{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:18:57Z","timestamp":1791389937540,"version":"4.3.3"},"reference-count":99,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51931001"],"award-info":[{"award-number":["51931001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102540"],"award-info":[{"award-number":["82102540"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.biomaterials.2022.121663","type":"journal-article","created":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T12:31:30Z","timestamp":1657024290000},"page":"121663","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":100,"special_numbering":"C","title":["High-strength biodegradable zinc alloy implants with antibacterial and osteogenic properties for the treatment of MRSA-induced rat osteomyelitis"],"prefix":"10.1016","volume":"287","author":[{"given":"Bo","family":"Jia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zechuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifu","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongtao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiufeng","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhui","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhua","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6206-1149","authenticated-orcid":false,"given":"Kerong","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9431","key":"10.1016\/j.biomaterials.2022.121663_bib1","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0140-6736(04)16727-5","article-title":"Osteomyelitis","volume":"364","author":"Lew","year":"2004","journal-title":"Lancet (London, England)"},{"issue":"2","key":"10.1016\/j.biomaterials.2022.121663_bib2","doi-asserted-by":"crossref","DOI":"10.1128\/CMR.00084-17","article-title":"Staphylococcal osteomyelitis: Disease progression, treatment challenges, and future directions","volume":"31","author":"Kavanagh","year":"2018","journal-title":"Clin. Microbiol. Rev."},{"issue":"6","key":"10.1016\/j.biomaterials.2022.121663_bib3","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1097\/00005373-198806000-00018","article-title":"Factors increasing the risk of infection in patients with open fractures","volume":"28","author":"Merritt","year":"1988","journal-title":"J. Trauma Acute Care Surg."},{"issue":"1","key":"10.1016\/j.biomaterials.2022.121663_bib4","doi-asserted-by":"crossref","DOI":"10.3402\/dfa.v5.24445","article-title":"Osteomyelitis in the diabetic foot","volume":"5","author":"Malhotra","year":"2014","journal-title":"Diabet. Foot Ankle"},{"issue":"9","key":"10.1016\/j.biomaterials.2022.121663_bib5","first-page":"721","article-title":"Probing to bone in infected pedal ulcers","volume":"274","author":"Nardone","year":"1995","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.biomaterials.2022.121663_bib6","doi-asserted-by":"crossref","first-page":"34","DOI":"10.2106\/JBJS.J.01915","article-title":"Pathologic fractures in children with acute Staphylococcus aureus osteomyelitis","volume":"94","author":"Belthur","year":"2012","journal-title":"JBJS"},{"issue":"10","key":"10.1016\/j.biomaterials.2022.121663_bib7","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1172\/JCI200320365","article-title":"The application of biofilm science to the study and control of chronic bacterial infections","volume":"112","author":"Costerton","year":"2003","journal-title":"J. Clin. Invest."},{"issue":"12","key":"10.1016\/j.biomaterials.2022.121663_bib8","doi-asserted-by":"crossref","first-page":"e01006","DOI":"10.1128\/JCM.01006-19","article-title":"Methicillin-resistant Staphylococcus aureus in hospitals: latest Trends and treatments based on bacteriophages","volume":"57","author":"\u00c1lvarez","year":"2019","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.biomaterials.2022.121663_bib9","article-title":"An update on clinical burden, diagnostic tools, and therapeutic options of Staphylococcus aureus","volume":"10","author":"Reddy","year":"2017","journal-title":"Infect. Dis. Res. Treat."},{"issue":"3","key":"10.1016\/j.biomaterials.2022.121663_bib10","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1086\/675289","article-title":"Activity of commonly used antimicrobial prophylaxis regimens against pathogens causing coronary artery bypass graft and arthroplasty surgical site infections in the United States, 2006-2009","volume":"35","author":"Berr\u00edos-Torres","year":"2014","journal-title":"Infect. Control Hosp. Epidemiol."