{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:30:38Z","timestamp":1792794638634,"version":"4.5.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:00:00Z","timestamp":1758758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001348","name":"A*STAR Research Entities","doi-asserted-by":"publisher","award":["H20c6a0033"],"award-info":[{"award-number":["H20c6a0033"]}],"id":[{"id":"10.13039\/501100001348","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001381","name":"National Research Foundation Singapore","doi-asserted-by":"publisher","award":["NRF2017_SISFP10"],"award-info":[{"award-number":["NRF2017_SISFP10"]}],"id":[{"id":"10.13039\/501100001381","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["MOH-001357"],"award-info":[{"award-number":["MOH-001357"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["MOH-001106"],"award-info":[{"award-number":["MOH-001106"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.biomaterials.2025.123742","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T01:42:15Z","timestamp":1758764535000},"page":"123742","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Development of a biodegradable smooth-surface microcarrier for retinal pigment epithelial cell expansion and maturation"],"prefix":"10.1016","volume":"327","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2578-293X","authenticated-orcid":false,"given":"Zengping","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7425-6736","authenticated-orcid":false,"given":"Daniel Soo Lin","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3835-8887","authenticated-orcid":false,"given":"Bhav Harshad","family":"Parikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdurrahmaan","family":"Al-Mubaarak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0801-6897","authenticated-orcid":false,"given":"Hang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binxia","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayuri","family":"Bhargava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zibiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian Jun","family":"Loh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biomaterials.2025.123742_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2020.100846","article-title":"The cell biology of the retinal pigment epithelium","author":"Lakkaraju","year":"2020","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.biomaterials.2025.123742_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1098406","article-title":"Stem cell-derived retinal pigment epithelium cell therapy: past and future directions","volume":"11","author":"Rohowetz","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"issue":"2","key":"10.1016\/j.biomaterials.2025.123742_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23020682","article-title":"Where are we with RPE replacement therapy? A translational review from the ophthalmologist perspective","volume":"23","author":"Raimondi","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"31","key":"10.1016\/j.biomaterials.2025.123742_bib4","article-title":"Age-related macular degeneration","volume":"7","author":"Fleckenstein","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"6","key":"10.1016\/j.biomaterials.2025.123742_bib5","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1097\/APO.0000000000000234","article-title":"Epidemiology of pathologic myopia in Asia and worldwide","volume":"5","author":"Wong","year":"2016","journal-title":"Asia Pac. J. Ophthalmol. (Phila)"},{"issue":"6","key":"10.1016\/j.biomaterials.2025.123742_bib6","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.ajo.2013.01.016","article-title":"Myopia-related fundus changes in Singapore adults with high myopia","volume":"155","author":"Chang","year":"2013","journal-title":"Am. J. Ophthalmol."},{"issue":"18","key":"10.1016\/j.biomaterials.2025.123742_bib7","doi-asserted-by":"crossref","first-page":"3827","DOI":"10.1038\/s41433-023-02624-7","article-title":"The economic burden of inherited retinal disease in Singapore: a prevalence-based cost-of-illness study","volume":"37","author":"Chay","year":"2023","journal-title":"Eye (Lond)"},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123742_bib8","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1186\/s13287-024-04007-5","article-title":"Advances in retinal pigment epithelial cell transplantation for retinal degenerative diseases","volume":"15","author":"Liu","year":"2024","journal-title":"Stem Cell Res. Ther."},{"issue":"4","key":"10.1016\/j.biomaterials.2025.123742_bib9","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.stem.2009.07.002","article-title":"Directed differentiation of human embryonic stem cells into functional retinal pigment epithelium cells","volume":"5","author":"Idelson","year":"2009","journal-title":"Cell Stem Cell"},{"issue":"5","key":"10.1016\/j.biomaterials.2025.123742_bib10","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/nprot.2009.33","article-title":"A protocol for the culture and differentiation of highly polarized human retinal pigment epithelial cells","volume":"4","author":"Sonoda","year":"2009","journal-title":"Nat. Protoc."