{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T16:49:10Z","timestamp":1788022150712,"version":"build-2784847793"},"reference-count":260,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401158"],"award-info":[{"award-number":["82401158"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271001"],"award-info":[{"award-number":["82271001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301018"],"award-info":[{"award-number":["82301018"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.biomaterials.2025.123748","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T15:19:44Z","timestamp":1759245584000},"page":"123748","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Advanced biomaterials regulating mitochondria for treatment of peri-implantitis"],"prefix":"10.1016","volume":"327","author":[{"given":"Ning","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bicong","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhong","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaying","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yani","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjin","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1780-8757","authenticated-orcid":false,"given":"Guoli","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.biomaterials.2025.123748_bib1","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.denabs.2020.08.031","volume":"65","year":"2020","journal-title":"Dent. Abstr."},{"issue":"Suppl 20","key":"10.1016\/j.biomaterials.2025.123748_bib2","first-page":"S246","article-title":"Peri-implantitis","volume":"45","author":"Schwarz","year":"2018","journal-title":"J. Clin. Periodontol."},{"issue":"7","key":"10.1016\/j.biomaterials.2025.123748_bib3","doi-asserted-by":"crossref","first-page":"4147","DOI":"10.3390\/ijerph19074147","article-title":"Incidence of peri-implantitis and relationship with different conditions: a retrospective study","volume":"19","author":"Astolfi","year":"2022","journal-title":"Int. J. Environ. Res. Publ. Health."},{"issue":"2","key":"10.1016\/j.biomaterials.2025.123748_bib4","first-page":"379","article-title":"Current concepts on the pathogenesis of peri-implantitis: a narrative review","volume":"15","author":"Fragkioudakis","year":"2021","journal-title":"Eur. J. Dermatol."},{"issue":"3","key":"10.1016\/j.biomaterials.2025.123748_bib5","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1113\/EP090988","article-title":"The role of mitochondria in the peri-implant microenvironment","volume":"108","author":"Zhang","year":"2023","journal-title":"Exp. Physiol."},{"issue":"2","key":"10.1016\/j.biomaterials.2025.123748_bib6","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/clr.13401","article-title":"Peri-implantitis and its prevention","volume":"30","author":"Berglundh","year":"2019","journal-title":"Clin. Oral Implants Res."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib7","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/prd.12417","article-title":"Surgical therapy of peri-implantitis","volume":"88","author":"Schwarz","year":"2022","journal-title":"Periodontol. 2000"},{"issue":"7","key":"10.1016\/j.biomaterials.2025.123748_bib8","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.3390\/antibiotics12071223","article-title":"A systematic review and meta-analysis of systemic and local antibiotic therapy in the surgical treatment of peri-implantitis","volume":"12","author":"Baus-Dom\u00ednguez","year":"2023","journal-title":"Antibiotics"},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib9","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/prd.12049","article-title":"Management of peri-implant mucositis and peri-implantitis","volume":"66","author":"Figuero","year":"2014","journal-title":"Periodontol. 2000"},{"issue":"5","key":"10.1016\/j.biomaterials.2025.123748_bib10","article-title":"Evaluation of adjuvant systems in non-surgical peri-implant treatment: a literature review","volume":"10","author":"Butera","year":"2022","journal-title":"Health Care"},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib11","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1186\/s12903-021-02020-1","article-title":"The efficacy of systemic antibiotics as an adjunct to surgical treatment of peri-implantitis: a systematic review","volume":"21","author":"\u00d8en","year":"2021","journal-title":"BMC Oral Health"},{"key":"10.1016\/j.biomaterials.2025.123748_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdent.2021.103790","article-title":"Efficacy of local antibiotic therapy in the treatment of peri-implantitis: a systematic review and meta-analysis","volume":"113","author":"Toledano","year":"2021","journal-title":"J. Dent."},{"issue":"3","key":"10.1016\/j.biomaterials.2025.123748_bib13","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/s40496-020-00279-x","article-title":"Current approaches for the non-surgical management of peri-implant diseases","volume":"7","author":"Roccuzzo","year":"2020","journal-title":"Current Oral Health Reports"},{"issue":"11","key":"10.1016\/j.biomaterials.2025.123748_bib14","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.3390\/antibiotics10111298","article-title":"Local\/topical antibiotics for peri-implantitis treatment: a systematic review","volume":"10","author":"Passarelli","year":"2021","journal-title":"Antibiotics"},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib15","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41551-021-00756-3","article-title":"Biomaterial vaccines capturing pathogen-associated molecular patterns protect against bacterial infections and septic shock","volume":"6","author":"Super","year":"2022","journal-title":"Nat. Biomed. Eng."},{"issue":"4","key":"10.1016\/j.biomaterials.2025.123748_bib16","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1563\/aaid-joi-D-18-00069","article-title":"Doxycycline release of dental implants with nanotube surface, coated with poly lactic-co-glycolic acid for extended pH-controlled drug delivery","volume":"45","author":"Al\u00e9cio","year":"2019","journal-title":"J. Oral Implantol."},{"issue":"5","key":"10.1016\/j.biomaterials.2025.123748_bib17","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1177\/0022034519831931","article-title":"MMP-8-Responsive polyethylene glycol hydrogel for intraoral drug delivery","volume":"98","author":"Guo","year":"2019","journal-title":"J. Dent. Res."},{"issue":"7","key":"10.1016\/j.biomaterials.2025.123748_bib18","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nrmicro2337","article-title":"Periodontitis: a polymicrobial disruption of host homeostasis","volume":"8","author":"Darveau","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"issue":"6","key":"10.1016\/j.biomaterials.2025.123748_bib19","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.2041-1014.2012.00663.x","article-title":"Beyond the red complex and into more complexity: the polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology","volume":"27","author":"Hajishengallis","year":"2012","journal-title":"Molecular oral microbiology"},{"issue":"7","key":"10.1016\/j.biomaterials.2025.123748_bib20","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nrmicro2337","article-title":"Periodontitis: a polymicrobial disruption of host homeostasis","volume":"8","author":"Darveau","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"issue":"10","key":"10.1016\/j.biomaterials.2025.123748_bib21","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/nrmicro2873","article-title":"The keystone-pathogen hypothesis","volume":"10","author":"Hajishengallis","year":"2012","journal-title":"Nat. Rev. Microbiol."},{"issue":"4","key":"10.1016\/j.biomaterials.2025.123748_bib22","doi-asserted-by":"crossref","first-page":"315","DOI":"10.3390\/cells13040315","article-title":"A mapping review of the pathogenesis of peri-implantitis: the biofilm-mediated inflammation and bone dysregulation (BIND) hypothesis","volume":"13","author":"Ng","year":"2024","journal-title":"Cell"},{"issue":"7940","key":"10.1016\/j.biomaterials.2025.123748_bib23","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/s41586-022-05499-y","article-title":"A plant-derived natural photosynthetic system for improving cell anabolism","volume":"612","author":"Chen","year":"2022","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.biomaterials.2025.123748_bib24","doi-asserted-by":"crossref","first-page":"737","DOI":"10.3390\/ijms25020737","article-title":"Mitochondria: an emerging unavoidable link in the pathogenesis of periodontitis caused by Porphyromonas gingivalis","volume":"25","author":"Luo","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.biomaterials.2025.123748_bib25","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.tibs.2016.01.001","article-title":"Mitochondrial cristae: where beauty meets functionality","volume":"41","author":"Cogliati","year":"2016","journal-title":"Trends Biochem. Sci."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib26","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/prd.12372","article-title":"Peri-implantitis is not periodontitis: scientific discoveries shed light on microbiome-biomaterial interactions that may determine disease phenotype","volume":"86","author":"Kotsakis","year":"2021","journal-title":"Periodontol. 2000"},{"issue":"2","key":"10.1016\/j.biomaterials.2025.123748_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/life12020218","article-title":"Pathogenic molecular mechanisms in periodontitis and peri-implantitis: role of advanced glycation end products","volume":"12","author":"Plemmenos","year":"2022","journal-title":"Life"},{"issue":"3","key":"10.1016\/j.biomaterials.2025.123748_bib28","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/cid.12592","article-title":"Osteopontin is essential for IL-1\u03b2 production and apoptosis in peri-implantitis","volume":"20","author":"Che","year":"2018","journal-title":"Clin. Implant Dent. Relat. Res."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib29","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s41522-024-00482-z","article-title":"Favorable subgingival plaque microbiome shifts are associated with clinical treatment for peri-implant diseases","volume":"10","author":"Bazzani","year":"2024","journal-title":"npj Biofilms and Microbiomes"},{"key":"10.1016\/j.biomaterials.2025.123748_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2025.1517154","article-title":"Microbial dysbiosis in periodontitis and peri-implantitis: pathogenesis, immune responses, and therapeutic","volume":"15","author":"Cui","year":"2025","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"7","key":"10.1016\/j.biomaterials.2025.123748_bib31","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1111\/jcpe.14147","article-title":"Periodontitis history shapes the early peri-implant microbiome formation: a metagenomic analysis","volume":"52","author":"Wang","year":"2025","journal-title":"J. Clin. Periodontol."