{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:31:03Z","timestamp":1791952263638,"version":"4.3.4"},"reference-count":87,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006477","name":"National Taiwan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006477","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 111-2221-E-002-052-MY3"],"award-info":[{"award-number":["NSTC 111-2221-E-002-052-MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["2023-1-137-2"],"award-info":[{"award-number":["2023-1-137-2"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.biomaterials.2025.123268","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T03:48:19Z","timestamp":1742269699000},"page":"123268","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Biodegradable, electroconductive self-healing hydrogel based on polydopamine-coated polyurethane nano-crosslinker for Parkinson's disease therapy"],"prefix":"10.1016","volume":"320","author":[{"given":"Tsai-Yu","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junpeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Hwei","family":"Tai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung-Kai","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3399-055X","authenticated-orcid":false,"given":"Shan-hui","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.biomaterials.2025.123268_bib1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41427-022-00362-y","article-title":"Recent trends in the development of hydrogel therapeutics for the treatment of central nervous system disorders","volume":"14","author":"Li","year":"2022","journal-title":"NPG Asia Mater."},{"issue":"10291","key":"10.1016\/j.biomaterials.2025.123268_bib2","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1016\/S0140-6736(21)00218-X","article-title":"Parkinson's disease","volume":"397","author":"Bloem","year":"2021","journal-title":"Lancet"},{"issue":"9996","key":"10.1016\/j.biomaterials.2025.123268_bib3","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","article-title":"Parkinson's disease","volume":"386","author":"Kalia","year":"2015","journal-title":"Lancet"},{"issue":"5646","key":"10.1016\/j.biomaterials.2025.123268_bib4","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1126\/science.1090278","article-title":"\u03b1-Synuclein locus triplication causes Parkinson's disease","volume":"302","author":"Singleton","year":"2003","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123268_bib5","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/mds.27228","article-title":"The changing landscape of surgery for Parkinson's Disease","volume":"33","author":"Lozano","year":"2018","journal-title":"Mov. Disord."},{"issue":"S1","key":"10.1016\/j.biomaterials.2025.123268_bib6","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/jnc.13750","article-title":"Current and experimental treatments of Parkinson disease: a guide for neuroscientists","volume":"139","author":"Oertel","year":"2016","journal-title":"J. Neurochem."},{"issue":"5","key":"10.1016\/j.biomaterials.2025.123268_bib7","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s10072-010-0245-1","article-title":"Parkinson's disease: oxidative stress and therapeutic approaches","volume":"31","author":"Surendran","year":"2010","journal-title":"Neurol. Sci."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123268_bib8","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s12929-021-00781-z","article-title":"An electrophysiological perspective on Parkinson's disease: symptomatic pathogenesis and therapeutic approaches","volume":"28","author":"Lee","year":"2021","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.biomaterials.2025.123268_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.995850","article-title":"Effect of acupuncture for non-motor symptoms in patients with Parkinson's disease: a systematic review and meta-analysis","volume":"14","author":"Li","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.biomaterials.2025.123268_bib10","article-title":"Effects of acupuncture on oxidative stress Amelioration via Nrf2\/ARE-related pathways in Alzheimer and Parkinson diseases","volume":"2021","author":"Huang","year":"2021","journal-title":"Evid. Based Complement. Alternat. Med."},{"issue":"5","key":"10.1016\/j.biomaterials.2025.123268_bib11","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1002\/stem.2613","article-title":"Electroacupuncture promotes central nervous system-dependent release of mesenchymal stem cells","volume":"35","author":"Salazar","year":"2017","journal-title":"Stem Cell."},{"issue":"4","key":"10.1016\/j.biomaterials.2025.123268_bib12","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1159\/000443101","article-title":"Electro-acupuncture promotes endogenous multipotential mesenchymal stem cell mobilization into the peripheral blood","volume":"38","author":"Liu","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123268_bib13","doi-asserted-by":"crossref","first-page":"8","DOI":"10.26599\/JNR.2019.9040003","article-title":"Yearbook of neurorestoratology","volume":"7","author":"Huang","year":"2018","journal-title":"J. Neurorestoratol."