{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T22:09:45Z","timestamp":1784585385289,"version":"3.55.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012154","name":"Graduate Research and Innovation Projects of Jiangsu Province","doi-asserted-by":"publisher","award":["KYCX24-0692"],"award-info":[{"award-number":["KYCX24-0692"]}],"id":[{"id":"10.13039\/501100012154","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81801839"],"award-info":[{"award-number":["81801839"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51873087"],"award-info":[{"award-number":["51873087"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.biomaterials.2026.124019","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T07:42:39Z","timestamp":1769758959000},"page":"124019","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["PRP-driven biomimetic liver tissue engineering: A cost-effective platform for high-efficiency expansion of mouse primary hepatocytes"],"prefix":"10.1016","volume":"330","author":[{"given":"Weixiao","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalei","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinmeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangliang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuyue","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuntao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxia","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9312-8278","authenticated-orcid":false,"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5555-1588","authenticated-orcid":false,"given":"Dongping","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.biomaterials.2026.124019_bib1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41422-018-0103-x","article-title":"Expansion and differentiation of human hepatocyte-derived liver progenitor-like cells and their use for the study of hepatotropic pathogens","volume":"29","author":"Fu","year":"2019","journal-title":"Cell Res."},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124019_bib2","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41575-020-0342-4","article-title":"Liver regeneration: biological and pathological mechanisms and implications","volume":"18","author":"Michalopoulos","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124019_bib3","doi-asserted-by":"crossref","DOI":"10.1038\/srep25187","article-title":"Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease","volume":"6","author":"Bell","year":"2016","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.biomaterials.2026.124019_bib4","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1038\/s12276-021-00579-x","article-title":"Hepatocyte organoids and cell transplantation: what the future holds","volume":"53","author":"Peng","year":"2021","journal-title":"Exp. Mol. Med."},{"issue":"6","key":"10.1016\/j.biomaterials.2026.124019_bib5","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/j.cell.2018.11.012","article-title":"Inflammatory cytokine TNF\u03b1 promotes the long-term expansion of primary hepatocytes in 3D culture","volume":"175","author":"Peng","year":"2018","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.biomaterials.2026.124019_bib6","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/j.cell.2018.11.013","article-title":"Long-Term expansion of functional mouse and human hepatocytes as 3D organoids","volume":"175","author":"Hu","year":"2018","journal-title":"Cell"},{"issue":"6438","key":"10.1016\/j.biomaterials.2026.124019_bib7","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1126\/science.aau7307","article-title":"Long-term functional maintenance of primary human hepatocytes in vitro","volume":"364","author":"Xiang","year":"2019","journal-title":"Science"},{"issue":"13","key":"10.1016\/j.biomaterials.2026.124019_bib8","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202003738","article-title":"A stretchable scaffold with electrochemical sensing for 3D culture, mechanical loading, and real-time monitoring of cells","volume":"8","author":"Qin","year":"2021","journal-title":"Adv. Sci."},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124019_bib9","doi-asserted-by":"crossref","DOI":"10.4103\/abr.abr_411_21","article-title":"Hormone therapy with or without platelet-rich plasma (PRP) for treatment asherman syndrome; A randomized clinical trial","volume":"12","author":"Naghshineh","year":"2023","journal-title":"Adv. Biomed. Res."