},{"issue":"17","key":"10.1016\/j.biomaterials.2022.121663_bib11","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.2106\/JBJS.N.01114","article-title":"The current state of screening and decolonization for the prevention of Staphylococcus aureus surgical site infection after total hip and knee arthroplasty","volume":"97","author":"Weiser","year":"2015","journal-title":"J. Bone Joint Surg. Am."},{"issue":"11","key":"10.1016\/j.biomaterials.2022.121663_bib12","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.2217\/fmb.11.117","article-title":"Scenery of Staphylococcus implant infections in orthopedics","volume":"6","author":"Montanaro","year":"2011","journal-title":"Future Microbiol."},{"issue":"1","key":"10.1016\/j.biomaterials.2022.121663_bib13","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1186\/s13287-019-1350-6","article-title":"Efficient in vivo bone formation by BMP-2 engineered human mesenchymal stem cells encapsulated in a projection stereolithographically fabricated hydrogel scaffold","volume":"10","author":"Lin","year":"2019","journal-title":"Stem Cell Res. Ther."},{"issue":"2","key":"10.1016\/j.biomaterials.2022.121663_bib14","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1053\/jhin.2001.1052","article-title":"Implant infections: a haven for opportunistic bacteria","volume":"49","author":"Schierholz","year":"2001","journal-title":"J. Hosp. Infect."},{"issue":"2","key":"10.1016\/j.biomaterials.2022.121663_bib15","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1302\/0301-620X.67B2.3980532","article-title":"Infection in experimental hip arthroplasties","volume":"67","author":"Southwood","year":"1985","journal-title":"J. Bone Joint Surg. Br."},{"issue":"11","key":"10.1016\/j.biomaterials.2022.121663_bib16","first-page":"3999","article-title":"Biodegradable ZnLiCa ternary alloys for critical-sized bone defect regeneration at load-bearing sites: in vitro and in vivo studies","volume":"6","author":"Zhang","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.biomaterials.2022.121663_bib17","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.actbio.2020.09.041","article-title":"Biodegradable Zn-Cu alloys show antibacterial activity against MRSA bone infection by inhibiting pathogen adhesion and biofilm formation","volume":"117","author":"Qu","year":"2020","journal-title":"Acta Biomater."},{"key":"10.1016\/j.biomaterials.2022.121663_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2021.129317","article-title":"Zn-0.4Li alloy shows great potential for the fixation and healing of bone fractures at load-bearing sites","volume":"417","author":"Yang","year":"2021","journal-title":"Chem. Eng. J."},{"issue":"6","key":"10.1016\/j.biomaterials.2022.121663_bib19","first-page":"1588","article-title":"Biodegradable Zn\u2013Sr alloy for bone regeneration in rat femoral condyle defect model: in vitro and in vivo studies","volume":"6","author":"Jia","year":"2021","journal-title":"Bioact. Mater."},{"issue":"1","key":"10.1016\/j.biomaterials.2022.121663_bib20","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/s41467-019-14153-7","article-title":"Alloying design of biodegradable zinc as promising bone implants for load-bearing applications","volume":"11","author":"Yang","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biomaterials.2022.121663_bib21","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.actbio.2018.03.007","article-title":"In vitro and in vivo studies on zinc-hydroxyapatite composites as novel biodegradable metal matrix composite for orthopedic applications","volume":"71","author":"Yang","year":"2018","journal-title":"Acta Biomater."},{"key":"10.1016\/j.biomaterials.2022.121663_bib22","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.actbio.2020.03.009","article-title":"In vitro and in vivo studies of Zn-Mn biodegradable metals designed for orthopedic applications","volume":"108","author":"Jia","year":"2020","journal-title":"Acta Biomater."