},{"issue":"9","key":"10.1016\/j.biomaterials.2025.123742_bib11","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1007\/s13346-023-01327-6","article-title":"Role of three-dimensional cell culture in therapeutics and diagnostics: an updated review","volume":"13","author":"Biju","year":"2023","journal-title":"Drug Deliv Transl Res"},{"key":"10.1016\/j.biomaterials.2025.123742_bib12","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.biomaterials.2018.07.016","article-title":"Large-scale production of stem cells utilizing microcarriers: a biomaterials engineering perspective from academic research to commercialized products","volume":"181","author":"Tavassoli","year":"2018","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123742_bib13","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s13578-020-00438-8","article-title":"Three dimensional microcarrier system in mesenchymal stem cell culture: a systematic review","volume":"10","author":"Koh","year":"2020","journal-title":"Cell Biosci."},{"issue":"2","key":"10.1016\/j.biomaterials.2025.123742_bib14","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jot.2015.02.003","article-title":"Past, present, and future of microcarrier-based tissue engineering","volume":"3","author":"Li","year":"2015","journal-title":"J. Orthopaed. Translat."},{"issue":"5110","key":"10.1016\/j.biomaterials.2025.123742_bib15","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/216064a0","article-title":"Growth of cell-strains and primary cells on micro-carriers in homogeneous culture","volume":"216","author":"Van Wezel","year":"1967","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.biomaterials.2025.123742_bib16","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/nrd817","article-title":"Encoding microcarriers: present and future technologies","volume":"1","author":"Braeckmans","year":"2002","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.biomaterials.2025.123742_bib17","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.msec.2016.03.089","article-title":"Alginate\/PEG based microcarriers with cleavable crosslinkage for expansion and non-invasive harvest of human umbilical cord blood mesenchymal stem cells","volume":"64","author":"Li","year":"2016","journal-title":"Mater. Sci. Eng. C"},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123742_bib18","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/btpr.110","article-title":"Scalable culture and cryopreservation of human embryonic stem cells on microcarriers","volume":"25","author":"Nie","year":"2009","journal-title":"Biotechnol. Prog."},{"issue":"5","key":"10.1016\/j.biomaterials.2025.123742_bib19","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1007\/s10616-015-9935-0","article-title":"A 3-D cell culture system to study epithelia functions using microcarriers","volume":"68","author":"Jakob","year":"2016","journal-title":"Cytotechnology"},{"issue":"8","key":"10.1016\/j.biomaterials.2025.123742_bib20","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1089\/ten.tec.2015.0579","article-title":"Superior red blood cell generation from human pluripotent stem cells through a novel microcarrier-based embryoid body platform","volume":"22","author":"Sivalingam","year":"2016","journal-title":"Tissue Eng. C Methods"},{"issue":"7","key":"10.1016\/j.biomaterials.2025.123742_bib21","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1002\/bit.26601","article-title":"Hollow microcarriers for large-scale expansion of anchorage-dependent cells in a stirred bioreactor","volume":"115","author":"YekrangSafakar","year":"2018","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.biomaterials.2025.123742_bib22","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3727\/096020198389979","article-title":"Striatal xenotransplantation of human retinal pigment epithelial cells attached to microcarriers in hemiparkinsonian rats ameliorates behavioral deficits without provoking a host immune response","volume":"11","author":"Cornfeldt","year":"2002","journal-title":"Cell Transplant."},{"issue":"7","key":"10.1016\/j.biomaterials.2025.123742_bib23","article-title":"Microcarrier-based culture of human pluripotent stem-cell-derived retinal pigmented epithelium","volume":"9","author":"Faynus","year":"2022","journal-title":"Bioengineering (Basel)"},{"issue":"4","key":"10.1016\/j.biomaterials.2025.123742_bib24","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1002\/btpr.1886","article-title":"Growth and functional harvesting of human mesenchymal stromal cells cultured on a microcarrier-based system","volume":"30","author":"Caruso","year":"2014","journal-title":"Biotechnol. Prog."