{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T03:31:14Z","timestamp":1789097474781,"version":"build-2803163510"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001348","name":"Agency for Science, Technology and Research","doi-asserted-by":"publisher","award":["H25J5a0024"],"award-info":[{"award-number":["H25J5a0024"]}],"id":[{"id":"10.13039\/501100001348","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013280","name":"Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","award":["23KJB180015"],"award-info":[{"award-number":["23KJB180015"]}],"id":[{"id":"10.13039\/501100013280","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["NRF-000352-00"],"award-info":[{"award-number":["NRF-000352-00"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001352","name":"National University of Singapore","doi-asserted-by":"publisher","award":["NUHSRO\/2021\/034\/TRP\/09\/Nanomedicine"],"award-info":[{"award-number":["NUHSRO\/2021\/034\/TRP\/09\/Nanomedicine"]}],"id":[{"id":"10.13039\/501100001352","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001352","name":"National University of Singapore","doi-asserted-by":"publisher","award":["23-0173-A0001"],"award-info":[{"award-number":["23-0173-A0001"]}],"id":[{"id":"10.13039\/501100001352","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001352","name":"National University of Singapore","doi-asserted-by":"publisher","award":["NUHSRO\/2020\/133\/Startup\/08"],"award-info":[{"award-number":["NUHSRO\/2020\/133\/Startup\/08"]}],"id":[{"id":"10.13039\/501100001352","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001352","name":"National University of Singapore","doi-asserted-by":"publisher","award":["NUHSRO\/2023\/008\/NUSMed\/ TCE \/LOA"],"award-info":[{"award-number":["NUHSRO\/2023\/008\/NUSMed\/ TCE \/LOA"]}],"id":[{"id":"10.13039\/501100001352","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32301179"],"award-info":[{"award-number":["32301179"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["CG21APR1005"],"award-info":[{"award-number":["CG21APR1005"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["MOH-001388-00"],"award-info":[{"award-number":["MOH-001388-00"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["MOH-001500-00"],"award-info":[{"award-number":["MOH-001500-00"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["MOH-001740-01"],"award-info":[{"award-number":["MOH-001740-01"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["MOH-001609-00"],"award-info":[{"award-number":["MOH-001609-00"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001459","name":"Ministry of Education - Singapore","doi-asserted-by":"publisher","award":["MOE-000387-00"],"award-info":[{"award-number":["MOE-000387-00"]}],"id":[{"id":"10.13039\/501100001459","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001459","name":"Ministry of Education - Singapore","doi-asserted-by":"publisher","award":["MOE-MOET32023-004"],"award-info":[{"award-number":["MOE-MOET32023-004"]}],"id":[{"id":"10.13039\/501100001459","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012217","name":"Xuzhou Medical University","doi-asserted-by":"publisher","award":["D2020035"],"award-info":[{"award-number":["D2020035"]}],"id":[{"id":"10.13039\/501100012217","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.biomaterials.2026.124170","type":"journal-article","created":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T07:27:21Z","timestamp":1774682841000},"page":"124170","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Injectable Cu2+ loaded rhein hydrogel for cross-amplifying osteosarcoma apoptosis and cuproptosis epitranscriptomically"],"prefix":"10.1016","volume":"332","author":[{"given":"Jianwei","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingyiwen","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaopeng","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianhui","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yining","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuang","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0718-9128","authenticated-orcid":false,"given":"Jianhua","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaxia","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.biomaterials.2026.124170_bib1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/s41572-022-00409-y","article-title":"Osteosarcoma","volume":"8","author":"Beird","year":"2022","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124170_bib2","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12938-021-00860-0","article-title":"Osteosarcoma: a review of current and future therapeutic approaches","volume":"20","author":"Zhao","year":"2021","journal-title":"Biomed. Eng. Online"},{"key":"10.1016\/j.biomaterials.2026.124170_bib3","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1051\/sicotj\/2017028","article-title":"Osteosarcoma: a comprehensive review","volume":"4","author":"Misaghi","year":"2018","journal-title":"SICOT J."