{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:25:24Z","timestamp":1790835924795,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004791","name":"Shenzhen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004791","id-type":"DOI","asserted-by":"publisher"}]},{"name":"One Hundred Talents Program of Shaanxi Province"},{"name":"National Natural Science Foundation of Shaanxi Province"},{"name":"State Key Laboratory of Military Stomatology"},{"name":"Student of Xi'an Jiaotong University"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.biomaterials.2020.120357","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T05:35:10Z","timestamp":1599024910000},"page":"120357","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":82,"special_numbering":"C","title":["Nanocomposite hydrogel with NIR\/magnet\/enzyme multiple responsiveness to accurately manipulate local drugs for on-demand tumor therapy"],"prefix":"10.1016","volume":"262","author":[{"given":"Pingyun","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianfeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqian","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongkang","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.biomaterials.2020.120357_bib1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/nrc1529","article-title":"Chemotherapy and the war on cancer","volume":"5","author":"Chabner","year":"2005","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.biomaterials.2020.120357_bib2","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ejpb.2015.03.018","article-title":"Advanced targeted therapies in cancer: drug nanocarriers, the future of chemotherapy","volume":"93","author":"P\u00e9rez-Herrero","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"4","key":"10.1016\/j.biomaterials.2020.120357_bib3","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.progpolymsci.2005.09.004","article-title":"Polymer\u2013drug conjugates: progress in polymeric prodrugs","volume":"31","author":"Khandare","year":"2006","journal-title":"Prog. Polym. Sci."},{"issue":"12","key":"10.1016\/j.biomaterials.2020.120357_bib4","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/nnano.2007.387","article-title":"Nanocarriers as an emerging platform for cancer therapy","volume":"2","author":"Peer","year":"2007","journal-title":"Nat. Nanotechnol."},{"issue":"2","key":"10.1016\/j.biomaterials.2020.120357_bib5","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nrd1632","article-title":"Recent advances with liposomes as pharmaceutical carriers","volume":"4","author":"Torchilin","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"issue":"2","key":"10.1016\/j.biomaterials.2020.120357_bib6","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1021\/acs.chemrev.5b00456","article-title":"Gated materials for on-command release of guest molecules","volume":"116","author":"Aznar","year":"2016","journal-title":"Chem. Rev."},{"issue":"44","key":"10.1016\/j.biomaterials.2020.120357_bib7","doi-asserted-by":"crossref","first-page":"6999","DOI":"10.1002\/adfm.201402339","volume":"24","year":"2014","journal-title":"Adv. Funct. Mater."},{"issue":"31","key":"10.1016\/j.biomaterials.2020.120357_bib8","doi-asserted-by":"crossref","first-page":"1801961","DOI":"10.1002\/adfm.201801961","article-title":"Core\u2013satellite mesoporous silica\u2013gold nanotheranostics for biological stimuli triggered multimodal cancer therapy","volume":"28","author":"Jin","year":"2018","journal-title":"Adv. Funct. Mater."},{"issue":"1","key":"10.1016\/j.biomaterials.2020.120357_bib9","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1039\/C3BM60148J","article-title":"Stimuli-responsive functionalized mesoporous silica nanoparticles for drug release in response to various biological stimuli","volume":"2","author":"Chen","year":"2014","journal-title":"Biomater. Sci."},{"issue":"19","key":"10.1016\/j.biomaterials.2020.120357_bib10","doi-asserted-by":"crossref","first-page":"11147","DOI":"10.1021\/acs.chemrev.5b00116","article-title":"Clinical translation of nanomedicine","volume":"115","author":"Min","year":"2015","journal-title":"Chem. Rev."},{"issue":"9","key":"10.1016\/j.biomaterials.2020.120357_bib11","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/nrd2614","article-title":"Nanoparticle therapeutics: an emerging treatment modality for cancer","volume":"7","author":"Davis","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"issue":"12","key":"10.1016\/j.biomaterials.2020.120357_bib12","article-title":"Albumin-bound paclitaxel","volume":"12","year":"2006","journal-title":"Clin. Canc. Res."},{"issue":"2","key":"10.1016\/j.biomaterials.2020.120357_bib13","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/nbt0206-163","article-title":"Designer combination therapy for cancer","volume":"24","author":"Lane","year":"2006","journal-title":"Nat. Biotechnol."},{"issue":"1","key":"10.1016\/j.biomaterials.2020.120357_bib14","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1038\/ncomms4364","article-title":"ATP-triggered anticancer drug delivery","volume":"5","author":"Mo","year":"2014","journal-title":"Nat. Commun."