},{"issue":"4","key":"10.1016\/j.biomaterials.2022.121663_bib23","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1021\/am4053317","article-title":"Superior antibacterial activity of zinc oxide\/graphene oxide composites originating from high zinc concentration localized around bacteria","volume":"6","author":"Wang","year":"2014","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.biomaterials.2022.121663_bib24","doi-asserted-by":"crossref","first-page":"87","DOI":"10.2147\/IJN.S186888","article-title":"Biosynthesis of zinc oxide nanoparticles using Albizia lebbeck stem bark, and evaluation of its antimicrobial, antioxidant, and cytotoxic activities on human breast cancer cell lines","volume":"14","author":"Umar","year":"2019","journal-title":"Int. J. Nanomed."},{"issue":"6","key":"10.1016\/j.biomaterials.2022.121663_bib25","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02391-18","article-title":"Chemical synergy between ionophore PBT2 and zinc reverses antibiotic resistance","volume":"9","author":"Bohlmann","year":"2018","journal-title":"mBio"},{"issue":"12","key":"10.1016\/j.biomaterials.2022.121663_bib26","first-page":"4607","article-title":"Zinc alloy-based bone internal fixation screw with antibacterial and anti-osteolytic properties","volume":"6","author":"Qu","year":"2021","journal-title":"Bioact. Mater."},{"issue":"11","key":"10.1016\/j.biomaterials.2022.121663_bib27","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1016\/j.jmst.2019.06.009","article-title":"High-performance hot-warm rolled Zn-0.8Li alloy with nano-sized metastable precipitates and sub-micron grains for biodegradable stents","volume":"35","author":"Li","year":"2019","journal-title":"J. Mater. Sci. Technol."},{"key":"10.1016\/j.biomaterials.2022.121663_bib28","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.actbio.2020.10.026","article-title":"Antibacterial effect of a copper-containing titanium alloy against implant-associated infection induced by methicillin-resistant Staphylococcus aureus","volume":"119","author":"Zhuang","year":"2021","journal-title":"Acta Biomater."},{"key":"10.1016\/j.biomaterials.2022.121663_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.coi.2019.04.002","article-title":"Metals as phagocyte antimicrobial effectors","volume":"60","author":"Sheldon","year":"2019","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.biomaterials.2022.121663_bib30","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.tiv.2016.08.007","article-title":"Oxidative stress generation of silver nanoparticles in three bacterial genera and its relationship with the antimicrobial activity","volume":"36","author":"Quinteros","year":"2016","journal-title":"Toxicol. Vitro"},{"issue":"3","key":"10.1016\/j.biomaterials.2022.121663_bib31","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1002\/jor.1100150314","article-title":"Characterization of a rabbit model of staphylococcal osteomyelitis","volume":"15","author":"Smeltzer","year":"1997","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.biomaterials.2022.121663_bib32","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.biomaterials.2016.08.031","article-title":"Biodegradable Mg-Cu alloy implants with antibacterial activity for the treatment of osteomyelitis: in vitro and in vivo evaluations","volume":"106","author":"Li","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2022.121663_bib33","series-title":"Materials Data on LiZn3 (SG:194) by Materials Project","author":"Persson","year":"2016"},{"key":"10.1016\/j.biomaterials.2022.121663_bib34","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.msec.2017.04.023","article-title":"Fabrication, mechanical properties and in vitro degradation behavior of newly developed ZnAg alloys for degradable implant applications","volume":"77","author":"Sikora-Jasinska","year":"2017","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"issue":"3","key":"10.1016\/j.biomaterials.2022.121663_bib35","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1002\/jbm.a.32090","article-title":"Cluster analysis of ribotyping profiles of Staphylococcus epidermidis isolates recovered from foreign body-associated orthopedic infections","volume":"88A","author":"Campoccia","year":"2008","journal-title":"J. Biomed. Mater. Res. A"},{"issue":"30","key":"10.1016\/j.biomaterials.2022.121663_bib36","doi-asserted-by":"crossref","first-page":"4108","DOI":"10.1016\/j.biomaterials.2008.07.006","article-title":"Molecular