{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:08:57Z","timestamp":1791378537345,"version":"4.3.2"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F31AI176844"],"award-info":[{"award-number":["F31AI176844"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI169686"],"award-info":[{"award-number":["R01AI169686"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1S10OD025223-01A1"],"award-info":[{"award-number":["1S10OD025223-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.biomaterials.2025.123786","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:42:35Z","timestamp":1760661755000},"page":"123786","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Co-localization of lymph node therapeutics enhances T cell activation and anti-tumor response"],"prefix":"10.1016","volume":"328","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9967-4758","authenticated-orcid":false,"given":"Ruochen","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2246-7053","authenticated-orcid":false,"given":"Senta M.","family":"Kapnick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4490-5859","authenticated-orcid":false,"given":"Camilla","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6115-1350","authenticated-orcid":false,"given":"Ryan A.","family":"McIlvaine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6771-5266","authenticated-orcid":false,"given":"Christopher J.","family":"Bridgeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1851-0300","authenticated-orcid":false,"given":"Sean T.","family":"Carey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6668-6928","authenticated-orcid":false,"given":"Christopher M.","family":"Jewell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biomaterials.2025.123786_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41408-021-00459-7","article-title":"CAR-T cell therapy: current limitations and potential strategies","volume":"11","author":"Sterner","year":"2021","journal-title":"Blood Cancer J."},{"key":"10.1016\/j.biomaterials.2025.123786_bib2","first-page":"1979","article-title":"Innovative strategies to advance CAR T cell therapy for solid tumors","volume":"10","author":"Huang","year":"2020","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.biomaterials.2025.123786_bib3","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/s41573-021-00189-2","article-title":"Navigating CAR-T cells through the solid-tumour microenvironment","volume":"20","author":"Hou","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.biomaterials.2025.123786_bib6","author":"BioNTech"},{"key":"10.1016\/j.biomaterials.2025.123786_bib9","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1600-065X.1997.tb00969.x","article-title":"Antigen localisation regulates immune responses in a dose- and time-dependent fashion: a geographical view of immune reactivity","volume":"156","author":"Zinkernagel","year":"1997","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.biomaterials.2025.123786_bib10","doi-asserted-by":"crossref","first-page":"17908","DOI":"10.1073\/pnas.0803725105","article-title":"Intralymphatic allergen administration renders specific immunotherapy faster and safer: a randomized controlled trial","volume":"105","author":"Senti","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.biomaterials.2025.123786_bib11","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/mt.2009.275","article-title":"Intranodal immunization with a vaccinia virus encoding multiple antigenic epitopes and costimulatory molecules in metastatic melanoma","volume":"18","author":"Adamina","year":"2010","journal-title":"Mol. Ther."},{"key":"10.1016\/j.biomaterials.2025.123786_bib12","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1016\/j.vaccine.2009.02.038","article-title":"Enhancing DNA vaccination by sequential injection of lymph nodes with plasmid vectors and peptides","volume":"27","author":"Smith","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.biomaterials.2025.123786_bib13","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1002\/hed.27739","article-title":"International guidelines for intratumoral and intranodal injection of NBTXR3 nanoparticles in head and neck cancers","volume":"46","author":"Liem","year":"2024","journal-title":"Head Neck"},{"key":"10.1016\/j.biomaterials.2025.123786_bib14","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1038\/s41467-024-45358-0","article-title":"Adjuvant dendritic cell therapy in stage IIIB\/C melanoma: the MIND-DC randomized phase III trial","volume":"15","author":"Bol","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biomaterials.2025.123786_bib15","article-title":"Intra-cervical lymphatic immunotherapy for dust mite-induced allergic rhinoconjunctivitis in children: a 3-year prospective randomized controlled trial","volume":"14","author":"Wang","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.biomaterials.2025.123786_bib16","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2022-006292","article-title":"Preclinical proof of concept for VivoVec, a lentiviral-based platform for in vivo CAR T-cell engineering","volume":"11","author":"Michels","year":"2023","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.biomaterials.2025.123786_bib17","doi-asserted-by":"crossref","first-page":"6451","DOI":"10.12998\/wjcc.v12.i31.6451","article-title":"Recent developments in immunotherapy approaches for allergic rhinitis","volume":"12","author":"Fu","year":"2024","journal-title":"World J. Clin. Cases"},{"key":"10.1016\/j.biomaterials.2025.123786_bib20","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/s41467-023-36225-5","article-title":"Engineering the lymph node environment promotes antigen-specific efficacy in type 1 diabetes and islet transplantation","volume":"14","author":"Gammon","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biomaterials.2025.123786_bib21","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jconrel.2017.02.034","article-title":"Low-dose controlled release of mTOR inhibitors maintains T cell plasticity and promotes central memory T cells","volume":"263","author":"Gammon","year":"2017","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.biomaterials.2025.123786_bib22","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.1016\/j.celrep.2016.08.033","article-title":"Reprogramming the local lymph node microenvironment promotes tolerance that is systemic and antigen specific","volume":"16","author":"Tostanoski","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.biomaterials.2025.123786_bib23","doi-asserted-by":"crossref","first-page":"4612","DOI":"10.1039\/D2BM00403H","article-title":"Spatial delivery of immune cues to lymph nodes to define therapeutic outcomes in cancer vaccination","volume":"10","author":"Andorko","year":"2022","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.biomaterials.2025.123786_bib24","article-title":"Local control of T cell fate in lymph nodes safely & durably reverses myelin-driven autoimmunity","author":"Kapnick","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.biomaterials.2025.123786_bib25","article-title":"Intra-lymph node injection of biodegradable polymer particles","volume":"50984","author":"Andorko","year":"2014","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.biomaterials.2025.123786_bib26","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1182\/blood-2006-05-022798","article-title":"Annexin-1 modulates T-cell activation and differentiation","volume":"109","author":"D'Acquisto","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.biomaterials.2025.123786_bib27","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/ni969","article-title":"Similarities and differences in CD4+ and CD8+ effector and memory T cell generation","volume":"4","author":"Seder","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.biomaterials.2025.123786_bib28","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1146\/annurev-immunol-032712-095910","article-title":"Pathways of antigen processing","volume":"31","author":"Blum","year":"2013","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.biomaterials.2025.123786_bib29","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1631\/jzus.B2000808","article-title":"Toll-like receptor 3 (TLR3) regulation mechanisms and roles in antiviral innate immune responses","volume":"22","author":"Chen","year":"2021","journal-title":"J. Zhejiang Univ. - Sci. B"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961225007057?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961225007057?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T04:36:54Z","timestamp":1781325414000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961225007057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":23,"alternative-id":["S0142961225007057"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2025.123786","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Co-localization of lymph node therapeutics enhances T cell activation and anti-tumor response","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2025.123786","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"123786"}}