{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T07:26:22Z","timestamp":1793949982922,"version":"4.8.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000148","name":"Canadian Anesthesiologists' Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000148","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.biomaterials.2026.124203","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:56:08Z","timestamp":1775436968000},"page":"124203","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Development of 1 month core-shell microspheres combination formulation containing teriparatide for osteoporosis treatment"],"prefix":"10.1016","volume":"333","author":[{"given":"Haoyuan","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangming","family":"Na","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zejing","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donglin","family":"Sui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9154-5556","authenticated-orcid":false,"given":"Guanghui","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biomaterials.2026.124203_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.beem.2021.101551","article-title":"Menopausal hormone therapy for the management of osteoporosis","volume":"35","author":"Gosset","year":"2021","journal-title":"Best Pract. Res. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.biomaterials.2026.124203_bib2","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/3071147","article-title":"Pharmacodynamic material basis and potential mechanism study of spatholobi caulis in reversing osteoporosis","volume":"2023","author":"Xiao","year":"2023","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.biomaterials.2026.124203_bib3","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.bone.2007.04.198","article-title":"Low bone mineral density is associated with bone microdamage accumulation in postmenopausal women with osteoporosis","volume":"41","author":"Stepan","year":"2007","journal-title":"Bone"},{"key":"10.1016\/j.biomaterials.2026.124203_bib4","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1056\/NEJMoa023110","article-title":"Bisphosphonate-induced osteopetrosis","volume":"349","author":"Whyte","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.biomaterials.2026.124203_bib5","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/S8756-3282(01)00414-8","article-title":"Effects of suppressed bone turnover by bisphosphonates on microdamage accumulation and biomechanical properties in clinically relevant skeletal sites in beagles","volume":"28","author":"Mashiba","year":"2001","journal-title":"Bone"},{"key":"10.1016\/j.biomaterials.2026.124203_bib6","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/jcb.10490","article-title":"Mediators of the biphasic responses of bone to intermittent and continuously administered parathyroid hormone","volume":"89","author":"Locklin","year":"2003","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.biomaterials.2026.124203_bib7","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.jconrel.2022.07.012","article-title":"Enhanced oral absorption of teriparatide with therapeutic potential for management of osteoporosis","volume":"349","author":"Subedi","year":"2022","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.biomaterials.2026.124203_bib8","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.1172\/JCI119491","article-title":"Parathyroid hormone exerts disparate effects on osteoblast differentiation depending on exposure time in rat osteoblastic cells","volume":"99","author":"Ishizuya","year":"1997","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.biomaterials.2026.124203_bib9","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201600901","article-title":"Preprogrammed long\u2010term systemic pulsatile delivery of parathyroid hormone to strengthen bone","volume":"6","author":"Dang","year":"2017","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.biomaterials.2026.124203_bib10","doi-asserted-by":"crossref","first-page":"5713","DOI":"10.1210\/en.2008-0369","article-title":"Differentiation and proliferation of periosteal osteoblast progenitors are differentially regulated by estrogens and intermittent parathyroid hormone administration","volume":"149","author":"Ogita","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.biomaterials.2026.124203_bib11","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1210\/jc.2007-2781","article-title":"Randomized trial of once-weekly parathyroid hormone (1-84) on bone mineral density and remodeling","volume":"93","author":"Black","year":"2008","journal-title":"J. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.biomaterials.2026.124203_bib12","doi-asserted-by":"crossref","first-page":"48868","DOI":"10.1074\/jbc.M208494200","article-title":"Parathyroid hormone stimulates receptor activator of NF\u03baB ligand and inhibits osteoprotegerin expression via protein kinase A activation of cAMP-response element-binding protein","volume":"277","author":"Fu","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biomaterials.2026.124203_bib13","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/S8756-3282(03)00202-3","article-title":"Anabolic and catabolic bone effects of human parathyroid hormone (1-34) are predicted by duration of hormone exposure","volume":"33","author":"Frolik","year":"2003","journal-title":"Bone"},{"key":"10.1016\/j.biomaterials.2026.124203_bib14","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/jcb.20438","article-title":"Molecular profile of catabolic versus anabolic treatment regimens of parathyroid hormone (PTH) in rat bone: an analysis by DNA microarray","volume":"95","author":"Onyia","year":"2005","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.biomaterials.2026.124203_bib15","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1038\/s41467-023-38597-0","article-title":"An injectable liposome-anchored teriparatide incorporated gallic acid-grafted gelatin hydrogel for osteoarthritis treatment","volume":"14","author":"Li","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biomaterials.2026.124203_bib16","first-page":"75","article-title":"A biomimetic and bioactive scaffold with intelligently pulsatile teriparatide delivery for local and systemic osteoporosis regeneration","volume":"19","author":"Che","year":"2023","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.biomaterials.2026.124203_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124853","article-title":"A lipid-based delivery platform for thermo-responsive delivery of teriparatide","volume":"667","author":"Schlosser","year":"2024","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.biomaterials.2026.124203_bib18","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1002\/jps.23191","article-title":"Fabrication and drug release study of double-layered microparticles of various sizes","volume":"101","author":"Lee","year":"2012","journal-title":"J. Pharmaceut. Sci."