epidemiology of Staphylococcus aureus from implant orthopaedic infections: ribotypes, agr polymorphism, leukocidal toxins and antibiotic resistance","volume":"29","author":"Campoccia","year":"2008","journal-title":"Biomaterials"},{"issue":"Suppl 1","key":"10.1016\/j.biomaterials.2022.121663_bib37","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1093\/cid\/cit614","article-title":"Methicillin-resistant Staphylococcus aureus therapy: past, present, and future","volume":"58","author":"Rodvold","year":"2014","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.biomaterials.2022.121663_bib38","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1146\/annurev-biochem-060614-034516","article-title":"Mechanisms of methicillin resistance in Staphylococcus aureus","volume":"84","author":"Peacock","year":"2015","journal-title":"Annu. Rev. Biochem."},{"issue":"5","key":"10.1016\/j.biomaterials.2022.121663_bib39","doi-asserted-by":"crossref","first-page":"2882","DOI":"10.1128\/jb.171.5.2882-2885.1989","article-title":"Expression and inducibility in Staphylococcus aureus of the mecA gene, which encodes a methicillin-resistant S. aureus-specific penicillin-binding protein","volume":"171","author":"Ubukata","year":"1989","journal-title":"J. Bacteriol."},{"issue":"2","key":"10.1016\/j.biomaterials.2022.121663_bib40","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1128\/jb.158.2.513-516.1984","article-title":"Low-affinity penicillin-binding protein associated with \u03b2-lactam resistance in Staphylococcus aureus","volume":"158","author":"Hartman","year":"1984","journal-title":"J. Bacteriol."},{"issue":"7","key":"10.1016\/j.biomaterials.2022.121663_bib41","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1128\/AAC.36.7.1367","article-title":"Mapping and characterization of multiple chromosomal factors involved in methicillin resistance in Staphylococcus aureus","volume":"36","author":"Berger-Bachi","year":"1992","journal-title":"Antimicrob. Agents Chemother."},{"issue":"3","key":"10.1016\/j.biomaterials.2022.121663_bib42","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1089\/mdr.1999.5.163","article-title":"Antibiotic resistance as a stress response: complete sequencing of a large number of chromosomal loci in Staphylococcus aureus strain COL that impact on the expression of resistance to methicillin","volume":"5","author":"Lencastre","year":"1999","journal-title":"Microb. Drug Resist."},{"issue":"3","key":"10.1016\/j.biomaterials.2022.121663_bib43","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00112-12","article-title":"Comparative genomics of vancomycin-resistant Staphylococcus aureus strains and their positions within the clade most commonly associated with Methicillin-resistant S. aureus hospital-acquired infection in the United States","volume":"3","author":"Kos","year":"2012","journal-title":"mBio"},{"issue":"3","key":"10.1016\/j.biomaterials.2022.121663_bib44","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1089\/sur.2008.9941","article-title":"History of the medical use of silver","volume":"10","author":"Alexander","year":"2009","journal-title":"Surg. Infect. (Larchmt)"},{"issue":"1","key":"10.1016\/j.biomaterials.2022.121663_bib45","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.snb.2008.11.003","article-title":"Novel potentiometric approach in glucose biosensor using silver nanoparticles as redox marker","volume":"137","author":"Ngeontae","year":"2009","journal-title":"Sens. Actuators, B"},{"issue":"17","key":"10.1016\/j.biomaterials.2022.121663_bib46","doi-asserted-by":"crossref","first-page":"3391","DOI":"10.1021\/j100214a025","article-title":"Adsorption and surface-enhanced Raman of dyes on silver and gold sols","volume":"86","author":"Lee","year":"1982","journal-title":"J. Phys. Chem."},{"issue":"4","key":"10.1016\/j.biomaterials.2022.121663_bib47","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3109\/1040841X.2012.713323","article-title":"Silver as an antimicrobial: facts and gaps in knowledge","volume":"39","author":"Maillard","year":"2013","journal-title":"Crit. Rev. Microbiol."