{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T12:37:35Z","timestamp":1793968655583,"version":"4.8.0"},"reference-count":236,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.biomaterials.2020.120355","type":"journal-article","created":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T20:31:50Z","timestamp":1599597110000},"page":"120355","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":203,"special_numbering":"C","title":["Lactoferrin, a multi-functional glycoprotein: Active therapeutic, drug nanocarrier & targeting ligand"],"prefix":"10.1016","volume":"263","author":[{"given":"Ahmed O.","family":"Elzoghby","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona A.","family":"Abdelmoneem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Islam A.","family":"Hassanin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud M.","family":"Abd Elwakil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manar A.","family":"Elnaggar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Mokhtar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-You","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kadria A.","family":"Elkhodairy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biomaterials.2020.120355_bib1","first-page":"55","article-title":"The Proteins in Whey, Whey. Compte rendu des Travaux du Laboratoire de Carlsberg Ser","volume":"23","author":"Sorensen","year":"1939","journal-title":"Chim."},{"issue":"13","key":"10.1016\/j.biomaterials.2020.120355_bib2","doi-asserted-by":"crossref","first-page":"3345","DOI":"10.1021\/ja01498a029","article-title":"The isolation of a red protein from Milk2","volume":"82","author":"Groves","year":"1960","journal-title":"J. Am. Chem. Soc."},{"issue":"1","key":"10.1016\/j.biomaterials.2020.120355_bib3","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0162-0134(92)84061-Q","article-title":"New perspectives on the structure and function of transferrins","volume":"47","author":"Baker","year":"1992","journal-title":"J. Inorg. Biochem."},{"issue":"1","key":"10.1016\/j.biomaterials.2020.120355_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/molecules21010004","article-title":"Introduction to Nanomedicine","volume":"21","author":"Astruc","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.biomaterials.2020.120355_bib5","series-title":"Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents","first-page":"243","article-title":"Chapter 8 - iron bond bovine lactoferrin for the treatment of cancers and anemia associated with cancer cachexia","author":"Aboda","year":"2020"},{"issue":"20","key":"10.1016\/j.biomaterials.2020.120355_bib6","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.2217\/nnm-2018-0110","article-title":"Aurora kinase B siRNA-loaded lactoferrin nanoparticles potentiate the efficacy of temozolomide in treating glioblastoma","volume":"13","author":"Kumari","year":"2018","journal-title":"Nanomedicine"},{"key":"10.1016\/j.biomaterials.2020.120355_bib7","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.foodhyd.2013.06.021","article-title":"Sensitivity of emulsions stabilised by bovine \u03b2-casein and lactoferrin to heat and CaCl2","volume":"35","author":"McCarthy","year":"2014","journal-title":"Food Hydrocolloids"},{"issue":"4","key":"10.1016\/j.biomaterials.2020.120355_bib8","doi-asserted-by":"crossref","first-page":"301. e1","DOI":"10.1016\/j.ijantimicag.2008.07.020","article-title":"Lactoferrin: structure, function and applications","volume":"33","author":"Gonz\u00e1lez-Ch\u00e1vez","year":"2009","journal-title":"Int. J. Antimicrob. Agents"},{"issue":"9","key":"10.1016\/j.biomaterials.2020.120355_bib9","doi-asserted-by":"crossref","first-page":"457","DOI":"10.17221\/1978-VETMED","article-title":"Lactoferrin: a review","volume":"53","author":"Adlerova","year":"2008","journal-title":"Vet. Med."},{"issue":"17","key":"10.1016\/j.biomaterials.2020.120355_bib10","doi-asserted-by":"crossref","first-page":"4269","DOI":"10.1016\/S0021-9258(19)63790-7","article-title":"Structural studies on bovine lactoferrin","volume":"245","author":"Castellino","year":"1970","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.biomaterials.2020.120355_bib11","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/0022-2836(89)90602-5","article-title":"Structure of human lactoferrin: crystallographic structure analysis and refinement at 2\u00b7 8 \u00c5 resolution","volume":"209","author":"Anderson","year":"1989","journal-title":"J. Mol. Biol."},{"issue":"1","key":"10.1016\/j.biomaterials.2020.120355_bib12","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1146\/annurev.nu.15.070195.000521","article-title":"Lactoferrin: molecular structure and biological function","volume":"15","author":"L\u00f6nnerdal","year":"1995","journal-title":"Annu. Rev. Nutr."},{"issue":"8","key":"10.1016\/j.biomaterials.2020.120355_bib13","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.2217\/nnm.14.209","article-title":"Nanocapsules loaded with iron-saturated bovine lactoferrin have antimicrobial therapeutic potential and maintain calcium, zinc and iron metabolism","volume":"10","author":"Gupta","year":"2015","journal-title":"Nanomedicine"},{"issue":"1","key":"10.1016\/j.biomaterials.2020.120355_bib14","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2217\/nnm.14.132","article-title":"Fe-bLf nanoformulation targets survivin to kill colon cancer stem cells and maintains absorption of iron, calcium and zinc","volume":"10","author":"Kanwar","year":"2015","journal-title":"Nanomedicine"},{"key":"10.1016\/j.biomaterials.2020.120355_bib15","doi-asserted-by":"crossref","first-page":"9703","DOI":"10.3390\/molecules20069703","article-title":"Multifunctional iron bound lactoferrin and nanomedicinal a pproaches to enhance its bioactive functions","volume":"20","author":"Kanwar","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.biomaterials.2020.120355_bib16","doi-asserted-by":"crossref","first-page":"705","DOI":"10.2147\/IJN.S151474","article-title":"Intranasal delivery of Huperzine A to the brain using lactoferrin-conjugated N-trimethylated chitosan surface-modified PLGA nanoparticles for treatment of Alzheimer's disease","volume":"13","author":"Meng","year":"2018","journal-title":"Int. J. Nanomed."},{"issue":"5","key":"10.1016\/j.biomaterials.2020.120355_bib17","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1093\/jb\/mvt073","article-title":"A lactoferrin-receptor, intelectin 1, affects uptake, sub-cellular localization and release of immunochemically detectable lactoferrin by intestinal epithelial Caco-2 cells","volume":"154","author":"Akiyama","year":"2013","journal-title":"J. Biochem."},{"issue":"3","key":"10.1016\/j.biomaterials.2020.120355_bib18","doi-asserted-by":"crossref","first-page":"249","DOI":"10.2217\/nnm.15.199","article-title":"Multimodal iron oxide (Fe3O4)-saturated lactoferrin nanocapsules as nanotheranostics for real-time imaging and breast cancer therapy of claudin-low, triple-negative (ER(-)\/PR(-)\/HER2(-))","volume":"11","author":"Kanwar","year":"2016","journal-title":"Nanomedicine"},{"issue":"1","key":"10.1016\/j.biomaterials.2020.120355_bib19","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1139\/bcb-2016-0039","article-title":"Role of CXC chemokine receptor type 4 as a lactoferrin receptor","volume":"95","author":"Takayama","year":"2017","journal-title":"Biochemistry and cell biology = Biochimie et biologie cellulaire"},{"issue":"9","key":"10.1016\/j.biomaterials.2020.120355_bib20","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1111\/j.1742-4658.2010.07620.x","article-title":"Human lactoferrin activates NF-kappaB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling","volume":"277","author":"Ando","year":"2010","journal-title":"FEBS J."},{"issue":"6","key":"10.1016\/j.biomaterials.2020.120355_bib21","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1113\/expphysiol.2006.034876","article-title":"Enteric\u2010formulated lactoferrin was more effectively transported into blood circulation from gastrointestinal tract in adult rats","volume":"91","author":"Takeuchi","year":"2006","journal-title":"Exp. Physiol."},{"issue":"10","key":"10.1016\/j.biomaterials.2020.120355_bib22","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/j.intimp.2007.05.019","article-title":"Uptake of ingested bovine lactoferrin and its accumulation in adult mouse tissues","volume":"7","author":"Fischer","year":"2007","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.biomaterials.2020.120355_bib23","series-title":"Development of a Novel Drug Delivery System to Enhance the Oral Bioavailability of Lactoferrin","author":"Yao","year":"2015"},{"key":"10.1016\/j.biomaterials.2020.120355_bib24","series-title":"Lactoferrin Receptors in Intestinal Brush Border Membranes, Lactoferrin","first-page":"171","author":"L\u00f6nnerdal","year":"1994"},{"issue":"8","key":"10.1016\/j.biomaterials.2020.120355_bib25","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1093\/jn\/131.8.2101","article-title":"Gastric digestion of bovine lactoferrin in vivo in adults","volume":"131","author":"Troost","year":"2001","journal-title":"J. Nutr."},{"issue":"9","key":"10.1016\/j.biomaterials.2020.120355_bib26","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1093\/jn\/132.9.2597","article-title":"Orally ingested human lactoferrin is digested and secreted in the upper gastrointestinal tract in vivo in women with ileostomies","volume":"132","author":"Troost","year":"2002","journal-title":"J. Nutr."},{"issue":"3","key":"10.1016\/j.biomaterials.2020.120355_bib27","first-page":"252","article-title":"Lactoferrin: a general review","volume":"80","author":"Levay","year":"1995","journal-title":"Haematologica"},{"issue":"3","key":"10.1016\/j.biomaterials.2020.120355_bib28","doi-asserted-by":"crossref","first-page":"31","DOI":"10.4172\/1948-5956.1000107","article-title":"Nano-lactoferrin in diagnostic, imaging and targeted delivery for cancer and infectious diseases","volume":"4","author":"Kanwar","year":"2012","journal-title":"J. Canc. Sci. Ther."