{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T23:52:00Z","timestamp":1794613920098,"version":"4.9.1"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001352","name":"National University of Singapore","doi-asserted-by":"publisher","award":["NUHSRO\/2020\/002\/NanoNash\/LOA"],"award-info":[{"award-number":["NUHSRO\/2020\/002\/NanoNash\/LOA"]}],"id":[{"id":"10.13039\/501100001352","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32402041"],"award-info":[{"award-number":["32402041"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015507","name":"Shandong First Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015507","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001459","name":"Ministry of Education - Singapore","doi-asserted-by":"publisher","award":["MOE-T2EP30223-0019"],"award-info":[{"award-number":["MOE-T2EP30223-0019"]}],"id":[{"id":"10.13039\/501100001459","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2023QH004"],"award-info":[{"award-number":["ZR2023QH004"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2024MH125"],"award-info":[{"award-number":["ZR2024MH125"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015508","name":"Shandong Academy of Medical Sciences","doi-asserted-by":"publisher","award":["922\\u2013001003130 185RC"],"award-info":[{"award-number":["922\\u2013001003130 185RC"]}],"id":[{"id":"10.13039\/501100015508","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["MOH-OFIRG21nov-0010"],"award-info":[{"award-number":["MOH-OFIRG21nov-0010"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["CG21APR1008"],"award-info":[{"award-number":["CG21APR1008"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["202228015"],"award-info":[{"award-number":["202228015"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.biomaterials.2024.122976","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T11:56:40Z","timestamp":1732881400000},"page":"122976","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Myocardial delivery of miR30d with peptide-functionalized milk-derived extracellular vesicles for targeted treatment of hypertrophic heart failure"],"prefix":"10.1016","volume":"316","author":[{"given":"Lingjun","family":"Tong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2859-9965","authenticated-orcid":false,"given":"Qiyue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yameng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengling","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiarun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenchao","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1613-4682","authenticated-orcid":false,"given":"Sitong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoyue","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaxi","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gert","family":"Storm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0898-4801","authenticated-orcid":false,"given":"Zhaoyang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7986-6082","authenticated-orcid":false,"given":"Jiong-Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"17","key":"10.1016\/j.biomaterials.2024.122976_bib1","doi-asserted-by":"crossref","first-page":"3272","DOI":"10.1093\/cvr\/cvac013","article-title":"Global burden of heart failure: a comprehensive and updated review of epidemiology","volume":"118","author":"Savarese","year":"2023","journal-title":"Cardiovasc. Res."},{"issue":"7","key":"10.1016\/j.biomaterials.2024.122976_bib2","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41569-018-0007-y","article-title":"Mechanisms of physiological and pathological cardiac hypertrophy","volume":"15","author":"Nakamura","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"issue":"1","key":"10.1016\/j.biomaterials.2024.122976_bib3","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1080\/14728222.2022.2031974","article-title":"Emerging therapeutic targets for cardiac hypertrophy","volume":"26","author":"Winkle","year":"2022","journal-title":"Expert Opin. Ther. Targets"},{"issue":"8","key":"10.1016\/j.biomaterials.2024.122976_bib4","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.117.003956","article-title":"Dose of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers and Outcomes in heart failure: a Meta-analysis","volume":"10","author":"Khan","year":"2017","journal-title":"Circ Heart Fail"},{"issue":"3","key":"10.1016\/j.biomaterials.2024.122976_bib5","doi-asserted-by":"crossref","first-page":"486","DOI":"10.20517\/evcna.2023.29","article-title":"MicroRNA biogenesis pathway alterations in aging","volume":"4","author":"Sanz-Ros","year":"2023","journal-title":"Extracell Vesicles Circ Nucl Acids"},{"issue":"6","key":"10.1016\/j.biomaterials.2024.122976_bib6","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.122.010010","article-title":"Comprehensive Transcriptomics Profiling of MicroRNA Reveals plasma circulating biomarkers of hypertrophic