},{"issue":"25","key":"10.1016\/j.biomaterials.2020.120357_bib15","doi-asserted-by":"crossref","first-page":"15857","DOI":"10.1021\/acsami.6b02562","article-title":"Light-induced hydrogel based on tumor-targeting mesoporous silica nanoparticles as a theranostic platform for sustained cancer treatment","volume":"8","author":"Chen","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"5","key":"10.1016\/j.biomaterials.2020.120357_bib16","doi-asserted-by":"crossref","first-page":"16014","DOI":"10.1038\/natrevmats.2016.14","article-title":"Analysis of nanoparticle delivery to tumours","volume":"1","author":"Wilhelm","year":"2016","journal-title":"Nature Reviews Materials"},{"issue":"8","key":"10.1016\/j.biomaterials.2020.120357_bib17","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/nrc1893","article-title":"Drug penetration in solid tumours","volume":"6","author":"Minchinton","year":"2006","journal-title":"Nat. Rev. Canc."},{"issue":"3","key":"10.1016\/j.biomaterials.2020.120357_bib18","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jconrel.2009.05.009","article-title":"An injectable drug delivery platform for sustained combination therapy","volume":"138","author":"Baumann","year":"2009","journal-title":"J. Contr. Release"},{"issue":"3","key":"10.1016\/j.biomaterials.2020.120357_bib19","doi-asserted-by":"crossref","DOI":"10.4161\/tisb.29528","article-title":"Barriers to drug delivery in solid tumors","volume":"2","author":"Sriraman","year":"2014","journal-title":"Tissue Barriers"},{"issue":"2","key":"10.1016\/j.biomaterials.2020.120357_bib20","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1039\/C3TB21016B","article-title":"Recent advances in hydrogel based drug delivery systems for the human body","volume":"2","author":"Vashist","year":"2014","journal-title":"J. Mater. Chem. B"},{"issue":"11","key":"10.1016\/j.biomaterials.2020.120357_bib21","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1002\/adfm.201301307","article-title":"Injectable hydrogels from triblock copolymers of vitamin E-functionalized polycarbonate and poly(ethylene glycol) for subcutaneous delivery of antibodies for cancer therapy","volume":"24","author":"Lee","year":"2014","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.biomaterials.2020.120357_bib22","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.biomaterials.2017.08.009","article-title":"Regulating cancer associated fibroblasts with losartan-loaded injectable peptide hydrogel to potentiate chemotherapy in inhibiting growth and lung metastasis of triple negative breast cancer","volume":"144","author":"Hu","year":"2017","journal-title":"Biomaterials"},{"issue":"4","key":"10.1016\/j.biomaterials.2020.120357_bib23","doi-asserted-by":"crossref","DOI":"10.1088\/1468-6996\/14\/4\/045005","article-title":"Preparation of chitosan\/mesoporous silica nanoparticle composite hydrogels for sustained co-delivery of biomacromolecules and small chemical drugs","volume":"14","author":"Zhu","year":"2013","journal-title":"Sci. Technol. Adv. Mater."},{"issue":"30","key":"10.1016\/j.biomaterials.2020.120357_bib24","doi-asserted-by":"crossref","first-page":"7631","DOI":"10.1016\/j.biomaterials.2010.07.004","article-title":"Intrathecal delivery of a polymeric nanocomposite hydrogel after spinal cord injury","volume":"31","author":"Baumann","year":"2010","journal-title":"Biomaterials"},{"issue":"8","key":"10.1016\/j.biomaterials.2020.120357_bib25","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1021\/bm4005639","article-title":"Agarose hydrogels embedded with pH-responsive diblock copolymer micelles for triggered release of substances","volume":"14","author":"Jin","year":"2013","journal-title":"Biomacromolecules"},{"issue":"1","key":"10.1016\/j.biomaterials.2020.120357_bib26","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0169-409X(01)00243-5","article-title":"Pulsatile drug release control using hydrogels","volume":"54","author":"Kikuchi","year":"2002","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"3","key":"10.1016\/j.biomaterials.2020.120357_bib27","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.jconrel.2008.06.008","article-title":"Magnetic hydrogel nanocomposites for remote controlled pulsatile drug release","volume":"130","author":"Satarkar","year":"2008","journal-title":"J. Contr. Release"},{"issue":"4","key":"10.1016\/j.biomaterials.2020.120357_bib28","doi-asserted-by":"crossref","DOI":"10.1002\/ange.201610618","article-title":"Frontispiz: photo-modulated therapeutic protein release from a hydrogel depot using visible light","volume":"129","author":"Basuki","year":"2017","journal-title":"Angew. Chem."},{"issue":"21","key":"10.1016\/j.biomaterials.2020.120357_bib29","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/adfm.201801000","article-title":"An injectable supramolecular polymer nanocomposite hydrogel for prevention of breast cancer recurrence with theranostic and mammoplastic functions","volume":"28","author":"Wu","year":"2018","journal-title":"Adv. Funct. Mater."},{"issue":"3","key":"10.1016\/j.biomaterials.2020.120357_bib30","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1073\/pnas.1714421115","article-title":"Novel concept of the smart NIR-light\u2013controlled drug release of black phosphorus nanostructure for cancer therapy","volume":"115","author":"Qiu","year":"2018","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"issue":"4","key":"10.1016\/j.biomaterials.2020.120357_bib31","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3109\/10717541003702769","article-title":"Polymeric micelles as a drug delivery system enhance cytotoxicity of vinorelbine through more intercellular accumulation","volume":"17","author":"Lu","year":"2010","journal-title":"Drug Deliv."