{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:32:34Z","timestamp":1790706754387,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.biomaterials.2020.120076","type":"journal-article","created":{"date-parts":[[2020,4,26]],"date-time":"2020-04-26T05:22:46Z","timestamp":1587878566000},"page":"120076","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"special_numbering":"C","title":["Enhanced Bax upregulating in mitochondria for deep tumor therapy based on SO2 prodrug loaded Au\u2013Ag hollow nanotriangles"],"prefix":"10.1016","volume":"250","author":[{"given":"Min","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianglan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilin","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jining","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biomaterials.2020.120076_bib1","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1021\/ja309812z","article-title":"Nanoparticle adhesion to the cell membrane and its effect on nanoparticle uptake efficiency","volume":"135","author":"Lesniak","year":"2013","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.biomaterials.2020.120076_bib2","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.jconrel.2013.09.026","article-title":"Mind the gap: a survey of how cancer drug carriers are susceptible to the gap between research and practice","volume":"172","author":"Stirland","year":"2013","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.biomaterials.2020.120076_bib3","doi-asserted-by":"crossref","first-page":"7305","DOI":"10.1021\/nn502372n","article-title":"Fumagillin prodrug nanotherapy suppresses macrophage inflammatory response via endothelial nitric oxide","volume":"8","author":"Zhou","year":"2014","journal-title":"ACS Nano"},{"key":"10.1016\/j.biomaterials.2020.120076_bib4","doi-asserted-by":"crossref","first-page":"14026","DOI":"10.1002\/anie.201504536","article-title":"X\u2010ray radiation\u2010controlled NO\u2010release for on\u2010demand depth\u2010independent hypoxic radiosensitization","volume":"54","author":"Fan","year":"2015","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.biomaterials.2020.120076_bib5","doi-asserted-by":"crossref","first-page":"10816","DOI":"10.1021\/acsnano.6b04921","article-title":"Ultrasound-triggered nitric oxide release platform based on energy transformation for targeted inhibition of pancreatic tumor","volume":"10","author":"Zhang","year":"2016","journal-title":"ACS Nano"},{"key":"10.1016\/j.biomaterials.2020.120076_bib6","doi-asserted-by":"crossref","first-page":"13804","DOI":"10.1021\/acsami.6b03737","article-title":"Light-responsive biodegradable nanomedicine overcomes multidrug resistance via NO-enhanced chemosensitization","volume":"8","author":"Fan","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.biomaterials.2020.120076_bib7","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1002\/anie.201610682","article-title":"Glucose\u2010responsive sequential generation of hydrogen peroxide and nitric oxide for synergistic cancer starving\u2010like\/gas therapy","volume":"56","author":"Fan","year":"2017","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.biomaterials.2020.120076_bib8","doi-asserted-by":"crossref","first-page":"6741","DOI":"10.1002\/adma.201502762","article-title":"NIR\u2010responsive on\u2010demand release of CO from metal carbonyl\u2010caged graphene oxide nanomedicine","volume":"27","author":"He","year":"2015","journal-title":"Adv. Mater."},{"key":"10.1016\/j.biomaterials.2020.120076_bib9","doi-asserted-by":"crossref","first-page":"5557","DOI":"10.1039\/C7CC01576C","article-title":"Intratumoral H2O2-triggered release of CO from a metal carbonyl-based nanomedicine for efficient CO therapy","volume":"53","author":"Jin","year":"2017","journal-title":"Chem. Commun."},{"key":"10.1016\/j.biomaterials.2020.120076_bib10","doi-asserted-by":"crossref","first-page":"1703822","DOI":"10.1002\/adma.201703822","article-title":"Photocatalyzing CO2 to CO for enhanced cancer therapy","volume":"29","author":"Zheng","year":"2017","journal-title":"Adv. Mater."},{"key":"10.1016\/j.biomaterials.2020.120076_bib11","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1111\/bph.12368","article-title":"Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part II. Pathophysiological and therapeutic aspects","volume":"171","author":"M\u00f3dis","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.biomaterials.2020.120076_bib12","doi-asserted-by":"crossref","first-page":"6336","DOI":"10.1021\/jacs.6b01373","article-title":"pH-controlled hydrogen sulfide release for myocardial ischemia-reperfusion injury","volume":"138","author":"Kang","year":"2016","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.biomaterials.2020.120076_bib13","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1111\/bph.12811","article-title":"The role of gasotransmitters NO, H2S and CO in