{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T22:33:29Z","timestamp":1780698809625,"version":"3.54.1"},"reference-count":88,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1S10OD02349701"],"award-info":[{"award-number":["1S10OD02349701"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR03145"],"award-info":[{"award-number":["R01AR03145"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006521","name":"Stanford University School of Medicine","doi-asserted-by":"publisher","award":["R01AR057837"],"award-info":[{"award-number":["R01AR057837"]}],"id":[{"id":"10.13039\/100006521","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006521","name":"Stanford University School of Medicine","doi-asserted-by":"publisher","award":["R01AR063717"],"award-info":[{"award-number":["R01AR063717"]}],"id":[{"id":"10.13039\/100006521","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006521","name":"Stanford University School of Medicine","doi-asserted-by":"publisher","award":["R01AR072613"],"award-info":[{"award-number":["R01AR072613"]}],"id":[{"id":"10.13039\/100006521","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006521","name":"Stanford University School of Medicine","doi-asserted-by":"publisher","award":["R01AR074458"],"award-info":[{"award-number":["R01AR074458"]}],"id":[{"id":"10.13039\/100006521","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006521","name":"Stanford University School of Medicine","doi-asserted-by":"publisher","award":["U01AR069395"],"award-info":[{"award-number":["U01AR069395"]}],"id":[{"id":"10.13039\/100006521","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.biomaterials.2021.120972","type":"journal-article","created":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T05:37:10Z","timestamp":1624253830000},"page":"120972","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["The efficacy of lapine preconditioned or genetically modified IL4 over-expressing bone marrow-derived mesenchymal stromal cells in corticosteroid-associated osteonecrosis of the femoral head in rabbits"],"prefix":"10.1016","volume":"275","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1339-0023","authenticated-orcid":false,"given":"Masahiro","family":"Maruyama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyedsina","family":"Moeinzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1623-6336","authenticated-orcid":false,"given":"Roberto Alfonso","family":"Guzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9513-9288","authenticated-orcid":false,"given":"Ning","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4386-1452","authenticated-orcid":false,"given":"Hunter W.","family":"Storaci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Utsunomiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7967-6596","authenticated-orcid":false,"given":"Elaine","family":"Lui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elijah Ejun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Rhee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiaki","family":"Takagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunzhi Peter","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1919-3717","authenticated-orcid":false,"given":"Stuart B.","family":"Goodman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.biomaterials.2021.120972_bib1","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.2106\/JBJS.19.01271","article-title":"Nontraumatic osteonecrosis of the femoral head: where do we stand today?: a 5-year update","volume":"102","author":"Mont","year":"2020","journal-title":"J Bone Joint Surg Am"},{"issue":"4 Suppl 1","key":"10.1016\/j.biomaterials.2021.120972_bib2","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1054\/arth.2002.33300","article-title":"Osteonecrosis: avoiding total hip arthroplasty","volume":"17","author":"Hungerford","year":"2002","journal-title":"J. Arthroplasty"},{"key":"10.1016\/j.biomaterials.2021.120972_bib3","first-page":"337","article-title":"Osteonecrosis of the hip: management in the 21st century","volume":"52","author":"Lieberman","year":"2003","journal-title":"Instr. Course Lect."},{"issue":"4","key":"10.1016\/j.biomaterials.2021.120972_bib4","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.jos.2016.03.008","article-title":"Clinical and basic research on steroid-induced osteonecrosis of the femoral head in Japan","volume":"21","author":"Kubo","year":"2016","journal-title":"J. Orthop. Sci."