},{"key":"10.1016\/j.biomaterials.2022.121663_bib48","doi-asserted-by":"crossref","DOI":"10.1038\/srep27689","article-title":"Sol-gel synthesis of thorn-like ZnO nanoparticles endorsing mechanical stirring effect and their antimicrobial activities: potential role as nano-antibiotics","volume":"6","author":"Khan","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biomaterials.2022.121663_bib49","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.biomaterials.2015.02.105","article-title":"Versatile antimicrobial peptide-based ZnO quantum dots for in vivo bacteria diagnosis and treatment with high specificity","volume":"53","author":"Chen","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2022.121663_bib50","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.actbio.2019.05.069","article-title":"Corrosion resistance and antibacterial activity of zinc-loaded montmorillonite coatings on biodegradable magnesium alloy AZ31","volume":"98","author":"Zou","year":"2019","journal-title":"Acta Biomater."},{"issue":"1","key":"10.1016\/j.biomaterials.2022.121663_bib51","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1080\/13880209.2016.1230636","article-title":"Antibacterial, antioxidant and anti-proliferative properties and zinc content of five south Portugal herbs","volume":"55","author":"Nunes","year":"2017","journal-title":"Pharm. Biol."},{"issue":"7","key":"10.1016\/j.biomaterials.2022.121663_bib52","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s10295-006-0139-7","article-title":"Silver as biocides in burn and wound dressings and bacterial resistance to silver compounds","volume":"33","author":"Silver","year":"2006","journal-title":"J. Ind. Microbiol. Biotechnol."},{"issue":"1","key":"10.1016\/j.biomaterials.2022.121663_bib53","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s11671-018-2532-3","article-title":"Properties of zinc oxide nanoparticles and their activity against microbes","volume":"13","author":"Siddiqi","year":"2018","journal-title":"Nanoscale Res. Lett."},{"issue":"5","key":"10.1016\/j.biomaterials.2022.121663_bib54","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1007\/s11051-010-9900-y","article-title":"A review of the antibacterial effects of silver nanomaterials and potential implications for human health and the environment","volume":"12","author":"Marambio-Jones","year":"2010","journal-title":"J. Nanoparticle Res."},{"issue":"4","key":"10.1016\/j.biomaterials.2022.121663_bib55","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1021\/pr0504079","article-title":"Proteomic analysis of the mode of antibacterial action of silver nanoparticles","volume":"5","author":"Lok","year":"2006","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.biomaterials.2022.121663_bib56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2018.09.052","article-title":"Mesoporous bioactive glasses: promising platforms for antibacterial strategies","volume":"81","author":"Kargozar","year":"2018","journal-title":"Acta Biomater."},{"issue":"4","key":"10.1016\/j.biomaterials.2022.121663_bib57","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.watres.2008.12.002","article-title":"Silver-ion-mediated reactive oxygen species generation affecting bactericidal activity","volume":"43","author":"Park","year":"2009","journal-title":"Water Res."},{"issue":"8","key":"10.1016\/j.biomaterials.2022.121663_bib58","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1021\/nl061025k","article-title":"Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm","volume":"6","author":"Xia","year":"2006","journal-title":"Nano Lett."},{"issue":"12","key":"10.1016\/j.biomaterials.2022.121663_bib59","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1006515","article-title":"Intracellular Zn(II) intoxication leads to dysregulation of the PerR regulon resulting in heme toxicity in Bacillus subtilis","volume":"12","author":"Chandrangsu","year":"2016","journal-title":"PLoS Genet."