},{"issue":"3","key":"10.1016\/j.biomaterials.2020.120355_bib29","first-page":"252","article-title":"Lactoferrin: a general review","volume":"80","author":"Levay","year":"1995","journal-title":"Haematologica"},{"key":"10.1016\/j.biomaterials.2020.120355_bib30","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ejogrb.2017.10.003","article-title":"Lactoferrin or ferrous salts for iron deficiency anemia in pregnancy: a meta-analysis of randomized trials","volume":"219","author":"Abu Hashim","year":"2017","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"issue":"1","key":"10.1016\/j.biomaterials.2020.120355_bib31","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1128\/MCB.23.1.178-185.2003","article-title":"Iron status in mice carrying a targeted disruption of lactoferrin","volume":"23","author":"Ward","year":"2003","journal-title":"Mol. Cell Biol."},{"issue":"5","key":"10.1016\/j.biomaterials.2020.120355_bib32","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1136\/adc.67.5.657","article-title":"Biological role of lactoferrin","volume":"67","author":"Sanchez","year":"1992","journal-title":"Arch. Dis. Child."},{"issue":"21","key":"10.1016\/j.biomaterials.2020.120355_bib33","doi-asserted-by":"crossref","first-page":"13391","DOI":"10.1016\/S0021-9258(18)90707-6","article-title":"The effect of human serum transferrin and milk lactoferrin on hydroxyl radical formation from superoxide and hydrogen peroxide","volume":"259","author":"Baldwin","year":"1984","journal-title":"J. Biol. Chem."},{"issue":"22","key":"10.1016\/j.biomaterials.2020.120355_bib34","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1007\/s00018-005-5372-0","article-title":"Lactoferrin: an important host defence against microbial and viral attack","volume":"62","author":"Valenti","year":"2005","journal-title":"Cell. Mol. Life Sci. : CMLS"},{"issue":"1","key":"10.1016\/j.biomaterials.2020.120355_bib35","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.biochi.2008.05.006","article-title":"A structural framework for understanding the multifunctional character of lactoferrin","volume":"91","author":"Baker","year":"2009","journal-title":"Biochimie"},{"issue":"11","key":"10.1016\/j.biomaterials.2020.120355_bib36","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.1128\/iai.56.11.2774-2781.1988","article-title":"Damage of the outer membrane of enteric gram-negative bacteria by lactoferrin and transferrin","volume":"56","author":"Ellison","year":"1988","journal-title":"Infect. Immun."},{"issue":"4","key":"10.1016\/j.biomaterials.2020.120355_bib37","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.clinthera.2016.01.006","article-title":"Prevention of necrotizing enterocolitis through manipulation of the intestinal microbiota of the premature infant","volume":"38","author":"Vongbhavit","year":"2016","journal-title":"Clin. Therapeut."},{"issue":"10","key":"10.1016\/j.biomaterials.2020.120355_bib38","first-page":"706","article-title":"Use of bovine lactoferrin for Helicobacter pylori eradication, Digestive and liver disease","volume":"35","author":"Di Mario","year":"2003","journal-title":"official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver"},{"issue":"5","key":"10.1016\/j.biomaterials.2020.120355_bib39","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1007\/s10534-014-9775-y","article-title":"Bactericidal effect of bovine lactoferrin and synthetic peptide lactoferrin chimera in Streptococcus pneumoniae and the decrease in luxS gene expression by lactoferrin","volume":"27","author":"Le\u00f3n-Sicairos","year":"2014","journal-title":"Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine"},{"key":"10.1016\/j.biomaterials.2020.120355_bib40","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.3389\/fmicb.2017.02633","article-title":"Bovine lactoferrin and lactoferrin-derived peptides inhibit the growth of Vibrio cholerae and other Vibrio species","volume":"8","author":"Acosta-Smith","year":"2017","journal-title":"Front. Microbiol."},{"issue":"22","key":"10.1016\/j.biomaterials.2020.120355_bib41","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1007\/s00018-005-5369-8","article-title":"Multifunctional roles of lactoferrin: a critical overview","volume":"62","author":"Ward","year":"2005","journal-title":"Cell. Mol. Life Sci. : CMLS"},{"issue":"3","key":"10.1016\/j.biomaterials.2020.120355_bib42","doi-asserted-by":"crossref","first-page":"031","DOI":"10.4172\/1948-5956.1000107","article-title":"Nano-lactoferrin in diagnostic, imaging and targeted delivery for cancer and infectious diseases","volume":"4","author":"Kanwar","year":"2012","journal-title":"J. Canc. Sci. Ther."},{"issue":"2","key":"10.1016\/j.biomaterials.2020.120355_bib43","doi-asserted-by":"crossref","first-page":"158","DOI":"10.2174\/157489111796064560","article-title":"Targeting hepatitis B virus and human papillomavirus induced carcinogenesis: novel patented therapeutics","volume":"6","author":"Kanwar","year":"2011","journal-title":"Recent Pat. Anti-Infect. Drug Discov."},{"issue":"8","key":"10.1016\/j.biomaterials.2020.120355_bib44","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0023710","article-title":"Inhibition of SARS pseudovirus cell entry by lactoferrin binding to heparan sulfate proteoglycans","volume":"6","author":"Lang","year":"2011","journal-title":"PloS One"},{"issue":"11","key":"10.1016\/j.biomaterials.2020.120355_bib45","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1093\/emboj\/cdg279","article-title":"Caspase 3 activation is essential for efficient influenza virus propagation","volume":"22","author":"Wurzer","year":"2003","journal-title":"EMBO J."},{"issue":"3","key":"10.1016\/j.biomaterials.2020.120355_bib46","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s10534-010-9323-3","article-title":"Bovine lactoferrin inhibits influenza A virus induced programmed cell death in vitro","volume":"23","author":"Pietrantoni","year":"2010","journal-title":"Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine"},{"issue":"8","key":"10.1016\/j.biomaterials.2020.120355_bib47","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1128\/AAC.47.8.2688-2691.2003","article-title":"Bovine lactoferrin inhibits adenovirus infection by interacting with viral structural polypeptides","volume":"47","author":"Pietrantoni","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"issue":"11","key":"10.1016\/j.biomaterials.2020.120355_bib48","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1111\/j.1440-1746.2007.04858.x","article-title":"Effect of lactoferrin in patients with chronic hepatitis C: combination therapy with interferon and ribavirin","volume":"22","author":"Kaito","year":"2007","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"4","key":"10.1016\/j.biomaterials.2020.120355_bib49","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1093\/jac\/46.4.577","article-title":"Inhibition of growth of Pneumocystis carinii by lactoferrins alone and in combination with pyrimethamine, clarithromycin and minocycline","volume":"46","author":"Cirioni","year":"2000","journal-title":"J. Antimicrob. Chemother."},{"issue":"Pt 12","key":"10.1016\/j.biomaterials.2020.120355_bib50","doi-asserted-by":"crossref","first-page":"3859","DOI":"10.1099\/mic.0.28121-0","article-title":"Human hololactoferrin: endocytosis and use as an iron source by the parasite Entamoeba histolytica","volume":"151","author":"Leon-Sicairos","year":"2005","journal-title":"Microbiology"},{"issue":"2","key":"10.1016\/j.biomaterials.2020.120355_bib51","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3121\/cmr.4.2.106","article-title":"Amoebicidal activity of milk, apo-lactoferrin, sIgA and lysozyme","volume":"4","author":"Leon-Sicairos","year":"2006","journal-title":"Clin. Med. Res."},{"issue":"3","key":"10.1016\/j.biomaterials.2020.120355_bib52","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1084\/jem.184.3.945","article-title":"Remnant lipoproteins inhibit malaria sporozoite invasion of hepatocytes","volume":"184","author":"Sinnis","year":"1996","journal-title":"J. Exp. Med."},{"issue":"1","key":"10.1016\/j.biomaterials.2020.120355_bib53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-4894(87)90072-5","article-title":"Plasmodium falciparum: inhibition in vitro with lactoferrin, desferriferrithiocin, and desferricrocin","volume":"63","author":"Fritsch","year":"1987","journal-title":"Exp. Parasitol."},{"issue":"6","key":"10.1016\/j.biomaterials.2020.120355_bib54","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1093\/infdis\/124.6.539","article-title":"Inhibition of growth of Candida albicans by iron-unsaturated lactoferrin: relation to host-defense mechanisms in chronic mucocutaneous candidiasis","volume":"124","author":"Kirkpatrick","year":"1971","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.biomaterials.2020.120355_bib55","series-title":"Synergistic Anti-candida Activities of Lactoferrin and the Lactoperoxidase System","author":"Nakano","year":"2019"},{"issue":"1","key":"10.1016\/j.biomaterials.2020.120355_bib56","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/cbf.3242","article-title":"Apoptotic effects of bovine apo-lactoferrin on HeLa tumor cells","volume":"35","author":"Luzi","year":"2017","journal-title":"Cell Biochem. Funct."},{"issue":"1","key":"10.1016\/j.biomaterials.2020.120355_bib57","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1139\/bcb-2016-0094","article-title":"Bovine lactoferrin and lactoferricin exert antitumor activities on human colorectal cancer cells (HT-29) by activating various signaling pathways","volume":"95","author":"Jiang","year":"2017","journal-title":"Biochem. Cell. Biol."},{"issue":"8","key":"10.1016\/j.biomaterials.2020.120355_bib58","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1080\/01635581.2014.956260","article-title":"Bovine lactoferrin induces cell cycle arrest and inhibits mTOR signaling in breast cancer cells","volume":"66","author":"Zhang","year":"2014","journal-title":"Nutr. Canc."},{"issue":"9","key":"10.1016\/j.biomaterials.2020.120355_bib59","first-page":"704","article-title":"Effects of adenovirus vectors mediated human lactoferrin cDNA on mice bearing EMT6 breast carcinoma","volume":"66","author":"Wang","year":"2011","journal-title":"Pharmazie"},{"issue":"38","key":"10.1016\/j.biomaterials.2020.120355_bib60","doi-asserted-by":"crossref","first-page":"62144","DOI":"10.18632\/oncotarget.11394","article-title":"Lactoferrin selectively triggers apoptosis in highly metastatic breast cancer cells through inhibition of plasmalemmal V-H+-ATPase","volume":"7","author":"Pereira","year":"2016","journal-title":"Oncotarget"},{"issue":"4","key":"10.1016\/j.biomaterials.2020.120355_bib61","first-page":"477","article-title":"Growth suppression effects of recombinant adenovirus expressing human lactoferrin on cervical cancer in vitro and in vivo","volume":"26","author":"Li","year":"2011","journal-title":"Cancer Biother. Radiopharm."