},{"issue":"21","key":"10.1016\/j.biomaterials.2021.120972_bib5","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.4103\/0366-6999.168017","article-title":"Prevalence of nontraumatic osteonecrosis of the femoral head and its associated risk factors in the Chinese population: results from a nationally representative survey","volume":"128","author":"Zhao","year":"2015","journal-title":"Chin. Med. J. (Engl)"},{"issue":"9","key":"10.1016\/j.biomaterials.2021.120972_bib6","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1016\/j.arth.2020.04.092","article-title":"Diagnosis of osteonecrosis of the femoral head: too little, too late, and independent of etiology","volume":"35","author":"Boontanapibul","year":"2020","journal-title":"J. Arthroplasty"},{"issue":"1","key":"10.1016\/j.biomaterials.2021.120972_bib7","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1186\/s13018-019-1359-7","article-title":"The efficacy and safety of core decompression for the treatment of femoral head necrosis: a systematic review and meta-analysis","volume":"14","author":"Hua","year":"2019","journal-title":"J. Orthop. Surg. Res."},{"issue":"9","key":"10.1016\/j.biomaterials.2021.120972_bib8","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.2106\/JBJS.RVW.18.00202","article-title":"Cell-based and scaffold-based therapies for joint preservation in early-stage osteonecrosis of the femoral head: a review of basic research","volume":"7","author":"Maruyama","year":"2019","journal-title":"JBJS Rev."},{"issue":"1","key":"10.1016\/j.biomaterials.2021.120972_bib9","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3109\/17453674.2015.1077418","article-title":"The role of \"cell therapy\" in osteonecrosis of the femoral head. A systematic review of the literature and meta-analysis of 7 studies","volume":"87","author":"Papakostidis","year":"2016","journal-title":"Acta Orthop."},{"key":"10.1016\/j.biomaterials.2021.120972_bib10","first-page":"9847015","article-title":"Insights into endothelial progenitor cells: origin, classification, potentials, and prospects","volume":"2018","author":"Chopra","year":"2018","journal-title":"Stem Cell. Int."},{"issue":"5411","key":"10.1016\/j.biomaterials.2021.120972_bib11","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1126\/science.284.5411.143","article-title":"Multilineage potential of adult human mesenchymal stem cells","volume":"284","author":"Pittenger Mf1","year":"1999","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.biomaterials.2021.120972_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0071602","article-title":"Bone marrow aspiration concentrate and platelet rich plasma for osteochondral repair in a porcine osteochondral defect model","volume":"8","author":"Betsch","year":"2013","journal-title":"PloS One"},{"issue":"1","key":"10.1016\/j.biomaterials.2021.120972_bib13","doi-asserted-by":"crossref","DOI":"10.1177\/2325967119893634","article-title":"Evaluation of the consistency and composition of commercially available bone marrow aspirate concentrate systems","volume":"8","author":"Dragoo","year":"2020","journal-title":"Orthop. J. Sports Med."},{"key":"10.1016\/j.biomaterials.2021.120972_bib14","doi-asserted-by":"crossref","DOI":"10.2106\/JBJS.20.02055","article-title":"Patient Age and cell concentration influence prevalence and concentration of progenitors in bone marrow aspirates: an analysis of 436 patients","author":"Mantripragada","year":"2021","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.biomaterials.2021.120972_bib15","doi-asserted-by":"crossref","first-page":"316","DOI":"10.3389\/fcell.2020.00316","article-title":"Limited potential or unfavorable manipulations? Strategies toward efficient mesenchymal stem\/stromal cell applications","volume":"8","author":"Lavrentieva","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"2","key":"10.1016\/j.biomaterials.2021.120972_bib16","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3727\/096368910X522234","article-title":"Beneficial effect of autologous transplantation of endothelial progenitor cells on steroid-induced femoral head osteonecrosis in rabbits","volume":"20","author":"Sun","year":"2011","journal-title":"Cell Transplant."