},{"key":"10.1016\/j.biomaterials.2025.123268_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120608","article-title":"Cryogel\/hydrogel biomaterials and acupuncture combined to promote diabetic skin wound healing through immunomodulation","volume":"269","author":"Chen","year":"2021","journal-title":"Biomaterials"},{"issue":"22","key":"10.1016\/j.biomaterials.2025.123268_bib15","doi-asserted-by":"crossref","first-page":"4224","DOI":"10.1021\/acschemneuro.1c00484","article-title":"Biomaterial strategies for restorative therapies in Parkinson's disease","volume":"12","author":"Mirzaei","year":"2021","journal-title":"ACS Chem. Neurosci."},{"issue":"11","key":"10.1016\/j.biomaterials.2025.123268_bib16","first-page":"1521","article-title":"Hydrogels for brain repair: application to Parkinson's disease, Expert Opin","volume":"19","author":"Del Campo-Montoya","year":"2022","journal-title":"Drug Deliv."},{"issue":"14","key":"10.1016\/j.biomaterials.2025.123268_bib17","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202101058","article-title":"Enhanced delivery of neuroactive drugs via nasal delivery with a self\u2010healing supramolecular gel","volume":"8","author":"Wang","year":"2021","journal-title":"Adv. Sci."},{"issue":"3","key":"10.1016\/j.biomaterials.2025.123268_bib18","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1039\/C9NR09283H","article-title":"Self-healing conductive hydrogels: preparation, properties and applications","volume":"12","author":"Deng","year":"2020","journal-title":"Nanoscale"},{"key":"10.1016\/j.biomaterials.2025.123268_bib19","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.ijbiomac.2017.07.130","article-title":"Injectable hydrogel based on quaternized chitosan, gelatin and dopamine as localized drug delivery system to treat Parkinson's disease","volume":"105","author":"Ren","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.biomaterials.2025.123268_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2022.137180","article-title":"An anti-inflammatory electroconductive hydrogel with self-healing property for the treatment of Parkinson's disease","volume":"446","author":"Xu","year":"2022","journal-title":"Chem. Eng. J."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123268_bib21","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1080\/10717544.2019.1636420","article-title":"Brain-targeted intranasal delivery of dopamine with borneol and lactoferrin co-modified nanoparticles for treating Parkinson's disease","volume":"26","author":"Tang","year":"2019","journal-title":"Drug Deliv."},{"key":"10.1016\/j.biomaterials.2025.123268_bib22","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.biomaterials.2015.09.039","article-title":"Functionalized composite scaffolds improve the engraftment of transplanted dopaminergic progenitors in a mouse model of Parkinson's disease","volume":"74","author":"Wang","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2025.123268_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fnano.2021.643507","article-title":"Biomaterials for neural tissue engineering","volume":"3","author":"Doblado","year":"2021","journal-title":"Front. Nanotechnol."},{"issue":"4","key":"10.1016\/j.biomaterials.2025.123268_bib24","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1080\/01932691.2017.1327818","article-title":"Waterborne polyurethanes: a review","volume":"39","author":"Honarkar","year":"2018","journal-title":"J. Dispersion Sci. Technol."},{"issue":"3","key":"10.1016\/j.biomaterials.2025.123268_bib25","doi-asserted-by":"crossref","DOI":"10.1002\/advs.201901388","article-title":"Self\u2010healing hydrogels and cryogels from biodegradable polyurethane nanoparticle crosslinked chitosan","volume":"7","author":"Lin","year":"2020","journal-title":"Adv. Sci."},{"issue":"4","key":"10.1016\/j.biomaterials.2025.123268_bib26","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1002\/nano.202100255","article-title":"Gold nanoparticles (GNPs) in biomedical and clinical applications: a review","volume":"3","author":"Anik","year":"2022","journal-title":"Nano Select"},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123268_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40824-023-00347-0","article-title":"Bioactive self-healing hydrogel based on tannic acid modified gold nano-crosslinker as an injectable brain implant for treating Parkinson's disease","volume":"27","author":"Xu","year":"2023","journal-title":"Biomater. Res."},{"key":"10.1016\/j.biomaterials.2025.123268_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.nanoen.2022.107393","article-title":"Engineering an integrated electroactive dressing to accelerate wound healing and monitor noninvasively progress of healing","volume":"99","author":"Nguyen","year":"2022","journal-title":"Nano Energy"},{"issue":"23","key":"10.1016\/j.biomaterials.2025.123268_bib29","article-title":"NIR-assisted MgO-based polydopamine nanoparticles for targeted treatment of Parkinson's disease through the blood\u2013brain barrier","volume":"11","author":"Gao","year":"2022","journal-title":"Adv. Healthcare Mater."