},{"key":"10.1016\/j.biomaterials.2020.120357_bib32","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1053\/j.seminoncol.2004.08.002","article-title":"Pegylated liposomal doxorubicin: proof of principle using preclinical animal models and pharmacokinetic studies","volume":"31","author":"Vail","year":"2004","journal-title":"Semin. Oncol."},{"issue":"31","key":"10.1016\/j.biomaterials.2020.120357_bib33","doi-asserted-by":"crossref","first-page":"7785","DOI":"10.1200\/JCO.2004.00.6148","article-title":"Phase I and pharmacokinetics trial of ABI-007, a novel nanoparticle formulation of paclitaxel in patients with advanced nonhematologic malignancies","volume":"23","author":"Nyman","year":"2005","journal-title":"J. Clin. Oncol."},{"issue":"23","key":"10.1016\/j.biomaterials.2020.120357_bib34","doi-asserted-by":"crossref","first-page":"3566","DOI":"10.1002\/adma.201500534","article-title":"A mechanically strong, highly stable, thermoplastic, and self-healable supramolecular polymer hydrogel","volume":"27","author":"Dai","year":"2015","journal-title":"Adv. Mater."},{"issue":"16","key":"10.1016\/j.biomaterials.2020.120357_bib35","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1002\/adhm.201600357","article-title":"Synthesis of ferromagnetic Fe0.6Mn0.4O nanoflowers as a new class of magnetic theranostic platform for in vivo T1-T2 dual-mode magnetic resonance imaging and magnetic hyperthermia therapy","volume":"5","author":"Liu","year":"2016","journal-title":"Advanced Healthcare Materials"},{"key":"10.1016\/j.biomaterials.2020.120357_bib36","series-title":"Advanced Functional Materials","article-title":"Stimuli-responsive scaffold for breast cancer treatment combining accurate photothermal therapy and adipose tissue regeneration","author":"Bai","year":"2019"},{"issue":"16","key":"10.1016\/j.biomaterials.2020.120357_bib37","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1002\/adma.201203700","article-title":"Prospects and challenges of graphene in biomedical applications","volume":"25","author":"Bitounis","year":"2013","journal-title":"Adv. Mater."},{"issue":"1","key":"10.1016\/j.biomaterials.2020.120357_bib38","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1080\/10717544.2019.1588424","article-title":"Application and design of esterase-responsive nanoparticles for cancer therapy","volume":"26","author":"Dong","year":"2019","journal-title":"Drug Deliv."},{"issue":"45","key":"10.1016\/j.biomaterials.2020.120357_bib39","doi-asserted-by":"crossref","first-page":"38700","DOI":"10.1021\/acsami.8b11349","article-title":"On-demand versatile prodrug nanomicelle for tumor-specific bioimaging and photothermal-chemo synergistic cancer therapy","volume":"10","author":"Su","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"4","key":"10.1016\/j.biomaterials.2020.120357_bib40","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1039\/c0nr00776e","article-title":"Controlled assembly of Fe3O4 magnetic nanoparticles on graphene oxide","volume":"3","author":"Zhang","year":"2011","journal-title":"Nanoscale"},{"issue":"4","key":"10.1016\/j.biomaterials.2020.120357_bib41","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.carbon.2009.11.037","article-title":"Preparation of graphene by the rapid and mild thermal reduction of graphene oxide induced by microwaves","volume":"48","author":"Chen","year":"2010","journal-title":"Carbon"},{"issue":"19","key":"10.1016\/j.biomaterials.2020.120357_bib42","doi-asserted-by":"crossref","first-page":"7985","DOI":"10.1021\/jp811377n","article-title":"Electrochemical reduction of oriented graphene oxide films: an in situ Raman spectroelectrochemical study","volume":"113","author":"Ramesha","year":"2009","journal-title":"J. Phys. Chem. C"},{"issue":"44","key":"10.1016\/j.biomaterials.2020.120357_bib43","doi-asserted-by":"crossref","first-page":"6999","DOI":"10.1002\/adfm.201402339","article-title":"Dual bioresponsive mesoporous silica nanocarrier as an \u201cAND\u201d logic gate for targeted drug delivery cancer cells","volume":"24","author":"Chen","year":"2014","journal-title":"Adv. Funct. Mater."},{"issue":"11","key":"10.1016\/j.biomaterials.2020.120357_bib44","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1039\/C6BM00597G","article-title":"A thermoresponsive supramolecular copolymer hydrogel for the embolization of kidney arteries","volume":"4","author":"Shi","year":"2016","journal-title":"Biomaterials Science"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961220306037?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961220306037?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T16:54:57Z","timestamp":1758905697000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961220306037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":44,"alternative-id":["S0142961220306037"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2020.120357","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nanocomposite hydrogel with NIR\/magnet\/enzyme multiple responsiveness to accurately manipulate local drugs for on-demand tumor therapy","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2020.120357","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"120357"}}