},{"issue":"3","key":"10.1016\/j.biomaterials.2025.123742_bib25","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.jcyt.2016.11.009","article-title":"Biodegradable poly-\u03b5-caprolactone microcarriers for efficient production of human mesenchymal stromal cells and secreted cytokines in batch and fed-batch bioreactors","volume":"19","author":"Lam","year":"2017","journal-title":"Cytotherapy"},{"issue":"12","key":"10.1016\/j.biomaterials.2025.123742_bib26","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.1021\/acs.langmuir.7b00125","article-title":"Tunable volumetric density and porous structure of spherical poly-epsilon-caprolactone microcarriers, as applied in human mesenchymal stem cell expansion","volume":"33","author":"Li","year":"2017","journal-title":"Langmuir"},{"issue":"3","key":"10.1016\/j.biomaterials.2025.123742_bib27","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/stem.1293","article-title":"An efficient nonviral method to generate integration-free human-induced pluripotent stem cells from cord blood and peripheral blood cells","volume":"31","author":"Okita","year":"2013","journal-title":"Stem Cell."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123742_bib28","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.1038\/s41467-022-30474-6","article-title":"A bio-functional polymer that prevents retinal scarring through modulation of NRF2 signalling pathway","volume":"13","author":"Parikh","year":"2022","journal-title":"Nat. Commun."},{"issue":"26","key":"10.1016\/j.biomaterials.2025.123742_bib29","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2214842120","article-title":"Single-cell transcriptomics reveals maturation of transplanted stem cell-derived retinal pigment epithelial cells toward native state","volume":"120","author":"Parikh","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123742_bib30","doi-asserted-by":"crossref","first-page":"e53","DOI":"10.1002\/cpsc.53","article-title":"Stem cell-derived retinal pigment epithelial layer model from adult human globes donated for corneal transplants","volume":"45","author":"Fernandes","year":"2018","journal-title":"Curr. Protoc. Stem Cell Biol."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123742_bib31","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-19777-2","article-title":"Customized strategies for high-yield purification of retinal pigment epithelial cells differentiated from different stem cell sources","volume":"12","author":"Regha","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biomaterials.2025.123742_bib32","first-page":"60","article-title":"Appropriately differentiated ARPE-19 cells regain phenotype and gene expression profiles similar to those of native RPE cells","volume":"23","author":"Samuel","year":"2017","journal-title":"Mol. Vis."},{"key":"10.1016\/j.biomaterials.2025.123742_bib33","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/978-1-62703-080-9_20","article-title":"Analysis of photoreceptor outer segment phagocytosis by RPE cells in culture","volume":"935","author":"Mao","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.biomaterials.2025.123742_bib34","article-title":"Large-scale purification of porcine or bovine photoreceptor outer segments for phagocytosis assays on retinal pigment epithelial cells","volume":"94","author":"Parinot","year":"2014","journal-title":"J. Vis. Exp."},{"issue":"3","key":"10.1016\/j.biomaterials.2025.123742_bib35","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.stemcr.2018.01.017","article-title":"Quantified F-actin morphology is predictive of phagocytic capacity of stem cell-derived retinal pigment epithelium","volume":"10","author":"Muller","year":"2018","journal-title":"Stem Cell Rep."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123742_bib36","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0021-9797(92)90010-J","article-title":"The molecular weight and temperature dependence of polymer surface tension: comprison of experiment with interface gradient theory","volume":"152","author":"Dee","year":"1991","journal-title":"J. Colloid Interface Sci."},{"issue":"7","key":"10.1016\/j.biomaterials.2025.123742_bib37","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/mabi.200800304","article-title":"Tissue engineering polymeric microcarriers with macroporous morphology and bone-bioactive surface","volume":"9","author":"Hong","year":"2009","journal-title":"Macromol. Biosci."},{"issue":"2","key":"10.1016\/j.biomaterials.2025.123742_bib38","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.biomaterials.2005.05.081","article-title":"Gas foamed open porous biodegradable polymeric microspheres","volume":"27","author":"Kim","year":"2006","journal-title":"Biomaterials"},{"issue":"8","key":"10.1016\/j.biomaterials.2025.123742_bib39","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1016\/j.msec.2012.07.045","article-title":"Preparation of open porous polycaprolactone microspheres and their applications as effective cell carriers in hydrogel system","volume":"32","author":"Qingchun Zhang","year":"2012","journal-title":"Mater. Sci. Eng. C"},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123742_bib40","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.colsurfb.2010.11.016","article-title":"Hydrolysis and biomineralization of porous PLA microspheres and their influence on cell growth","volume":"85","author":"Xudong Shi","year":"2011","journal-title":"Colloids Surf. B Biointerfaces"},{"issue":"2","key":"10.1016\/j.biomaterials.2025.123742_bib41","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0002-9394(14)70583-5","article-title":"Retinal pigment epithelial cell count, distribution, and correlations in normal human eyes","volume":"121","author":"Panda-Jonas","year":"1996","journal-title":"Am. J. Ophthalmol."