},{"issue":"29","key":"10.1016\/j.biomaterials.2025.123268_bib30","doi-asserted-by":"crossref","first-page":"6952","DOI":"10.1016\/j.biomaterials.2012.06.067","article-title":"Polydopamine-mediated surface modification of scaffold materials for human neural stem cell engineering","volume":"33","author":"Yang","year":"2012","journal-title":"Biomaterials"},{"issue":"31","key":"10.1016\/j.biomaterials.2025.123268_bib31","article-title":"An acellular, self\u2010healed Trilayer Cryogel for osteochondral regeneration in rabbits","volume":"13","author":"Chen","year":"2024","journal-title":"Adv. Healthcare Mater."},{"issue":"9","key":"10.1016\/j.biomaterials.2025.123268_bib32","doi-asserted-by":"crossref","first-page":"7523","DOI":"10.1021\/acsami.7b19865","article-title":"Polydopamine surface chemistry: a decade of Discovery","volume":"10","author":"Ryu","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"2","key":"10.1016\/j.biomaterials.2025.123268_bib33","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0306-4522(00)00199-8","article-title":"Effect of high-frequency stimulation of the subthalamic nucleus on the neuronal activities of the substantia nigra pars reticulata and ventrolateral nucleus of the thalamus in the rat","volume":"99","author":"Benazzouz","year":"2000","journal-title":"Neuroscience"},{"issue":"2","key":"10.1016\/j.biomaterials.2025.123268_bib34","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0165-0270(80)90021-7","article-title":"AChE-stained horizontal sections of the rat brain in stereotaxic coordinates","volume":"3","author":"Paxinos","year":"1980","journal-title":"J. Neurosci. Methods"},{"issue":"4","key":"10.1016\/j.biomaterials.2025.123268_bib35","doi-asserted-by":"crossref","first-page":"612","DOI":"10.3390\/biom11040612","article-title":"Treatment options for motor and non-motor symptoms of Parkinson's disease","volume":"11","author":"Church","year":"2021","journal-title":"Biomolecules"},{"issue":"4","key":"10.1016\/j.biomaterials.2025.123268_bib36","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1007\/s00044-024-03203-5","article-title":"Motor and non-motor symptoms, drugs, and their mode of action in Parkinson's disease (PD): a review","volume":"33","author":"Saini","year":"2024","journal-title":"Med. Chem. Res."},{"issue":"6","key":"10.1016\/j.biomaterials.2025.123268_bib37","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1159\/000515351","article-title":"Biomaterial strategies to bolster neural stem cell-mediated repair of the central nervous system","volume":"211","author":"Tejeda","year":"2022","journal-title":"Cells Tissues Organs"},{"issue":"10","key":"10.1016\/j.biomaterials.2025.123268_bib38","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.4103\/1673-5374.336132","article-title":"Biomaterial and tissue-engineering strategies for the treatment of brain neurodegeneration","volume":"17","author":"Martinez","year":"2022","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.biomaterials.2025.123268_bib39","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.649891","article-title":"Neurorepair and regeneration of the brain: a decade of bioscaffolds and engineered microtissue","volume":"9","author":"Zamproni","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"5","key":"10.1016\/j.biomaterials.2025.123268_bib40","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.stem.2019.10.001","article-title":"Clinical translation of pluripotent stem cell therapies: challenges and considerations","volume":"25","author":"Desgres","year":"2019","journal-title":"Cell Stem Cell"},{"issue":"9","key":"10.1016\/j.biomaterials.2025.123268_bib41","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/s41578-020-0209-x","article-title":"Engineered biomaterials for in situ tissue regeneration","volume":"5","author":"Gaharwar","year":"2020","journal-title":"Nat. Rev. Mater."},{"key":"10.1016\/j.biomaterials.2025.123268_bib42","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.actbio.2022.03.014","article-title":"Biomaterials for recruiting and activating endogenous stem cells in situ tissue regeneration","volume":"143","author":"Safina","year":"2022","journal-title":"Acta Biomater."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123268_bib43","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s40824-023-00347-0","article-title":"Bioactive self-healing hydrogel based on tannic acid modified gold nano-crosslinker as an injectable brain implant for treating Parkinson's disease","volume":"27","author":"Xu","year":"2023","journal-title":"Biomater. Res."