},{"issue":"10","key":"10.1016\/j.biomaterials.2026.124170_bib4","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/s41571-021-00519-8","article-title":"Advancing therapy for osteosarcoma","volume":"18","author":"Gill","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"51","key":"10.1016\/j.biomaterials.2026.124170_bib5","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202303059","article-title":"Organic sonodynamic materials for combination cancer immunotherapy","volume":"35","author":"Zhang","year":"2023","journal-title":"Adv Mater"},{"issue":"6586","key":"10.1016\/j.biomaterials.2026.124170_bib6","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1126\/science.abf0529","article-title":"Copper induces cell death by targeting lipoylated TCA cycle proteins","volume":"375","author":"Tsvetkov","year":"2022","journal-title":"Science"},{"issue":"13","key":"10.1016\/j.biomaterials.2026.124170_bib7","doi-asserted-by":"crossref","first-page":"6282","DOI":"10.1039\/D5CS00083A","article-title":"Cuproptosis: mechanisms and nanotherapeutic strategies in cancer and beyond","volume":"54","author":"Mao","year":"2025","journal-title":"Chem. Soc. Rev."},{"issue":"11","key":"10.1016\/j.biomaterials.2026.124170_bib8","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1038\/s41418-024-01341-2","article-title":"Dysregulated Wnt\/beta-catenin signaling confers resistance to cuproptosis in cancer cells","volume":"31","author":"Liu","year":"2024","journal-title":"Cell Death Differ."},{"issue":"12","key":"10.1016\/j.biomaterials.2026.124170_bib9","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1038\/s41388-022-02214-z","article-title":"M(6)A demethylase FTO-mediated downregulation of DACT1 mRNA stability promotes Wnt signaling to facilitate osteosarcoma progression","volume":"41","author":"Lv","year":"2022","journal-title":"Oncogene"},{"issue":"7397","key":"10.1016\/j.biomaterials.2026.124170_bib10","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nature11112","article-title":"Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq","volume":"485","author":"Dominissini","year":"2012","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124170_bib11","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1038\/s41467-022-29665-y","article-title":"Inducible and reversible RNA N(6)-methyladenosine editing","volume":"13","author":"Shi","year":"2022","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.biomaterials.2026.124170_bib12","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/s41568-020-0253-2","article-title":"Role of RNA modifications in cancer","volume":"20","author":"Barbieri","year":"2020","journal-title":"Nat. Rev. Cancer"},{"issue":"8","key":"10.1016\/j.biomaterials.2026.124170_bib13","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/s41571-023-00774-x","article-title":"The roles and implications of RNA m(6)A modification in cancer","volume":"20","author":"Deng","year":"2023","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"12","key":"10.1016\/j.biomaterials.2026.124170_bib14","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nchembio.687","article-title":"N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO","volume":"7","author":"Jia","year":"2011","journal-title":"Nat. Chem. Biol."},{"issue":"6596","key":"10.1016\/j.biomaterials.2026.124170_bib15","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1126\/science.abe9582","article-title":"FTO mediates LINE1 m(6)A demethylation and chromatin regulation in mESCs and mouse development","volume":"376","author":"Wei","year":"2022","journal-title":"Science"},{"issue":"43","key":"10.1016\/j.biomaterials.2026.124170_bib16","doi-asserted-by":"crossref","first-page":"17963","DOI":"10.1021\/ja3064149","article-title":"Development of cell-active N6-methyladenosine RNA demethylase FTO inhibitor","volume":"134","author":"Chen","year":"2012","journal-title":"J. Am. Chem. Soc."