cardiomyopathy and Dysregulated signaling pathways","volume":"16","author":"Liang","year":"2023","journal-title":"Circ Heart Fail"},{"issue":"7820","key":"10.1016\/j.biomaterials.2024.122976_bib7","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/s41586-020-2586-0","article-title":"Position-specific oxidation of miR-1 encodes cardiac hypertrophy","volume":"584","author":"Seok","year":"2020","journal-title":"Nature"},{"issue":"17","key":"10.1016\/j.biomaterials.2024.122976_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/cells12172145","article-title":"Extracellular vesicle MicroRNAs in heart failure: pathophysiological mediators and therapeutic targets","volume":"12","author":"Tian","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.biomaterials.2024.122976_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104108","article-title":"Targeting miR-30d reverses pathological cardiac hypertrophy","volume":"81","author":"Li","year":"2022","journal-title":"EBioMedicine"},{"issue":"1","key":"10.1016\/j.biomaterials.2024.122976_bib10","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1161\/CIRCRESAHA.120.317244","article-title":"Mir-30d regulates cardiac remodeling by intracellular and Paracrine signaling","volume":"128","author":"Li","year":"2021","journal-title":"Circ. Res."},{"issue":"25","key":"10.1016\/j.biomaterials.2024.122976_bib11","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1161\/CIRCULATIONAHA.114.013220","article-title":"Circulating MicroRNA-30d is associated with response to cardiac Resynchronization therapy in heart failure and regulates cardiomyocyte apoptosis: a translational Pilot study","volume":"131","author":"Melman","year":"2015","journal-title":"Circulation"},{"issue":"21","key":"10.1016\/j.biomaterials.2024.122976_bib12","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.012880","article-title":"Deficiency of MicroRNA miR-1954 promotes cardiac remodeling and fibrosis","volume":"8","author":"Chiasson","year":"2019","journal-title":"J. Am. Heart Assoc."},{"issue":"2","key":"10.1016\/j.biomaterials.2024.122976_bib13","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1172\/JCI45938","article-title":"Comparison of different miR-21 inhibitor chemistries in a cardiac disease model","volume":"121","author":"Thum","year":"2011","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.biomaterials.2024.122976_bib14","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/mt.2011.177","article-title":"Neutralizing antibodies against AAV serotypes 1, 2, 6, and 9 in sera of commonly used animal models","volume":"20","author":"Rapti","year":"2012","journal-title":"Mol. Ther."},{"issue":"7","key":"10.1016\/j.biomaterials.2024.122976_bib15","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/s41565-021-00931-2","article-title":"Extracellular vesicles as a next-generation drug delivery platform","volume":"16","author":"Herrmann","year":"2021","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.biomaterials.2024.122976_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.05.011","article-title":"Extracellular vesicles as a drug delivery system: a systematic review of preclinical studies","volume":"175","author":"Escude Martinez de Castilla","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.biomaterials.2024.122976_bib17","series-title":"Extracellular Vesicle 2","article-title":"Multifunctional exosome-driven pancreatic cancer diagnostics and therapeutics","author":"Zhang","year":"2023"},{"issue":"2","key":"10.1016\/j.biomaterials.2024.122976_bib18","doi-asserted-by":"crossref","first-page":"150","DOI":"10.20517\/evcna.2021.25","article-title":"New insights of engineering plant exosome-like nanovesicles as a nanoplatform for therapeutics and drug delivery","volume":"3","author":"Shinge","year":"2022","journal-title":"Extracell Vesicles Circ Nucl Acids"},{"issue":"5","key":"10.1016\/j.biomaterials.2024.122976_bib19","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1161\/CIRCULATIONAHA.122.063759","article-title":"Extracellular Vesicle-encapsulated Adeno-associated Viruses for therapeutic gene delivery to the heart","volume":"148","author":"Li","year":"2023","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.biomaterials.2024.122976_bib20","doi-asserted-by":"crossref","first-page":"4444","DOI":"10.1021\/acsnano.9b10033","article-title":"Endocytosis of extracellular vesicles and release of their Cargo from Endosomes","volume":"14","author":"Joshi","year":"2020","journal-title":"ACS Nano"},{"issue":"11","key":"10.1016\/j.biomaterials.2024.122976_bib21","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2307800120","article-title":"Endosomal escape: a bottleneck for LNP-mediated therapeutics","volume":"121","author":"Chatterjee","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"12","key":"10.1016\/j.biomaterials.2024.122976_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241210194","article-title":"Milk