{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T18:48:04Z","timestamp":1789238884243,"version":"build-2803163510"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100017542","name":"Beijing Hospital","doi-asserted-by":"publisher","award":["BJ-2022-118"],"award-info":[{"award-number":["BJ-2022-118"]}],"id":[{"id":"10.13039\/501100017542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017542","name":"Beijing Hospital","doi-asserted-by":"publisher","award":["BJ-2025-122"],"award-info":[{"award-number":["BJ-2025-122"]}],"id":[{"id":"10.13039\/501100017542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005149","name":"Cancer Hospital Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2021-I2M-1-050"],"award-info":[{"award-number":["2021-I2M-1-050"]}],"id":[{"id":"10.13039\/501100005149","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005149","name":"Cancer Hospital Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2023-I2M-QJ-016"],"award-info":[{"award-number":["2023-I2M-QJ-016"]}],"id":[{"id":"10.13039\/501100005149","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005149","name":"Cancer Hospital Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2021-I2M-1-066"],"award-info":[{"award-number":["2021-I2M-1-066"]}],"id":[{"id":"10.13039\/501100005149","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019018","name":"Chinese Academy of Medical Sciences Initiative for Innovative Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52273281"],"award-info":[{"award-number":["52273281"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22378429"],"award-info":[{"award-number":["22378429"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51937011"],"award-info":[{"award-number":["51937011"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82203534"],"award-info":[{"award-number":["82203534"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.biomaterials.2025.123772","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T23:23:53Z","timestamp":1759965833000},"page":"123772","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Targeted depletion of intratumoral bacteria using PEGylated metronidazole to augment cancer treatment efficacy"],"prefix":"10.1016","volume":"327","author":[{"given":"Xijun","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiran","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caixia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiani","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxiao","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2938-818X","authenticated-orcid":false,"given":"Jie","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.biomaterials.2025.123772_bib1","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1016\/j.clinthera.2016.03.026","article-title":"Current challenges in cancer treatment","volume":"38","author":"Zugazagoitia","year":"2016","journal-title":"Clin. Ther."},{"key":"10.1016\/j.biomaterials.2025.123772_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.176013","article-title":"Cancer chemotherapy resistance: mechanisms and recent breakthrough in targeted drug delivery","volume":"958","author":"Davodabadi","year":"2023","journal-title":"Eur. J. Pharmacol."},{"issue":"11","key":"10.1016\/j.biomaterials.2025.123772_bib3","doi-asserted-by":"crossref","first-page":"9663","DOI":"10.1007\/s11033-023-08809-3","article-title":"Cancer treatment therapies: traditional to modern approaches to combat cancers","volume":"50","author":"Kaur","year":"2023","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.biomaterials.2025.123772_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2021.100796","article-title":"Anticancer drug resistance: an update and perspective","volume":"59","author":"Nussinov","year":"2021","journal-title":"Drug Resist. Updates"},{"issue":"9","key":"10.1016\/j.biomaterials.2025.123772_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21093233","article-title":"Mechanisms of multidrug resistance in cancer chemotherapy","volume":"21","author":"Bukowski","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"7782","key":"10.1016\/j.biomaterials.2025.123772_bib6","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/s41586-019-1730-1","article-title":"A view on drug resistance in cancer","volume":"575","author":"Vasan","year":"2019","journal-title":"Nature"},{"issue":"6494","key":"10.1016\/j.biomaterials.2025.123772_bib7","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1126\/science.aay9189","article-title":"The human tumor microbiome is composed of tumor type-specific intracellular bacteria","volume":"368","author":"Nejman","year":"2020","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123772_bib8","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","article-title":"Hallmarks of cancer: new dimensions","volume":"12","author":"Hanahan","year":"2022","journal-title":"Cancer Discov."