},{"issue":"5","key":"10.1016\/j.biomaterials.2021.120972_bib17","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1002\/sctm.20-0346","article-title":"Cotransplantation of mesenchymal stem cells and endothelial progenitor cells for treating steroid-induced osteonecrosis of the femoral head","volume":"10","author":"Xu","year":"2021","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.biomaterials.2021.120972_bib18","doi-asserted-by":"crossref","first-page":"386","DOI":"10.3389\/fendo.2020.00386","article-title":"Modulation of the inflammatory response and bone healing","volume":"11","author":"Maruyama","year":"2020","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"8","key":"10.1016\/j.biomaterials.2021.120972_bib19","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1002\/jcp.24330","article-title":"Activation and promotion of adipose stem cells by tumour necrosis factor-alpha preconditioning for bone regeneration","volume":"228","author":"Lu","year":"2013","journal-title":"J. Cell. Physiol."},{"issue":"21\u201322","key":"10.1016\/j.biomaterials.2021.120972_bib20","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1089\/ten.tea.2016.0548","article-title":"Priming adipose stem cells with tumor necrosis factor-alpha preconditioning potentiates their exosome efficacy for bone regeneration","volume":"23","author":"Lu","year":"2017","journal-title":"Tissue Eng."},{"key":"10.1016\/j.biomaterials.2021.120972_bib21","doi-asserted-by":"crossref","first-page":"1318256","DOI":"10.1155\/2016\/1318256","article-title":"Cytokines TNF-alpha, IL-6, IL-17F, and IL-4 differentially affect osteogenic differentiation of human adipose stem cells","volume":"2016","author":"Bastidas-Coral","year":"2016","journal-title":"Stem Cell. Int."},{"issue":"1","key":"10.1016\/j.biomaterials.2021.120972_bib22","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1186\/s13287-017-0730-z","article-title":"Preconditioning of murine mesenchymal stem cells synergistically enhanced immunomodulation and osteogenesis","volume":"8","author":"Lin","year":"2017","journal-title":"Stem Cell Res. Ther."},{"issue":"7","key":"10.1016\/j.biomaterials.2021.120972_bib23","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1016\/j.actbio.2012.03.042","article-title":"Revision joint replacement, wear particles, and macrophage polarization","volume":"8","author":"Rao","year":"2012","journal-title":"Acta Biomater."},{"issue":"9","key":"10.1016\/j.biomaterials.2021.120972_bib24","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1002\/jbm.a.35759","article-title":"The effect of local IL-4 delivery or CCL2 blockade on implant fixation and bone structural properties in a mouse model of wear particle induced osteolysis","volume":"104","author":"Sato","year":"2016","journal-title":"J. Biomed. Mater. Res."},{"issue":"19","key":"10.1016\/j.biomaterials.2021.120972_bib25","doi-asserted-by":"crossref","first-page":"5482","DOI":"10.7150\/thno.28315","article-title":"Development of an accurate and proactive immunomodulatory strategy to improve bone substitute material-mediated osteogenesis and angiogenesis","volume":"8","author":"Zheng","year":"2018","journal-title":"Theranostics"},{"issue":"8","key":"10.1016\/j.biomaterials.2021.120972_bib26","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.jcyt.2018.06.009","article-title":"Transplanted interleukin-4--secreting mesenchymal stromal cells show extended survival and increased bone mineral density in the murine femur","volume":"20","author":"Lin","year":"2018","journal-title":"Cytotherapy"},{"issue":"11","key":"10.1016\/j.biomaterials.2021.120972_bib27","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1002\/jbm.a.36982","article-title":"Interleukin-4 overexpressing mesenchymal stem cells within gelatin-based microribbon hydrogels enhance bone healing in a murine long bone critical-size defect model","volume":"108","author":"Ueno","year":"2020","journal-title":"J. Biomed. Mater. Res."},{"issue":"6","key":"10.1016\/j.biomaterials.2021.120972_bib28","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1089\/ten.teb.2014.0086","article-title":"Review of collagen I hydrogels for bioengineered tissue microenvironments: characterization of mechanics, structure, and transport","volume":"20","author":"Antoine","year":"2014","journal-title":"Tissue Eng. B Rev."