnetic resonance imaging","volume":"34","author":"Burke","year":"2013","journal-title":"Semin. Ultrasound CT MRI"},{"key":"10.1016\/j.biomaterials.2019.119600_bib7","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.ejrad.2008.02.011","article-title":"Nephrogenic systemic fibrosis associated with gadolinium based contrast agents: a summary of the medical literature reporting","volume":"66","author":"Broome","year":"2008","journal-title":"Eur. J. Radiol."},{"key":"10.1016\/j.biomaterials.2019.119600_bib8","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1148\/rg.296095517","article-title":"Nephrogenic systemic fibrosis and its impact on abdominal imaging","volume":"29","author":"Prince","year":"2009","journal-title":"RadioGraphics"},{"key":"10.1016\/j.biomaterials.2019.119600_bib9","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1148\/radiol.2016160674","article-title":"Global and regional brain assessment with quantitative MR imaging in patients with prior exposure to linear gadolinium-based contrast agents","volume":"283","author":"Kuno","year":"2017","journal-title":"Radiology"},{"key":"10.1016\/j.biomaterials.2019.119600_bib10","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.3174\/ajnr.A4615","article-title":"Gadolinium-based contrast agent accumulation and toxicity: an update","volume":"37","author":"Ramalho","year":"2016","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"10.1016\/j.biomaterials.2019.119600_bib11","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/nnano.2016.72","article-title":"A pH-activatable nanoparticle with signal-amplification capabilities for non-invasive imaging of tumour malignancy","volume":"11","author":"Mi","year":"2016","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.biomaterials.2019.119600_bib12","doi-asserted-by":"crossref","first-page":"3560","DOI":"10.1016\/j.biomaterials.2012.01.062","article-title":"The use of silica coated MnO nanoparticles to control MRI relaxivity in response to specific physiological changes","volume":"33","author":"Lee","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2019.119600_bib13","doi-asserted-by":"crossref","first-page":"10589","DOI":"10.1002\/anie.201103108","article-title":"Urchin\u2010shaped manganese oxide nanoparticles as pH\u2010responsive activatable T1 contrast agents for magnetic resonance imaging","volume":"50","author":"Kim","year":"2011","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.biomaterials.2019.119600_bib14","doi-asserted-by":"crossref","first-page":"3438","DOI":"10.1021\/nn1019779","article-title":"Biocompatible and pH-sensitive PLGA encapsulated MnO nanocrystals for molecular and cellular MRI","volume":"5","author":"Bennewitz","year":"2011","journal-title":"ACS Nano"},{"key":"10.1016\/j.biomaterials.2019.119600_bib15","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.actbio.2015.11.036","article-title":"Mesoporous manganese silicate coated silica nanoparticles as multi-stimuli-responsive T1-MRI contrast agents and drug delivery carriers","volume":"30","author":"Li","year":"2016","journal-title":"Acta Biomater."},{"key":"10.1016\/j.biomaterials.2019.119600_bib16","doi-asserted-by":"crossref","first-page":"5373","DOI":"10.1021\/acsami.5b00727","article-title":"pH-responsive iron manganese silicate nanoparticles as T1-T2* dual-modal imaging probes for tumor diagnosis","volume":"7","author":"Chen","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.biomaterials.2019.119600_bib17","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1021\/ar3000986","article-title":"Mesoporous silica nanoparticle nanocarriers: biofunctionality and biocompatibility","volume":"46","author":"Tarn","year":"2013","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.biomaterials.2019.119600_bib18","doi-asserted-by":"crossref","first-page":"7126","DOI":"10.1016\/j.biomaterials.2012.06.059","article-title":"Manganese oxide-based multifunctionalized mesoporous silica nanoparticles for pH-responsive MRI, ultrasonography and circumvention of MDR in cancer cells","volume":"33","author":"Chen","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2019.119600_bib19","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1039\/C5CS00699F","article-title":"In vivo degeneration and the fate of inorganic nanoparticles","volume":"45","author":"Feliu","year":"2016","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.biomaterials.2019.119600_bib20","doi-asserted-by":"crossref","first-page":"7151","DOI":"10.1021\/nn101643u","article-title":"Effects of nanoparticle size on cellular uptake and liver MRI with polyvinylpyrrolidone-coated iron oxide nanoparticles","volume":"4","author":"Huang","year":"2010","journal-title":"ACS Nano"},{"key":"10.1016\/j.biomaterials.2019.119600_bib21","doi-asserted-by":"crossref","first-page":"8941","DOI":"10.1016\/j.biomaterials.2013.08.009","article-title":"Mn2+-doped silica nanoparticles for hepatocyte-targeted detection of liver cancer in T1-weighted MRI","volume":"34","author":"Kim","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2019.119600_bib22","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1080\/02841859709172407","article-title":"Cardiovascular safety of MnDPDP and MnCl2","volume":"38","author":"Jynge","year":"1997","journal-title":"Acta Radiol."},{"key":"10.1016\/j.biomaterials.2019.119600_bib23","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/j.crad.2008.04.018","article-title":"Mangafodipir trisodium-enhanced MRI of hepatocellular carcinoma: correlation with histological characteristics","volume":"63","author":"Kim","year":"2008","journal-title":"Clin. Radiol."