},{"issue":"3","key":"10.1016\/j.biomaterials.2020.120355_bib62","doi-asserted-by":"crossref","first-page":"820","DOI":"10.3892\/ol.2013.1776","article-title":"Inhibitory effects of human lactoferrin on U14 cervical carcinoma through upregulation of the immune response","volume":"7","author":"Shi","year":"2014","journal-title":"Oncology letters"},{"key":"10.1016\/j.biomaterials.2020.120355_bib63","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2018.00200","article-title":"Bovine milk lactoferrin selectively kills highly metastatic prostate cancer PC-3 and osteosarcoma MG-63 cells in vitro","volume":"8","author":"Guedes","year":"2018","journal-title":"Frontiers in oncology"},{"issue":"6","key":"10.1016\/j.biomaterials.2020.120355_bib64","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1097\/MPG.0b013e318230a419","article-title":"Bovine lactoferrin can be taken up by the human intestinal lactoferrin receptor and exert bioactivities","volume":"53","author":"Lonnerdal","year":"2011","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"issue":"2","key":"10.1016\/j.biomaterials.2020.120355_bib65","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1207\/S15327914NC382_8","article-title":"Orally administered lactoferrin exerts an antimetastatic effect and enhances production of IL-18 in the intestinal epithelium","volume":"38","author":"Kuhara","year":"2000","journal-title":"Nutr. Canc."},{"issue":"36","key":"10.1016\/j.biomaterials.2020.120355_bib66","doi-asserted-by":"crossref","first-page":"4273","DOI":"10.1038\/onc.2012.434","article-title":"Lactotransferrin acts as a tumor suppressor in nasopharyngeal carcinoma by repressing AKT through multiple mechanisms","volume":"32","author":"Deng","year":"2013","journal-title":"Oncogene"},{"issue":"3","key":"10.1016\/j.biomaterials.2020.120355_bib67","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s10534-010-9341-1","article-title":"E2F1-directed activation of Bcl-2 is correlated with lactoferrin-induced apoptosis in Jurkat leukemia T lymphocytes","volume":"23","author":"Lee","year":"2010","journal-title":"Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine"},{"issue":"3","key":"10.1016\/j.biomaterials.2020.120355_bib68","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1139\/o06-048","article-title":"Human lactoferrin controls the level of retinoblastoma protein and its activity","volume":"84","author":"Son","year":"2006","journal-title":"Biochemistry and cell biology = Biochimie et biologie cellulaire"},{"issue":"4","key":"10.1016\/j.biomaterials.2020.120355_bib69","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.3168\/jds.2012-6153","article-title":"Bovine lactoferrin inhibits lung cancer growth through suppression of both inflammation and expression of vascular endothelial growth factor","volume":"96","author":"Tung","year":"2013","journal-title":"J. Dairy Sci."},{"issue":"1","key":"10.1016\/j.biomaterials.2020.120355_bib70","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0191683","article-title":"Molecular mechanism of inhibitory effects of bovine lactoferrin on the growth of oral squamous cell carcinoma","volume":"13","author":"Chea","year":"2018","journal-title":"PloS One"},{"issue":"24","key":"10.1016\/j.biomaterials.2020.120355_bib71","doi-asserted-by":"crossref","first-page":"8683","DOI":"10.1158\/1078-0432.CCR-04-0988","article-title":"Lactoferrin down-regulates G1 cyclin-dependent kinases during growth arrest of head and neck cancer cells","volume":"10","author":"Xiao","year":"2004","journal-title":"Clin. Canc. Res. : an official journal of the American Association for Cancer Research"},{"issue":"4","key":"10.1016\/j.biomaterials.2020.120355_bib72","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.3171\/2014.12.JNS14512","article-title":"In vitro and in vivo effect of human lactoferrin on glioblastoma growth","volume":"123","author":"Arcella","year":"2015","journal-title":"J. Neurosurg."},{"issue":"38","key":"10.1016\/j.biomaterials.2020.120355_bib73","doi-asserted-by":"crossref","first-page":"62144","DOI":"10.18632\/oncotarget.11394","article-title":"Lactoferrin selectively triggers apoptosis in highly metastatic breast cancer cells through inhibition of plasmalemmal V-H+-ATPase","volume":"7","author":"Pereira","year":"2016","journal-title":"Oncotarget"},{"issue":"3","key":"10.1016\/j.biomaterials.2020.120355_bib74","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1152\/physrev.00035.2015","article-title":"The function of V-ATPases in cancer","volume":"96","author":"Stransky","year":"2016","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.biomaterials.2020.120355_bib75","doi-asserted-by":"crossref","first-page":"200","DOI":"10.3389\/fonc.2018.00200","article-title":"Bovine milk lactoferrin selectively kills highly metastatic prostate cancer PC-3 and osteosarcoma MG-63 cells in vitro","volume":"8","author":"Guedes","year":"2018","journal-title":"Frontiers in oncology"},{"key":"10.1016\/j.biomaterials.2020.120355_bib76","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1186\/s12885-015-1441-4","article-title":"Iron-free and iron-saturated bovine lactoferrin inhibit survivin expression and differentially modulate apoptosis in breast cancer","volume":"15","author":"Gibbons","year":"2015","journal-title":"BMC Canc."},{"key":"10.1016\/j.biomaterials.2020.120355_bib77","doi-asserted-by":"crossref","first-page":"32062","DOI":"10.1038\/srep32062","article-title":"Doxorubicin conjugated to immunomodulatory anticancer lactoferrin displays improved cytotoxicity overcoming prostate cancer chemo resistance and inhibits tumour development in TRAMP mice","volume":"6","author":"Shankaranarayanan","year":"2016","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.biomaterials.2020.120355_bib78","doi-asserted-by":"crossref","DOI":"10.1002\/smll.201803703","article-title":"Holo-lactoferrin modified liposome for relieving tumor hypoxia and enhancing radiochemotherapy of cancer","volume":"15","author":"Zhang","year":"2019","journal-title":"Small"},{"issue":"3","key":"10.1016\/j.biomaterials.2020.120355_bib79","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1139\/o11-054","article-title":"Roles of lactoferrin on skin wound healing","volume":"90","author":"Takayama","year":"2012","journal-title":"Biochemistry and cell biology = Biochimie et biologie cellulaire"},{"issue":"1","key":"10.1016\/j.biomaterials.2020.120355_bib80","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1365-2133.2010.09748.x","article-title":"Human lactoferrin stimulates skin keratinocyte function and wound re-epithelialization","volume":"163","author":"Tang","year":"2010","journal-title":"Br. J. Dermatol."},{"issue":"2","key":"10.1016\/j.biomaterials.2020.120355_bib81","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.jss.2007.12.754","article-title":"Talactoferrin stimulates wound healing with modulation of inflammation","volume":"149","author":"Engelmayer","year":"2008","journal-title":"J. Surg. Res."},{"issue":"6","key":"10.1016\/j.biomaterials.2020.120355_bib82","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1080\/03639040601085334","article-title":"Preparation and in vitro characteristics of lactoferrin-loaded chitosan microparticles","volume":"33","author":"Onishi","year":"2007","journal-title":"Drug Dev. Ind. Pharm."},{"issue":"12","key":"10.1016\/j.biomaterials.2020.120355_bib83","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1248\/yakushi.129.1507","article-title":"Preparation and in vitro evaluation of chitosan-coated alginate\/calcium complex microparticles loaded with fluorescein-labeled lactoferrin","volume":"129","author":"Koyama","year":"2009","journal-title":"Yakugaku Zasshi"},{"issue":"8","key":"10.1016\/j.biomaterials.2020.120355_bib84","doi-asserted-by":"crossref","first-page":"879","DOI":"10.3109\/03639040903567109","article-title":"Preparation of chitosan\/alginate\/calcium complex microparticles loaded with lactoferrin and their efficacy on carrageenan-induced edema in rats","volume":"36","author":"Onishi","year":"2010","journal-title":"Drug Dev. Ind. Pharm."},{"issue":"10","key":"10.1016\/j.biomaterials.2020.120355_bib85","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.2217\/nnm.12.29","article-title":"Novel alginate-enclosed chitosan-calcium phosphate-loaded iron-saturated bovine lactoferrin nanocarriers for oral delivery in colon cancer therapy","volume":"7","author":"Kanwar","year":"2012","journal-title":"Nanomedicine"},{"issue":"26","key":"10.1016\/j.biomaterials.2020.120355_bib86","doi-asserted-by":"crossref","first-page":"7522","DOI":"10.1016\/j.biomaterials.2014.04.109","article-title":"The effect of oral administration of iron saturated-bovine lactoferrin encapsulated chitosan-nanocarriers on osteoarthritis","volume":"35","author":"Samarasinghe","year":"2014","journal-title":"Biomaterials"},{"issue":"9","key":"10.1016\/j.biomaterials.2020.120355_bib87","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1248\/bpb.28.1717","article-title":"Liposomalization of lactoferrin enhanced it's anti-inflammatory effects via oral administration","volume":"28","author":"Ishikado","year":"2005","journal-title":"Biol. Pharm. Bull."},{"issue":"3","key":"10.1016\/j.biomaterials.2020.120355_bib88","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s10534-010-9312-6","article-title":"Liposomalization of lactoferrin enhanced its anti-tumoral effects on melanoma cells","volume":"23","author":"Roseanu","year":"2010","journal-title":"Biometals"},{"key":"10.1016\/j.biomaterials.2020.120355_bib89","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.fct.2013.05.038","article-title":"Comparison of anticancer activity between lactoferrin nanoliposome and lactoferrin in Caco-2 cells in vitro","volume":"59","author":"Ma","year":"2013","journal-title":"Food Chem. Toxicol."