},{"issue":"3","key":"10.1016\/j.biomaterials.2021.120972_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0122500","article-title":"Tunable collagen I hydrogels for engineered physiological tissue micro-environments","volume":"10","author":"Antoine","year":"2015","journal-title":"PloS One"},{"issue":"3","key":"10.1016\/j.biomaterials.2021.120972_bib30","doi-asserted-by":"crossref","first-page":"387","DOI":"10.2217\/rme.09.2","article-title":"Delivering stem cells to the heart in a collagen matrix reduces relocation of cells to other organs as assessed by nanoparticle technology","volume":"4","author":"Dai","year":"2009","journal-title":"Regen. Med."},{"issue":"9","key":"10.1016\/j.biomaterials.2021.120972_bib31","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1016\/j.ymthe.2018.07.022","article-title":"It's all in the delivery: designing hydrogels for cell and non-viral gene therapies","volume":"26","author":"Youngblood","year":"2018","journal-title":"Mol. Ther."},{"issue":"2","key":"10.1016\/j.biomaterials.2021.120972_bib32","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1039\/C1SM06513K","article-title":"Shear-thinning hydrogels for biomedical applications","volume":"8","author":"Guvendiren","year":"2012","journal-title":"Soft Matter"},{"issue":"8","key":"10.1016\/j.biomaterials.2021.120972_bib33","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/mabi.200600069","article-title":"Alginate hydrogels as biomaterials","volume":"6","author":"Augst","year":"2006","journal-title":"Macromol. Biosci."},{"issue":"2","key":"10.1016\/j.biomaterials.2021.120972_bib34","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/jbm.a.30103","article-title":"Peptide-modified alginate surfaces as a growth permissive substrate for neurite outgrowth","volume":"71a","author":"Dhoot","year":"2004","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.biomaterials.2021.120972_bib35","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.actbio.2016.11.016","article-title":"3D culture of human pluripotent stem cells in RGD-alginate hydrogel improves retinal tissue development","volume":"49","author":"Hunt","year":"2017","journal-title":"Acta Biomater."},{"issue":"27","key":"10.1016\/j.biomaterials.2021.120972_bib36","doi-asserted-by":"crossref","first-page":"7012","DOI":"10.1016\/j.biomaterials.2010.05.078","article-title":"The use of human mesenchymal stem cells encapsulated in RGD modified alginate microspheres in the repair of myocardial infarction in the rat","volume":"31","author":"Yu","year":"2010","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.biomaterials.2021.120972_bib37","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3109\/15419069509081275","article-title":"Function and receptor specificity of a minimal 20-kilodalton cell adhesive fragment of fibronectin","volume":"3","author":"Akiyama","year":"1995","journal-title":"Cell Adhes. Commun."},{"issue":"4","key":"10.1016\/j.biomaterials.2021.120972_bib38","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1002\/term.248","article-title":"Immobilization of fibronectin in chitosan substrates improves cell adhesion and proliferation","volume":"4","author":"Custodio","year":"2010","journal-title":"J. Tissue Eng. Regen. M"},{"issue":"9","key":"10.1016\/j.biomaterials.2021.120972_bib39","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.jcyt.2017.06.008","article-title":"Establishment of NF-kappaB sensing and interleukin-4 secreting mesenchymal stromal cells as an \"on-demand\" drug delivery system to modulate inflammation","volume":"19","author":"Lin","year":"2017","journal-title":"Cytotherapy"},{"issue":"8","key":"10.1016\/j.biomaterials.2021.120972_bib40","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1002\/jbm.b.34340","article-title":"Osteogenic ability of rat bone marrow concentrate is at least as efficacious as mesenchymal stem cells in vitro","volume":"107","author":"Kohno","year":"2019","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"issue":"3\u20134","key":"10.1016\/j.biomaterials.2021.120972_bib41","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1089\/ten.tea.2018.0130","article-title":"Effect of electron