},{"issue":"4","key":"10.1016\/j.biomaterials.2026.124170_bib17","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.ccell.2019.03.006","article-title":"Small-Molecule targeting of oncogenic FTO demethylase in Acute Myeloid leukemia","volume":"35","author":"Huang","year":"2019","journal-title":"Cancer Cell"},{"issue":"4","key":"10.1016\/j.biomaterials.2026.124170_bib18","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1158\/0008-5472.CAN-15-1519","article-title":"A small-molecule antagonist of the beta-Catenin\/TCF4 interaction blocks the self-renewal of cancer stem cells and suppresses tumorigenesis","volume":"76","author":"Fang","year":"2016","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124170_bib19","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1038\/s41467-019-09601-3","article-title":"Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation","volume":"10","author":"Zheng","year":"2019","journal-title":"Nat. Commun."},{"issue":"17","key":"10.1016\/j.biomaterials.2026.124170_bib20","doi-asserted-by":"crossref","first-page":"11200","DOI":"10.1021\/acsnano.4c00155","article-title":"Injectable hydrogel Mucosal vaccine elicits protective immunity against respiratory viruses","volume":"18","author":"Fu","year":"2024","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124170_bib21","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s12951-021-00804-9","article-title":"A sonosensitiser-based polymeric nanoplatform for chemo-sonodynamic combination therapy of lung cancer","volume":"19","author":"Zhang","year":"2021","journal-title":"J Nanobiotechnology"},{"issue":"11","key":"10.1016\/j.biomaterials.2026.124170_bib22","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.1039\/D1BM00198A","article-title":"Oxygen-carrying nanoparticle-based chemo-sonodynamic therapy for tumor suppression and autoimmunity activation","volume":"9","author":"Zhang","year":"2021","journal-title":"Biomater. Sci."},{"issue":"3","key":"10.1016\/j.biomaterials.2026.124170_bib23","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nmeth.3735","article-title":"A genetically targetable near-infrared photosensitizer","volume":"13","author":"He","year":"2016","journal-title":"Nat. Methods"},{"key":"10.1016\/j.biomaterials.2026.124170_bib24","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.redox.2017.04.016","article-title":"Redox environment in stem and differentiated cells: a quantitative approach","volume":"12","author":"Lyublinskaya","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.biomaterials.2026.124170_bib25","first-page":"19875","article-title":"Carrier-Free photodynamic bioregulators inhibiting lactic acid efflux combined with immune checkpoint blockade for triple-negative breast cancer immunotherapy","author":"Chen","year":"2024","journal-title":"ACS Nano"},{"issue":"17","key":"10.1016\/j.biomaterials.2026.124170_bib26","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202309215","article-title":"An ellagic acid coordinated copper-based nanoplatform for efficiently overcoming cancer chemoresistance by cuproptosis and synergistic inhibition of cancer cell stemness","volume":"20","author":"Lu","year":"2024","journal-title":"Small"},{"issue":"11","key":"10.1016\/j.biomaterials.2026.124170_bib27","doi-asserted-by":"crossref","first-page":"10206","DOI":"10.1021\/acsnano.3c00326","article-title":"Type-I AIE photosensitizer loaded biomimetic System boosting cuproptosis to inhibit breast cancer metastasis and rechallenge","volume":"17","author":"Ning","year":"2023","journal-title":"ACS Nano"},{"issue":"40","key":"10.1016\/j.biomaterials.2026.124170_bib28","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202205013","article-title":"A hollow amorphous bimetal organic framework for synergistic Cuproptosis\/Ferroptosis\/Apoptosis anticancer therapy via disrupting intracellular redox homeostasis and Copper\/Iron metabolisms","volume":"32","author":"Xu","year":"2022","journal-title":"Adv. Funct. Mater."}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961226001948?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961226001948?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T08:09:18Z","timestamp":1777277358000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961226001948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":28,"alternative-id":["S0142961226001948"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2026.124170","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Injectable Cu2+ loaded rhein hydrogel for cross-amplifying osteosarcoma apoptosis and cuproptosis epitranscriptomically","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2026.124170","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"124170"}}