},{"issue":"1","key":"10.1016\/j.biomaterials.2022.121663_bib60","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-34366-y","article-title":"Penetration of an antimicrobial zinc-sugar alcohol complex into Streptococcus mutans biofilms","volume":"8","author":"Lim","year":"2018","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.biomaterials.2022.121663_bib61","doi-asserted-by":"crossref","first-page":"5120","DOI":"10.1128\/AAC.00825-10","article-title":"Impact of silver-containing wound dressings on bacterial biofilm viability and susceptibility to antibiotics during prolonged treatment","volume":"54","author":"Kostenko","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.biomaterials.2022.121663_bib62","doi-asserted-by":"crossref","first-page":"410","DOI":"10.3389\/fcimb.2018.00410","article-title":"Zinc blockade of SOS response inhibits horizontal transfer of antibiotic resistance genes in enteric bacteria","volume":"8","author":"Crane","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.biomaterials.2022.121663_bib63","article-title":"Development of biodegradable Zn-1X binary alloys with nutrient alloying elements Mg, Ca and Sr","volume":"5","author":"Li","year":"2015","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.biomaterials.2022.121663_bib64","doi-asserted-by":"crossref","first-page":"755","DOI":"10.3390\/ijms19030755","article-title":"Mechanical characteristics, in vitro degradation, cytotoxicity, and antibacterial evaluation of Zn-4.0Ag alloy as a biodegradable material","volume":"19","author":"Li","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.biomaterials.2022.121663_bib65","doi-asserted-by":"crossref","first-page":"609","DOI":"10.3390\/ma13030609","article-title":"Microstructures and mechanical properties of laser-sintered commercially pure Ti and Ti-6Al-4V alloy for dental applications","volume":"13","author":"Okazaki","year":"2020","journal-title":"Materials (Basel)"},{"issue":"10","key":"10.1016\/j.biomaterials.2022.121663_bib66","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/j.biomaterials.2007.12.021","article-title":"The development of binary Mg-Ca alloys for use as biodegradable materials within bone","volume":"29","author":"Li","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2022.121663_bib67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mser.2014.01.001","article-title":"Biodegradable metals","volume":"77","author":"Zheng","year":"2014","journal-title":"Mater. Sci. Eng. R"},{"key":"10.1016\/j.biomaterials.2022.121663_bib68","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.actbio.2017.08.021","article-title":"Study on the Mg-Li-Zn ternary alloy system with improved mechanical properties, good degradation performance and different responses to cells","volume":"62","author":"Liu","year":"2017","journal-title":"Acta Biomater."},{"issue":"6","key":"10.1016\/j.biomaterials.2022.121663_bib69","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1016\/j.actbio.2012.02.018","article-title":"In vitro and in vivo studies on a Mg-Sr binary alloy system developed as a new kind of biodegradable metal","volume":"8","author":"Gu","year":"2012","journal-title":"Acta Biomater."},{"key":"10.1016\/j.biomaterials.2022.121663_bib70","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.actbio.2017.10.004","article-title":"Development of magnesium-based biodegradable metals with dietary trace element germanium as orthopaedic implant applications","volume":"64","author":"Bian","year":"2017","journal-title":"Acta Biomater."},{"issue":"21","key":"10.1016\/j.biomaterials.2022.121663_bib71","doi-asserted-by":"crossref","first-page":"5713","DOI":"10.1007\/s10853-009-3770-7","article-title":"A review on biodegradable polymeric materials for bone tissue engineering applications","volume":"44","author":"Sabir","year":"2009","journal-title":"J. Mater. Sci."},{"key":"10.1016\/j.biomaterials.2022.121663_bib72","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.actbio.2019.11.013","article-title":"Comparative in vitro study on binary Mg-RE (Sc, Y, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb and Lu) alloy systems","volume":"102","author":"Liu","year":"2020","journal-title":"Acta Biomater."},{"issue":"5","key":"10.1016\/j.biomaterials.2022.121663_bib73","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/j.actbio.2009.10.006","article-title":"Developments in metallic biodegradable stents","volume":"6","author":"Hermawan","year":"2010","journal-title":"Acta Biomater."},{"key":"10.1016\/j.biomaterials.2022.121663_bib74","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.biomaterials.2015.06.031","article-title":"In vitro and in vivo studies on the degradation of high-purity Mg (99.99wt.