},{"issue":"2","key":"10.1016\/j.biomaterials.2025.123748_bib32","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1600-051X.1998.tb02419.x","article-title":"Microbial complexes in subgingival plaque","volume":"25","author":"Socransky","year":"1998","journal-title":"J. Clin. Periodontol."},{"issue":"11","key":"10.1016\/j.biomaterials.2025.123748_bib33","doi-asserted-by":"crossref","first-page":"4697","DOI":"10.1021\/acsbiomaterials.2c00540","article-title":"Preventing peri-implantitis: the quest for a next generation of titanium dental implants","volume":"8","author":"Hasan","year":"2022","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"3","key":"10.1016\/j.biomaterials.2025.123748_bib34","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/jopr.13270","article-title":"Microbiological profile and human immune response associated with peri-implantitis: a systematic review","volume":"30","author":"Kensara","year":"2021","journal-title":"J. Prosthodont."},{"issue":"2","key":"10.1016\/j.biomaterials.2025.123748_bib35","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1159\/000181144","article-title":"Corruption of innate immunity by bacterial proteases","volume":"1","author":"Potempa","year":"2009","journal-title":"J. Innate Immun."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib36","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41522-020-00155-7","article-title":"Strong oral plaque microbiome signatures for dental implant diseases identified by strain-resolution metagenomics","volume":"6","author":"Ghensi","year":"2020","journal-title":"npj Biofilms and Microbiomes"},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/geriatrics7010012","article-title":"The red and Orange complex subgingival microbiome of cognitive impairment and cognitively normal elderly with periodontitis","volume":"7","author":"Tadjoedin","year":"2022","journal-title":"Geriatrics"},{"issue":"4","key":"10.1016\/j.biomaterials.2025.123748_bib38","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/jopr.13743","article-title":"Microbiological profile of peri-implantitis: analyses of peri-implant microbiome","volume":"33","author":"Kensara","year":"2024","journal-title":"J. Prosthodont. : official journal of the American College of Prosthodontists"},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib39","first-page":"7","article-title":"Unraveling the microbial mosaic and inflammatory core of peri-implantitis","volume":"104","author":"Casarin","year":"2025","journal-title":"J. Dent. Res."},{"issue":"4","key":"10.1016\/j.biomaterials.2025.123748_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/dj13040148","article-title":"Exploring peri-implantitis risk-factors: a cross-sectional study","volume":"13","author":"Iu\u015fan","year":"2025","journal-title":"Dent. J."},{"issue":"6","key":"10.1016\/j.biomaterials.2025.123748_bib41","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1002\/JPER.21-0423","article-title":"Biome-microbiome interactions in peri-implantitis: a pilot investigation","volume":"93","author":"Ganesan","year":"2022","journal-title":"J. Periodontol."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib42","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-23322-6","article-title":"An ionic silver coating prevents implant-associated infection by anaerobic bacteria in vitro and in vivo in mice","volume":"12","author":"Soma","year":"2022","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.biomaterials.2025.123748_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/antibiotics13090908","article-title":"Antimicrobial effects of metal coatings or physical, chemical modifications of titanium dental implant surfaces for prevention of peri-implantitis: a systematic review of in vivo studies","volume":"13","author":"Gkioka","year":"2024","journal-title":"Antibiotics"},{"issue":"5","key":"10.1016\/j.biomaterials.2025.123748_bib44","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.dental.2025.03.008","article-title":"The influence of ZnO content in YSZ-ZnO composite ceramics on bacterial growth and cell behaviour for the prevention of peri-implant inflammation","volume":"41","author":"Jennes","year":"2025","journal-title":"Dent. Mater. : official publication of the Academy of Dental Materials"},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib45","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1186\/s12903-025-06563-5","article-title":"Quorum quenching by Est816: a novel approach to control Porphyromonas gingivalis pathogenicity","volume":"25","author":"Zhao","year":"2025","journal-title":"BMC Oral Health"},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib46","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s41368-021-00134-4","article-title":"Porphyromonas gingivalis infection promotes mitochondrial dysfunction through Drp1-dependent mitochondrial fission in endothelial cells","volume":"13","author":"Xu","year":"2021","journal-title":"Int. J. Oral Sci."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib47","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12964-023-01283-1","article-title":"CXXC5 mitigates P. Gingivalis-inhibited cementogenesis by influencing mitochondrial biogenesis","volume":"22","author":"Ma","year":"2024","journal-title":"Cell Commun. Signal. : CCS"},{"key":"10.1016\/j.biomaterials.2025.123748_bib48","article-title":"Dnmt3a-mediated DNA methylation regulates P. Gingivalis-suppressed cementoblast mineralization partially via mitochondria-dependent apoptosis pathway","author":"Liu","year":"2025","journal-title":"Inflammation"},{"issue":"2","key":"10.1016\/j.biomaterials.2025.123748_bib49","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25020737","article-title":"Mitochondria: an emerging unavoidable link in the pathogenesis of periodontitis caused by Porphyromonas gingivalis","volume":"25","author":"Luo","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.biomaterials.2025.123748_bib50","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1111\/clr.12387","article-title":"Assessment of periodontal and opportunistic flora in patients with peri-implantitis","volume":"26","author":"Albertini","year":"2015","journal-title":"Clin. Oral Implants Res."},{"key":"10.1016\/j.biomaterials.2025.123748_bib51","first-page":"137","article-title":"STAT3-specific nanocarrier for shRNA\/drug dual delivery and tumor synergistic therapy","volume":"41","author":"Sun","year":"2024","journal-title":"Bioact. Mater."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib52","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1186\/s12903-022-02304-0","article-title":"HSP90AA1 promotes the inflammation in human gingival fibroblasts induced by Porphyromonas gingivalis lipopolysaccharide via regulating of autophagy","volume":"22","author":"Zhang","year":"2022","journal-title":"BMC Oral Health"},{"key":"10.1016\/j.biomaterials.2025.123748_bib53","doi-asserted-by":"crossref","DOI":"10.1111\/jre.13416","article-title":"Porphyromonas gingivalis induces endothelial dysfunction through Sirt3-Dependent CypD acetylation","author":"Xu","year":"2025","journal-title":"J. Periodontal. Res."},{"issue":"4","key":"10.1016\/j.biomaterials.2025.123748_bib54","doi-asserted-by":"crossref","first-page":"497","DOI":"10.2217\/fmb.12.17","article-title":"Oxidative stress resistance in Porphyromonas gingivalis","volume":"7","author":"Henry","year":"2012","journal-title":"Future Microbiol."},{"issue":"2","key":"10.1016\/j.biomaterials.2025.123748_bib55","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/jre.12388","article-title":"Porphyromonas gingivalis-induced production of reactive oxygen species, tumor necrosis factor-\u03b1, interleukin-6, CXCL8 and CCL2 by neutrophils from localized aggressive periodontitis and healthy donors: modulating actions of red blood cells and resolvin E1","volume":"52","author":"Damgaard","year":"2017","journal-title":"J. Periodontal. Res."},{"issue":"8","key":"10.1016\/j.biomaterials.2025.123748_bib56","doi-asserted-by":"crossref","first-page":"3665","DOI":"10.1111\/odi.14286","article-title":"PINK1-mediated mitophagy reduced inflammatory responses to Porphyromonas gingivalis in macrophages","volume":"29","author":"Jiang","year":"2023","journal-title":"Oral Dis."},{"issue":"5","key":"10.1016\/j.biomaterials.2025.123748_bib57","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1177\/00220345221146097","article-title":"Porphyromonas gingivalis evades immune clearance by regulating lysosome efflux","volume":"102","author":"Liu","year":"2023","journal-title":"J. Dent. Res."},{"issue":"5","key":"10.1016\/j.biomaterials.2025.123748_bib58","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1177\/00220345221146097","article-title":"Porphyromonas gingivalis evades immune clearance by regulating lysosome efflux","volume":"102","author":"Liu","year":"2023","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.biomaterials.2025.123748_bib59","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2025.1613366","article-title":"Porphyromonas gingivalis hijacks mitophagy and lysosomal function to persist in endothelial cells","volume":"15","author":"Zheng","year":"2025","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"8","key":"10.1016\/j.biomaterials.2025.123748_bib60","doi-asserted-by":"crossref","first-page":"3571","DOI":"10.1111\/odi.14292","article-title":"Involvement of ferroptosis in Porphyromonas gingivalis lipopolysaccharide-stimulated periodontitis in vitro and in vivo","volume":"29","author":"Qiao","year":"2023","journal-title":"Oral Dis."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib61","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s41368-021-00134-4","article-title":"Porphyromonas gingivalis infection promotes mitochondrial dysfunction through Drp1-dependent mitochondrial fission in endothelial cells","volume":"13","author":"Xu","year":"2021","journal-title":"Int. J. Oral Sci."},{"issue":"15","key":"10.1016\/j.biomaterials.2025.123748_bib62","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1111\/jcmm.17796","article-title":"RhoA\/ROCK1 regulates the mitochondrial dysfunction through Drp1 induced by Porphyromonas gingivalis in endothelial cells","volume":"27","author":"Dong","year":"2023","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.biomaterials.2025.123748_bib63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phrs.2014.10.007","article-title":"Lipophilic antioxidants prevent lipopolysaccharide-induced mitochondrial dysfunction through mitochondrial biogenesis improvement","volume":"91","author":"Bull\u00f3n","year":"2015","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib64","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/jre.12941","article-title":"Abnormal mitochondrial structure and function are retained in gingival tissues and human gingival fibroblasts from patients with chronic periodontitis","volume":"57","author":"Liu","year":"2022","journal-title":"J. Periodontal. Res."