},{"issue":"7","key":"10.1016\/j.biomaterials.2020.120355_bib90","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1248\/bpb.33.1253","article-title":"Amino group PEGylation of bovine lactoferrin by linear polyethylene glycol-p-nitrophenyl active esters","volume":"33","author":"Kato","year":"2010","journal-title":"Biol. Pharmaceut. Bull."},{"issue":"11","key":"10.1016\/j.biomaterials.2020.120355_bib91","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1021\/bc800258v","article-title":"Development of poly(ethylene glycol) conjugated lactoferrin for oral administration","volume":"19","author":"Nojima","year":"2008","journal-title":"Bioconjugate Chem."},{"issue":"9","key":"10.1016\/j.biomaterials.2020.120355_bib92","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1007\/s11095-009-9925-z","article-title":"Lactoferrin conjugated with 40-kDa branched poly(ethylene glycol) has an improved circulating half-life","volume":"26","author":"Nojima","year":"2009","journal-title":"Pharm. Res. (N. Y.)"},{"issue":"7","key":"10.1016\/j.biomaterials.2020.120355_bib93","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/j.fct.2009.03.030","article-title":"PEGylated lactoferrin enhanced its hepatoprotective effects on acute liver injury induced by carbon tetrachloride in rats","volume":"47","author":"Sugiyama","year":"2009","journal-title":"Food Chem. Toxicol."},{"issue":"1\u20132","key":"10.1016\/j.biomaterials.2020.120355_bib94","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.ijpharm.2007.05.032","article-title":"Formulation and evaluation of lactoferrin bioadhesive tablets","volume":"343","author":"Takahashi","year":"2007","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.biomaterials.2020.120355_bib95","first-page":"6355","article-title":"Oral administration of encapsulated bovine lactoferrin protein nanocapsules against intracellular parasite Toxoplasma gondii","volume":"10","author":"Anand","year":"2015","journal-title":"Int. J. Nanomed."},{"issue":"1","key":"10.1016\/j.biomaterials.2020.120355_bib96","doi-asserted-by":"crossref","first-page":"6602","DOI":"10.1038\/s41598-017-06888-4","article-title":"Overcoming blood brain barrier with a dual purpose Temozolomide loaded Lactoferrin nanoparticles for combating glioma (SERP-17-12433)","volume":"7","author":"Kumari","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biomaterials.2020.120355_bib97","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.ijbiomac.2016.10.110","article-title":"Lactoferrin nanoparticle mediated targeted delivery of 5-fluorouracil for enhanced therapeutic efficacy","volume":"95","author":"Kumari","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"issue":"9","key":"10.1016\/j.biomaterials.2020.120355_bib98","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1007\/s11095-018-2457-7","article-title":"Evaluation of antiproliferative activity, safety and biodistribution of oxaliplatin and 5-fluorouracil loaded lactoferrin nanoparticles for the management of colon adenocarcinoma: an in vitro and an in vivo study","volume":"35","author":"Ahmed","year":"2018","journal-title":"Pharm. Res. (N. Y.)"},{"issue":"6","key":"10.1016\/j.biomaterials.2020.120355_bib99","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/21691401.2016.1202259","article-title":"Optimization of desolvation process for fabrication of lactoferrin nanoparticles using quality by design approach","volume":"45","author":"Pandey","year":"2017","journal-title":"Artificial cells, nanomedicine, and biotechnology"},{"issue":"10","key":"10.1016\/j.biomaterials.2020.120355_bib100","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.1021\/jf0209342","article-title":"Cold-set globular protein gels: interactions, structure and rheology as a function of protein concentration","volume":"51","author":"Alting","year":"2003","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.biomaterials.2020.120355_bib101","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jconrel.2018.08.012","article-title":"Antiglioma via regulating oxidative stress and remodeling tumor-associated macrophage using lactoferrin-mediated biomimetic codelivery of simvastatin\/fenretinide","volume":"287","author":"Mo","year":"2018","journal-title":"J. Contr. Release"},{"issue":"5","key":"10.1016\/j.biomaterials.2020.120355_bib102","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1021\/acs.nanolett.9b00021","article-title":"Reprogramming tumor immune microenvironment (TIME) and metabolism via biomimetic targeting codelivery of shikonin\/JQ1","volume":"19","author":"Wang","year":"2019","journal-title":"Nano Lett."},{"issue":"10","key":"10.1016\/j.biomaterials.2020.120355_bib103","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23102678","article-title":"Preservation of cichoric acid antioxidant properties loaded in heat treated lactoferrin nanoparticles","volume":"23","author":"Li","year":"2018","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.biomaterials.2020.120355_bib104","doi-asserted-by":"crossref","first-page":"86","DOI":"10.3109\/10717544.2013.766781","article-title":"Studies on lactoferrin nanoparticles of gambogic acid for oral delivery","volume":"20","author":"Zhang","year":"2013","journal-title":"Drug Deliv."},{"key":"10.1016\/j.biomaterials.2020.120355_bib105","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.2147\/DDDT.S133997","article-title":"Preparation, characterization, and in vitro\/vivo studies of oleanolic acid-loaded lactoferrin nanoparticles","volume":"11","author":"Xia","year":"2017","journal-title":"Drug Des. Dev. Ther."},{"issue":"5","key":"10.1016\/j.biomaterials.2020.120355_bib106","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/j.foodhyd.2010.11.010","article-title":"Formation and characterization of lactoferrin\/pectin electrostatic complexes: impact of composition, pH and thermal treatment","volume":"25","author":"Bengoechea","year":"2011","journal-title":"Food Hydrocolloids"},{"key":"10.1016\/j.biomaterials.2020.120355_bib107","first-page":"33","volume":"vol. 102","author":"Il'ina","year":"2016"},{"issue":"12","key":"10.1016\/j.biomaterials.2020.120355_bib108","doi-asserted-by":"crossref","first-page":"9827","DOI":"10.1021\/la1001013","article-title":"Fabrication and morphological characterization of biopolymer particles formed by electrostatic complexation of heat treated lactoferrin and anionic polysaccharides","volume":"26","author":"Peinado","year":"2010","journal-title":"Langmuir"},{"issue":"28","key":"10.1016\/j.biomaterials.2020.120355_bib109","doi-asserted-by":"crossref","first-page":"5720","DOI":"10.1021\/acs.jafc.7b01848","article-title":"Biocompatible polyelectrolyte complex nanoparticles from lactoferrin and pectin as potential vehicles for antioxidative curcumin","volume":"65","author":"Yan","year":"2017","journal-title":"J. Agric. Food Chem."},{"issue":"16","key":"10.1016\/j.biomaterials.2020.120355_bib110","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.2217\/nnm-2018-0039","article-title":"Inhalable lactoferrin-chondroitin nanocomposites for combined delivery of doxorubicin and ellagic acid to lung carcinoma","volume":"13","author":"Abd Elwakil","year":"2018","journal-title":"Nanomedicine"},{"issue":"2","key":"10.1016\/j.biomaterials.2020.120355_bib111","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1039\/C8FO02146E","article-title":"Fabrication and characterization of functional protein-polysaccharide-polyphenol complexes assembled from lactoferrin, hyaluronic acid and (-)-epigallocatechin gallate","volume":"10","author":"Liu","year":"2019","journal-title":"Food Funct"},{"issue":"3","key":"10.1016\/j.biomaterials.2020.120355_bib112","first-page":"626","article-title":"Formulation and in vitro evaluation of curcumin-lactoferrin conjugated nanostructures for cancerous cells, Artificial cells","volume":"46","author":"Chaharband","year":"2018","journal-title":"nanomedicine, and biotechnology"},{"issue":"12","key":"10.1016\/j.biomaterials.2020.120355_bib113","doi-asserted-by":"crossref","first-page":"4418","DOI":"10.1021\/mp4002014","article-title":"Enhanced brain delivery of deferasirox-lactoferrin conjugates for iron chelation therapy in neurodegenerative disorders: in vitro and in vivo studies","volume":"10","author":"Kamalinia","year":"2013","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.biomaterials.2020.120355_bib114","doi-asserted-by":"crossref","first-page":"110824","DOI":"10.1016\/j.colsurfb.2020.110824","article-title":"Synthesis of lactoferrin mesoporous silica nanoparticles for pemetrexed\/ellagic acid synergistic breast cancer therapy","volume":"188","author":"Ali","year":"2020","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.biomaterials.2020.120355_bib115","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.foodchem.2016.02.155","article-title":"Utilization of interfacial engineering to improve physicochemical stability of beta-carotene emulsions: multilayer coatings formed using protein and protein-polyphenol conjugates","volume":"205","author":"Liu","year":"2016","journal-title":"Food Chem."},{"issue":"20","key":"10.1016\/j.biomaterials.2020.120355_bib116","doi-asserted-by":"crossref","first-page":"15641","DOI":"10.1039\/C4RA10802G","article-title":"Structural characterization and functional evaluation of lactoferrin\u2013polyphenol conjugates formed by free-radical graft copolymerization","volume":"5","author":"Liu","year":"2015","journal-title":"RSC Adv."},{"issue":"95","key":"10.1016\/j.biomaterials.2020.120355_bib117","doi-asserted-by":"crossref","first-page":"78215","DOI":"10.1039\/C5RA15261E","article-title":"Glycosylation improves the functional characteristics of chlorogenic acid\u2013lactoferrin conjugate","volume":"5","author":"Liu","year":"2015","journal-title":"RSC Adv."},{"key":"10.1016\/j.biomaterials.2020.120355_bib118","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ejpb.2018.04.023","article-title":"Self-assembled amphiphilic zein-lactoferrin micelles for tumor targeted co-delivery of rapamycin and wogonin to breast cancer","volume":"128","author":"Sabra","year":"2018","journal-title":"Eur. J. Pharm. Biopharm. : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V"},{"issue":"5","key":"10.1016\/j.biomaterials.2020.120355_bib119","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1016\/j.xphs.2018.11.044","article-title":"Magnetically guided self-assembled protein micelles for enhanced delivery of dasatinib to human triple-negative breast cancer cells","volume":"108","author":"Sabra","year":"2019","journal-title":"J. Pharmaceut. Sci."