},{"key":"10.1016\/j.biomaterials.2026.124203_bib19","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.actbio.2015.08.051","article-title":"Delivery of doxorubicin and paclitaxel from double-layered microparticles: the effects of layer thickness and dual-drug vs. single-drug loading","volume":"27","author":"Lee","year":"2015","journal-title":"Acta Biomater."},{"key":"10.1016\/j.biomaterials.2026.124203_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpharm.2011.01.027","article-title":"Why and how to prepare biodegradable, monodispersed, polymeric microparticles in the field of pharmacy?","volume":"407","author":"Tran","year":"2011","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.biomaterials.2026.124203_bib21","doi-asserted-by":"crossref","first-page":"25869","DOI":"10.1021\/acsami.4c04010","article-title":"Development of 1 month sustained-release microspheres containing liraglutide for type 2 diabetes treatment","volume":"16","author":"Gao","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.biomaterials.2026.124203_bib22","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.jconrel.2024.09.043","article-title":"Preparation and in vitro\/in vivo evaluation of uniform-sized Goserelin-loaded sustained release microspheres","volume":"375","author":"Qin","year":"2024","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.biomaterials.2026.124203_bib23","doi-asserted-by":"crossref","first-page":"S125","DOI":"10.1016\/8756-3282(95)00285-L","article-title":"FDA guidelines and animal models for osteoporosis","volume":"17","author":"Thompson","year":"1995","journal-title":"Bone"},{"key":"10.1016\/j.biomaterials.2026.124203_bib24","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/j.actbio.2009.10.028","article-title":"Manipulation of process parameters to achieve different ternary phase microparticle configurations","volume":"6","author":"Lee","year":"2010","journal-title":"Acta Biomater."},{"key":"10.1016\/j.biomaterials.2026.124203_bib25","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jcis.2020.01.071","article-title":"Controllable fabrication of biodegradable Janus and multi-layered particles with hierarchically porous structure","volume":"566","author":"Biswal","year":"2020","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.biomaterials.2026.124203_bib26","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s10856-011-4508-z","article-title":"Designing drug-loaded multi-layered polymeric microparticles","volume":"23","author":"Lee","year":"2012","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"10.1016\/j.biomaterials.2026.124203_bib27","series-title":"Novel Membrane Emulsification: Principles, Preparation, Processes, and Bioapplications","author":"Ma","year":"2023"},{"key":"10.1016\/j.biomaterials.2026.124203_bib28","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00198-010-1501-1","article-title":"Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: a need for international reference standards","volume":"22","author":"Vasikaran","year":"2011","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.biomaterials.2026.124203_bib29","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/S2213-8587(17)30184-5","article-title":"Use of bone turnover markers in postmenopausal osteoporosis","volume":"5","author":"Eastell","year":"2017","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.biomaterials.2026.124203_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1136561","article-title":"Triple-gene deletion for osteocalcin significantly impairs the alignment of hydroxyapatite crystals and collagen in mice","volume":"14","author":"Xu","year":"2023","journal-title":"Front. Physiol."},{"key":"10.1016\/j.biomaterials.2026.124203_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.mex.2024.103136","article-title":"Osteoclast visualization: tartrate-resistant acid phosphatase activity staining using NewFuchsin compatible with non-aqueous mounting and tissue clearing","volume":"14","author":"Nakamura","year":"2025","journal-title":"MethodsX"},{"key":"10.1016\/j.biomaterials.2026.124203_bib32","series-title":"Ultradian Rhythms from Molecules to Mind","first-page":"229","article-title":"Pulsatile hormone secretion: mechanisms, significance and evaluation","author":"Veldhuis","year":"2008"},{"key":"10.1016\/j.biomaterials.2026.124203_bib33","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1210\/endrev\/bnaf013","article-title":"The chronobiology of hormone administration: \u201cdoctor, What Time Should I Take My Medication?\u201d","volume":"46","author":"Colonnello","year":"2025","journal-title":"Endocr. Rev."}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961226002279?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961226002279?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T06:34:07Z","timestamp":1793946847000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961226002279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":33,"alternative-id":["S0142961226002279"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2026.124203","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of 1 month core-shell microspheres combination formulation containing teriparatide for osteoporosis treatment","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2026.124203","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"124203"}}