},{"key":"10.1016\/j.biomaterials.2025.123748_bib65","article-title":"Mitochondrial DNA efflux maintained in gingival fibroblasts of patients with periodontitis through ROS\/mPTP pathway","volume":"2022","author":"Liu","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib66","first-page":"1","article-title":"Increase in sequence variation of the D310 region and decrease of the copy number of mitochondrial DNA in gingival tissues from patients with chronic periodontitis","volume":"21","author":"Yi-Shing","year":"2023","journal-title":"The Changhua Journal of Medicine"},{"issue":"2","key":"10.1016\/j.biomaterials.2025.123748_bib67","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41580-023-00661-4","article-title":"Mechanisms and regulation of human mitochondrial transcription","volume":"25","author":"Tan","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.biomaterials.2025.123748_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.archoralbio.2021.105173","article-title":"Gene expression profiles of mitochondria-endoplasmic reticulum tethering in human gingival fibroblasts in response to periodontal pathogens","volume":"128","author":"Aral","year":"2021","journal-title":"Arch. Oral Biol."},{"issue":"3","key":"10.1016\/j.biomaterials.2025.123748_bib69","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.tibs.2015.01.002","article-title":"UPR, autophagy, and mitochondria crosstalk underlies the ER stress response","volume":"40","author":"Senft","year":"2015","journal-title":"Trends Biochem. Sci."},{"issue":"2","key":"10.1016\/j.biomaterials.2025.123748_bib70","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.3390\/ijms25021024","article-title":"Mitochondrial dysfunction in periodontitis and associated systemic diseases: implications for pathomechanisms and therapeutic strategies","volume":"25","author":"Deng","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.biomaterials.2025.123748_bib71","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24020950","article-title":"LPS induces mitochondrial dysfunction mediated by neuroinflammation through oxidative stress","volume":"24","author":"Verma","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biomaterials.2025.123748_bib72","doi-asserted-by":"crossref","first-page":"351","DOI":"10.3389\/fcimb.2017.00351","article-title":"Metabolic remodeling, inflammasome activation, and pyroptosis in macrophages stimulated by Porphyromonas gingivalis and its outer membrane vesicles","volume":"7","author":"Fleetwood","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib73","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.bbrc.2019.11.074","article-title":"Porphyromonas gingivalis triggers inflammatory responses in periodontal ligament cells by succinate-succinate dehydrogenase\u2013HIF\u20131\u03b1 axis","volume":"522","author":"Su","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib74","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1186\/s12951-023-02244-z","article-title":"Reprogramming mitochondrial metabolism of macrophages by miRNA-released microporous coatings to prevent peri-implantitis","volume":"21","author":"Zhang","year":"2023","journal-title":"J. Nanobiotechnol."},{"issue":"16","key":"10.1016\/j.biomaterials.2025.123748_bib75","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202500112RR","article-title":"Acetylcholine suppression by P. gingivalis extracellular vesicles drives osteoclastogenesis and bone loss via the Cyp4f40","volume":"39","author":"Chen","year":"2025","journal-title":"FASEB J. : official publication of the Federation of American Societies for Experimental Biology"},{"issue":"2","key":"10.1016\/j.biomaterials.2025.123748_bib76","doi-asserted-by":"crossref","first-page":"218","DOI":"10.3390\/life12020218","article-title":"Pathogenic molecular mechanisms in periodontitis and peri-implantitis: role of advanced glycation end products","volume":"12","author":"Plemmenos","year":"2022","journal-title":"Life"},{"issue":"5\u20136","key":"10.1016\/j.biomaterials.2025.123748_bib77","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1159\/000521720","article-title":"Advanced glycation end products induced mitochondrial dysfunction of chondrocytes through repression of AMPK\u03b1-SIRT1-PGC-1\u03b1 pathway","volume":"107","author":"Yang","year":"2022","journal-title":"Pharmacology"},{"issue":"4","key":"10.1016\/j.biomaterials.2025.123748_bib78","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/omi.12224","article-title":"Tannerella forsythia-produced methylglyoxal causes accumulation of advanced glycation endproducts to trigger cytokine secretion in human monocytes","volume":"33","author":"Settem","year":"2018","journal-title":"Molecular oral microbiology"},{"issue":"2","key":"10.1016\/j.biomaterials.2025.123748_bib79","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1600-0765.2007.01003.x","article-title":"Pro-inflammatory cytokine production from normal human fibroblasts is induced by Tannerella forsythia detaching factor","volume":"43","author":"Tomi","year":"2008","journal-title":"J. Periodontal. Res."},{"issue":"2","key":"10.1016\/j.biomaterials.2025.123748_bib80","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1042\/BJ20150388","article-title":"Characterization of a sialate-O-acetylesterase (NanS) from the oral pathogen Tannerella forsythia that enhances sialic acid release by NanH, its cognate sialidase","volume":"472","author":"Phansopa","year":"2015","journal-title":"Biochem. J."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib81","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1021\/acs.molpharmaceut.8b00861","article-title":"Sialic acid-functionalized PEG\u2013PLGA microspheres loading mitochondrial-targeting-modified curcumin for acute lung injury therapy","volume":"16","author":"Jin","year":"2019","journal-title":"Mol. Pharm."},{"issue":"11","key":"10.1016\/j.biomaterials.2025.123748_bib82","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19113585","article-title":"Potential causes of titanium particle and ion release in implant dentistry: a systematic review","volume":"19","author":"Delgado-Ruiz","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib83","doi-asserted-by":"crossref","first-page":"104","DOI":"10.4012\/dmj.25.104","article-title":"Corrosion behavior of pure titanium and titanium alloys in various concentrations of acidulated phosphate fluoride (APF) solutions","volume":"25","author":"Matono","year":"2006","journal-title":"Dent. Mater. J."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib84","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/jbm.a.32183","article-title":"Titanium IV ions induced human osteoclast differentiation and enhanced bone resorption in vitro","volume":"91","author":"Cadosch","year":"2009","journal-title":"J. Biomed. Mater. Res."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib85","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41368-023-00256-x","article-title":"Titanium particles in peri-implantitis: distribution, pathogenesis and prospects","volume":"15","author":"Chen","year":"2023","journal-title":"Int. J. Oral Sci."},{"key":"10.1016\/j.biomaterials.2025.123748_bib86","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tox.2014.10.016","article-title":"Release of titanium ions from an implant surface and their effect on cytokine production related to alveolar bone resorption","volume":"327","author":"Wachi","year":"2015","journal-title":"Toxicology"},{"issue":"7","key":"10.1016\/j.biomaterials.2025.123748_bib87","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1016\/j.tiv.2010.07.023","article-title":"Titanium ion induces necrosis and sensitivity to lipopolysaccharide in gingival epithelial-like cells","volume":"24","author":"Makihira","year":"2010","journal-title":"Toxicol. Vitro : an international journal published in association with BIBRA"},{"issue":"22","key":"10.1016\/j.biomaterials.2025.123748_bib88","doi-asserted-by":"crossref","first-page":"13152","DOI":"10.1039\/D0RA09395E","article-title":"Impact of exogenous metal ions on peri-implant bone metabolism: a review","volume":"11","author":"Chen","year":"2021","journal-title":"RSC Adv."},{"key":"10.1016\/j.biomaterials.2025.123748_bib89","article-title":"Emerging factors affecting peri-implant bone metabolism","volume":"2000","author":"Insua","year":"2023","journal-title":"Periodontol"},{"key":"10.1016\/j.biomaterials.2025.123748_bib90","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2023.03.032","article-title":"Insight into the effect of biomaterials on osteogenic differentiation of mesenchymal stem cells: a review from a mitochondrial perspective","volume":"164","author":"Feng","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.biomaterials.2025.123748_bib91","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2020.111285","article-title":"A study of titanium and magnesium particle-induced oxidative stress and toxicity to human osteoblasts","volume":"117","author":"Wang","year":"2020","journal-title":"Mater. Sci. Eng. C"},{"issue":"52","key":"10.1016\/j.biomaterials.2025.123748_bib92","doi-asserted-by":"crossref","first-page":"40429","DOI":"10.1074\/jbc.M606596200","article-title":"Down-regulation of manganese-superoxide dismutase through phosphorylation of FOXO3a by Akt in explanted vascular smooth muscle cells from old rats","volume":"281","author":"Li","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib93","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3892\/mmr.2020.11094","article-title":"Excessive production of mitochondrion-derived reactive oxygen species induced by titanium ions leads to autophagic cell death of osteoblasts via the SIRT3\/SOD2 pathway","volume":"22","author":"Wang","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.biomaterials.2025.123748_bib94","first-page":"1095","article-title":"Titanium dioxide nanoparticles enhance production of superoxide anion and alter the antioxidant system in human osteoblast cells","volume":"10","author":"Niska","year":"2015","journal-title":"Int. J. Nanomed."},{"issue":"5","key":"10.1016\/j.biomaterials.2025.123748_bib95","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1111\/jre.13152","article-title":"The role of mitochondrial dysfunction in periodontitis: from mechanisms to therapeutic strategy","volume":"58","author":"Jiang","year":"2023","journal-title":"J. Periodontal. Res."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib96","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.jds.2024.06.013","article-title":"Titanium particle-induced inflammasome in human gingival epithelial cells","volume":"20","author":"Wakuda","year":"2025","journal-title":"J. Dent. Sci."