},{"issue":"32","key":"10.1016\/j.biomaterials.2025.123742_bib42","doi-asserted-by":"crossref","first-page":"13158","DOI":"10.1073\/pnas.0705963104","article-title":"Photoreceptor outer segment phagocytosis attenuates oxidative stress-induced apoptosis with concomitant neuroprotectin D1 synthesis","volume":"104","author":"Mukherjee","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123742_bib43","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1146\/annurev-pharmtox-010919-023245","article-title":"Retinal pigment epithelium replacement therapy for age-related macular degeneration: are we there yet?","volume":"60","author":"Sharma","year":"2020","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"10","key":"10.1016\/j.biomaterials.2025.123742_bib44","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.jcyt.2016.06.016","article-title":"Biodegradable ECM-coated PCL microcarriers support scalable human early MSC expansion and in vivo bone formation","volume":"18","author":"Shekaran","year":"2016","journal-title":"Cytotherapy"},{"issue":"9","key":"10.1016\/j.biomaterials.2025.123742_bib45","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1089\/ten.tec.2013.0348","article-title":"Utilizing PCL microcarriers for high-purity isolation of primary endothelial cells for tissue engineering","volume":"20","author":"Guang-Zhen Jin","year":"2014","journal-title":"Tissue Eng. C Methods"},{"issue":"12","key":"10.1016\/j.biomaterials.2025.123742_bib46","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1016\/j.stem.2023.11.004","article-title":"Safety and stable survival of stem-cell-derived retinal organoid for 2 years in patients with retinitis pigmentosa","volume":"30","author":"Hirami","year":"2023","journal-title":"Cell Stem Cell"},{"issue":"3","key":"10.1016\/j.biomaterials.2025.123742_bib47","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1039\/C5CS00065C","article-title":"Macroporous materials: microfluidic fabrication, functionalization and applications","volume":"46","author":"Wang","year":"2017","journal-title":"Chem. Soc. Rev."},{"issue":"2","key":"10.1016\/j.biomaterials.2025.123742_bib48","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1089\/biores.2013.0001","article-title":"Microcarrier culture for efficient expansion and osteogenic differentiation of human fetal mesenchymal stem cells","volume":"2","author":"Goh","year":"2013","journal-title":"Biores. Open Access"},{"key":"10.1016\/j.biomaterials.2025.123742_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.108305","article-title":"Functional assessment of cryopreserved clinical grade hESC-RPE cells as a qualified cell source for stem cell therapy of retinal degenerative diseases","volume":"202","author":"Li","year":"2021","journal-title":"Exp. Eye Res."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123742_bib50","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1186\/s13287-022-03141-2","article-title":"Determining the optimal stage for cryopreservation of human embryonic stem cell-derived retinal pigment epithelial cells","volume":"13","author":"Zhang","year":"2022","journal-title":"Stem Cell Res. Ther."},{"issue":"9","key":"10.1016\/j.biomaterials.2025.123742_bib51","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1016\/j.biomaterials.2005.09.019","article-title":"The in vivo degradation, absorption and excretion of PCL-based implant","volume":"27","author":"Sun","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2025.123742_bib52","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/278932","article-title":"PEDF and VEGF-A output from human retinal pigment epithelial cells grown on novel microcarriers","volume":"2012","author":"Falk","year":"2012","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.biomaterials.2025.123742_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2020.100849","article-title":"Extracellular vesicle therapy for retinal diseases","volume":"79","author":"Mead","year":"2020","journal-title":"Prog. Retin. Eye Res."}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961225006611?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961225006611?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T09:00:17Z","timestamp":1780477217000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961225006611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":53,"alternative-id":["S0142961225006611"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2025.123742","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of a biodegradable smooth-surface microcarrier for retinal pigment epithelial cell expansion and maturation","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2025.123742","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"123742"}}