},{"key":"10.1016\/j.biomaterials.2026.124019_bib10","doi-asserted-by":"crossref","unstructured":"D. Qiu, X. Xiao, W. Wang, W. Zhang, X. Wang, Platelet-rich plasma improves pregnancy outcomes in moderate to severe intrauterine adhesion: a retrospective cohort study, J. Clin. Med.12 (4) (2023)1319.","DOI":"10.3390\/jcm12041319"},{"key":"10.1016\/j.biomaterials.2026.124019_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2022.113096","article-title":"Sodium alginate hydrogel containing platelet-rich plasma for wound healing","volume":"222","author":"Wang","year":"2023","journal-title":"Colloids Surf. B Biointerfaces"},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124019_bib12","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jhep.2018.09.007","article-title":"Small molecule-mediated reprogramming of human hepatocytes into bipotent progenitor cells","volume":"70","author":"Kim","year":"2019","journal-title":"J. Hepatol."},{"issue":"6","key":"10.1016\/j.biomaterials.2026.124019_bib13","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.jhep.2011.03.027","article-title":"SOCS1 controls liver regeneration by regulating HGF signaling in hepatocytes","volume":"55","author":"Gui","year":"2011","journal-title":"J. Hepatol."},{"issue":"Supplement_1","key":"10.1016\/j.biomaterials.2026.124019_bib14","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1182\/blood-2019-122144","article-title":"Hyperphosphatemia contributes to inflammation and iron dysregulation in models of normal and impaired renal function","volume":"134","author":"Czaya","year":"2019","journal-title":"Blood"},{"issue":"Supplement_1","key":"10.1016\/j.biomaterials.2026.124019_bib15","doi-asserted-by":"crossref","first-page":"370","DOI":"10.2337\/db20-370-OR","article-title":"370-OR: hepatic FGF21 expression is under the regulation of the canonical wnt signaling pathway","volume":"69","author":"Badakhshi","year":"2020","journal-title":"Diabetes"},{"issue":"5","key":"10.1016\/j.biomaterials.2026.124019_bib16","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.kint.2018.11.031","article-title":"Identification of platelet-derived growth factor C as a mediator of both renal fibrosis and hypertension","volume":"95","author":"van Roeyen","year":"2019","journal-title":"Kidney Int."},{"key":"10.1016\/j.biomaterials.2026.124019_bib17","unstructured":"H. Nakamura T Fau - Teramoto, A. Teramoto H Fau - Ichihara, A. Ichihara, Purification and Characterization of a Growth Factor from Rat Platelets for Mature Parenchymal Hepatocytes in Primary Cultures, (27-8424 (Print))."},{"issue":"6","key":"10.1016\/j.biomaterials.2026.124019_bib18","doi-asserted-by":"crossref","DOI":"10.1002\/hep.29340","article-title":"Pericentral hepatocytes produce insulin\u2010like growth factor\u20102 to promote liver regeneration during selected injuries in mice","volume":"66","author":"Liu","year":"2017","journal-title":"Hepatology"},{"issue":"11","key":"10.1016\/j.biomaterials.2026.124019_bib19","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/j.bcp.2005.08.020","article-title":"Inhibition of insulin\/IGF-1 receptor signaling enhances bile acid toxicity in primary hepatocytes","volume":"70","author":"Dent","year":"2005","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.biomaterials.2026.124019_bib20","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.carbpol.2017.10.077","article-title":"Post-sulfonation of cellulose nanofibrils with a one-step reaction to improve dispersibility","volume":"181","author":"Luo","year":"2018","journal-title":"Carbohydr. Polym."},{"issue":"43","key":"10.1016\/j.biomaterials.2026.124019_bib21","doi-asserted-by":"crossref","first-page":"24539","DOI":"10.1039\/D1TA07254D","article-title":"Facile gelation of a fully polymeric conductive hydrogel activated by liquid metal nanoparticles","volume":"9","author":"Wang","year":"2021","journal-title":"J. Mater. Chem. A"},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124019_bib22","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1186\/s13287-022-03164-9","article-title":"Clinical application of a double-modified sulfated bacterial cellulose scaffold material loaded with FGFR2-modified adipose-derived stem cells in urethral reconstruction","volume":"13","author":"Zhu","year":"2022","journal-title":"Stem Cell Res. Ther."