},{"issue":"2","key":"10.1016\/j.biomaterials.2025.123772_bib9","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.tim.2022.08.010","article-title":"Fusobacterium nucleatum, a key pathogenic factor and microbial biomarker for colorectal cancer","volume":"31","author":"Wang","year":"2023","journal-title":"Trends Microbiol."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123772_bib10","doi-asserted-by":"crossref","first-page":"3259","DOI":"10.1038\/s41467-020-16967-2","article-title":"Breast cancer colonization by Fusobacterium nucleatum accelerates tumor growth and metastatic progression","volume":"11","author":"Parhi","year":"2020","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123772_bib11","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/prd.12426","article-title":"Fusobacterium nucleatum and cancer","volume":"89","author":"Alon-Maimon","year":"2022","journal-title":"Periodontol"},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123772_bib12","doi-asserted-by":"crossref","DOI":"10.1080\/20002297.2022.2145729","article-title":"Fusobacterium nucleatum and its associated systemic diseases: epidemiologic studies and possible mechanisms","volume":"15","author":"Fan","year":"2023","journal-title":"J. Oral Microbiol."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123772_bib13","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s41392-022-01304-4","article-title":"Intratumoral microbiota: roles in cancer initiation, development and therapeutic efficacy","volume":"8","author":"Yang","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"11","key":"10.1016\/j.biomaterials.2025.123772_bib14","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1016\/j.ccell.2023.09.012","article-title":"Tumor-resident Lactobacillus iners confer chemoradiation resistance through lactate-induced metabolic rewiring","volume":"41","author":"Colbert","year":"2023","journal-title":"Cancer Cell"},{"issue":"4","key":"10.1016\/j.biomaterials.2025.123772_bib15","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.cell.2024.01.004","article-title":"Streptococcus anginosus promotes gastric inflammation, atrophy, and tumorigenesis in mice","volume":"187","author":"Fu","year":"2024","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.biomaterials.2025.123772_bib16","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.arcmed.2017.11.004","article-title":"Gut microbiome and antibiotics","volume":"48","author":"Iizumi","year":"2017","journal-title":"Arch. Med. Res."},{"issue":"12","key":"10.1016\/j.biomaterials.2025.123772_bib17","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/s41579-023-00933-y","article-title":"Antibiotic perturbations to the gut microbiome","volume":"21","author":"Fishbein","year":"2023","journal-title":"Nat. Rev. Microbiol."},{"issue":"2","key":"10.1016\/j.biomaterials.2025.123772_bib18","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1021\/acs.biomac.0c01695","article-title":"Design of a PEGylated antimicrobial prodrug with species-specific activation","volume":"22","author":"O'Leary","year":"2021","journal-title":"Biomacromolecules"},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123772_bib19","doi-asserted-by":"crossref","DOI":"10.1002\/btm2.10600","article-title":"PEGylated therapeutics in the clinic","volume":"9","author":"Gao","year":"2024","journal-title":"Bioeng. Transl. Med"},{"key":"10.1016\/j.biomaterials.2025.123772_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2025.125758","article-title":"Unraveling the pharmaceutical excipient-drug interactions: the effects of polyethylene glycol copolymers on drug metabolism and transport systems","volume":"680","author":"Shang","year":"2025","journal-title":"Int. J. Pharm."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123772_bib21","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1021\/acsnano.4c05906","article-title":"pH-Responsive polyethylene glycol engagers for enhanced brain delivery of PEGylated nanomedicine to treat glioblastoma","volume":"19","author":"Meng","year":"2025","journal-title":"ACS Nano"},{"issue":"3","key":"10.1016\/j.biomaterials.2025.123772_bib22","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.cell.2017.07.008","article-title":"Fusobacterium nucleatum promotes chemoresistance to colorectal cancer by modulating autophagy","volume":"170","author":"Yu","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.biomaterials.2025.123772_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2023.1101291","article-title":"Fusobacterium nucleatum induces a tumor microenvironment with diminished adaptive