},{"issue":"45","key":"10.1016\/j.biomaterials.2025.123268_bib44","article-title":"Injectable, micellar chitosan self\u2010healing hydrogel for asynchronous dual\u2010drug delivery to treat stroke rats","volume":"33","author":"Lin","year":"2023","journal-title":"Adv. Funct. Mater."},{"issue":"36","key":"10.1016\/j.biomaterials.2025.123268_bib45","doi-asserted-by":"crossref","first-page":"40108","DOI":"10.1021\/acsami.0c11433","article-title":"Semi-interpenetrating polymer network of hyaluronan and chitosan self-healing hydrogels for central nervous system repair","volume":"12","author":"Liu","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.biomaterials.2025.123268_bib46","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1007\/s11831-019-09352-w","article-title":"Fifty shades of brain: a review on the mechanical testing and modeling of brain tissue","volume":"27","author":"Budday","year":"2020","journal-title":"Arch. Comput. Methods Eng."},{"issue":"7","key":"10.1016\/j.biomaterials.2025.123268_bib47","first-page":"1243","article-title":"Biomaterials and neural regeneration, neural regener","volume":"15","author":"Liu","year":"2020","journal-title":"Res."},{"issue":"25","key":"10.1016\/j.biomaterials.2025.123268_bib48","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201907792","article-title":"Surface topography and electrical signaling: single and synergistic effects on neural differentiation of stem cells","volume":"30","author":"Eftekhari","year":"2020","journal-title":"Adv. Funct. Mater."},{"issue":"32","key":"10.1016\/j.biomaterials.2025.123268_bib49","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202007429","article-title":"Electroactive biomaterials and systems for cell fate determination and tissue regeneration: design and applications","volume":"33","author":"Liu","year":"2021","journal-title":"Adv. Mater."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123268_bib50","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202301494","article-title":"State of the art and current challenges on electroactive biomaterials and strategies for neural tissue regeneration","volume":"13","author":"Marques-Almeida","year":"2024","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.biomaterials.2025.123268_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.cis.2022.102689","article-title":"Polydopamine at biological interfaces","volume":"305","author":"Alfieri","year":"2022","journal-title":"Adv. Colloid Interface Sci."},{"issue":"24","key":"10.1016\/j.biomaterials.2025.123268_bib52","doi-asserted-by":"crossref","first-page":"6046","DOI":"10.1021\/acs.langmuir.7b00671","article-title":"Rapid deposition of uniform polydopamine coatings on nanoparticle surfaces with controllable thickness","volume":"33","author":"Orishchin","year":"2017","journal-title":"Langmuir"},{"key":"10.1016\/j.biomaterials.2025.123268_bib53","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.msec.2019.03.024","article-title":"An injectable conductive Gelatin-PANI hydrogel system serves as a promising carrier to deliver BMSCs for Parkinson's disease treatment","volume":"100","author":"Xue","year":"2019","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"issue":"35","key":"10.1016\/j.biomaterials.2025.123268_bib54","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202470215","article-title":"Neural tissue-like, not supraphysiological, electrical conductivity stimulates neuronal lineage specification through calcium signaling and epigenetic modification","volume":"11","author":"Li","year":"2024","journal-title":"Adv. Sci."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123268_bib55","doi-asserted-by":"crossref","DOI":"10.1002\/mabi.202000123","article-title":"Conductive biomaterials as substrates for neural stem cells differentiation towards neuronal lineage cells","volume":"21","author":"Farokhi","year":"2021","journal-title":"Macromol. Biosci."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123268_bib56","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/s41531-022-00324-9","article-title":"Altered neural cell junctions and ion-channels leading to disrupted neuron communication in Parkinson's disease","volume":"8","author":"Choudhury","year":"2022","journal-title":"NPJ Parkinsons Dis."},{"issue":"4","key":"10.1016\/j.biomaterials.2025.123268_bib57","doi-asserted-by":"crossref","first-page":"384","DOI":"10.4103\/wjtcm.wjtcm_41_20","article-title":"Neuroendocrine-immune regulating mechanisms for the anti-inflammatory and analgesic actions of acupuncture","volume":"6","author":"Xu","year":"2020","journal-title":"World J. Tradit. Chin. Med."},{"issue":"7","key":"10.1016\/j.biomaterials.2025.123268_bib58","doi-asserted-by":"crossref","first-page":"687","DOI":"10.4252\/wjsc.v15.i7.687","article-title":"Neural stem cells for Parkinson's disease management: challenges, nanobased support, and prospects","volume":"15","author":"Oz","year":"2023","journal-title":"World J. Stem Cell."