},{"issue":"4","key":"10.1016\/j.biomaterials.2026.124019_bib23","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.biomaterials.2004.02.049","article-title":"Bacterial cellulose as a potential scaffold for tissue engineering of cartilage","volume":"26","author":"Svensson","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2026.124019_bib24","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.biomaterials.2019.02.004","article-title":"Varying PEG density to control stress relaxation in alginate-PEG hydrogels for 3D cell culture studies","volume":"200","author":"Nam","year":"2019","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124019_bib25","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/s41563-022-01400-4","article-title":"Matrix viscoelasticity controls spatiotemporal tissue organization","volume":"22","author":"Elosegui-Artola","year":"2023","journal-title":"Nat. Mater."},{"issue":"3","key":"10.1016\/j.biomaterials.2026.124019_bib26","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/nmat4489","article-title":"Hydrogels with tunable stress relaxation regulate stem cell fate and activity","volume":"15","author":"Chaudhuri","year":"2016","journal-title":"Nat. Mater."},{"issue":"4","key":"10.1016\/j.biomaterials.2026.124019_bib27","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1007\/s10570-018-2208-2","article-title":"TEMPO oxidation and high-speed blending as a combined approach to disassemble bacterial cellulose","volume":"26","author":"do Nascimento","year":"2019","journal-title":"Cellulose"},{"key":"10.1016\/j.biomaterials.2026.124019_bib28","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1016\/j.ijbiomac.2021.06.001","article-title":"Conformational and rheological properties of bacterial cellulose sulfate","volume":"183","author":"Song","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.biomaterials.2026.124019_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122615","article-title":"Locationally activated PRP via an injectable dual-network hydrogel for endometrial regeneration","volume":"309","author":"Qi","year":"2024","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2026.124019_bib30","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.actbio.2021.04.010","article-title":"A 3D-printed PRP-GelMA hydrogel promotes osteochondral regeneration through M2 macrophage polarization in a rabbit model","volume":"128","author":"Jiang","year":"2021","journal-title":"Acta Biomater."},{"issue":"9","key":"10.1016\/j.biomaterials.2026.124019_bib31","doi-asserted-by":"crossref","first-page":"3837","DOI":"10.7150\/thno.109091","article-title":"Neural-enhancing PRP\/Alg\/GelMA triple-network hydrogel for neurogenesis and angiogenesis after spinal cord injury via PI3K\/AKT\/mTOR signaling pathway","volume":"15","author":"Yun","year":"2025","journal-title":"Theranostics"},{"key":"10.1016\/j.biomaterials.2026.124019_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2020.124728","article-title":"Construction of physically crosslinked chitosan\/sodium alginate\/calcium ion double-network hydrogel and its application to heavy metal ions removal","volume":"393","author":"Tang","year":"2020","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.biomaterials.2026.124019_bib33","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.carbpol.2017.10.036","article-title":"A composite hydrogel of chitosan\/heparin\/poly (\u03b3-glutamic acid) loaded with superoxide dismutase for wound healing","volume":"180","author":"Zhang","year":"2018","journal-title":"Carbohydr. Polym."},{"issue":"32","key":"10.1016\/j.biomaterials.2026.124019_bib34","article-title":"Tunable viscoelasticity of alginate hydrogels via serial autoclaving","volume":"13","author":"Moheimani","year":"2024","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.biomaterials.2026.124019_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmbbm.2020.104038","article-title":"Hyperelastic and viscoelastic characterization of hepatic tissue under uniaxial tension in time and frequency domain","volume":"112","author":"Estermann","year":"2020","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.biomaterials.2026.124019_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.compositesb.2023.110857","article-title":"Synergistic chondrogenesis promotion and arthroscopic articular cartilage restoration via injectable dual-drug-loaded sulfated hyaluronic acid hydrogel for stem cell therapy","volume":"263","author":"Gao","year":"2023","journal-title":"Compos. B Eng."},{"key":"10.1016\/j.biomaterials.2026.124019_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/S0021-9290(06)83543-8","article-title":"Mechanical properties of kidney and liver tissues in shear","volume":"39","author":"Nicolle","year":"2006","journal-title":"J. Biomech."