exosomes: next-generation agents for delivery of Anticancer drugs and therapeutic nucleic acids","volume":"24","author":"Timofeeva","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.biomaterials.2024.122976_bib23","doi-asserted-by":"crossref","first-page":"339","DOI":"10.20517\/evcna.2023.25","article-title":"Milk-borne small extracellular vesicles: kinetics and mechanisms of transport, distribution, and elimination","volume":"4","author":"Ngu","year":"2023","journal-title":"Extracell Vesicles Circ Nucl Acids"},{"issue":"1","key":"10.1016\/j.biomaterials.2024.122976_bib24","doi-asserted-by":"crossref","DOI":"10.1080\/20013078.2018.1440132","article-title":"Biocompatibility of highly purified bovine milk-derived extracellular vesicles","volume":"7","author":"Somiya","year":"2018","journal-title":"J. Extracell. Vesicles"},{"issue":"8","key":"10.1016\/j.biomaterials.2024.122976_bib25","article-title":"Oral administration of bovine milk-derived extracellular vesicles Alters the gut microbiota and enhances intestinal immunity in mice","volume":"64","author":"Tong","year":"2020","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.biomaterials.2024.122976_bib26","first-page":"138","article-title":"Oral TNF-alpha siRNA delivery via milk-derived exosomes for effective treatment of inflammatory bowel disease","volume":"34","author":"Han","year":"2024","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.biomaterials.2024.122976_bib27","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.jconrel.2023.12.058","article-title":"Reprogramming tumor-associated macrophages by a dually targeted milk exosome system as a potent monotherapy for cancer","volume":"366","author":"Chen","year":"2024","journal-title":"J. Contr. Release"},{"issue":"1","key":"10.1016\/j.biomaterials.2024.122976_bib28","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1080\/10717544.2021.2023699","article-title":"Milk exosomes-mediated miR-31-5p delivery accelerates diabetic wound healing through promoting angiogenesis","volume":"29","author":"Yan","year":"2022","journal-title":"Drug Deliv."},{"issue":"5","key":"10.1016\/j.biomaterials.2024.122976_bib29","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.yjmcc.2011.02.003","article-title":"Identification of targeting peptides for ischemic myocardium by in vivo phage display","volume":"50","author":"Kanki","year":"2011","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"15","key":"10.1016\/j.biomaterials.2024.122976_bib30","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.008737","article-title":"Engineered exosomes with ischemic myocardium-targeting peptide for targeted therapy in myocardial infarction","volume":"7","author":"Wang","year":"2018","journal-title":"J. Am. Heart Assoc."},{"issue":"9","key":"10.1016\/j.biomaterials.2024.122976_bib31","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.jacc.2009.04.072","article-title":"The case for myocardial ischemia in hypertrophic cardiomyopathy","volume":"54","author":"Maron","year":"2009","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.biomaterials.2024.122976_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102655","article-title":"miR-125b-5p in adipose derived stem cells exosome alleviates pulmonary microvascular endothelial cells ferroptosis via Keap1\/Nrf2\/GPX4 in sepsis lung injury","volume":"62","author":"Shen","year":"2023","journal-title":"Redox Biol."},{"issue":"3","key":"10.1016\/j.biomaterials.2024.122976_bib33","doi-asserted-by":"crossref","first-page":"e124","DOI":"10.1002\/ctm2.124","article-title":"Osteocrin attenuates inflammation, oxidative stress, apoptosis, and cardiac dysfunction in doxorubicin-induced cardiotoxicity","volume":"10","author":"Hu","year":"2020","journal-title":"Clin. Transl. Med."},{"issue":"4","key":"10.1016\/j.biomaterials.2024.122976_bib34","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/s41569-023-00946-3","article-title":"The role of the NLRP3 inflammasome and pyroptosis in cardiovascular diseases","volume":"21","author":"Toldo","year":"2024","journal-title":"Nat. Rev. Cardiol."},{"issue":"2","key":"10.1016\/j.biomaterials.2024.122976_bib35","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1093\/cvr\/cvu259","article-title":"Independent roles of the priming and the triggering of the NLRP3 inflammasome in the heart","volume":"105","author":"Toldo","year":"2015","journal-title":"Cardiovasc. Res."