myocardial ischaemia\/reperfusion injury and cardioprotection by preconditioning, postconditioning and remote conditioning","volume":"172","author":"Andreadou","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.biomaterials.2020.120076_bib14","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1039\/C7BM00699C","article-title":"Precision gas therapy using intelligent nanomedicine","volume":"5","author":"He","year":"2017","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.biomaterials.2020.120076_bib15","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.3109\/08958370902798463","article-title":"Vasodilator effect of gaseous sulfur dioxide and regulation of its level by Ach in rat vascular tissues","volume":"21","author":"Meng","year":"2009","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.biomaterials.2020.120076_bib16","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1021\/jm201023g","article-title":"Design, synthesis, and evaluation of thiol-activated sources of sulfur dioxide (SO2) as antimycobacterial agents","volume":"55","author":"Malwal","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.biomaterials.2020.120076_bib17","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.biomaterials.2018.02.011","article-title":"A glutathione-responsive sulfur dioxide polymer prodrug as a nanocarrier for combating drug-resistance in cancer chemotherapy","volume":"178","author":"Shen","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2020.120076_bib18","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.lfs.2013.12.027","article-title":"Sulfur dioxide, a double-faced molecule in mammals","volume":"98","author":"Wang","year":"2014","journal-title":"Life Sci."},{"key":"10.1016\/j.biomaterials.2020.120076_bib19","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/8961951","article-title":"Endogenous sulfur dioxide: a new member of gasotransmitter family in the cardiovascular system","volume":"2016","author":"Huang","year":"2016","journal-title":"Oxid. Med. Cell. Longevity"},{"key":"10.1016\/j.biomaterials.2020.120076_bib20","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/751075","article-title":"Noble metal nanoparticles applications in cancer","volume":"2012","author":"Conde","year":"2012","journal-title":"J. Drug. Delivery"},{"key":"10.1016\/j.biomaterials.2020.120076_bib21","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1080\/1061186X.2017.1387790","article-title":"The promising potentials of capped gold nanoparticles for drug delivery systems","volume":"26","author":"Khoshnevisan","year":"2018","journal-title":"J. Drug Target."},{"key":"10.1016\/j.biomaterials.2020.120076_bib22","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1080\/10717540490433895","article-title":"Colloidal gold: a novel nanoparticle vector for tumor directed drug delivery","volume":"11","author":"Paciotti","year":"2004","journal-title":"Drug Deliv."},{"key":"10.1016\/j.biomaterials.2020.120076_bib23","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1021\/bc9002212","article-title":"Tamoxifen-poly (ethylene glycol)-thiol gold nanoparticle conjugates: enhanced potency and selective delivery for breast cancer treatment","volume":"20","author":"Dreaden","year":"2009","journal-title":"Bioconjugate Chem."},{"key":"10.1016\/j.biomaterials.2020.120076_bib24","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1021\/cm903357q","article-title":"Smart core-shell hybrid nanogels with Ag nanoparticle core for cancer cell imaging and gel shell for pH-regulated drug delivery","volume":"22","author":"Wu","year":"2010","journal-title":"Chem. Mater."},{"key":"10.1016\/j.biomaterials.2020.120076_bib25","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1002\/adfm.201101960","article-title":"Photo-and pH-triggered release of anticancer drugs from mesoporous silica-coated Pd@Ag nanoparticles","volume":"22","author":"Fang","year":"2012","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.biomaterials.2020.120076_bib26","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1007\/s00204-014-1245-3","article-title":"The optical, photothermal, and facile surface chemical properties of gold and silver nanoparticles in biodiagnostics, therapy, and drug delivery","volume":"88","author":"Austin","year":"2014","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.biomaterials.2020.120076_bib27","doi-asserted-by":"crossref","first-page":"12582","DOI":"10.1039\/c3nr04304e","article-title":"A dealloying process of core-shell Au@ AuAg nanorods for porous nanorods with enhanced catalytic activity","volume":"5","author":"Guo","year":"2013","journal-title":"Nanoscale"},{"key":"10.1016\/j.biomaterials.2020.120076_bib28","doi-asserted-by":"crossref","first-page":"6722","DOI":"10.1021\/la400728k","article-title":"Synthesis of hollow Ag-Au bimetallic nanoparticles in polyelectrolyte multilayers","volume":"29","author":"Zhang","year":"2013","journal-title":"Langmuir"},{"key":"10.1016\/j.biomaterials.2020.120076_bib29","doi-asserted-by":"crossref","first-page":"7073","DOI":"10.1039\/C6RA25956A","article-title":"A flexible conductive film prepared by the oriented stacking of Ag and Au\/Ag alloy nanoplates and its chemically roughened surface for explosive SERS detection and cell adhesion","volume":"7","author":"Sun","year":"2017","journal-title":"RSC Adv."