immunity against colorectal cancers","volume":"13","author":"Kim","year":"2023","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"2","key":"10.1016\/j.biomaterials.2025.123772_bib24","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.chom.2013.07.007","article-title":"Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment","volume":"14","author":"Kostic","year":"2013","journal-title":"Cell Host Microbe"},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123772_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22010173","article-title":"PI3K\/AKT\/mTOR signaling pathway in breast cancer: from molecular landscape to clinical aspects","volume":"22","author":"Miricescu","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biomaterials.2025.123772_bib26","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/1681972","article-title":"Fusobacterium nucleatum facilitates apoptosis, ROS generation, and inflammatory cytokine production by activating AKT\/MAPK and NF-\u03baB signaling pathways in human gingival fibroblasts","volume":"2019","author":"Kang","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.biomaterials.2025.123772_bib27","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jare.2023.04.007","article-title":"The exoprotein Gbp of Fusobacterium nucleatum promotes THP-1 cell lipid deposition by binding to CypA and activating PI3K-AKT\/MAPK\/NF-\u03baB pathways","volume":"57","author":"Shen","year":"2024","journal-title":"J. Adv. Res."},{"issue":"2","key":"10.1016\/j.biomaterials.2025.123772_bib28","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.chom.2013.07.012","article-title":"Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin\/\u03b2-catenin signaling via its FadA adhesin","volume":"14","author":"Rubinstein","year":"2013","journal-title":"Cell Host Microbe"},{"issue":"4","key":"10.1016\/j.biomaterials.2025.123772_bib29","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201847638","article-title":"Fusobacterium nucleatum promotes colorectal cancer by inducing Wnt\/\u03b2-catenin modulator Annexin A1","volume":"20","author":"Rubinstein","year":"2019","journal-title":"EMBO Rep."},{"issue":"8","key":"10.1016\/j.biomaterials.2025.123772_bib30","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/j.cell.2022.02.027","article-title":"Tumor-resident intracellular microbiota promotes metastatic colonization in breast cancer","volume":"185","author":"Fu","year":"2022","journal-title":"Cell"},{"issue":"Pt A","key":"10.1016\/j.biomaterials.2025.123772_bib31","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.addr.2015.09.012","article-title":"PEGylation as a strategy for improving nanoparticle-based drug and gene delivery","volume":"99","author":"Suk","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.biomaterials.2025.123772_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.114079","article-title":"To PEGylate or not to PEGylate: immunological properties of nanomedicine's most popular component, polyethylene glycol and its alternatives","volume":"180","author":"Shi","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123772_bib33","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-003779","article-title":"Association of antibiotic treatment with immune-related adverse events in patients with cancer receiving immunotherapy","volume":"10","author":"Jing","year":"2022","journal-title":"J. Immunother. Cancer"},{"issue":"24","key":"10.1016\/j.biomaterials.2025.123772_bib34","doi-asserted-by":"crossref","first-page":"4654","DOI":"10.1158\/0008-5472.CAN-22-0455","article-title":"Disruption of the gut microbiota confers Cisplatin resistance in epithelial ovarian cancer","volume":"82","author":"Chambers","year":"2022","journal-title":"Cancer Res."},{"issue":"49","key":"10.1016\/j.biomaterials.2025.123772_bib35","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202206765","article-title":"Dual-cascade responsive nanoparticles enhance pancreatic cancer therapy by eliminating tumor-resident intracellular bacteria","volume":"34","author":"Kang","year":"2022","journal-title":"Adv. Mater."