},{"issue":"6","key":"10.1016\/j.biomaterials.2025.123748_bib97","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.11607\/jomi.6077","article-title":"Titanium activates the DNA damage response pathway in oral epithelial cells: a pilot study","volume":"32","author":"Su\u00e1rez-L\u00f3pez Del Amo","year":"2017","journal-title":"Int. J. Oral Maxillofac. Implants"},{"key":"10.1016\/j.biomaterials.2025.123748_bib98","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102337","article-title":"Cellular redox imbalance on the crossroad between mitochondrial dysfunction, senescence, and proliferation","volume":"53","author":"Bakalova","year":"2022","journal-title":"Redox Biol."},{"issue":"8","key":"10.1016\/j.biomaterials.2025.123748_bib99","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0134541","article-title":"Titanium dioxide nanoparticles trigger loss of function and perturbation of mitochondrial dynamics in primary hepatocytes","volume":"10","author":"Natarajan","year":"2015","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.biomaterials.2025.123748_bib100","doi-asserted-by":"crossref","first-page":"R170","DOI":"10.1016\/j.cub.2018.01.004","article-title":"Mitophagy and quality control mechanisms in mitochondrial maintenance","volume":"28","author":"Pickles","year":"2018","journal-title":"Curr. Biol. : CB"},{"issue":"14","key":"10.1016\/j.biomaterials.2025.123748_bib101","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.7150\/ijbs.46627","article-title":"The role of autophagy and mitophagy in bone metabolic disorders","volume":"16","author":"Wang","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.biomaterials.2025.123748_bib102","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.cbi.2018.09.015","article-title":"Titanium dioxide nanoparticles induce proteostasis disruption and autophagy in human trophoblast cells","volume":"296","author":"Zhang","year":"2018","journal-title":"Chem. Biol. Interact."},{"issue":"2","key":"10.1016\/j.biomaterials.2025.123748_bib103","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1039\/D2BM01528E","article-title":"Micro\/nano-modified titanium surfaces accelerate osseointegration via Rab7-dependent mitophagy","volume":"11","author":"Tang","year":"2023","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.biomaterials.2025.123748_bib104","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.jhazmat.2014.12.064","article-title":"Interactions between nano-TiO2 and the oral cavity: impact of nanomaterial surface hydrophilicity\/hydrophobicity","volume":"286","author":"Teubl","year":"2015","journal-title":"J. Hazard Mater."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib105","doi-asserted-by":"crossref","DOI":"10.1038\/srep23615","article-title":"Trojan-like internalization of anatase titanium dioxide nanoparticles by human osteoblast cells","volume":"6","author":"Ribeiro","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biomaterials.2025.123748_bib106","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.bbrc.2022.12.088","article-title":"CypD-mediated mitochondrial dysfunction contributes to titanium ion-induced MC3T3-E1 cell injury","volume":"644","author":"Mao","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"8","key":"10.1016\/j.biomaterials.2025.123748_bib107","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1007\/s10856-011-4375-7","article-title":"Analysis of the cytotoxicity of differentially sized titanium dioxide nanoparticles in murine MC3T3-E1 preosteoblasts","volume":"22","author":"Zhang","year":"2011","journal-title":"J. Mater. Sci. Mater. Med."},{"issue":"2","key":"10.1016\/j.biomaterials.2025.123748_bib108","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/s41576-020-00284-x","article-title":"Extreme heterogeneity of human mitochondrial DNA from organelles to populations","volume":"22","author":"Stewart","year":"2021","journal-title":"Nat. Rev. Genet."},{"issue":"11","key":"10.1016\/j.biomaterials.2025.123748_bib109","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1902\/jop.2006.060108","article-title":"New evidence of premature oxidative DNA damage: mitochondrial DNA deletion in gingival tissue of patients with periodontitis","volume":"77","author":"Canak\u00e7i","year":"2006","journal-title":"J. Periodontol."},{"issue":"12","key":"10.1016\/j.biomaterials.2025.123748_bib110","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.it.2019.10.008","article-title":"Emerging role of mitochondrial DNA as a major driver of inflammation and disease progression","volume":"40","author":"Zhong","year":"2019","journal-title":"Trends Immunol."},{"issue":"2","key":"10.1016\/j.biomaterials.2025.123748_bib111","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/jat.4534","article-title":"The toxicological effects of nano titanium dioxide on target organs and mechanisms of toxicity","volume":"44","author":"Li","year":"2024","journal-title":"Journal of applied toxicology : JAT"},{"issue":"11","key":"10.1016\/j.biomaterials.2025.123748_bib112","doi-asserted-by":"crossref","DOI":"10.1088\/0957-4484\/27\/11\/112001","article-title":"Murine liver damage caused by exposure to nano-titanium dioxide","volume":"27","author":"Hong","year":"2016","journal-title":"Nanotechnology"},{"issue":"12","key":"10.1016\/j.biomaterials.2025.123748_bib113","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1002\/JPER.23-0573","article-title":"Peri-implantitis induction and resolution around zirconia versus titanium implants","volume":"95","author":"Esplin","year":"2024","journal-title":"J. Periodontol."},{"issue":"8","key":"10.1016\/j.biomaterials.2025.123748_bib114","doi-asserted-by":"crossref","first-page":"690","DOI":"10.3390\/antibiotics13080690","article-title":"Peri-implant microbial signature shifts in titanium, zirconia and ceria-stabilized zirconia reinforced with alumina sites subjected to experimental peri-implantitis: a preclinical study in dogs","volume":"13","author":"L\u00f3pez-P\u00edriz","year":"2024","journal-title":"Antibiotics"},{"issue":"2","key":"10.1016\/j.biomaterials.2025.123748_bib115","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1177\/09506608251314251","article-title":"Applications, modifications, and manufacturing of polyetheretherketone (PEEK) in dental implantology: a comprehensive critical review","volume":"70","author":"Alqutaibi","year":"2025","journal-title":"Int. Mater. Rev."},{"issue":"3","key":"10.1016\/j.biomaterials.2025.123748_bib116","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.prosdent.2022.08.027","article-title":"Polyetheretherketone subperiosteal implant retaining a maxillary fixed prosthesis: a case series","volume":"132","author":"El-Sawy","year":"2024","journal-title":"J. Prosthet. Dent"},{"issue":"Suppl 4","key":"10.1016\/j.biomaterials.2025.123748_bib117","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1600-0501.2009.01785.x","article-title":"Are ceramic implants a viable alternative to titanium implants? A systematic literature review","volume":"20","author":"Andreiotelli","year":"2009","journal-title":"Clin. Oral Implants Res."},{"issue":"11","key":"10.1016\/j.biomaterials.2025.123748_bib118","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1007\/s00264-024-06289-z","article-title":"Long-term follow-up of bone density changes in total hip arthroplasty: comparative analysis from a randomized controlled trial of a porous titanium construct shell vs. a porous coated shell","volume":"48","author":"Axenhus","year":"2024","journal-title":"Int. Orthop."},{"issue":"5","key":"10.1016\/j.biomaterials.2025.123748_bib119","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.dental.2025.03.008","article-title":"The influence of ZnO content in YSZ-ZnO composite ceramics on bacterial growth and cell behaviour for the prevention of peri-implant inflammation","volume":"41","author":"Jennes","year":"2025","journal-title":"Dent. Mater."},{"issue":"8","key":"10.1016\/j.biomaterials.2025.123748_bib120","doi-asserted-by":"crossref","DOI":"10.3390\/antibiotics13080690","article-title":"Peri-implant microbial signature shifts in titanium, zirconia and ceria-stabilized zirconia reinforced with alumina sites subjected to experimental peri-implantitis: a preclinical study in dogs","volume":"13","author":"L\u00f3pez-P\u00edriz","year":"2024","journal-title":"Antibiotics"},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib121","doi-asserted-by":"crossref","DOI":"10.1002\/jbm.a.37866","article-title":"The role of implant coronal surface properties on early adhesion of streptococcus Oralis-An in vitro comparative study","volume":"113","author":"Wang","year":"2025","journal-title":"J. Biomed. Mater. Res."},{"issue":"3","key":"10.1016\/j.biomaterials.2025.123748_bib122","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1002\/JPER.23-0205","article-title":"Impact of surface characteristics on the peri-implant microbiome in health and disease","volume":"95","author":"Sinjab","year":"2024","journal-title":"J. Periodontol."},{"key":"10.1016\/j.biomaterials.2025.123748_bib123","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1466417","article-title":"Role of immune dysregulation in peri-implantitis","volume":"15","author":"Huang","year":"2024","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib124","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/prd.12532","article-title":"Emerging factors affecting peri-implant bone metabolism","volume":"94","author":"Insua","year":"2024","journal-title":"Periodontol. 2000"},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib125","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41368-023-00256-x","article-title":"Titanium particles in peri-implantitis: distribution, pathogenesis and prospects","volume":"15","author":"Chen","year":"2023","journal-title":"Int. J. Oral Sci."},{"issue":"4","key":"10.1016\/j.biomaterials.2025.123748_bib126","doi-asserted-by":"crossref","DOI":"10.3390\/cells13040315","article-title":"A mapping review of the pathogenesis of peri-implantitis: the biofilm-mediated inflammation and bone dysregulation (BIND) hypothesis","volume":"13","author":"Ng","year":"2024","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib127","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1186\/s10020-025-01290-7","article-title":"Cross-talk between NLRP3 and AIM2 inflammasomes in macrophage activation by LPS and titanium ions","volume":"31","author":"Carrillo-G\u00e1lvez","year":"2025","journal-title":"Mol. Med."