%) screw with femoral intracondylar fractured rabbit model","volume":"64","author":"Han","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2022.121663_bib75","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.jmbbm.2016.03.018","article-title":"Novel Zn-based alloys for biodegradable stent applications: design, development and in vitro degradation","volume":"60","author":"Mostaed","year":"2016","journal-title":"J. Mech. Behav. Biomed. Mater."},{"issue":"15","key":"10.1016\/j.biomaterials.2022.121663_bib76","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2018.03.005","article-title":"Zinc-based alloys for degradable vascular stent applications","volume":"71","author":"Mostaed","year":"2018","journal-title":"Acta Biomater."},{"issue":"18","key":"10.1016\/j.biomaterials.2022.121663_bib77","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201805402","article-title":"Fundamental theory of biodegradable metals-definition, criteria, and design","volume":"29","author":"Liu","year":"2019","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.biomaterials.2022.121663_bib78","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.matdes.2015.12.128","article-title":"Micro-alloying with Mn in Zn\u2013Mg alloy for future biodegradable metals application","volume":"94","author":"Liu","year":"2016","journal-title":"Mater. Des."},{"key":"10.1016\/j.biomaterials.2022.121663_bib79","article-title":"Development of biodegradable Zn-1X binary alloys with nutrient alloying elements Mg, Ca and Sr","volume":"5","author":"Li","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biomaterials.2022.121663_bib80","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.actbio.2020.03.009","article-title":"In vitro and in vivo studies of Zn-Mn biodegradable metals designed for orthopedic applications","volume":"108","author":"Jia","year":"2020","journal-title":"Acta Biomater."},{"key":"10.1016\/j.biomaterials.2022.121663_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2019.109896","article-title":"Hemocompatibility of biodegradable Zn-0.8wt% (Cu, Mn, Li) alloys","volume":"104","author":"Yin","year":"2019","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"10.1016\/j.biomaterials.2022.121663_bib82","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.actbio.2019.07.038","article-title":"Challenges in the use of zinc and its alloys as biodegradable metals: perspective from biomechanical compatibility","volume":"97","author":"Li","year":"2019","journal-title":"Acta Biomater."},{"key":"10.1016\/j.biomaterials.2022.121663_bib83","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jmbbm.2017.05.013","article-title":"Potential biodegradable Zn-Cu binary alloys developed for cardiovascular implant applications","volume":"72","author":"Tang","year":"2017","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.biomaterials.2022.121663_bib84","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.actbio.2020.01.022","article-title":"Controllable biodegradation and enhanced osseointegration of ZrO2-nanofilm coated Zn-Li alloy: in vitro and in vivo studies","volume":"105","author":"Yuan","year":"2020","journal-title":"Acta Biomater."},{"issue":"6","key":"10.1016\/j.biomaterials.2022.121663_bib85","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.jmst.2017.11.026","article-title":"Fabrication and characterization of novel biodegradable Zn-Mn-Cu alloys","volume":"34","author":"Shi","year":"2017","journal-title":"J. Mater. Sci. Technol."},{"key":"10.1016\/j.biomaterials.2022.121663_bib86","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.matlet.2015.07.151","article-title":"Microstructure, mechanical properties, in vitro degradation behavior and hemocompatibility of novel Zn\u2013Mg\u2013Sr alloys as biodegradable metals","volume":"162","author":"Liu","year":"2016","journal-title":"Mater. Lett."},{"key":"10.1016\/j.biomaterials.2022.121663_bib87","series-title":"Biomaterials in Clinical Practice","author":"Zivic","year":"2017"},{"issue":"10","key":"10.1016\/j.biomaterials.2022.121663_bib88","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1007\/s40195-017-0585-4","article-title":"Microstructure, mechanical properties and fracture behavior of as-extruded Zn\u2013Mg binary alloys","volume":"30","author":"Wang","year":"2017","journal-title":"Acta Metall. Sin. (Engl. Lett.)"