},{"issue":"3","key":"10.1016\/j.biomaterials.2020.120355_bib120","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1021\/acs.molpharmaceut.6b01017","article-title":"Food protein based core-shell nanocarriers for oral drug delivery: effect of shell composition on in vitro and in vivo functional performance of zein nanocarriers","volume":"14","author":"Alqahtani","year":"2017","journal-title":"Mol. Pharm."},{"issue":"30","key":"10.1016\/j.biomaterials.2020.120355_bib121","doi-asserted-by":"crossref","first-page":"26731","DOI":"10.1021\/acsami.9b10164","article-title":"Dual-targeted lactoferrin shell-oily core nanocapsules for synergistic targeted\/herbal therapy of hepatocellular carcinoma","volume":"11","author":"Abdelmoneem","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"12","key":"10.1016\/j.biomaterials.2020.120355_bib122","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0051960","article-title":"Efficacy, safety and anticancer activity of protein nanoparticle-based delivery of doxorubicin through intravenous administration in rats","volume":"7","author":"Golla","year":"2012","journal-title":"PloS One"},{"issue":"7","key":"10.1016\/j.biomaterials.2020.120355_bib123","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/hiv.12475","article-title":"An oral formulation of efavirenz-loaded lactoferrin nanoparticles with improved biodistribution and pharmacokinetic profile","volume":"18","author":"Kumar","year":"2017","journal-title":"HIV Med."},{"key":"10.1016\/j.biomaterials.2020.120355_bib124","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.ijbiomac.2014.07.041","article-title":"Carboplatin loaded protein nanoparticles exhibit improve anti-proliferative activity in retinoblastoma cells","volume":"70","author":"Ahmed","year":"2014","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.biomaterials.2020.120355_bib125","doi-asserted-by":"crossref","first-page":"119783","DOI":"10.1016\/j.biomaterials.2020.119783","article-title":"Small-sized gadolinium oxide based nanoparticles for high-efficiency theranostics of orthotopic glioblastoma","volume":"235","author":"Shen","year":"2020","journal-title":"Biomaterials"},{"issue":"11","key":"10.1016\/j.biomaterials.2020.120355_bib126","doi-asserted-by":"crossref","first-page":"11355","DOI":"10.1021\/acsnano.8b06201","article-title":"Fenton-reaction-acceleratable magnetic nanoparticles for ferroptosis therapy of orthotopic brain tumors","volume":"12","author":"Shen","year":"2018","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.biomaterials.2020.120355_bib127","doi-asserted-by":"crossref","first-page":"5925","DOI":"10.1038\/s41598-020-62429-6","article-title":"Combined chemo-magnetic field-photothermal breast cancer therapy based on porous magnetite nanospheres","volume":"10","author":"Sharifi","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biomaterials.2020.120355_bib128","series-title":"Engineering, Antimetastatic Activity of Lactoferrin-Coated Mesoporous Maghemite Nanoparticles in Breast Cancer Enabled by Combination Therapy","author":"Sharifi","year":"2020"},{"key":"10.1016\/j.biomaterials.2020.120355_bib129","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.msec.2017.03.309","article-title":"Lactoferrin modified graphene oxide iron oxide nanocomposite for glioma-targeted drug delivery, Materials science & engineering","volume":"77","author":"Song","year":"2017","journal-title":"C, Materials for biological applications"},{"issue":"10","key":"10.1016\/j.biomaterials.2020.120355_bib130","doi-asserted-by":"crossref","first-page":"9420","DOI":"10.1021\/acsnano.6b04414","article-title":"The penetrated delivery of drug and energy to tumors by lipo-graphene nanosponges for photolytic therapy","volume":"10","author":"Su","year":"2016","journal-title":"ACS Nano"},{"issue":"25","key":"10.1016\/j.biomaterials.2020.120355_bib131","doi-asserted-by":"crossref","first-page":"7899","DOI":"10.1021\/jacs.6b02699","article-title":"Silver-lactoferrin nanocomplexes as a potent antimicrobial agent","volume":"138","author":"Pomastowski","year":"2016","journal-title":"J. Am. Chem. Soc."},{"issue":"9","key":"10.1016\/j.biomaterials.2020.120355_bib132","first-page":"4969","article-title":"Antimicrobial activity of multifaceted lactoferrin or graphene oxide functionalized silver nanocomposites biosynthesized using mushroom waste and chitosan","volume":"10","author":"Abdalla","year":"2020"},{"key":"10.1016\/j.biomaterials.2020.120355_bib133","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.cej.2018.12.084","article-title":"Lactoferrin adsorption onto silver nanoparticle interface: implications of corona on protein conformation, nanoparticle cytotoxicity and the formulation adjuvanticity","volume":"361","author":"Nayak","year":"2019","journal-title":"Chem. Eng. J."},{"issue":"20","key":"10.1016\/j.biomaterials.2020.120355_bib134","first-page":"2637","article-title":"Lactoferrin-tagged quantum dots-based theranostic nanocapsules for combined COX-2 inhibitor\/herbal therapy of breast cancer","volume":"13","author":"AbdElhamid","year":"2018"},{"issue":"24","key":"10.1016\/j.biomaterials.2020.120355_bib135","doi-asserted-by":"crossref","first-page":"20410","DOI":"10.1021\/acsami.7b03504","article-title":"Vitro study of receptor-mediated silica nanoparticles delivery across blood\u2013brain barrier","volume":"9","author":"Song","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.biomaterials.2020.120355_bib136","first-page":"110824","volume":"vol. 188","author":"Ali","year":"2020"},{"issue":"12","key":"10.1016\/j.biomaterials.2020.120355_bib137","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1039\/c0nr00377h","article-title":"Luminescent quantum clusters of gold in transferrin family protein, lactoferrin exhibiting FRET","volume":"2","author":"Xavier","year":"2010","journal-title":"Nanoscale"},{"issue":"11","key":"10.1016\/j.biomaterials.2020.120355_bib138","doi-asserted-by":"crossref","first-page":"8816","DOI":"10.1021\/nn202901a","article-title":"Understanding the evolution of luminescent gold quantum clusters in protein templates","volume":"5","author":"Chaudhari","year":"2011","journal-title":"ACS Nano"},{"issue":"3","key":"10.1016\/j.biomaterials.2020.120355_bib139","doi-asserted-by":"crossref","first-page":"212","DOI":"10.3109\/1061186X.2015.1068320","article-title":"Lactoferrin bioconjugated solid lipid nanoparticles: a new drug delivery system for potential brain targeting","volume":"24","author":"Singh","year":"2016","journal-title":"J. Drug Target."},{"issue":"2","key":"10.1016\/j.biomaterials.2020.120355_bib140","doi-asserted-by":"crossref","first-page":"2862","DOI":"10.3390\/ijms14022862","article-title":"In vitro and in vivo evaluation of lactoferrin-conjugated liposomes as a novel carrier to improve the brain delivery","volume":"14","author":"Huang","year":"2013","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.biomaterials.2020.120355_bib141","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/j.nano.2015.04.006","article-title":"Tumor regression following intravenous administration of lactoferrin- and lactoferricin-bearing dendriplexes","volume":"11","author":"Lim","year":"2015","journal-title":"Nanomedicine"},{"issue":"12","key":"10.1016\/j.biomaterials.2020.120355_bib142","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.2174\/1381612043384826","article-title":"New technologies for drug delivery across the blood brain barrier","volume":"10","author":"Kabanov","year":"2004","journal-title":"Curr. Pharmaceut. Des."},{"issue":"22","key":"10.1016\/j.biomaterials.2020.120355_bib143","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1007\/s00018-005-5371-1","article-title":"Mammalian lactoferrin receptors: structure and function","volume":"62","author":"Suzuki","year":"2005","journal-title":"Cell. Mol. Life Sci."},{"issue":"2","key":"10.1016\/j.biomaterials.2020.120355_bib144","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.biomaterials.2007.09.024","article-title":"The use of lactoferrin as a ligand for targeting the polyamidoamine-based gene delivery system to the brain","volume":"29","author":"Huang","year":"2008","journal-title":"Biomaterials"},{"issue":"11","key":"10.1016\/j.biomaterials.2020.120355_bib145","doi-asserted-by":"crossref","first-page":"7011","DOI":"10.1074\/jbc.274.11.7011","article-title":"Receptor-mediated transcytosis of lactoferrin through the blood-brain barrier","volume":"274","author":"Fillebeen","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"22","key":"10.1016\/j.biomaterials.2020.120355_bib146","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.2174\/1381612822666160204120829","article-title":"Natural polymeric nanoparticles for brain-targeting: implications on drug and gene delivery","volume":"22","author":"Elzoghby","year":"2016","journal-title":"Curr. Pharmaceut. Des."},{"issue":"5","key":"10.1016\/j.biomaterials.2020.120355_bib147","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/s41563-019-0566-2","article-title":"The entry of nanoparticles into solid tumours","volume":"19","author":"Sindhwani","year":"2020","journal-title":"Nat. Mater."},{"issue":"6","key":"10.1016\/j.biomaterials.2020.120355_bib148","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1021\/mp100277h","article-title":"Lactoferrin-conjugated biodegradable polymersome holding doxorubicin and tetrandrine for chemotherapy of glioma rats","volume":"7","author":"Pang","year":"2010","journal-title":"Mol. Pharm."},{"issue":"1\u20132","key":"10.1016\/j.biomaterials.2020.120355_bib149","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.ejps.2011.07.007","article-title":"Lactoferrin modified doxorubicin-loaded procationic liposomes for the treatment of gliomas","volume":"44","author":"Chen","year":"2011","journal-title":"Eur. J. Pharmaceut. Sci."