},{"key":"10.1016\/j.biomaterials.2019.119600_bib24","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ymeth.2009.03.014","article-title":"Tumor models and specific contrast agents for small animal imaging in oncology","volume":"48","author":"Ni","year":"2009","journal-title":"Methods"},{"key":"10.1016\/j.biomaterials.2019.119600_bib25","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1002\/smll.201402379","article-title":"Mechanistic insight into the yolk@shell transformation of MnO@Silica nanospheres incorporating Ni2+ ions toward a colloidal hollow nanoreactor","volume":"11","author":"Kim","year":"2015","journal-title":"Small"},{"key":"10.1016\/j.biomaterials.2019.119600_bib26","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1080\/02841859709172402","article-title":"Comparison of manganese biodistribution and MR contrast enhancement in rats after intravenous injection of MnDPDP and MnCl2","volume":"38","author":"Ni","year":"1997","journal-title":"Acta Radiol."},{"key":"10.1016\/j.biomaterials.2019.119600_bib27","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1002\/jmri.1880080325","article-title":"Uptake of mangafodipir trisodium in liver metastases from endocrine tumors","volume":"8","author":"Wang","year":"1998","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.biomaterials.2019.119600_bib28","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/(SICI)1522-2586(199908)10:2<193::AID-JMRI13>3.0.CO;2-2","article-title":"Unexpected MR\u2010T1 enhancement of endocrine liver metastases with mangafodipir","volume":"10","author":"Mathieu","year":"1999","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.biomaterials.2019.119600_bib29","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/jmri.22024","article-title":"Decreased incidence of NSF in patients on dialysis after changing gadolinium contrast\u2010enhanced MRI protocols","volume":"31","author":"Martin","year":"2010","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.biomaterials.2019.119600_bib30","first-page":"638","article-title":"MnDPDP for MR imaging of the liver: results of an independent image evaluation of the European phase III studies","volume":"38","author":"Rummey","year":"1997","journal-title":"Acta Radiol."},{"key":"10.1016\/j.biomaterials.2019.119600_bib31","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1080\/02841859709172405","article-title":"Clinical implications of studies with MnDPDP in animal models of hepatic abnormalities","volume":"38","author":"Ni","year":"1997","journal-title":"Acta Radiol."},{"key":"10.1016\/j.biomaterials.2019.119600_bib32","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1002\/jmri.20557","article-title":"Mangafodipir trisodium\u2010enhanced MRI for the detection and characterization of focal hepatic lesions: is delayed imaging useful?","volume":"23","author":"Chung","year":"2006","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.biomaterials.2019.119600_bib33","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1148\/radiology.188.1.8390071","article-title":"Experimental liver cancers: Mn-DPDP-enhanced rims in MR-microangiographic-histologic correlation study","volume":"188","author":"Ni","year":"1993","journal-title":"Radiology"},{"key":"10.1016\/j.biomaterials.2019.119600_bib34","doi-asserted-by":"crossref","first-page":"4131","DOI":"10.1021\/nn200809t","article-title":"Use of size and a copolymer design feature to improve the biodistribution and the enhanced permeability and retention effect of doxorubicin-loaded mesoporous silica nanoparticles in a murine xenograft tumor model","volume":"5","author":"Meng","year":"2011","journal-title":"ACS Nano"},{"key":"10.1016\/j.biomaterials.2019.119600_bib35","doi-asserted-by":"crossref","first-page":"11937","DOI":"10.1073\/pnas.1613466113","article-title":"Hypoxia-activated cytotoxic agent tirapazamine enhances hepatic artery ligation-induced killing of liver tumor in HBx transgenic mice","volume":"113","author":"Lin","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.biomaterials.2019.119600_bib36","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1002\/jmri.21504","article-title":"Manganese\u2010enhanced MRI of the rat visual pathway: acute neural toxicity, contrast enhancement, axon resolution, axonal transport, and clearance of Mn2+","volume":"28","author":"Thuen","year":"2008","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.biomaterials.2019.119600_bib37a","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1258\/ar.2012.120034","article-title":"A new manganese-based oral contrast agent (CMC-001) for liver MRI: pharmacological and pharmaceutical aspects","volume":"53","author":"Jorgensen","year":"2012","journal-title":"Acta Radiol."},{"key":"10.1016\/j.biomaterials.2019.119600_bib37b","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.mam.2005.07.003","article-title":"Nutritional aspects of manganese homeostasis","volume":"26","author":"Aschner","year":"2005","journal-title":"Mol. Asp. Med."}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961219306994?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961219306994?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T16:52:57Z","timestamp":1758905577000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961219306994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":38,"alternative-id":["S0142961219306994"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2019.119600","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential characterization of hepatic tumors in MR imaging by burst-released Mn2+-ions from hollow manganese-silicate nanoparticles in the liver","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2019.119600","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"119600"}}