beam sterilization on three-dimensional-printed polycaprolactone\/beta-tricalcium phosphate scaffolds for bone tissue engineering","volume":"25","author":"Bruyas","year":"2019","journal-title":"Tissue Eng Pt A"},{"issue":"3","key":"10.1016\/j.biomaterials.2021.120972_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0059147","article-title":"Effect of CD44 binding peptide conjugated to an engineered inert matrix on maintenance of breast cancer stem cells and tumorsphere formation","volume":"8","author":"Yang","year":"2013","journal-title":"PloS One"},{"issue":"3\u20134","key":"10.1016\/j.biomaterials.2021.120972_bib43","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1089\/ten.tea.2018.0083","article-title":"Sequential zonal chondrogenic differentiation of mesenchymal stem cells in cartilage matrices","volume":"25","author":"Moeinzadeh","year":"2019","journal-title":"Tissue Eng Pt A"},{"key":"10.1016\/j.biomaterials.2021.120972_bib44","article-title":"The efficacy of core decompression for steroid-associated osteonecrosis of the femoral head in rabbits","author":"Maruyama","year":"2020","journal-title":"J. Orthop. Res."},{"issue":"1","key":"10.1016\/j.biomaterials.2021.120972_bib45","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00256-015-2269-3","article-title":"Problems with the pathological diagnosis of osteonecrosis","volume":"45","author":"Parajuli","year":"2016","journal-title":"Skeletal Radiol."},{"issue":"5","key":"10.1016\/j.biomaterials.2021.120972_bib46","doi-asserted-by":"crossref","first-page":"755","DOI":"10.2106\/00004623-198567050-00010","article-title":"Steroid-induced accumulation of lipid in the osteocytes of the rabbit femoral head. A histochemical and electron microscopic study","volume":"67","author":"Kawai","year":"1985","journal-title":"J Bone Joint Surg Am"},{"issue":"11","key":"10.1016\/j.biomaterials.2021.120972_bib47","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1002\/art.1780401119","article-title":"Effects of pulse methylprednisolone on bone and marrow tissues: corticosteroid-induced osteonecrosis in rabbits","volume":"40","author":"Yamamoto","year":"1997","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.biomaterials.2021.120972_bib48","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.biomaterials.2018.09.030","article-title":"The effects of a functionally-graded scaffold and bone marrow-derived mononuclear cells on steroid-induced femoral head osteonecrosis","volume":"187","author":"Maruyama","year":"2018","journal-title":"Biomaterials"},{"issue":"7\u20138","key":"10.1016\/j.biomaterials.2021.120972_bib49","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1089\/ten.tea.2011.0391","article-title":"Improving viability of stem cells during syringe needle flow through the design of hydrogel cell carriers","volume":"18","author":"Aguado","year":"2012","journal-title":"Tissue Eng Pt A"},{"issue":"1","key":"10.1016\/j.biomaterials.2021.120972_bib50","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/cyto.a.23171","article-title":"Isolation and characterization of canine placenta-derived mesenchymal stromal cells for the treatment of neurological disorders in dogs","volume":"93a","author":"Long","year":"2018","journal-title":"Cytometry"},{"issue":"6","key":"10.1016\/j.biomaterials.2021.120972_bib51","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1002\/mabi.201300567","article-title":"Effect of cell density on mesenchymal stem cells aggregation in RGD-alginate 3D matrices under osteoinductive conditions","volume":"14","author":"Maia","year":"2014","journal-title":"Macromol. Biosci."},{"issue":"4","key":"10.1016\/j.biomaterials.2021.120972_bib52","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1089\/ten.2006.12.821","article-title":"Behavior of adult human mesenchymal stem cells entrapped in alginate-GRGDY beads","volume":"12","author":"Markusen","year":"2006","journal-title":"Tissue Eng."},{"issue":"3","key":"10.1016\/j.biomaterials.2021.120972_bib53","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s11626-013-9702-5","article-title":"Characterization and differentiation potential of rabbit mesenchymal stem cells for translational regenerative medicine","volume":"50","author":"Bakhtina","year":"2014","journal-title":"In Vitro Cell. Dev. Biol. Anim."