},{"issue":"45","key":"10.1016\/j.biomaterials.2025.123772_bib36","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202306281","article-title":"Antibacterial Fusobacterium nucleatum-Mimicking nanomedicine to selectively eliminate tumor-colonized bacteria and enhance immunotherapy against colorectal cancer","volume":"35","author":"Chen","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.biomaterials.2025.123772_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2023.101994","article-title":"Clearing intratumoral bacteria to augment tumor-therapeutic response by engineering antimicrobial dendritic mesoporous silica nanomedicine","author":"Chen","year":"2023","journal-title":"Nano Today"},{"issue":"8","key":"10.1016\/j.biomaterials.2025.123772_bib38","doi-asserted-by":"crossref","first-page":"7335","DOI":"10.1021\/acsnano.2c11305","article-title":"Synergistic target of intratumoral microbiome and tumor by metronidazole-fluorouridine nanoparticles","volume":"17","author":"Gao","year":"2023","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123772_bib39","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2022.2073785","article-title":"Periodontitis pathogen Porphyromonas gingivalis promotes pancreatic tumorigenesis via neutrophil elastase from tumor-associated neutrophils","volume":"14","author":"Tan","year":"2022","journal-title":"Gut Microbes"},{"key":"10.1016\/j.biomaterials.2025.123772_bib40","doi-asserted-by":"crossref","DOI":"10.1093\/procel\/pwae005","article-title":"Microbiota enterotoxigenic Bacteroides fragilis-secreted BFT-1 promotes breast cancer cell stemness and chemoresistance through its functional receptor NOD1","author":"Ma","year":"2024","journal-title":"Protein Cell"},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123772_bib41","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13046-018-0985-y","article-title":"Fusobacterium nucleatum promotes chemoresistance to 5-fluorouracil by upregulation of BIRC3 expression in colorectal cancer","volume":"38","author":"Zhang","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.biomaterials.2025.123772_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2024.03.021","article-title":"A pan-cancer analysis of the microbiome in metastatic cancer","author":"Battaglia","year":"2024","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.biomaterials.2025.123772_bib43","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.immuni.2015.01.010","article-title":"Binding of the Fap2 protein of Fusobacterium nucleatum to human inhibitory receptor TIGIT protects tumors from immune cell attack","volume":"42","author":"Gur","year":"2015","journal-title":"Immunity"},{"issue":"6","key":"10.1016\/j.biomaterials.2025.123772_bib44","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2019.1581531","article-title":"Fusobacterium nucleatum supresses anti-tumor immunity by activating CEACAM1","volume":"8","author":"Gur","year":"2019","journal-title":"OncoImmunology"},{"key":"10.1016\/j.biomaterials.2025.123772_bib45","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.pharmthera.2017.02.037","article-title":"PI3K-AKT-mTOR inhibitors in breast cancers: from tumor cell signaling to clinical trials","volume":"175","author":"Dey","year":"2017","journal-title":"Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.biomaterials.2025.123772_bib46","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12943-021-01476-7","article-title":"circCDYL2 promotes trastuzumab resistance via sustaining HER2 downstream signaling in breast cancer","volume":"21","author":"Ling","year":"2022","journal-title":"Mol. Cancer"},{"issue":"24","key":"10.1016\/j.biomaterials.2025.123772_bib47","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.4263","article-title":"Extraction and electrophoretic analysis of bacterial lipopolysaccharides and outer membrane proteins","volume":"11","author":"Lee","year":"2021","journal-title":"Bio. Protoc."},{"key":"10.1016\/j.biomaterials.2025.123772_bib48","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jconrel.2016.03.037","article-title":"A small molecule nanodrug consisting of amphiphilic targeting ligand-chemotherapy drug conjugate for targeted cancer therapy","volume":"230","author":"Mou","year":"2016","journal-title":"J. Contr. Release"},{"issue":"2","key":"10.1016\/j.biomaterials.2025.123772_bib49","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.lungcan.2013.07.016","article-title":"Evaluation of EGFR protein expression by immunohistochemistry using H-score and the magnification rule: re-analysis of the SATURN study","volume":"82","author":"Mazi\u00e8res","year":"2013","journal-title":"Lung Cancer"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014296122500691X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014296122500691X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T09:05:55Z","timestamp":1780477555000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S014296122500691X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":49,"alternative-id":["S014296122500691X"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2025.123772","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeted depletion of intratumoral bacteria using PEGylated metronidazole to augment cancer treatment efficacy","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2025.123772","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"123772"}}