},{"issue":"1","key":"10.1016\/j.biomaterials.2020.120355_bib150","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1021\/mp400189j","article-title":"Co-administration of dual-targeting nanoparticles with penetration enhancement peptide for antiglioblastoma therapy","volume":"11","author":"Miao","year":"2014","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.biomaterials.2020.120355_bib151","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.msec.2018.12.139","article-title":"Hyaluronic acid tethered pH-responsive alloy-drug nanoconjugates for multimodal therapy of glioblastoma: an intranasal route approach","volume":"98","author":"Pandey","year":"2019","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"10.1016\/j.biomaterials.2020.120355_bib152","doi-asserted-by":"crossref","first-page":"6547","DOI":"10.2147\/IJN.S120939","article-title":"Intranasal delivery of rotigotine to the brain with lactoferrin-modified PEG-PLGA nanoparticles for Parkinson's disease treatment","volume":"11","author":"Bi","year":"2016","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.biomaterials.2020.120355_bib153","doi-asserted-by":"crossref","first-page":"273","DOI":"10.2147\/IJN.S151475","article-title":"Lactoferrin-modified rotigotine nanoparticles for enhanced nose-to-brain delivery: LESA-MS\/MS-based drug biodistribution, pharmacodynamics, and neuroprotective effects","volume":"13","author":"Yan","year":"2018","journal-title":"Int. J. Nanomed."},{"issue":"2","key":"10.1016\/j.biomaterials.2020.120355_bib154","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/fsn3.388","article-title":"A nutritional supplement containing lactoferrin stimulates the immune system, extends lifespan, and reduces amyloid \u03b2 peptide toxicity in Caenorhabditis elegans","volume":"5","author":"Martorell","year":"2017","journal-title":"Food science & nutrition"},{"key":"10.1016\/j.biomaterials.2020.120355_bib155","doi-asserted-by":"crossref","first-page":"10729","DOI":"10.1038\/srep10729","article-title":"The protective effect of lactoferrin on ventral mesencephalon neurons against MPP + is not connected with its iron binding ability","volume":"5","author":"Wang","year":"2015","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.biomaterials.2020.120355_bib156","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/jnc.14857","article-title":"Lactoferrin protects against iron dysregulation, oxidative stress, and apoptosis in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease in mice","volume":"152","author":"Liu","year":"2020","journal-title":"J. Neurochem."},{"key":"10.1016\/j.biomaterials.2020.120355_bib157","doi-asserted-by":"crossref","first-page":"101090","DOI":"10.1016\/j.redox.2018.101090","article-title":"Lactoferrin ameliorates dopaminergic neurodegeneration and motor deficits in MPTP-treated mice","volume":"21","author":"Xu","year":"2019","journal-title":"Redox biology"},{"issue":"1","key":"10.1016\/j.biomaterials.2020.120355_bib158","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1080\/10717544.2019.1636420","article-title":"Brain-targeted intranasal delivery of dopamine with borneol and lactoferrin co-modified nanoparticles for treating Parkinson's disease","volume":"26","author":"Tang","year":"2019","journal-title":"Drug Deliv."},{"key":"10.1016\/j.biomaterials.2020.120355_bib159","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.neuint.2016.01.006","article-title":"Neuroprotective effect of curcumin-loaded lactoferrin nano particles against rotenone induced neurotoxicity","volume":"95","author":"Bollimpelli","year":"2016","journal-title":"Neurochem. Int."},{"issue":"5492","key":"10.1016\/j.biomaterials.2020.120355_bib160","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1126\/science.290.5492.767","article-title":"Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease","volume":"290","author":"Kordower","year":"2000","journal-title":"Science"},{"issue":"1\u20132","key":"10.1016\/j.biomaterials.2020.120355_bib161","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jns.2009.09.032","article-title":"Gene therapy using lactoferrin-modified nanoparticles in a rotenone-induced chronic Parkinson model","volume":"290","author":"Huang","year":"2010","journal-title":"J. Neurol. Sci."},{"issue":"7","key":"10.1016\/j.biomaterials.2020.120355_bib162","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24071323","article-title":"Lactoferrin in aseptic and septic inflammation","volume":"24","author":"Lepanto","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.biomaterials.2020.120355_bib163","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.biopha.2018.12.118","article-title":"A pilot study on the effect of lactoferrin on Alzheimer's disease pathological sequelae: impact of the p-Akt\/PTEN pathway","volume":"111","author":"Mohamed","year":"2019","journal-title":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie"},{"issue":"13","key":"10.1016\/j.biomaterials.2020.120355_bib164","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1038\/npp.2017.8","article-title":"Intranasal lactoferrin enhances \u03b1-secretase-dependent amyloid precursor protein processing via the ERK1\/2-CREB and HIF-1\u03b1 pathways in an Alzheimer's disease mouse model","volume":"42","author":"Guo","year":"2017","journal-title":"Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology"},{"key":"10.1016\/j.biomaterials.2020.120355_bib165","doi-asserted-by":"crossref","first-page":"102834","DOI":"10.1016\/j.ebiom.2020.102834","article-title":"Decreased salivary lactoferrin levels are specific to Alzheimer's disease","volume":"57","author":"Gonz\u00e1lez-S\u00e1nchez","year":"2020","journal-title":"EBioMedicine"},{"issue":"8","key":"10.1016\/j.biomaterials.2020.120355_bib166","doi-asserted-by":"crossref","first-page":"3789","DOI":"10.1021\/acschemneuro.9b00286","article-title":"Behavioral and biochemical implications of dendrimeric rivastigmine in memory-deficit and Alzheimer's induced rodents","volume":"10","author":"Gothwal","year":"2019","journal-title":"ACS Chem. Neurosci."},{"issue":"22","key":"10.1016\/j.biomaterials.2020.120355_bib167","doi-asserted-by":"crossref","first-page":"5954","DOI":"10.1016\/j.biomaterials.2014.03.082","article-title":"Protection of SK-N-MC cells against beta-amyloid peptide-induced degeneration using neuron growth factor-loaded liposomes with surface lactoferrin","volume":"35","author":"Kuo","year":"2014","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.biomaterials.2020.120355_bib168","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s11095-011-0513-7","article-title":"Self-assembled polymersomes conjugated with lactoferrin as novel drug carrier for brain delivery","volume":"29","author":"Yu","year":"2012","journal-title":"Pharm. Res. (N. Y.)"},{"issue":"6","key":"10.1016\/j.biomaterials.2020.120355_bib169","doi-asserted-by":"crossref","first-page":"3250","DOI":"10.1039\/C3NR05196J","article-title":"The proton permeability of self-assembled polymersomes and their neuroprotection by enhancing a neuroprotective peptide across the blood-brain barrier after modification with lactoferrin","volume":"6","author":"Yu","year":"2014","journal-title":"Nanoscale"},{"issue":"6","key":"10.1016\/j.biomaterials.2020.120355_bib170","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1002\/adhm.201500750","article-title":"Dual-targeting lactoferrin-conjugated polymerized magnetic polydiacetylene-assembled nanocarriers with self-responsive fluorescence\/magnetic resonance imaging for in vivo brain tumor therapy","volume":"5","author":"Fang","year":"2016","journal-title":"Adv Healthc Mater"},{"issue":"1","key":"10.1016\/j.biomaterials.2020.120355_bib171","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ijpharm.2014.12.070","article-title":"Targeting delivery of etoposide to inhibit the growth of human glioblastoma multiforme using lactoferrin- and folic acid-grafted poly(lactide-co-glycolide) nanoparticles","volume":"479","author":"Kuo","year":"2015","journal-title":"Int. J. Pharm."},{"issue":"1\u20132","key":"10.1016\/j.biomaterials.2020.120355_bib172","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ijpharm.2015.12.054","article-title":"Brain targeted delivery of carmustine using solid lipid nanoparticles modified with tamoxifen and lactoferrin for antitumor proliferation","volume":"499","author":"Kuo","year":"2016","journal-title":"Int. J. Pharm."},{"issue":"6","key":"10.1016\/j.biomaterials.2020.120355_bib173","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1021\/mp500238m","article-title":"Lactoferrin-modified poly(ethylene glycol)-grafted BSA nanoparticles as a dual-targeting carrier for treating brain gliomas","volume":"11","author":"Su","year":"2014","journal-title":"Mol. Pharm."},{"issue":"30","key":"10.1016\/j.biomaterials.2020.120355_bib174","doi-asserted-by":"crossref","first-page":"7418","DOI":"10.1016\/j.biomaterials.2013.05.078","article-title":"pH\/temperature sensitive magnetic nanogels conjugated with Cy5.5-labled lactoferrin for MR and fluorescence imaging of glioma in rats","volume":"34","author":"Jiang","year":"2013","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.biomaterials.2020.120355_bib175","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ijpharm.2014.12.057","article-title":"Lactoferrin- and antitransferrin-modified liposomes for brain targeting of the NK3 receptor agonist senktide: preparation and in vivo evaluation","volume":"479","author":"De Luca","year":"2015","journal-title":"Int. J. Pharm."},{"issue":"9","key":"10.1016\/j.biomaterials.2020.120355_bib176","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1002\/jgm.1361","article-title":"Neuroprotection in a 6-hydroxydopamine-lesioned Parkinson model using lactoferrin-modified nanoparticles","volume":"11","author":"Huang","year":"2009","journal-title":"J. Gene Med."},{"issue":"1\u20132","key":"10.1016\/j.biomaterials.2020.120355_bib177","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.ijpharm.2011.05.062","article-title":"Lactoferrin conjugated PEG-PLGA nanoparticles for brain delivery: preparation, characterization and efficacy in Parkinson's disease","volume":"415","author":"Hu","year":"2011","journal-title":"Int. J. Pharm."},{"issue":"15","key":"10.1016\/j.biomaterials.2020.120355_bib178","doi-asserted-by":"crossref","first-page":"3870","DOI":"10.1016\/j.biomaterials.2013.02.003","article-title":"Lactoferrin-modified PEG-co-PCL nanoparticles for enhanced brain delivery of NAP peptide following intranasal administration","volume":"34","author":"Liu","year":"2013","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.biomaterials.2020.120355_bib179","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.ejps.2010.03.007","article-title":"Lactoferrin-modified procationic liposomes as a novel drug carrier for brain delivery","volume":"40","author":"Chen","year":"2010","journal-title":"Eur. J. Pharmaceut. Sci."