},{"issue":"24","key":"10.1016\/j.biomaterials.2025.123268_bib59","doi-asserted-by":"crossref","first-page":"31864","DOI":"10.1021\/acsami.4c08603","article-title":"Polydopamine adhesion: catechol, amine, dihydroxyindole, and aggregation dynamics","volume":"16","author":"Lim","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"6","key":"10.1016\/j.biomaterials.2025.123268_bib60","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.biomaterials.2008.10.028","article-title":"In vitro behavior of neural stem cells in response to different chemical functional groups","volume":"30","author":"Ren","year":"2009","journal-title":"Biomaterials"},{"issue":"3","key":"10.1016\/j.biomaterials.2025.123268_bib61","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.neulet.2009.03.042","article-title":"The promotion of peripheral nerve regeneration by chitooligosaccharides in the rat nerve crush injury model","volume":"454","author":"Jiang","year":"2009","journal-title":"Neurosci. Lett."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123268_bib62","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/J.ENG.2017.01.014","article-title":"Biophysical regulation of cell behavior\u2014cross talk between substrate stiffness and nanotopography","volume":"3","author":"Yang","year":"2017","journal-title":"Engineering"},{"issue":"9","key":"10.1016\/j.biomaterials.2025.123268_bib63","doi-asserted-by":"crossref","first-page":"4426","DOI":"10.1529\/biophysj.108.132217","article-title":"Substrate modulus directs neural stem cell behavior","volume":"95","author":"Saha","year":"2008","journal-title":"Biophys. J."},{"issue":"24","key":"10.1016\/j.biomaterials.2025.123268_bib64","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.21037\/atm-21-6189","article-title":"Impact of hydrogel stiffness on the induced neural stem cells modulation","volume":"9","author":"Liang","year":"2021","journal-title":"Ann. Transl. Med."},{"issue":"7","key":"10.1016\/j.biomaterials.2025.123268_bib65","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.3390\/antiox10071088","article-title":"Oxidative-signaling in neural stem cell-mediated plasticity: implications for neurodegenerative diseases","volume":"10","author":"Santos","year":"2021","journal-title":"Antioxidants"},{"issue":"11","key":"10.1016\/j.biomaterials.2025.123268_bib66","first-page":"3904","article-title":"Biofabrication of natural hydrogels for cardiac, neural, and bone tissue engineering applications","volume":"6","author":"Elkhoury","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.biomaterials.2025.123268_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.122031","article-title":"Effect and mechanism of acupuncture on endogenous and exogenous stem cells in disease treatment: a therapeutic review","volume":"331","author":"Gao","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.biomaterials.2025.123268_bib68","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/8056904","article-title":"Differential modulation of NF-\u03baB in neurons and astrocytes underlies neuroprotection and antigliosis activity of natural antioxidant molecules","volume":"2019","author":"Martorana","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.biomaterials.2025.123268_bib69","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2022.889719","article-title":"ROS-influenced regulatory cross-talk with Wnt signaling pathway during perinatal development","volume":"9","author":"Chatterjee","year":"2022","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.biomaterials.2025.123268_bib70","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.bcp.2017.04.029","article-title":"Modulation of neurogenesis via neurotrophic factors in acupuncture treatments for neurological diseases","volume":"141","author":"Shin","year":"2017","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123268_bib71","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1186\/s13287-022-03139-w","article-title":"Priming mesenchymal stem cells with \u03b1-synuclein enhances neuroprotective properties through induction of autophagy in Parkinsonian models","volume":"13","author":"Shin","year":"2022","journal-title":"Stem Cell Res. Ther."},{"issue":"7","key":"10.1016\/j.biomaterials.2025.123268_bib72","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202002944","article-title":"Mesenchymal stem cells for neurological disorders","volume":"8","author":"Andrzejewska","year":"2021","journal-title":"Adv. Sci."},{"key":"10.1016\/j.biomaterials.2025.123268_bib73","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.expneurol.2017.11.006","article-title":"Impaired glutamatergic projection from the motor cortex to the subthalamic nucleus in 6-hydroxydopamine-lesioned hemi-parkinsonian rats","volume":"300","author":"Wang","year":"2018","journal-title":"Exp. Neurol."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123268_bib74","doi-asserted-by":"crossref","first-page":"112","DOI":"10.4103\/1673-5374.264470","article-title":"Effect of stromal cell-derived factor-1\/CXCR4 axis in neural stem cell transplantation for Parkinson's disease","volume":"15","author":"Xu","year":"2020","journal-title":"Neural. Regen. Res."