},{"key":"10.1016\/j.biomaterials.2021.120972_bib54","series-title":"In-situ Stable Injectable Collagen-Based Hydrogels for Cell and Growth Factor Delivery","author":"Moeinzadeh","year":"2020"},{"key":"10.1016\/j.biomaterials.2021.120972_bib55","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.3389\/fimmu.2018.01658","article-title":"Critical role of tumor necrosis factor signaling in mesenchymal stem cell-based therapy for autoimmune and inflammatory diseases","volume":"9","author":"Yan","year":"2018","journal-title":"Front. Immunol."},{"issue":"12","key":"10.1016\/j.biomaterials.2021.120972_bib56","doi-asserted-by":"crossref","first-page":"6984","DOI":"10.1016\/S0021-9258(18)83528-1","article-title":"Internalization of human interleukin 4 and transient down-regulation of its receptor in the CD23-inducible jijoye cells","volume":"264","author":"Galizzi","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biomaterials.2021.120972_bib57","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.biomaterials.2014.10.017","article-title":"Sequential delivery of immunomodulatory cytokines to facilitate the M1-to-M2 transition of macrophages and enhance vascularization of bone scaffolds","volume":"37","author":"Spiller","year":"2015","journal-title":"Biomaterials"},{"issue":"3","key":"10.1016\/j.biomaterials.2021.120972_bib58","doi-asserted-by":"crossref","first-page":"e563","DOI":"10.1002\/mgg3.563","article-title":"IL-4 gene polymorphisms and their relation to steroid-induced osteonecrosis of the femoral head in Chinese population","volume":"7","author":"Jin","year":"2019","journal-title":"Mol. Genet .Genomic Med."},{"issue":"4","key":"10.1016\/j.biomaterials.2021.120972_bib59","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s10735-014-9571-6","article-title":"STAT1-caspase 3 pathway in the apoptotic process associated with steroid-induced necrosis of the femoral head","volume":"45","author":"Xu","year":"2014","journal-title":"J. Mol. Histol."},{"issue":"8","key":"10.1016\/j.biomaterials.2021.120972_bib60","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1007\/s10495-017-1383-1","article-title":"Fludarabine inhibits STAT1-mediated up-regulation of caspase-3 expression in dexamethasone-induced osteoblasts apoptosis and slows the progression of steroid-induced avascular necrosis of the femoral head in rats","volume":"22","author":"Feng","year":"2017","journal-title":"Apoptosis"},{"issue":"4","key":"10.1016\/j.biomaterials.2021.120972_bib61","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22265","article-title":"Downregulating STAT1\/caspase-3 signaling with fludarabine to alleviate progression in a rat model of steroid-induced avascular necrosis of the femoral head","volume":"33","author":"Lin","year":"2019","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.biomaterials.2021.120972_bib62","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.3389\/fphar.2020.01195","article-title":"The protective effect of luteolin in glucocorticoid-induced osteonecrosis of the femoral head","volume":"11","author":"Yan","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"4","key":"10.1016\/j.biomaterials.2021.120972_bib63","first-page":"3111","article-title":"IFNgamma induces apoptosis in human melanocytes by activating the JAK1\/STAT1 signaling pathway","volume":"22","author":"Su","year":"2020","journal-title":"Mol. Med. Rep."},{"issue":"4","key":"10.1016\/j.biomaterials.2021.120972_bib64","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/cdd.2016.162","article-title":"STAT1 mediates transmembrane TNF-alpha-induced formation of death-inducing signaling complex and apoptotic signaling via TNFR1","volume":"24","author":"Jiang","year":"2017","journal-title":"Cell Death Differ."},{"issue":"9","key":"10.1016\/j.biomaterials.2021.120972_bib65","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/s41577-018-0029-z","article-title":"IFNgamma: signalling, epigenetics and roles in immunity, metabolism, disease and cancer immunotherapy","volume":"18","author":"Ivashkiv","year":"2018","journal-title":"Nat. Rev. Immunol."