},{"issue":"7","key":"10.1016\/j.biomaterials.2020.120355_bib180","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0103298","article-title":"Lactoferrin deficiency promotes colitis-associated colorectal dysplasia in mice","volume":"9","author":"Ye","year":"2014","journal-title":"PloS One"},{"issue":"5","key":"10.1016\/j.biomaterials.2020.120355_bib181","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1007\/s10534-014-9747-2","article-title":"Inhibition of intestinal polyp growth by oral ingestion of bovine lactoferrin and immune cells in the large intestine","volume":"27","author":"Iigo","year":"2014","journal-title":"Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine"},{"issue":"11","key":"10.1016\/j.biomaterials.2020.120355_bib182","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1158\/1940-6207.CAPR-08-0208","article-title":"Effect of orally administered bovine lactoferrin on the growth of adenomatous colorectal polyps in a randomized, placebo-controlled clinical trial","volume":"2","author":"Kozu","year":"2009","journal-title":"Canc. Prev. Res."},{"issue":"8","key":"10.1016\/j.biomaterials.2020.120355_bib183","doi-asserted-by":"crossref","first-page":"762","DOI":"10.2174\/187152011797378616","article-title":"Effect of selenium-saturated bovine lactoferrin (Se-bLF) on antioxidant enzyme activities in human gut epithelial cells under oxidative stress","volume":"11","author":"Burrow","year":"2011","journal-title":"Anti Canc. Agents Med. Chem."},{"issue":"5","key":"10.1016\/j.biomaterials.2020.120355_bib184","first-page":"5688","article-title":"Inhibition of DMH-DSS-induced colorectal cancer by liposomal bovine lactoferrin in rats","volume":"14","author":"Sugihara","year":"2017","journal-title":"Oncology letters"},{"key":"10.1016\/j.biomaterials.2020.120355_bib185","first-page":"1349","article-title":"Theranostic multimodular potential of zinc-doped ferrite-saturated metal-binding protein-loaded novel nanocapsules in cancers","volume":"11","author":"Kamalapuram","year":"2016","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.biomaterials.2020.120355_bib186","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.biomaterials.2015.07.055","article-title":"LNA aptamer based multi-modal, Fe3O4-saturated lactoferrin (Fe3O4-bLf) nanocarriers for triple positive (EpCAM, CD133, CD44) colon tumor targeting and NIR, MRI and CT imaging","volume":"71","author":"Roy","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2020.120355_bib187","first-page":"5123","article-title":"Lactoferrin-modified PEGylated liposomes loaded with doxorubicin for targeting delivery to hepatocellular carcinoma","volume":"10","author":"Wei","year":"2015","journal-title":"Int. J. Nanomed."},{"issue":"19","key":"10.1016\/j.biomaterials.2020.120355_bib188","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.2217\/nnm-2018-0134","article-title":"Decorating protein nanospheres with lactoferrin enhances oral COX-2 inhibitor\/herbal therapy of hepatocellular carcinoma","volume":"13","author":"Abdelmoneem","year":"2018","journal-title":"Nanomedicine"},{"key":"10.1016\/j.biomaterials.2020.120355_bib189","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jconrel.2018.08.026","article-title":"Dual-targeted casein micelles as green nanomedicine for synergistic phytotherapy of hepatocellular carcinoma","volume":"287","author":"Abdelmoneem","year":"2018","journal-title":"J. Contr. Release"},{"issue":"1","key":"10.1016\/j.biomaterials.2020.120355_bib190","doi-asserted-by":"crossref","first-page":"5925","DOI":"10.1038\/s41598-020-62429-6","article-title":"Combined chemo-magnetic field-photothermal breast cancer therapy based on porous magnetite nanospheres","volume":"10","author":"Sharifi","year":"2020","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.biomaterials.2020.120355_bib191","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1080\/17425247.2018.1505858","article-title":"Lactoferrin-decorated vs PEGylated zein nanospheres for combined aromatase inhibitor and herbal therapy of breast cancer","volume":"15","author":"El-Lakany","year":"2018","journal-title":"Expet Opin. Drug Deliv."},{"issue":"46","key":"10.1016\/j.biomaterials.2020.120355_bib192","doi-asserted-by":"crossref","first-page":"9189","DOI":"10.1039\/C7TB02599H","article-title":"Chlorin e6 loaded lactoferrin nanoparticles for enhanced photodynamic therapy","volume":"5","author":"Adimoolam","year":"2017","journal-title":"J. Mater. Chem. B"},{"issue":"2","key":"10.1016\/j.biomaterials.2020.120355_bib193","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3109\/10717544.2013.877100","article-title":"Lactoferrin-appended solid lipid nanoparticles of paclitaxel for effective management of bronchogenic carcinoma","volume":"22","author":"Pandey","year":"2015","journal-title":"Drug Deliv."},{"key":"10.1016\/j.biomaterials.2020.120355_bib194","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.jconrel.2017.11.036","article-title":"Inhalable particulate drug delivery systems for lung cancer therapy: nanoparticles, microparticles, nanocomposites and nanoaggregates","volume":"269","author":"Abdelaziz","year":"2018","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.biomaterials.2020.120355_bib195","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.ejpb.2018.06.027","article-title":"Inhalable multi-compartmental phospholipid enveloped lipid core nanocomposites for localized mTOR inhibitor\/herbal combined therapy of lung carcinoma","volume":"130","author":"Kabary","year":"2018","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"2","key":"10.1016\/j.biomaterials.2020.120355_bib196","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1021\/acsbiomaterials.9b01639","article-title":"Inhalable lactoferrin\/chondroitin-functionalized monoolein nanocomposites for localized lung cancer targeting","volume":"6","author":"Abdelaziz","year":"2020","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"3","key":"10.1016\/j.biomaterials.2020.120355_bib197","doi-asserted-by":"crossref","first-page":"184","DOI":"10.31768\/2312-8852.2018.40(3):184-189","article-title":"Effects of exogenous lactoferrin on phenotypic profile and invasiveness of human prostate cancer cells (DU145 and LNCaP) in vitro","volume":"40","author":"Zadvornyi","year":"2018","journal-title":"Exp. Oncol."},{"issue":"1","key":"10.1016\/j.biomaterials.2020.120355_bib198","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1080\/10717544.2018.1440666","article-title":"Regression of prostate tumors after intravenous administration of lactoferrin-bearing polypropylenimine dendriplexes encoding TNF-alpha, TRAIL, and interleukin-12","volume":"25","author":"Altwaijry","year":"2018","journal-title":"Drug Deliv."},{"issue":"20","key":"10.1016\/j.biomaterials.2020.120355_bib199","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.2217\/nnm-2018-0196","article-title":"Lactoferrin-tagged quantum dots-based theranostic nanocapsules for combined COX-2 inhibitor\/herbal therapy of breast cancer","volume":"13","author":"AbdElhamid","year":"2018","journal-title":"Nanomedicine"},{"issue":"3","key":"10.1016\/j.biomaterials.2020.120355_bib200","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1002\/jcp.1041530306","article-title":"Lactoferrin binding sites and nuclear localization in K562(S) cells","volume":"153","author":"Garr\u00e9","year":"1992","journal-title":"J. Cell. Physiol."},{"issue":"3","key":"10.1016\/j.biomaterials.2020.120355_bib201","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1042\/BA20010038","article-title":"Identification of an import signal for, and the nuclear localization of, human lactoferrin","volume":"34","author":"Penco","year":"2001","journal-title":"Biotechnol. Appl. Biochem."},{"issue":"2","key":"10.1016\/j.biomaterials.2020.120355_bib202","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0008-8749(03)00006-6","article-title":"Lactoferrin down-regulates the LPS-induced cytokine production in monocytic cells via NF-kappa B","volume":"220","author":"H\u00e5versen","year":"2002","journal-title":"Cell. Immunol."},{"issue":"1","key":"10.1016\/j.biomaterials.2020.120355_bib203","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s13567-019-0694-3","article-title":"Lactoferrin translocates to the nucleus of bovine rectal epithelial cells in the presence of Escherichia coli O157:H7","volume":"50","author":"Rybarczyk","year":"2019","journal-title":"Vet. Res."},{"issue":"3","key":"10.1016\/j.biomaterials.2020.120355_bib204","article-title":"Identification of a short cell-penetrating peptide from bovine lactoferricin for intracellular delivery of DNA in human A549 cells","volume":"11","author":"Liu","year":"2016","journal-title":"PloS One"},{"issue":"3","key":"10.1016\/j.biomaterials.2020.120355_bib205","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1023\/B:BIOM.0000027710.13543.3f","article-title":"Cellular internalization of lactoferrin in intestinal epithelial cells","volume":"17","author":"Ashida","year":"2004","journal-title":"Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine"},{"issue":"1","key":"10.1016\/j.biomaterials.2020.120355_bib206","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.biochi.2008.05.005","article-title":"Immunomodulatory effects of lactoferrin on antigen presenting cells","volume":"91","author":"Puddu","year":"2009","journal-title":"Biochimie"},{"issue":"22","key":"10.1016\/j.biomaterials.2020.120355_bib207","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1007\/s00018-005-5370-2","article-title":"Lactoferrin: a modulator of immune and inflammatory responses","volume":"62","author":"Legrand","year":"2005","journal-title":"Cell. Mol. Life Sci. : CMLS"},{"issue":"2","key":"10.1016\/j.biomaterials.2020.120355_bib208","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1017\/S0022029997002732","article-title":"Bovine lactoferrin induces both mucosal and systemic immune response in mice","volume":"65","author":"Debbabi","year":"1998","journal-title":"J. Dairy Res."