},{"issue":"11","key":"10.1016\/j.biomaterials.2025.123748_bib128","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2021.166217","article-title":"Caspase-3 and gasdermin E detection in peri-implantitis","volume":"1867","author":"Chen","year":"2021","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib129","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1038\/s41467-019-09397-2","article-title":"Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation","volume":"10","author":"Rogers","year":"2019","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.biomaterials.2025.123748_bib130","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.bbrc.2019.11.080","article-title":"High glucose inhibits proliferation and differentiation of osteoblast in alveolar bone by inducing pyroptosis","volume":"522","author":"Yang","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib131","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nri.2015.7","article-title":"Converging roles of caspases in inflammasome activation, cell death and innate immunity","volume":"16","author":"Man","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.biomaterials.2025.123748_bib132","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.2147\/JIR.S450706","article-title":"The critical role of pyroptosis in peri-implantitis","volume":"17","author":"Chen","year":"2024","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.biomaterials.2025.123748_bib133","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114249","article-title":"ACLY inhibitor reduced porphyromonas gingivalis-induced pyroptosis by suppressing microtubules acetylation in macrophages","volume":"150","author":"Mao","year":"2025","journal-title":"Int. Immunopharmacol."},{"issue":"2","key":"10.1016\/j.biomaterials.2025.123748_bib134","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2023.113612","article-title":"Ebselen restores peri-implantitis-induced osteogenic inhibition via suppressing BMSCs ferroptosis","volume":"427","author":"Huang","year":"2023","journal-title":"Exp. Cell Res."},{"issue":"9","key":"10.1016\/j.biomaterials.2025.123748_bib135","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202105043","article-title":"Mitochondrial regulation of ferroptosis","volume":"220","author":"Gan","year":"2021","journal-title":"J. Cell Biol."},{"issue":"3","key":"10.1016\/j.biomaterials.2025.123748_bib136","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1007\/s10735-025-10467-7","article-title":"Porphyromonas gingivalis induced DNA oxidative stress damage by iron overload to deplete CTCF expression and prevent osteogenic differentiation of periodontal ligament stem cells","volume":"56","author":"Zhang","year":"2025","journal-title":"J. Mol. Histol."},{"key":"10.1016\/j.biomaterials.2025.123748_bib137","first-page":"336","article-title":"A two-pronged approach to inhibit ferroptosis of MSCs caused by the iron overload in postmenopausal osteoporosis and promote osseointegration of titanium implant","volume":"41","author":"Yang","year":"2024","journal-title":"Bioact. Mater."},{"issue":"4","key":"10.1016\/j.biomaterials.2025.123748_bib138","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/jre.12224","article-title":"In vivo osteoprotegerin gene therapy preventing bone loss induced by periodontitis","volume":"50","author":"Tang","year":"2015","journal-title":"J. Periodontal. Res."},{"key":"10.1016\/j.biomaterials.2025.123748_bib139","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2019.114784","article-title":"Cytotoxicity and oxidative stress induced by nickel and titanium ions from dental alloys on cells of gastrointestinal tract","volume":"383","author":"Rincic Mlinaric","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"9","key":"10.1016\/j.biomaterials.2025.123748_bib140","doi-asserted-by":"crossref","first-page":"6248","DOI":"10.1021\/am501266a","article-title":"Nano-hydroxyapatite and nano-titanium dioxide exhibit different subcellular distribution and apoptotic profile in human oral epithelium","volume":"6","author":"Tay","year":"2014","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"11","key":"10.1016\/j.biomaterials.2025.123748_bib141","doi-asserted-by":"crossref","first-page":"2968","DOI":"10.1002\/jbm.a.36150","article-title":"Titanium-released from dental implant enhances pre-osteoblast adhesion by ROS modulating crucial intracellular pathways","volume":"105","author":"Rossi","year":"2017","journal-title":"J. Biomed. Mater. Res."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib142","doi-asserted-by":"crossref","DOI":"10.1080\/20002297.2024.2334578","article-title":"Role of ferroptosis in porphyromonas gingivalis-induced impairment of epithelial junction","volume":"16","author":"Shi","year":"2024","journal-title":"J. Oral Microbiol."},{"issue":"null","key":"10.1016\/j.biomaterials.2025.123748_bib143","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.2147\/JIR.S450706","article-title":"The critical role of pyroptosis in peri-implantitis","volume":"17","author":"Chen","year":"2024","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.biomaterials.2025.123748_bib144","article-title":"The role and mechanisms of gram-negative bacterial outer membrane vesicles in inflammatory diseases","volume":"14","author":"Chen","year":"2023","journal-title":"Front. Immunol."},{"issue":"8","key":"10.1016\/j.biomaterials.2025.123748_bib145","doi-asserted-by":"crossref","DOI":"10.1002\/advs.201902536","article-title":"Biomineral precursor formation is initiated by transporting calcium and phosphorus clusters from the endoplasmic reticulum to mitochondria","volume":"7","author":"Tang","year":"2020","journal-title":"Adv. Sci."},{"issue":"8","key":"10.1016\/j.biomaterials.2025.123748_bib146","doi-asserted-by":"crossref","first-page":"5461","DOI":"10.1111\/odi.14969","article-title":"Porphyromonas gingivalis OMVs promoting endothelial dysfunction via the STING pathway in periodontitis","volume":"30","author":"Chen","year":"2024","journal-title":"Oral Dis."},{"issue":"2","key":"10.1016\/j.biomaterials.2025.123748_bib147","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/jbmr.4756","article-title":"STAT3\/Mitophagy axis coordinates macrophage NLRP3 inflammasome activation and inflammatory bone loss","volume":"38","author":"Zhu","year":"2023","journal-title":"J. Bone Miner. Res. : the official journal of the American Society for Bone and Mineral Research"},{"issue":"9","key":"10.1016\/j.biomaterials.2025.123748_bib148","doi-asserted-by":"crossref","first-page":"4957","DOI":"10.1007\/s00784-023-05115-x","article-title":"Titanium alloys with varying surface micro-area potential differences have antibacterial abilities and a favorable cellular response","volume":"27","author":"Wang","year":"2023","journal-title":"Clin. Oral Invest."},{"issue":"4","key":"10.1016\/j.biomaterials.2025.123748_bib149","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202204871","article-title":"Mitochondrial transfer regulates cell fate through metabolic remodeling in osteoporosis","volume":"10","author":"Cai","year":"2023","journal-title":"Adv. Sci."},{"issue":"42","key":"10.1016\/j.biomaterials.2025.123748_bib150","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202406287","article-title":"An engineered hierarchical hydrogel with immune responsiveness and targeted mitochondrial transfer to augmented bone regeneration","volume":"11","author":"Cai","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.biomaterials.2025.123748_bib151","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2024.08.008","article-title":"Targeted mitochondrial nanomaterials in biomedicine: advances in therapeutic strategies and imaging modalities","volume":"186","author":"Chen","year":"2024","journal-title":"Acta Biomater."},{"issue":"3","key":"10.1016\/j.biomaterials.2025.123748_bib152","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s13205-022-03131-4","article-title":"Antioxidant-biocompatible and stable catalase-based gelatin-alginate hydrogel scaffold with thermal wound healing capability: immobilization and delivery approach","volume":"12","author":"Abdel-Mageed","year":"2022","journal-title":"3 Biotech"},{"issue":"24","key":"10.1016\/j.biomaterials.2025.123748_bib153","doi-asserted-by":"crossref","first-page":"27634","DOI":"10.1021\/acsami.2c05166","article-title":"Manganese oxide nanozyme-doped diatom for safe and efficient treatment of peri-implantitis","volume":"14","author":"Lee","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.biomaterials.2025.123748_bib154","article-title":"In situ forming and biocompatible hyaluronic acid hydrogel with reactive oxygen species-scavenging activity to improve traumatic brain injury repair by suppressing oxidative stress and neuroinflammation","volume":"15","author":"Zhang","year":"2022","journal-title":"Mater. Today Bio"},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib155","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1080\/17435390.2017.1416202","article-title":"Reactive oxygen species damage drives cardiac and mitochondrial dysfunction following acute nano-titanium dioxide inhalation exposure","volume":"12","author":"Nichols","year":"2018","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.biomaterials.2025.123748_bib156","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.redox.2014.11.006","article-title":"Mitochondrial dynamics and mitochondrial quality control","volume":"4","author":"Ni","year":"2015","journal-title":"Redox Biol."},{"issue":"2","key":"10.1016\/j.biomaterials.2025.123748_bib157","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/jbmr.4756","article-title":"STAT3\/Mitophagy axis coordinates macrophage NLRP3 inflammasome activation and inflammatory bone loss","volume":"38","author":"Zhu","year":"2023","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.biomaterials.2025.123748_bib158","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.actbio.2019.07.007","article-title":"Nanotopography on titanium promotes osteogenesis via autophagy-mediated signaling between YAP and \u03b2-catenin","volume":"96","author":"Li","year":"2019","journal-title":"Acta Biomater."},{"key":"10.1016\/j.biomaterials.2025.123748_bib159","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2019.110513","article-title":"The Wnt\/\u03b2-catenin signaling pathway is regulated by titanium with nanotopography to induce osteoblast differentiation","volume":"184","author":"Abuna","year":"2019","journal-title":"Colloids Surf., B"},{"issue":"5","key":"10.1016\/j.biomaterials.2025.123748_bib160","doi-asserted-by":"crossref","DOI":"10.3892\/ijmm.2022.5128","article-title":"Hypoxia-induced mitophagy regulates proliferation, migration and odontoblastic differentiation of human dental pulp cells through FUN14 domain-containing 1","volume":"49","author":"Liu","year":"2022","journal-title":"Int. J. Mol. Med."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib161","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13010090","article-title":"Ultra-small iron nanoparticles target mitochondria inducing autophagy, acting on mitochondrial DNA and reducing respiration","volume":"13","author":"Rivas-Garc\u00eda","year":"2021","journal-title":"Pharmaceutics"},{"issue":"5","key":"10.1016\/j.biomaterials.2025.123748_bib162","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1016\/j.nano.2017.02.020","article-title":"Nanoparticle mediated PPAR\u03b3 gene delivery on dental implants improves osseointegration via mitochondrial biogenesis in diabetes mellitus rat model","volume":"13","author":"Lee","year":"2017","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"issue":"5","key":"10.1016\/j.biomaterials.2025.123748_bib163","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1177\/0022034515573833","article-title":"PPAR\u03b3 maintains homeostasis through autophagy regulation in dental pulp","volume":"94","author":"Lee","year":"2015","journal-title":"J. Dent. Res."