},{"key":"10.1016\/j.biomaterials.2022.121663_bib89","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.actbio.2020.02.024","article-title":"A pure zinc membrane with degradability and osteogenesis promotion for guided bone regeneration: in vitro and in vivo studies","volume":"106","author":"Guo","year":"2020","journal-title":"Acta Biomater."},{"issue":"3","key":"10.1016\/j.biomaterials.2022.121663_bib90","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3390\/met8030153","article-title":"The suitability of Zn\u20131.3%Fe alloy as a biodegradable implant material","volume":"8","author":"Kafri","year":"2018","journal-title":"Metals"},{"key":"10.1016\/j.biomaterials.2022.121663_bib91","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.mattod.2018.05.018","article-title":"Current status and outlook on the clinical translation of biodegradable metals","volume":"23","author":"Han","year":"2019","journal-title":"Mater. Today"},{"key":"10.1016\/j.biomaterials.2022.121663_bib92","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.120905","article-title":"Zn0.8Li0.1Sr\u2014a biodegradable metal with high mechanical strength comparable to pure Ti for the treatment of osteoporotic bone fractures: in vitro and in vivo studies","volume":"275","author":"Zhang","year":"2021","journal-title":"Biomaterials"},{"issue":"4","key":"10.1016\/j.biomaterials.2022.121663_bib93","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1189\/jlb.3VMA1014-482R","article-title":"Neutrophil-derived MRP-14 is up-regulated in infectious osteomyelitis and stimulates osteoclast generation","volume":"98","author":"Dapunt","year":"2015","journal-title":"J. Leukoc. Biol."},{"issue":"7","key":"10.1016\/j.biomaterials.2022.121663_bib94","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0040586","article-title":"Staphylococcus aureus protein A plays a critical role in mediating bone destruction and bone loss in osteomyelitis","volume":"7","author":"Widaa","year":"2012","journal-title":"PLoS One"},{"issue":"5S Suppl","key":"10.1016\/j.biomaterials.2022.121663_bib95","article-title":"Function and mechanism of zinc metalloenzymes","volume":"130","author":"McCall","year":"2000","journal-title":"J. Nutr."},{"issue":"1\u20132","key":"10.1016\/j.biomaterials.2022.121663_bib96","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s11010-009-0358-0","article-title":"Role of nutritional zinc in the prevention of osteoporosis","volume":"338","author":"Yamaguchi","year":"2010","journal-title":"Mol. Cell. Biochem."},{"issue":"4","key":"10.1016\/j.biomaterials.2022.121663_bib97","article-title":"Runx2\/Osterix and zinc uptake synergize to orchestrate osteogenic differentiation and citrate containing bone apatite formation","volume":"5","author":"Fu","year":"2018","journal-title":"Adv. Sci. (Weinh)"},{"issue":"5","key":"10.1016\/j.biomaterials.2022.121663_bib98","doi-asserted-by":"crossref","first-page":"356","DOI":"10.4162\/nrp.2010.4.5.356","article-title":"Zinc may increase bone formation through stimulating cell proliferation, alkaline phosphatase activity and collagen synthesis in osteoblastic MC3T3-E1 cells","volume":"4","author":"Seo","year":"2010","journal-title":"Nutr. Res. Pract."},{"issue":"7","key":"10.1016\/j.biomaterials.2022.121663_bib99","doi-asserted-by":"crossref","first-page":"6809","DOI":"10.1021\/acsami.8b20634","article-title":"Mechanical strength, biodegradation, and in vitro and in vivo biocompatibility of Zn biomaterials","volume":"11","author":"Zhu","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961222003039?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961222003039?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:16:41Z","timestamp":1758907001000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961222003039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":99,"alternative-id":["S0142961222003039"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2022.121663","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High-strength biodegradable zinc alloy implants with antibacterial and osteogenic properties for the treatment of MRSA-induced rat osteomyelitis","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2022.121663","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"121663"}}