},{"issue":"17","key":"10.1016\/j.biomaterials.2024.122976_bib36","doi-asserted-by":"crossref","first-page":"8570","DOI":"10.7150\/thno.62046","article-title":"Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the gut microbiota","volume":"11","author":"Tong","year":"2021","journal-title":"Theranostics"},{"issue":"15","key":"10.1016\/j.biomaterials.2024.122976_bib37","doi-asserted-by":"crossref","first-page":"eade5041","DOI":"10.1126\/sciadv.ade5041","article-title":"Milk-derived extracellular vesicles protect intestinal barrier integrity in the gut-liver axis","volume":"9","author":"Tong","year":"2023","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.biomaterials.2024.122976_bib38","doi-asserted-by":"crossref","first-page":"9193","DOI":"10.1038\/s41598-017-09451-3","article-title":"Leukocytic Toll-like receptor 2 Deficiency Preserves cardiac function and reduces fibrosis in Sustained pressure overload","volume":"7","author":"Wang","year":"2017","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.biomaterials.2024.122976_bib39","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12466","article-title":"Gut-liver axis: potential mechanisms of action of food-derived extracellular vesicles","volume":"13","author":"Zhang","year":"2024","journal-title":"J. Extracell. Vesicles"},{"issue":"5","key":"10.1016\/j.biomaterials.2024.122976_bib40","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2012854118","article-title":"GRK5 is a regulator of fibroblast activation and cardiac fibrosis","volume":"118","author":"Eguchi","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.biomaterials.2024.122976_bib41","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/s13578-020-00497-x","article-title":"CXCR7: a beta-arrestin-biased receptor that potentiates cell migration and recruits beta-arrestin2 exclusively through Gbetagamma subunits and GRK2","volume":"10","author":"Nguyen","year":"2020","journal-title":"Cell Biosci."},{"issue":"5","key":"10.1016\/j.biomaterials.2024.122976_bib42","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1073\/pnas.0409534102","article-title":"Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor","volume":"102","author":"Ren","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biomaterials.2024.122976_bib43","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cellsig.2017.02.008","article-title":"Regulation of inflammation by beta-arrestins: not just receptor tales","volume":"41","author":"Freedman","year":"2018","journal-title":"Cell. Signal."},{"key":"10.1016\/j.biomaterials.2024.122976_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119364","article-title":"The role and mechanism of beta-arrestin2 in signal transduction","volume":"275","author":"Ma","year":"2021","journal-title":"Life Sci."},{"issue":"12","key":"10.1016\/j.biomaterials.2024.122976_bib45","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1161\/CIRCRESAHA.116.304475","article-title":"GRK5-mediated exacerbation of pathological cardiac hypertrophy involves facilitation of nuclear NFAT activity","volume":"115","author":"Hullmann","year":"2014","journal-title":"Circ. Res."},{"issue":"3","key":"10.1016\/j.biomaterials.2024.122976_bib46","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nbt1073","article-title":"Adeno-associated virus serotype 8 efficiently delivers genes to muscle and heart","volume":"23","author":"Wang","year":"2005","journal-title":"Nat. Biotechnol."},{"issue":"24","key":"10.1016\/j.biomaterials.2024.122976_bib47","doi-asserted-by":"crossref","first-page":"7709","DOI":"10.1039\/D3BM01275A","article-title":"Nanocarriers for gene delivery to the cardiovascular system","volume":"11","author":"Shi","year":"2023","journal-title":"Biomater. Sci."},{"issue":"4","key":"10.1016\/j.biomaterials.2024.122976_bib48","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/s44161-023-00232-y","article-title":"Nanomedicines for cardiovascular disease","volume":"2","author":"Smith","year":"2023","journal-title":"Nature Cardiovascular Research"},{"key":"10.1016\/j.biomaterials.2024.122976_bib49","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.addr.2021.04.017","article-title":"Illuminating RNA trafficking and functional delivery by extracellular vesicles","volume":"174","author":"de Voogt","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"1","key":"10.1016\/j.biomaterials.2024.122976_bib50","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1186\/s12951-023-02173-x","article-title":"Probing milk extracellular vesicles for intestinal delivery of RNA therapies","volume":"21","author":"Zhang","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.biomaterials.2024.122976_bib51","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/978-1-4939-7652-2_15","article-title":"Milk-derived extracellular vesicles for therapeutic delivery of small interfering RNAs","volume":"1740","author":"Matsuda","year":"2018","journal-title":"Methods Mol. Biol."},{"issue":"3","key":"10.1016\/j.biomaterials.2024.122976_bib52","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22031105","article-title":"Bovine milk-derived exosomes as a drug delivery vehicle for miRNA-based therapy","volume":"22","author":"Del Pozo-Acebo","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.biomaterials.2024.122976_bib53","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201700009","article-title":"Characterization and biological function of milk-derived miRNAs","volume":"61","author":"Golan-Gerstl","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"issue":"1","key":"10.1016\/j.biomaterials.2024.122976_bib54","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1021\/mp300500y","article-title":"Targeted gene delivery to ischemic myocardium by homing peptide-guided polymeric carrier","volume":"10","author":"Won","year":"2013","journal-title":"Mol. Pharm."