},{"key":"10.1016\/j.biomaterials.2026.124019_bib38","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.ics.2005.03.117","article-title":"A robotic indenter for minimally invasive characterization of soft tissues","volume":"1281","author":"Samur","year":"2005","journal-title":"Int. Congr. Ser."},{"issue":"3","key":"10.1016\/j.biomaterials.2026.124019_bib39","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1747-1567.2002.tb00069.x","article-title":"TeMPeST I-D: an instrument for measuring solid organ soft tissue properties","volume":"26","author":"Ottensmeyer","year":"2002","journal-title":"Exp. Tech."},{"key":"10.1016\/j.biomaterials.2026.124019_bib40","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.actbio.2016.08.055","article-title":"Sample, testing and analysis variables affecting liver mechanical properties: a review","volume":"45","author":"Mattei","year":"2016","journal-title":"Acta Biomater."},{"key":"10.1016\/j.biomaterials.2026.124019_bib41","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.jmbbm.2019.07.028","article-title":"Sex- and age-specific mechanical properties of liver tissue under dynamic loading conditions","volume":"99","author":"MacManus","year":"2019","journal-title":"J. Mech. Behav. Biomed. Mater."},{"issue":"2","key":"10.1016\/j.biomaterials.2026.124019_bib42","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/nbm.1030","article-title":"Liver fibrosis: non-invasive assessment with MR elastography","volume":"19","author":"Huwart","year":"2006","journal-title":"NMR Biomed."},{"issue":"2","key":"10.1016\/j.biomaterials.2026.124019_bib43","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1159\/000481344","article-title":"An experimental study to measure the mechanical properties of the human liver","volume":"36","author":"Karimi","year":"2017","journal-title":"Dig. Dis."},{"issue":"2","key":"10.1016\/j.biomaterials.2026.124019_bib44","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0168-8278(99)80073-7","article-title":"Epidermal growth factor- and hepatocyte growth factor-receptor activity in serum-free cultures of human hepatocytes","volume":"30","author":"Runge","year":"1999","journal-title":"J. Hepatol."},{"issue":"22","key":"10.1016\/j.biomaterials.2026.124019_bib45","doi-asserted-by":"crossref","first-page":"3733","DOI":"10.1016\/j.biomaterials.2009.03.039","article-title":"Cultivating liver cells on printed arrays of hepatocyte growth factor","volume":"30","author":"Jones","year":"2009","journal-title":"Biomaterials"},{"issue":"17","key":"10.1016\/j.biomaterials.2026.124019_bib46","doi-asserted-by":"crossref","first-page":"e109","DOI":"10.1093\/nar\/gkn434","article-title":"A probabilistic generative model for GO enrichment analysis","volume":"36","author":"Lu","year":"2008","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"10.1016\/j.biomaterials.2026.124019_bib47","doi-asserted-by":"crossref","first-page":"D587","DOI":"10.1093\/nar\/gkac963","article-title":"KEGG for taxonomy-based analysis of pathways and genomes","volume":"51","author":"Kanehisa","year":"2023","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124019_bib48","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1038\/s41467-020-16123-w","article-title":"Sequential Ras\/MAPK and PI3K\/AKT\/mTOR pathways recruitment drives basal extrusion in the prostate-like gland of drosophila","volume":"11","author":"Rambur","year":"2020","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.biomaterials.2026.124019_bib49","doi-asserted-by":"crossref","DOI":"10.1002\/hep.30818","volume":"71","author":"Dimri","year":"2020","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.biomaterials.2026.124019_bib50","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1093\/nar\/gkad1187","article-title":"Gene set correlation enrichment analysis for interpreting and annotating gene expression profiles","volume":"52","author":"Chang","year":"2023","journal-title":"Nucleic Acids Res."},{"issue":"7","key":"10.1016\/j.biomaterials.2026.124019_bib51","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/s41578-020-0199-8","article-title":"Synthetic alternatives to Matrigel","volume":"5","author":"Aisenbrey","year":"2020","journal-title":"Nat. Rev. Mater."