},{"issue":"null","key":"10.1016\/j.biomaterials.2025.123748_bib164","doi-asserted-by":"crossref","first-page":"8693","DOI":"10.2147\/IJN.S218640","article-title":"Ta-Coated titanium surface with superior bacteriostasis and osseointegration","volume":"14","author":"Zhang","year":"2019","journal-title":"Int. J. Nanomed."},{"issue":"7","key":"10.1016\/j.biomaterials.2025.123748_bib165","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1161\/CIRCULATIONAHA.118.037216","article-title":"Glucose-sensitive myokine\/cardiokine MG53 regulates systemic insulin response and metabolic homeostasis","volume":"139","author":"Wu","year":"2019","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.biomaterials.2025.123748_bib166","article-title":"The antibacterial property of zinc oxide\/graphene oxide modified porous polyetheretherketone againstS","volume":"17","author":"Yang","year":"2022","journal-title":"sanguinis, F. nucleatumandP. gingivalis, Biomedical materials (Bristol, England)"},{"issue":"30","key":"10.1016\/j.biomaterials.2025.123748_bib167","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202301733","article-title":"A dual-antioxidative coating on transmucosal component of implant to repair connective tissue barrier for treatment of peri-implantitis","volume":"12","author":"Li","year":"2023","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.biomaterials.2025.123748_bib168","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.jconrel.2023.10.016","article-title":"Fluoride releasing photothermal responsive TiO2 matrices for antibiosis, biosealing and bone regeneration","volume":"363","author":"Xue","year":"2023","journal-title":"J. Contr. Release"},{"issue":"11","key":"10.1016\/j.biomaterials.2025.123748_bib169","doi-asserted-by":"crossref","first-page":"13622","DOI":"10.1021\/acsami.4c02119","article-title":"Surface-engineered titanium with nanoceria to enhance soft tissue integration via reactive oxygen species modulation and nanotopographical sensing","volume":"16","author":"Shim","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"6","key":"10.1016\/j.biomaterials.2025.123748_bib170","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1111\/jre.12915","article-title":"Porphyromonas gingivalis survival skills: immune evasion","volume":"56","author":"Zheng","year":"2021","journal-title":"J. Periodontal. Res."},{"issue":"3","key":"10.1016\/j.biomaterials.2025.123748_bib171","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.03787-21","article-title":"Proteolytic activity-independent activation of the immune response by gingipains from Porphyromonas gingivalis","volume":"13","author":"Ciaston","year":"2022","journal-title":"mBio"},{"issue":"Pt A","key":"10.1016\/j.biomaterials.2025.123748_bib172","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.anaerobe.2015.04.004","article-title":"Bacterial profiles and proteolytic activity in peri-implantitis versus healthy sites","volume":"35","author":"Neilands","year":"2015","journal-title":"Anaerobe"},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib173","doi-asserted-by":"crossref","DOI":"10.1080\/20002297.2017.1340085","article-title":"Porphyromonas gingivalis disturbs host-commensal homeostasis by changing complement function","volume":"9","author":"Olsen","year":"2017","journal-title":"J. Oral Microbiol."},{"issue":"5","key":"10.1016\/j.biomaterials.2025.123748_bib174","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1111\/omi.12433","article-title":"Exploring the genetic and functional diversity of Porphyromonas gingivalis long fimbriae","volume":"38","author":"Meyer","year":"2023","journal-title":"Molecular oral microbiology"},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib175","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/s42003-020-01621-w","article-title":"Porphyromonas gingivalis fimbrial protein Mfa5 contains a von Willebrand factor domain and an intramolecular isopeptide","volume":"4","author":"Heidler","year":"2021","journal-title":"Commun. Biol."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib176","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02262-20","article-title":"PorZ, an essential component of the type IX secretion system of Porphyromonas gingivalis, delivers anionic lipopolysaccharide to the PorU sortase for transpeptidase processing of T9SS cargo proteins","volume":"12","author":"Madej","year":"2021","journal-title":"mBio"},{"issue":"6","key":"10.1016\/j.biomaterials.2025.123748_bib177","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/omi.12268","article-title":"Type IX secretion system is pivotal for expression of gingipain-associated virulence of Porphyromonas gingivalis","volume":"34","author":"Benedyk","year":"2019","journal-title":"Molecular oral microbiology"},{"issue":"4","key":"10.1016\/j.biomaterials.2025.123748_bib178","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/omi.12413","article-title":"Gingipains are the important virulence factors of Porphyromonas gingivalis downregulating B10 cells","volume":"38","author":"Zou","year":"2023","journal-title":"Molecular oral microbiology"},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib179","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/s41368-021-00136-2","article-title":"Porphyromonas gingivalis exacerbates ulcerative colitis via Porphyromonas gingivalis peptidylarginine deiminase","volume":"13","author":"Zhao","year":"2021","journal-title":"Int. J. Oral Sci."},{"key":"10.1016\/j.biomaterials.2025.123748_bib180","doi-asserted-by":"crossref","first-page":"4553","DOI":"10.2147\/IJN.S139178","article-title":"Peptide-modified nanoparticles inhibit formation of Porphyromonas gingivalis biofilms with Streptococcus gordonii","volume":"12","author":"Kalia","year":"2017","journal-title":"Int. J. Nanomed."},{"issue":"10","key":"10.1016\/j.biomaterials.2025.123748_bib181","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1016\/j.dental.2018.06.026","article-title":"Antimicrobial photodynamic active biomaterials for periodontal regeneration","volume":"34","author":"Sigusch","year":"2018","journal-title":"Dent. Mater."},{"issue":"8","key":"10.1016\/j.biomaterials.2025.123748_bib182","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2018.e00719","article-title":"Periodontal reconstruction by heparan sulfate mimetic-based matrix therapy in porphyromonas gingivalis-infected mice","volume":"4","author":"Coyac","year":"2018","journal-title":"Heliyon"},{"key":"10.1016\/j.biomaterials.2025.123748_bib183","doi-asserted-by":"crossref","first-page":"6769","DOI":"10.2147\/IJN.S175865","article-title":"Decreased Porphyromonas gingivalis adhesion and improved biocompatibility on tetracycline-loaded TiO(2) nanotubes: an in vitro study","volume":"13","author":"Sun","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.biomaterials.2025.123748_bib184","doi-asserted-by":"crossref","first-page":"926","DOI":"10.3389\/fchem.2019.00926","article-title":"Rapid release polymeric fibers for inhibition of Porphyromonas gingivalis adherence to Streptococcus gordonii","volume":"7","author":"Mahmoud","year":"2019","journal-title":"Front. Chem."},{"key":"10.1016\/j.biomaterials.2025.123748_bib185","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121069","article-title":"Topical treatment of periodontitis using an iongel","volume":"276","author":"Nakajima","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2025.123748_bib186","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2022.138899","article-title":"Porous polydroxyalkanoates (PHA) scaffolds with antibacterial property for oral soft tissue regeneration","volume":"451","author":"Chen","year":"2023","journal-title":"Chem. Eng. J."},{"issue":"Pt 6","key":"10.1016\/j.biomaterials.2025.123748_bib187","article-title":"Photothermal-promoted multi-functional gallic acid grafted chitosan hydrogel containing tannic acid miniaturized particles for peri-implantitis","volume":"253","author":"Shen","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"33","key":"10.1016\/j.biomaterials.2025.123748_bib188","doi-asserted-by":"crossref","first-page":"23308","DOI":"10.1039\/D3RA03414C","article-title":"Prolonged release of an antimicrobial peptide GL13K-loaded thermosensitive hydrogel on a titanium surface improves its antibacterial and anti-inflammatory properties","volume":"13","author":"Zhou","year":"2023","journal-title":"RSC Adv."},{"key":"10.1016\/j.biomaterials.2025.123748_bib189","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdent.2023.104624","article-title":"Calcium phosphate cement with minocycline hydrochloride-loaded gelatine microspheres for peri-implantitis treatment","volume":"136","author":"Liu","year":"2023","journal-title":"J. Dent."},{"issue":"32","key":"10.1016\/j.biomaterials.2025.123748_bib190","doi-asserted-by":"crossref","first-page":"21077","DOI":"10.1021\/acsnano.4c02316","article-title":"Erythrocyte-mimicking nanovesicle targeting Porphyromonas gingivalis for periodontitis","volume":"18","author":"Tang","year":"2024","journal-title":"ACS Nano"},{"issue":"11","key":"10.1016\/j.biomaterials.2025.123748_bib191","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1016\/j.dental.2024.09.012","article-title":"Antimicrobial adhesive self-healing hydrogels for efficient dental biofilm removal from periodontal tissue","volume":"40","author":"Kim","year":"2024","journal-title":"Dent. Mater."},{"issue":"4","key":"10.1016\/j.biomaterials.2025.123748_bib192","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1177\/00220345211051599","article-title":"The type IX secretion system and its role in bacterial function and pathogenesis","volume":"101","author":"Veith","year":"2021","journal-title":"J. Dent. Res."},{"issue":"10","key":"10.1016\/j.biomaterials.2025.123748_bib193","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/s41594-019-0297-8","article-title":"The molecular mechanism of cotranslational membrane protein recognition and targeting by SecA","volume":"26","author":"Wang","year":"2019","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib194","doi-asserted-by":"crossref","first-page":"25","DOI":"10.4161\/bact.1.1.14868","article-title":"The lysis cassette of bacteriophage \u0444KMV encodes a signal-arrest-release endolysin and a pinholin","volume":"1","author":"Briers","year":"2011","journal-title":"Bacteriophage"},{"issue":"3","key":"10.1016\/j.biomaterials.2025.123748_bib195","doi-asserted-by":"crossref","first-page":"447","DOI":"10.3390\/microorganisms8030447","article-title":"Identification and in vitro characterization of a novel phage endolysin that targets gram-negative bacteria","volume":"8","author":"Bai","year":"2020","journal-title":"Microorganisms"},{"issue":"12","key":"10.1016\/j.biomaterials.2025.123748_bib196","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1902\/jop.2004.75.12.1663","article-title":"Distribution of systemic ciprofloxacin and doxycycline to gingiva and gingival crevicular fluid","volume":"75","author":"Lavda","year":"2004","journal-title":"J. Periodontol."