},{"key":"10.1016\/j.biomaterials.2020.120076_bib30","doi-asserted-by":"crossref","first-page":"12559","DOI":"10.1021\/acs.langmuir.6b02064","article-title":"Reverse size dependences of the cellular uptake of triangular and spherical gold nanoparticles","volume":"32","author":"Nambara","year":"2016","journal-title":"Langmuir"},{"key":"10.1016\/j.biomaterials.2020.120076_bib31","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1021\/nn505468v","article-title":"Dissecting the molecular mechanism of apoptosis during photothermal therapy using gold nanoprisms","volume":"9","author":"P\u00e9rez-Hern\u00e1ndez","year":"2014","journal-title":"ACS Nano"},{"key":"10.1016\/j.biomaterials.2020.120076_bib32","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1021\/acsnano.5b00021","article-title":"Elucidating the fundamental mechanisms of cell death triggered by photothermal therapy","volume":"9","author":"Melamed","year":"2015","journal-title":"ACS Nano"},{"key":"10.1016\/j.biomaterials.2020.120076_bib33","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1021\/jm201023g","article-title":"Design, synthesis, and evaluation of thiol-activated sources of sulfur dioxide (SO2) as antimycobacterial agents","volume":"55","author":"Malwal","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.biomaterials.2020.120076_bib34","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1039\/C4OB02466D","article-title":"Benzosulfones as photochemically activated sulfur dioxide (SO2) donors","volume":"13","author":"Malwal","year":"2015","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.biomaterials.2020.120076_bib35","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1021\/acschembio.6b00106","article-title":"Benzothiazole sulfinate: a water-soluble and slow-releasing sulfur dioxide donor","volume":"11","author":"Day","year":"2016","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.biomaterials.2020.120076_bib36","first-page":"89","article-title":"Sulphur dioxide: a potent glutathione depleting agent","volume":"114","author":"Langley-Evans","year":"1996","journal-title":"Toxicol. Endo."},{"key":"10.1016\/j.biomaterials.2020.120076_bib37","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.tox.2005.08.016","article-title":"Expression of apoptosis-related genes in livers from rats exposed to sulfur dioxide","volume":"216","author":"Bai","year":"2005","journal-title":"Toxicology"},{"key":"10.1016\/j.biomaterials.2020.120076_bib38","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1080\/08958370701399885","article-title":"Protein oxidation and DNA\u2013protein crosslink induced by sulfur dioxide in lungs, livers, and hearts from mice","volume":"19","author":"Xie","year":"2007","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.biomaterials.2020.120076_bib39","doi-asserted-by":"crossref","first-page":"8758","DOI":"10.1007\/s11356-019-04319-7","article-title":"Sulfur dioxide induces apoptosis via reactive oxygen species generation in rat cardiomyocytes","volume":"26","author":"Li","year":"2019","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.biomaterials.2020.120076_bib40","doi-asserted-by":"crossref","first-page":"18931","DOI":"10.1021\/ja2080345","article-title":"A systematic study of the synthesis of silver nanoplates: is citrate a \u201cmagic\u201d reagent?","volume":"133","author":"Zhang","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.biomaterials.2020.120076_bib41","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.snb.2012.03.034","article-title":"A novel coumarin-based fluorescent probe for selective detection of bissulfite anions in water and sugar samples","volume":"166","author":"Yang","year":"2012","journal-title":"Sens. Actuators, B"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961220303227?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961220303227?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T16:52:15Z","timestamp":1758905535000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961220303227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":41,"alternative-id":["S0142961220303227"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2020.120076","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enhanced Bax upregulating in mitochondria for deep tumor therapy based on SO2 prodrug loaded Au\u2013Ag hollow nanotriangles","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2020.120076","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"120076"}}