},{"issue":"4, Supplement 1","key":"10.1016\/j.biomaterials.2026.124019_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/S0016-5085(08)61438-9","article-title":"S2068 histopathological study of chronic hepatitis B: a comparative study of ishak and metavir scoring systems","volume":"134","author":"Mohamadnejad","year":"2008","journal-title":"Gastroenterology"},{"issue":"26","key":"10.1016\/j.biomaterials.2026.124019_bib53","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202313270","article-title":"Cucurbit[8]uril mediated supramolecular and photocrosslinked interpenetrating network hydrogel matrices for 3D-Bioprinting","volume":"36","author":"Wang","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.biomaterials.2026.124019_bib54","doi-asserted-by":"crossref","unstructured":"S. Nam, V.K. Gupta, H.-p. Lee, J.Y. Lee, K.M. Wisdom, S. Varma, E.M. Flaum, C. Davis, R.B. West, O. Chaudhuri, Cell cycle progression in confining microenvironments is regulated by a growth-responsive TRPV4-PI3K\/Akt-p27Kip1 signaling axis, Sci. Adv. 5(8) eaaw6171.","DOI":"10.1126\/sciadv.aaw6171"},{"issue":"47","key":"10.1016\/j.biomaterials.2026.124019_bib55","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202403890","article-title":"Injectable GelMA hydrogel microspheres with sustained release of platelet-rich plasma for the treatment of thin endometrium","volume":"20","author":"Yuan","year":"2024","journal-title":"Small"},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124019_bib56","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/prd.12565","article-title":"How to explain the beneficial effects of platelet-rich plasma","volume":"97","author":"Gruber","year":"2025","journal-title":"Periodontol. 2000"},{"issue":"18","key":"10.1016\/j.biomaterials.2026.124019_bib57","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.scib.2019.07.033","article-title":"A small molecule cocktail breaks the bottleneck of human primary hepatocytes culture","volume":"64","author":"Xia","year":"2019","journal-title":"Science Bulletin"},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124019_bib58","doi-asserted-by":"crossref","first-page":"3940","DOI":"10.1038\/s41467-024-47869-2","article-title":"Hepatocytes differentiate into intestinal epithelial cells through a hybrid epithelial\/mesenchymal cell state in culture","volume":"15","author":"Miura","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biomaterials.2026.124019_bib59","doi-asserted-by":"crossref","unstructured":"B. Deng, Y. Ma, J. Huang, R. He, M. Luo, L. Mao, E. Zhang, Y. Zhao, X. Wang, Q. Wang, M. Pang, Y. Mao, H. Yang, L. Liu, P. Huang, Revitalizing liver function in mice with liver failure through transplantation of 3D-bioprinted liver with expanded primary hepatocytes, Sci. Adv. 10(23) eado1550.","DOI":"10.1126\/sciadv.ado1550"},{"key":"10.1016\/j.biomaterials.2026.124019_bib60","doi-asserted-by":"crossref","unstructured":"X. Zhang, B. Gong, F. Rao, H. Hu, F. Tian, Y. Lu, L. Zhang, Y. Xia, J. Xue, Spatiotemporally controlled delivery of biological effectors from nanofiber scaffolds accelerates skin wound healing in porcine models, Sci. Adv. 11(42) eadz5302.","DOI":"10.1126\/sciadv.adz5302"},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124019_bib61","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1186\/s13287-020-01745-0","article-title":"HGF and IL-10 expressing ALB::GFP reporter cells generated from iPSCs show robust anti-fibrotic property in acute fibrotic liver model","volume":"11","author":"Choi","year":"2020","journal-title":"Stem Cell Res. Ther."},{"issue":"7","key":"10.1016\/j.biomaterials.2026.124019_bib62","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1053\/j.gastro.2010.02.054","article-title":"Thrombocytopenia exacerbates cholestasis-induced liver fibrosis in mice","volume":"138","author":"Kodama","year":"2010","journal-title":"Gastroenterology"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961226000438?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961226000438?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T04:14:08Z","timestamp":1782188048000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961226000438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":62,"alternative-id":["S0142961226000438"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2026.124019","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PRP-driven biomimetic liver tissue engineering: A cost-effective platform for high-efficiency expansion of mouse primary hepatocytes","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2026.124019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"124019"}}