},{"key":"10.1016\/j.biomaterials.2025.123268_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexmp.2020.104416","article-title":"HIF-1\u03b1\/SDF-1\/CXCR4 axis reduces neuronal apoptosis via enhancing the bone marrow-derived mesenchymal stromal cell migration in rats with traumatic brain injury","volume":"114","author":"Guo","year":"2020","journal-title":"Exp. Mol. Pathol."},{"issue":"4","key":"10.1016\/j.biomaterials.2025.123268_bib76","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1755-5949.2009.00115.x","article-title":"TGF-\u03b21 pathway as a new target for neuroprotection in Alzheimer's disease","volume":"17","author":"Caraci","year":"2011","journal-title":"CNS Neurosci. Ther."},{"issue":"47","key":"10.1016\/j.biomaterials.2025.123268_bib77","article-title":"Tissue programmed hydrogels functionalized with GDNF improve human neural grafts in Parkinson's disease","volume":"31","author":"Hunt","year":"2021","journal-title":"Adv. Funct. Mater."},{"issue":"16","key":"10.1016\/j.biomaterials.2025.123268_bib78","article-title":"Self\u2010healing hydrogels: the next paradigm shift in tissue engineering?","volume":"6","author":"Talebian","year":"2019","journal-title":"Adv. Sci."},{"key":"10.1016\/j.biomaterials.2025.123268_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2023.102465","article-title":"Cytoelectric coupling: electric fields sculpt neural activity and \u201ctune\u201d the brain's infrastructure","volume":"226","author":"Pinotsis","year":"2023","journal-title":"Prog. Neurobiol."},{"issue":"3","key":"10.1016\/j.biomaterials.2025.123268_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.imr.2022.100871","article-title":"Biopotential changes of acupuncture points by acupuncture stimulation","volume":"11","author":"Cho","year":"2022","journal-title":"Integr. Med. Res."},{"issue":"10","key":"10.1016\/j.biomaterials.2025.123268_bib81","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1038\/s41593-018-0242-x","article-title":"Microglia in neurodegeneration","volume":"21","author":"Hickman","year":"2018","journal-title":"Nat. Neurosci."},{"issue":"7","key":"10.1016\/j.biomaterials.2025.123268_bib82","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.3390\/cells12071012","article-title":"Microglia mediated neuroinflammation in Parkinson's disease","volume":"12","author":"Isik","year":"2023","journal-title":"Cells"},{"issue":"23","key":"10.1016\/j.biomaterials.2025.123268_bib83","doi-asserted-by":"crossref","first-page":"19436","DOI":"10.1021\/acsami.8b04718","article-title":"Modulation of macrophage phenotype by biodegradable polyurethane nanoparticles: possible relation between macrophage polarization and immune response of nanoparticles","volume":"10","author":"Huang","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"13","key":"10.1016\/j.biomaterials.2025.123268_bib84","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202103317","article-title":"Polydopamine decorated microneedles with Fe\u2010MSC\u2010derived nanovesicles encapsulation for wound healing","volume":"9","author":"Ma","year":"2022","journal-title":"Adv. Sci."},{"issue":"11","key":"10.1016\/j.biomaterials.2025.123268_bib85","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.5966\/sctm.2015-0217","article-title":"Mesenchymal stem cells modulate the functional properties of microglia via TGF-\u03b2 secretion","volume":"5","author":"Noh","year":"2016","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.biomaterials.2025.123268_bib86","series-title":"Assessments, Treatments and Modeling in Aging and Neurological Disease","first-page":"539","article-title":"Linking aging and animal models to neurodegeneration: the striatum, substantia nigra, and Parkinson's disease","author":"Ureshino","year":"2021"},{"issue":"7","key":"10.1016\/j.biomaterials.2025.123268_bib87","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.3390\/molecules29071470","article-title":"Long-term impact of diffuse traumatic brain injury on neuroinflammation and catecholaminergic signaling: potential relevance for Parkinson's disease risk","volume":"29","author":"Wee","year":"2024","journal-title":"Molecules"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961225001875?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961225001875?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:31:06Z","timestamp":1777642266000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961225001875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":87,"alternative-id":["S0142961225001875"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2025.123268","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biodegradable, electroconductive self-healing hydrogel based on polydopamine-coated polyurethane nano-crosslinker for Parkinson's disease therapy","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2025.123268","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"123268"}}