},{"issue":"4","key":"10.1016\/j.biomaterials.2020.120355_bib209","doi-asserted-by":"crossref","first-page":"525","DOI":"10.3945\/jn.113.190264","article-title":"Dietary bovine lactoferrin alters mucosal and systemic immune cell responses in neonatal piglets","volume":"144","author":"Comstock","year":"2014","journal-title":"J. Nutr."},{"issue":"9","key":"10.1016\/j.biomaterials.2020.120355_bib210","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.nutres.2008.05.007","article-title":"Bovine lactoferrin supplementation supports immune and antioxidant status in healthy human males","volume":"28","author":"Mulder","year":"2008","journal-title":"Nutr. Res. (N.Y.)"},{"issue":"6","key":"10.1016\/j.biomaterials.2020.120355_bib211","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1002\/jlb.55.6.771","article-title":"P-selectin-dependent leukocyte recruitment and intestinal mucosal injury induced by lactoferrin","volume":"55","author":"Kurose","year":"1994","journal-title":"J. Leukoc. Biol."},{"issue":"1\u20132","key":"10.1016\/j.biomaterials.2020.120355_bib212","first-page":"63","article-title":"Phagocytosis-enhancing effect of lactoferrin on bovine peripheral blood monocytes in vitro and in vivo","volume":"35","author":"Szuster-Ciesielska","year":"1995","journal-title":"Arch. Vet. Pol."},{"issue":"5","key":"10.1016\/j.biomaterials.2020.120355_bib213","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1080\/03639045.2019.1569039","article-title":"Neuropharmacokinetic evaluation of lactoferrin-treated indinavir-loaded nanoemulsions: remarkable brain delivery enhancement","volume":"45","author":"Karami","year":"2019","journal-title":"Drug Dev. Ind. Pharm."},{"issue":"10","key":"10.1016\/j.biomaterials.2020.120355_bib214","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0140399","article-title":"Improved safety, bioavailability and pharmacokinetics of zidovudine through lactoferrin nanoparticles during oral administration in rats","volume":"10","author":"Kumar","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.biomaterials.2020.120355_bib215","doi-asserted-by":"crossref","first-page":"25479","DOI":"10.1038\/srep25479","article-title":"Triple combination MPT vaginal microbicide using curcumin and efavirenz loaded lactoferrin nanoparticles","volume":"6","author":"Lakshmi","year":"2016","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.biomaterials.2020.120355_bib216","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s11095-016-2048-4","article-title":"Triple drug combination of zidovudine, efavirenz and lamivudine loaded lactoferrin nanoparticles: an effective nano first-line regimen for HIV therapy","volume":"34","author":"Kumar","year":"2017","journal-title":"Pharm. Res. (N. Y.)"},{"issue":"2","key":"10.1016\/j.biomaterials.2020.120355_bib217","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1080\/10495398.2017.1313269","article-title":"Effects of recombinant human lactoferrin on osteoblast growth and bone status in piglets","volume":"29","author":"Li","year":"2018","journal-title":"Anim. Biotechnol."},{"issue":"6","key":"10.1016\/j.biomaterials.2020.120355_bib218","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1002\/adhm.201300496","article-title":"Recombinant human lactoferrin as a biomaterial for bone tissue engineering: mechanism of antiapoptotic and osteogenic activity","volume":"3","author":"Amini","year":"2014","journal-title":"Advanced healthcare materials"},{"issue":"21\u201322","key":"10.1016\/j.biomaterials.2020.120355_bib219","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.1089\/ten.tea.2013.0506","article-title":"Enzymatically cross-linked bovine lactoferrin as injectable hydrogel for cell delivery","volume":"20","author":"Amini","year":"2014","journal-title":"Tissue Eng."},{"issue":"12","key":"10.1016\/j.biomaterials.2020.120355_bib220","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20122880","article-title":"Activation of TGF-beta canonical and noncanonical signaling in bovine lactoferrin-induced osteogenic activity of C3H10T1\/2 mesenchymal stem cells","volume":"20","author":"Li","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.biomaterials.2020.120355_bib221","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/jbm.a.35170","article-title":"Effect of hydroxyapatite nanocrystals functionalized with lactoferrin in osteogenic differentiation of mesenchymal stem cells","volume":"103","author":"Montesi","year":"2015","journal-title":"J. Biomed. Mater. Res."},{"issue":"7","key":"10.1016\/j.biomaterials.2020.120355_bib222","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0132633","article-title":"Coupling hydroxyapatite nanocrystals with lactoferrin as a promising strategy to fine regulate bone homeostasis","volume":"10","author":"Montesi","year":"2015","journal-title":"PloS One"},{"issue":"2","key":"10.1016\/j.biomaterials.2020.120355_bib223","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.nano.2014.08.004","article-title":"In vivo toxicity of cationic micelles and liposomes","volume":"11","author":"Knudsen","year":"2015","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"issue":"9","key":"10.1016\/j.biomaterials.2020.120355_bib224","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/nbt.3330","article-title":"Principles of nanoparticle design for overcoming biological barriers to drug delivery","volume":"33","author":"Blanco","year":"2015","journal-title":"Nat. Biotechnol."},{"issue":"2","key":"10.1016\/j.biomaterials.2020.120355_bib225","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/cr.2015.9","article-title":"Cationic nanocarriers induce cell necrosis through impairment of Na+\/K+-ATPase and cause subsequent inflammatory response","volume":"25","author":"Wei","year":"2015","journal-title":"Cell Res."},{"issue":"6","key":"10.1016\/j.biomaterials.2020.120355_bib226","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1113\/expphysiol.2006.034876","article-title":"Enteric-formulated lactoferrin was more effectively transported into blood circulation from gastrointestinal tract in adult rats","volume":"91","author":"Takeuchi","year":"2006","journal-title":"Exp. Physiol."},{"issue":"13","key":"10.1016\/j.biomaterials.2020.120355_bib227","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1001\/jama.2009.1403","article-title":"S. For the Italian task force for the, t.I.S.o.N. Prevention of neonatal fungal infections, bovine lactoferrin supplementation for prevention of late-onset sepsis in very low-birth-weight neonates: a randomized trial","volume":"302","author":"Manzoni","year":"2009","journal-title":"J. Am. Med. Assoc."},{"issue":"1","key":"10.1016\/j.biomaterials.2020.120355_bib228","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1542\/peds.2011-0279","article-title":"Bovine lactoferrin prevents invasive fungal infections in very low birth weight infants: a randomized controlled trial","volume":"129","author":"Manzoni","year":"2012","journal-title":"Pediatrics"},{"issue":"3","key":"10.1016\/j.biomaterials.2020.120355_bib230","doi-asserted-by":"crossref","first-page":"121","DOI":"10.11599\/germs.2012.1022","volume":"2","author":"Solomons","year":"2012","journal-title":"Talactoferrin, Germs"},{"issue":"6","key":"10.1016\/j.biomaterials.2020.120355_bib231","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.biotechadv.2010.07.002","article-title":"Recombinant human lactoferrin: a valuable protein for pharmaceutical products and functional foods","volume":"28","author":"Conesa","year":"2010","journal-title":"Biotechnol. Adv."},{"issue":"13","key":"10.1016\/j.biomaterials.2020.120355_bib232","doi-asserted-by":"crossref","first-page":"6425","DOI":"10.1158\/0008-5472.CAN-06-4080","article-title":"Requirement for IFN-gamma, CD8+ T lymphocytes, and NKT cells in talactoferrin-induced inhibition of neu+ tumors","volume":"67","author":"Spadaro","year":"2007","journal-title":"Canc. Res."},{"issue":"5","key":"10.1016\/j.biomaterials.2020.120355_bib233","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1097\/MPG.0000000000000481","article-title":"Comparison of bioactivities of talactoferrin and lactoferrins from human and bovine milk","volume":"59","author":"Jiang","year":"2014","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"issue":"6","key":"10.1016\/j.biomaterials.2020.120355_bib234","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1111\/j.1365-2672.1992.tb05007.x","article-title":"Antibacterial spectrum of lactoferricin B, a potent bactericidal peptide derived from the N-terminal region of bovine lactoferrin","volume":"73","author":"Bellamy","year":"1992","journal-title":"J. Appl. Bacteriol."},{"issue":"11","key":"10.1016\/j.biomaterials.2020.120355_bib235","doi-asserted-by":"crossref","first-page":"348","DOI":"10.15698\/cst2019.11.204","article-title":"LTX-315 sequentially promotes lymphocyte-independent and lymphocyte-dependent antitumor effects","volume":"3","author":"Liao","year":"2019","journal-title":"Cell Stress"},{"issue":"1","key":"10.1016\/j.biomaterials.2020.120355_bib236","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13058-018-1092-x","article-title":"Combining the oncolytic peptide LTX-315 with doxorubicin demonstrates therapeutic potential in a triple-negative breast cancer model","volume":"21","author":"Camilio","year":"2019","journal-title":"Breast Cancer Res."},{"issue":"29","key":"10.1016\/j.biomaterials.2020.120355_bib237","doi-asserted-by":"crossref","first-page":"26599","DOI":"10.18632\/oncotarget.5613","article-title":"The oncolytic peptide LTX-315 kills cancer cells through Bax\/Bak-regulated mitochondrial membrane permeabilization","volume":"6","author":"Zhou","year":"2015","journal-title":"Oncotarget"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961220306013?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961220306013?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T16:54:38Z","timestamp":1758905678000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961220306013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":236,"alternative-id":["S0142961220306013"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2020.120355","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lactoferrin, a multi-functional glycoprotein: Active therapeutic, drug nanocarrier & targeting ligand","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2020.120355","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"120355"}}