},{"issue":"9","key":"10.1016\/j.biomaterials.2021.120972_bib66","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1002\/jor.24619","article-title":"Curcumin prevents osteocyte apoptosis by inhibiting M1-type macrophage polarization in mice model of glucocorticoid-associated osteonecrosis of the femoral head","volume":"38","author":"Jin","year":"2020","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.biomaterials.2021.120972_bib67","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.3389\/fimmu.2019.01084","article-title":"Macrophage polarization: different gene signatures in M1(LPS+) vs. Classically and M2(LPS-) vs. Alternatively activated macrophages","volume":"10","author":"Orecchioni","year":"2019","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.biomaterials.2021.120972_bib68","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1007\/s00198-015-3474-6","article-title":"IL-4 administration exerts preventive effects via suppression of underlying inflammation and TNF-alpha-induced apoptosis in steroid-induced osteonecrosis","volume":"27","author":"Wu","year":"2016","journal-title":"Osteoporos. Int."},{"issue":"11","key":"10.1016\/j.biomaterials.2021.120972_bib69","doi-asserted-by":"crossref","first-page":"20520","DOI":"10.1002\/jcp.28652","article-title":"IL-6 counteracts the inhibitory effect of IL-4 on osteogenic differentiation of human adipose stem cells","volume":"234","author":"Bastidas-Coral","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.biomaterials.2021.120972_bib70","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.biomaterials.2017.12.025","article-title":"Mesenchymal stem cell-macrophage crosstalk and bone healing","volume":"196","author":"Pajarinen","year":"2019","journal-title":"Biomaterials"},{"issue":"11","key":"10.1016\/j.biomaterials.2021.120972_bib71","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.1002\/jor.23553","article-title":"Pro-inflammatory M1 macrophages promote Osteogenesis by mesenchymal stem cells via the COX-2-prostaglandin E2 pathway","volume":"35","author":"Lu","year":"2017","journal-title":"J. Orthop. Res."},{"issue":"1","key":"10.1016\/j.biomaterials.2021.120972_bib72","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13287-016-0276-5","article-title":"The effects of immunomodulation by macrophage subsets on osteogenesis in vitro","volume":"7","author":"Loi","year":"2016","journal-title":"Stem Cell Res. Ther."},{"issue":"10","key":"10.1016\/j.biomaterials.2021.120972_bib73","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1302\/2046-3758.810.BJR-2018-0231.R2","article-title":"Precise immunomodulation of the M1 to M2 macrophage transition enhances mesenchymal stem cell osteogenesis and differs by sex","volume":"8","author":"Nathan","year":"2019","journal-title":"Bone Joint Res."},{"issue":"11","key":"10.1016\/j.biomaterials.2021.120972_bib74","doi-asserted-by":"crossref","first-page":"8672","DOI":"10.1128\/jvi.71.11.8672-8677.1997","article-title":"Overexpression of interleukin-4 delays virus clearance in mice infected with respiratory syncytial virus","volume":"71","author":"Fischer","year":"1997","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.biomaterials.2021.120972_bib75","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1084\/jem.20140643","article-title":"mTOR inhibition rescues osteopenia in mice with systemic sclerosis","volume":"212","author":"Chen","year":"2015","journal-title":"J. Exp. Med."},{"issue":"4","key":"10.1016\/j.biomaterials.2021.120972_bib76","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.immuni.2019.03.018","article-title":"The cytokines of asthma","volume":"50","author":"Lambrecht","year":"2019","journal-title":"Immunity"},{"issue":"24","key":"10.1016\/j.biomaterials.2021.120972_bib77","doi-asserted-by":"crossref","first-page":"6223","DOI":"10.1158\/1078-0432.CCR-18-1687","article-title":"Tracking cell transplants in femoral osteonecrosis with magnetic resonance imaging: a proof-of-concept study in patients","volume":"24","author":"Theruvath","year":"2018","journal-title":"Clin. Canc. Res."},{"issue":"7","key":"10.1016\/j.biomaterials.2021.120972_bib78","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1007\/s00264-018-3956-1","article-title":"Animal models of steroid-induced osteonecrosis of the femoral head-a comprehensive research review up to 2018","volume":"42","author":"Xu","year":"2018","journal-title":"Int. Orthop."