},{"issue":"2","key":"10.1016\/j.biomaterials.2025.123748_bib197","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1002\/jbm.b.31152","article-title":"Biomaterial and antibiotic strategies for peri-implantitis: a review","volume":"88","author":"Norowski","year":"2009","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"issue":"8","key":"10.1016\/j.biomaterials.2025.123748_bib198","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1902\/jop.2002.73.8.835","article-title":"Effect of locally delivered minocycline microspheres on markers of bone resorption","volume":"73","author":"Oringer","year":"2002","journal-title":"J. Periodontol."},{"issue":"4","key":"10.1016\/j.biomaterials.2025.123748_bib199","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1902\/jop.2003.74.4.420","article-title":"Probing depth changes following 2 years of periodontal maintenance therapy including adjunctive controlled release of chlorhexidine","volume":"74","author":"Soskolne","year":"2003","journal-title":"J. Periodontol."},{"issue":"10","key":"10.1016\/j.biomaterials.2025.123748_bib200","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1902\/jop.1983.54.10.575","article-title":"Monolithic tetracycline-containing fibers for controlled delivery to periodontal pockets","volume":"54","author":"Goodson","year":"1983","journal-title":"J. Periodontol."},{"issue":"10","key":"10.1016\/j.biomaterials.2025.123748_bib201","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1016\/j.dental.2021.08.002","article-title":"Intelligent pH-responsive dental sealants to prevent long-term microleakage","volume":"37","author":"Li","year":"2021","journal-title":"Dent. Mater."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib202","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1080\/10717544.2022.2037788","article-title":"Effect of pH-sensitive nanoparticles on inhibiting oral biofilms","volume":"29","author":"Peng","year":"2022","journal-title":"Drug Deliv."},{"issue":"4","key":"10.1016\/j.biomaterials.2025.123748_bib203","doi-asserted-by":"crossref","DOI":"10.3390\/ph9040067","article-title":"pH dependent antimicrobial peptides and proteins, their mechanisms of action and potential as therapeutic agents","volume":"9","author":"Malik","year":"2016","journal-title":"Pharmaceuticals"},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib204","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1159\/000508458","article-title":"The pH-Responsive property of antimicrobial peptide GH12 enhances its anticaries effects at acidic pH","volume":"55","author":"Jiang","year":"2021","journal-title":"Caries Res."},{"key":"10.1016\/j.biomaterials.2025.123748_bib205","article-title":"Debridement of contaminated implants using air-polishing coupled with pH-responsive maximin H5-embedded metal-organic frameworks","volume":"11","author":"Zhu","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.biomaterials.2025.123748_bib206","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.jcis.2021.06.050","article-title":"pH-responsive aminolipid nanocarriers for antimicrobial peptide delivery","volume":"603","author":"Gontsarik","year":"2021","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.biomaterials.2025.123748_bib207","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ics.2005.06.071","article-title":"Microbial ecosystem in the oral cavity: metabolic diversity in an ecological niche and its relationship with oral diseases","volume":"1284","author":"Takahashi","year":"2005","journal-title":"Int. Congr. Ser."},{"key":"10.1016\/j.biomaterials.2025.123748_bib208","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.crbiot.2021.05.006","article-title":"Microbial therapeutic enzymes: a promising area of biopharmaceuticals","volume":"3","author":"Vachher","year":"2021","journal-title":"Current Research in Biotechnology"},{"key":"10.1016\/j.biomaterials.2025.123748_bib209","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/329121","article-title":"A broader view: microbial enzymes and their relevance in industries, medicine, and beyond","volume":"2013","author":"Gurung","year":"2013","journal-title":"BioMed Res. Int."},{"issue":"14","key":"10.1016\/j.biomaterials.2025.123748_bib210","doi-asserted-by":"crossref","first-page":"16006","DOI":"10.1021\/acsami.9b22964","article-title":"Injectable MMP-responsive nanotube-modified gelatin hydrogel for dental infection ablation","volume":"12","author":"Ribeiro","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"31","key":"10.1016\/j.biomaterials.2025.123748_bib211","doi-asserted-by":"crossref","first-page":"36880","DOI":"10.1021\/acsami.1c08855","article-title":"Gingipain-responsive thermosensitive hydrogel loaded with SDF-1 facilitates in situ periodontal tissue regeneration","volume":"13","author":"Liu","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.biomaterials.2025.123748_bib212","first-page":"1","article-title":"Smart dental materials for antimicrobial applications","volume":"24","author":"Montoya","year":"2023","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.biomaterials.2025.123748_bib213","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdent.2023.104624","article-title":"Calcium phosphate cement with minocycline hydrochloride-loaded gelatine microspheres for peri-implantitis treatment","volume":"136","author":"Liu","year":"2023","journal-title":"J. Dent."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib214","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/s41467-022-28675-0","article-title":"Inhibition of SRP-dependent protein secretion by the bacterial alarmone (p)ppGpp","volume":"13","author":"Czech","year":"2022","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib215","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41522-020-0115-4","article-title":"Synthesis of ppGpp impacts type IX secretion and biofilm matrix formation in Porphyromonas gingivalis","volume":"6","author":"Kim","year":"2020","journal-title":"npj Biofilms and Microbiomes"},{"issue":"9","key":"10.1016\/j.biomaterials.2025.123748_bib216","doi-asserted-by":"crossref","first-page":"4684","DOI":"10.1093\/nar\/gkz211","article-title":"Growth suppression by altered (p)ppGpp levels results from non-optimal resource allocation in Escherichia coli","volume":"47","author":"Zhu","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.biomaterials.2025.123748_bib217","first-page":"192","article-title":"A review on current research status of the surface modification of Zn-based biodegradable metals","volume":"7","author":"Yuan","year":"2022","journal-title":"Bioact. Mater."},{"issue":"9","key":"10.1016\/j.biomaterials.2025.123748_bib218","doi-asserted-by":"crossref","first-page":"9010","DOI":"10.1021\/acsnano.7b03513","article-title":"Photo-inspired antibacterial activity and wound healing acceleration by hydrogel embedded with Ag\/Ag@AgCl\/ZnO nanostructures","volume":"11","author":"Mao","year":"2017","journal-title":"ACS Nano"},{"key":"10.1016\/j.biomaterials.2025.123748_bib219","doi-asserted-by":"crossref","DOI":"10.1016\/j.anaerobe.2020.102153","article-title":"Biofunctionalized zinc peroxide nanoparticles inhibit peri-implantitis associated anaerobes and Aggregatibacter actinomycetemcomitans pH-dependent","volume":"62","author":"Fr\u00f6ber","year":"2020","journal-title":"Anaerobe"},{"key":"10.1016\/j.biomaterials.2025.123748_bib220","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.actbio.2019.03.027","article-title":"Advanced antibacterial activity of biocompatible tantalum nanofilm via enhanced local innate immunity","volume":"89","author":"Yang","year":"2019","journal-title":"Acta Biomater."},{"issue":"32","key":"10.1016\/j.biomaterials.2025.123748_bib221","doi-asserted-by":"crossref","first-page":"21077","DOI":"10.1021\/acsnano.4c02316","article-title":"Erythrocyte-mimicking nanovesicle targeting Porphyromonas gingivalis for periodontitis","volume":"18","author":"Tang","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.biomaterials.2025.123748_bib222","doi-asserted-by":"crossref","DOI":"10.1016\/j.anaerobe.2020.102153","article-title":"Biofunctionalized zinc peroxide nanoparticles inhibit peri-implantitis associated anaerobes and Aggregatibacter actinomycetemcomitans pH-dependent","volume":"62","author":"Frober","year":"2020","journal-title":"Anaerobe"},{"issue":"3","key":"10.1016\/j.biomaterials.2025.123748_bib223","doi-asserted-by":"crossref","first-page":"145","DOI":"10.11005\/jbm.2022.29.3.145","article-title":"The role of titanium particles and ions in the pathogenesis of peri-implantitis","volume":"29","author":"Asa'ad","year":"2022","journal-title":"J Bone Metab"},{"key":"10.1016\/j.biomaterials.2025.123748_bib224","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.actbio.2021.10.019","article-title":"Titanium surface with nanospikes tunes macrophage polarization to produce inhibitory factors for osteoclastogenesis through nanotopographic cues","volume":"137","author":"Kartikasari","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.biomaterials.2025.123748_bib225","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.bbrc.2021.09.021","article-title":"Micro\/nano topography of selective laser melting titanium inhibits osteoclastogenesis via mediation of macrophage polarization","volume":"581","author":"Zhou","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib226","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s13770-024-00680-y","article-title":"Development of zinc-containing Chitosan\/Gelatin coatings with immunomodulatory effect for soft tissue sealing around dental implants","volume":"22","author":"Han","year":"2025","journal-title":"Tissue Engineering and Regenerative Medicine."},{"issue":"32","key":"10.1016\/j.biomaterials.2025.123748_bib227","doi-asserted-by":"crossref","first-page":"41855","DOI":"10.1021\/acsami.4c06430","article-title":"Infection-sensitive SPION\/PLGA scaffolds promote periodontal regeneration via antibacterial activity and macrophage-phenotype modulation","volume":"16","author":"Guo","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.biomaterials.2025.123748_bib228","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.omtm.2020.06.001","article-title":"Adenovirus-mediated LAMA3 transduction enhances hemidesmosome formation and periodontal reattachment during wound healing, molecular therapy","volume":"18","author":"Li","year":"2020","journal-title":"Methods & clinical development"},{"issue":"11","key":"10.1016\/j.biomaterials.2025.123748_bib229","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1177\/00220345231176520","article-title":"CREB3L2 regulates hemidesmosome formation during epithelial sealing","volume":"102","author":"Li","year":"2023","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.biomaterials.2025.123748_bib230","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.actbio.2022.11.029","article-title":"Porous composite hydrogels with improved MSC survival for robust epithelial sealing around implants and M2 macrophage polarization","volume":"157","author":"Li","year":"2023","journal-title":"Acta Biomater."