},{"issue":"1","key":"10.1016\/j.biomaterials.2024.122976_bib55","doi-asserted-by":"crossref","first-page":"6058","DOI":"10.1038\/s41467-024-50312-1","article-title":"Inhalable cardiac targeting peptide modified nanomedicine prevents pressure overload heart failure in male mice","volume":"15","author":"Weng","year":"2024","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.biomaterials.2024.122976_bib56","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1161\/01.CIR.91.1.161","article-title":"Myocardial fibrosis and stiffness with hypertrophy and heart failure in the spontaneously hypertensive rat","volume":"91","author":"Conrad","year":"1995","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.biomaterials.2024.122976_bib57","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1056\/NEJMoa1002659","article-title":"Myocardial fibrosis as an early manifestation of hypertrophic cardiomyopathy","volume":"363","author":"Ho","year":"2010","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.biomaterials.2024.122976_bib58","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1159\/000490078","article-title":"Exosomes from MiR-30d-5p-ADSCs reverse acute ischemic Stroke-induced, Autophagy-mediated brain injury by promoting M2 Microglial\/macrophage polarization","volume":"47","author":"Jiang","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"issue":"1","key":"10.1016\/j.biomaterials.2024.122976_bib59","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1186\/s13054-021-03775-3","article-title":"Exosomal miR-30d-5p of neutrophils induces M1 macrophage polarization and primes macrophage pyroptosis in sepsis-related acute lung injury","volume":"25","author":"Jiao","year":"2021","journal-title":"Crit. Care"},{"issue":"10","key":"10.1016\/j.biomaterials.2024.122976_bib60","doi-asserted-by":"crossref","first-page":"e1479","DOI":"10.1038\/cddis.2014.430","article-title":"MicroRNA-30d regulates cardiomyocyte pyroptosis by directly targeting foxo3a in diabetic cardiomyopathy","volume":"5","author":"Li","year":"2014","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.biomaterials.2024.122976_bib61","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1093\/cvr\/cvab044","article-title":"G protein-coupled receptor kinase 5 (GRK5) contributes to impaired cardiac function and immune cell recruitment in post-ischemic heart failure","volume":"118","author":"de Lucia","year":"2022","journal-title":"Cardiovasc. Res."},{"issue":"18","key":"10.1016\/j.biomaterials.2024.122976_bib62","doi-asserted-by":"crossref","first-page":"2706","DOI":"10.1038\/emboj.2009.215","article-title":"Beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling","volume":"28","author":"Barthet","year":"2009","journal-title":"EMBO J."},{"issue":"7","key":"10.1016\/j.biomaterials.2024.122976_bib63","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0232507","article-title":"Lack of sexual dimorphism in a mouse model of isoproterenol-induced cardiac dysfunction","volume":"15","author":"Grant","year":"2020","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.biomaterials.2024.122976_bib64","doi-asserted-by":"crossref","first-page":"H643","DOI":"10.1152\/ajpheart.00044.2022","article-title":"Age and sex hormones modulate left ventricle regional response to angiotensin II in male and female mice","volume":"323","author":"Walsh-Wilkinson","year":"2022","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"19","key":"10.1016\/j.biomaterials.2024.122976_bib65","doi-asserted-by":"crossref","first-page":"9243","DOI":"10.7150\/thno.63354","article-title":"Tissue factor cytoplasmic domain exacerbates post-infarct left ventricular remodeling via orchestrating cardiac inflammation and angiogenesis","volume":"11","author":"Chong","year":"2021","journal-title":"Theranostics"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961224005118?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961224005118?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T18:07:31Z","timestamp":1777486051000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961224005118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":65,"alternative-id":["S0142961224005118"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2024.122976","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Myocardial delivery of miR30d with peptide-functionalized milk-derived extracellular vesicles for targeted treatment of hypertrophic heart failure","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2024.122976","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"122976"}}