},{"issue":"1","key":"10.1016\/j.biomaterials.2021.120972_bib79","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1302\/0301-620X.67B1.3155745","article-title":"Idiopathic bone necrosis of the femoral head. Early diagnosis and treatment","volume":"67","author":"Ficat","year":"1985","journal-title":"J. Bone Joint Surg. Br."},{"key":"10.1016\/j.biomaterials.2021.120972_bib80","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jot.2019.12.004","article-title":"Guidelines for clinical diagnosis and treatment of osteonecrosis of the femoral head in adults (2019 version)","volume":"21","author":"Zhao","year":"2020","journal-title":"J. Orthop. Translat."},{"issue":"10","key":"10.1016\/j.biomaterials.2021.120972_bib81","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1002\/art.20517","article-title":"Combined effects of an anticoagulant and a lipid-lowering agent on the prevention of steroid-induced osteonecrosis in rabbits","volume":"50","author":"Motomura","year":"2004","journal-title":"Arthritis Rheum."},{"issue":"9","key":"10.1016\/j.biomaterials.2021.120972_bib82","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/S0730-725X(97)00159-8","article-title":"Initial MRI findings of non-traumatic osteonecrosis of the femoral head in renal allograft recipients","volume":"15","author":"Kubo","year":"1997","journal-title":"Magn. Reson. Imaging"},{"issue":"7","key":"10.1016\/j.biomaterials.2021.120972_bib83","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/S0730-725X(01)00424-6","article-title":"Initial changes of non-traumatic osteonecrosis of femoral head in fat suppression images: bone marrow edema was not found before the appearance of band patterns","volume":"19","author":"Fujioka M","year":"2001","journal-title":"Magn. Reson. Imaging"},{"issue":"5","key":"10.1016\/j.biomaterials.2021.120972_bib84","doi-asserted-by":"crossref","DOI":"10.1002\/jgm.3015","article-title":"Gene therapy clinical trials worldwide to 2017: an update","volume":"20","author":"Ginn","year":"2018","journal-title":"J. Gene Med."},{"issue":"7","key":"10.1016\/j.biomaterials.2021.120972_bib85","doi-asserted-by":"crossref","first-page":"e1012","DOI":"10.1212\/WNL.0000000000011440","article-title":"Efficacy and safety of intravenous mesenchymal stem cells for ischemic stroke","volume":"96","author":"Chung","year":"2021","journal-title":"Neurology"},{"issue":"15\u201316","key":"10.1016\/j.biomaterials.2021.120972_bib86","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1089\/ten.tea.2018.0292","article-title":"Preconditioned or IL4-secreting mesenchymal stem cells enhanced osteogenesis at different stages","volume":"25","author":"Lin","year":"2019","journal-title":"Tissue Eng."},{"issue":"3","key":"10.1016\/j.biomaterials.2021.120972_bib87","doi-asserted-by":"crossref","first-page":"4203","DOI":"10.1096\/fj.201801845R","article-title":"Trained murine mesenchymal stem cells have anti-inflammatory effect on macrophages, but defective regulation on T-cell proliferation","volume":"33","author":"Lin","year":"2019","journal-title":"Faseb. J."},{"key":"10.1016\/j.biomaterials.2021.120972_bib88","doi-asserted-by":"crossref","first-page":"631063","DOI":"10.3389\/fcell.2021.631063","article-title":"Different effects of intramedullary injection of mesenchymal stem cells during the acute vs. Chronic inflammatory phase on bone healing in the murine continuous polyethylene particle infusion model","volume":"9","author":"Utsunomiya","year":"2021","journal-title":"Front. Cell Dev. Biol."}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961221003288?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961221003288?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:12:03Z","timestamp":1758906723000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961221003288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":88,"alternative-id":["S0142961221003288"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2021.120972","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The efficacy of lapine preconditioned or genetically modified IL4 over-expressing bone marrow-derived mesenchymal stromal cells in corticosteroid-associated osteonecrosis of the femoral head in rabbits","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2021.120972","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"120972"}}