},{"issue":"3","key":"10.1016\/j.biomaterials.2025.123748_bib231","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1039\/D1BM01649K","article-title":"Dual keratinocyte-attachment and anti-inflammatory coatings for soft tissue sealing around transmucosal oral implants","volume":"10","author":"Boda","year":"2022","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.biomaterials.2025.123748_bib232","first-page":"1","article-title":"Bio-clickable mussel-inspired peptides improve titanium-based material osseointegration synergistically with immunopolarization-regulation","volume":"9","author":"Sun","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.biomaterials.2025.123748_bib233","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.jcis.2021.07.079","article-title":"Bioinspired peptide adhesion on Ti implants alleviates wear particle-induced inflammation and improves interfacial osteogenesis","volume":"605","author":"Guo","year":"2022","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.biomaterials.2025.123748_bib234","doi-asserted-by":"crossref","first-page":"rbab076","DOI":"10.1093\/rb\/rbab076","article-title":"Hydroxyapatite composited PEEK with 3D porous surface enhances osteoblast differentiation through mediating NO by macrophage","volume":"9","author":"Liu","year":"2022","journal-title":"Regen. Biomater."},{"issue":"10","key":"10.1016\/j.biomaterials.2025.123748_bib235","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.3390\/molecules27103205","article-title":"Study of the osteoimmunomodulatory properties of curcumin-modified copper-bearing titanium","volume":"27","author":"Chen","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.biomaterials.2025.123748_bib236","doi-asserted-by":"crossref","first-page":"456","DOI":"10.3390\/jfb14090456","article-title":"Manganese-implanted titanium modulates the crosstalk between bone marrow mesenchymal stem cells and macrophages to improve osteogenesis","volume":"9","author":"Ye","year":"2023","journal-title":"J. Funct. Biomater. 14"},{"key":"10.1016\/j.biomaterials.2025.123748_bib237","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.127366","article-title":"Photothermal-promoted multi-functional gallic acid grafted chitosan hydrogel containing tannic acid miniaturized particles for peri-implantitis","volume":"253","author":"Shen","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib238","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.dental.2023.10.023","article-title":"Effect of functionalized titanium particles with dexamethasone-loaded nanospheres on macrophage polarization and activity","volume":"40","author":"Chato-Astrain","year":"2024","journal-title":"Dent. Mater."},{"issue":"24","key":"10.1016\/j.biomaterials.2025.123748_bib239","doi-asserted-by":"crossref","DOI":"10.3390\/ma14247588","article-title":"Periodontal bifunctional biomaterials: progress and perspectives","volume":"14","author":"Huang","year":"2021","journal-title":"Materials"},{"issue":"6","key":"10.1016\/j.biomaterials.2025.123748_bib240","article-title":"Immunomodulatory biomaterials against bacterial infections: progress, challenges, and future perspectives","volume":"4","author":"Zhang","year":"2023","journal-title":"Innovation"},{"key":"10.1016\/j.biomaterials.2025.123748_bib241","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122772","article-title":"Programmed surface platform orchestrates anti-bacterial ability and time-sequential bone healing for implant-associated infection","volume":"313","author":"Yu","year":"2025","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2025.123748_bib242","first-page":"520","article-title":"Puerarin@Chitosan composite for infected bone repair through mimicking the bio-functions of antimicrobial peptides","volume":"21","author":"Ouyang","year":"2023","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.biomaterials.2025.123748_bib243","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120614","article-title":"A versatile nanocomposite based on nanoceria for antibacterial enhancement and protection from aPDT-aggravated inflammation via modulation of macrophage polarization","volume":"268","author":"Sun","year":"2021","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib244","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1007\/s12598-024-02935-y","article-title":"Ce-doped defective titanium oxide coating with antibacterial, antioxidant and anti-inflammatory properties for potential application of peri-implantitis treatment","volume":"44","author":"Chen","year":"2025","journal-title":"Rare Met."},{"key":"10.1016\/j.biomaterials.2025.123748_bib245","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.actbio.2019.06.023","article-title":"Surface treatments on titanium implants via nanostructured ceria for antibacterial and anti-inflammatory capabilities","volume":"94","author":"Li","year":"2019","journal-title":"Acta Biomater."},{"key":"10.1016\/j.biomaterials.2025.123748_bib246","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.132612","article-title":"Potential of quaternized chitins in peri-implantitis treatment: in vitro evaluation of antibacterial, anti-inflammatory, and antioxidant properties","volume":"272","author":"Lin","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.biomaterials.2025.123748_bib247","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3389\/fmicb.2019.00150","article-title":"Deciphering the antibacterial mode of action of alpha-mangostin on Staphylococcus epidermidis RP62A through an integrated transcriptomic and proteomic approach","volume":"10","author":"Sivaranjani","year":"2019","journal-title":"Front. Microbiol."},{"issue":"3","key":"10.1016\/j.biomaterials.2025.123748_bib248","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/s10266-014-0160-7","article-title":"Alpha-mangostin suppresses IL-6 and IL-8 expression in P. gingivalis LPS-stimulated human gingival fibroblasts","volume":"103","author":"Yiemwattana","year":"2015","journal-title":"Odontology"},{"issue":"8","key":"10.1016\/j.biomaterials.2025.123748_bib249","doi-asserted-by":"crossref","first-page":"5027","DOI":"10.1021\/acsbiomaterials.4c00997","article-title":"Enhanced stability of \u03b1-Mangostin-Rich extract and selective cytotoxicity against cancer cells via encapsulation in antioxidant nanoparticles (AME@NanoAOX)","volume":"10","author":"Suttithumsatid","year":"2024","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.biomaterials.2025.123748_bib250","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120534","article-title":"Covalent grafting of hyperbranched poly-L-lysine on Ti-based implants achieves dual functions of antibacteria and promoted osteointegration in vivo","volume":"269","author":"Yang","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2025.123748_bib251","doi-asserted-by":"crossref","DOI":"10.1016\/j.compositesb.2024.111258","article-title":"Surface-activated 3D-printed PEEK implant enhances anti-infection and osteogenesis","volume":"273","author":"Wang","year":"2024","journal-title":"Compos. B Eng."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib252","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/clr.14354","article-title":"Hyperbranched Poly-l-Lysine modified titanium surface with enhanced osseointegration, bacteriostasis, and anti-inflammatory properties for implant application: an experimental in vivo study","volume":"36","author":"Jiang","year":"2025","journal-title":"Clin. Oral Implants Res."},{"issue":"2","key":"10.1016\/j.biomaterials.2025.123748_bib253","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.matt.2021.11.017","article-title":"Immunomodulatory microneedle patch for periodontal tissue regeneration","volume":"5","author":"Zhang","year":"2022","journal-title":"Matter"},{"issue":"Suppl","key":"10.1016\/j.biomaterials.2025.123748_bib254","doi-asserted-by":"crossref","first-page":"325","DOI":"10.11607\/jomi.2014suppl.g5.3","article-title":"The therapy of peri-implantitis: a systematic review","volume":"29","author":"Heitz-Mayfield","year":"2014","journal-title":"Int. J. Oral Maxillofac. Implants"},{"key":"10.1016\/j.biomaterials.2025.123748_bib255","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/978-3-319-11038-7_4","article-title":"Peri-implant infections of oral biofilm etiology","volume":"830","author":"Belibasakis","year":"2015","journal-title":"Adv. Exp. Med. Biol."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123748_bib256","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s12903-017-0428-8","article-title":"Location of unaccessible implant surface areas during debridement in simulated peri-implantitis therapy","volume":"17","author":"Steiger-Ronay","year":"2017","journal-title":"BMC Oral Health"},{"issue":"5","key":"10.1016\/j.biomaterials.2025.123748_bib257","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms8050661","article-title":"The microbiome of peri-implantitis: a systematic review and meta-analysis","volume":"8","author":"Sahrmann","year":"2020","journal-title":"Microorganisms"},{"issue":"3","key":"10.1016\/j.biomaterials.2025.123748_bib258","first-page":"Cd008676","article-title":"Chlorhexidine mouthrinse as an adjunctive treatment for gingival health","volume":"3","author":"James","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"issue":"4","key":"10.1016\/j.biomaterials.2025.123748_bib259","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/j.1600-0501.2007.01476.x","article-title":"Clinical and microbiological analysis of subjects treated with Br\u00e5nemark or AstraTech implants: a 7-year follow-up study","volume":"19","author":"Renvert","year":"2008","journal-title":"Clin. Oral Implants Res."},{"issue":"2","key":"10.1016\/j.biomaterials.2025.123748_bib260","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/jre.12707","article-title":"Biomaterial-based possibilities for managing peri-implantitis","volume":"55","author":"de Avila","year":"2020","journal-title":"J. Periodontal. Res."}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961225006672?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961225006672?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T08:52:04Z","timestamp":1780476724000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961225006672"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":260,"alternative-id":["S0142961225006672"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2025.123748","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Advanced biomaterials regulating mitochondria for treatment of peri-implantitis","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2025.123748","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"123748"}}