{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T10:24:12Z","timestamp":1794565452757,"version":"4.9.1"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32402041"],"award-info":[{"award-number":["32402041"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2023QH004"],"award-info":[{"award-number":["ZR2023QH004"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2024MH125"],"award-info":[{"award-number":["ZR2024MH125"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["202228015"],"award-info":[{"award-number":["202228015"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015508","name":"Shandong Academy of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015508","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015507","name":"Shandong First Medical University","doi-asserted-by":"publisher","award":["922-001003130 185RC"],"award-info":[{"award-number":["922-001003130 185RC"]}],"id":[{"id":"10.13039\/501100015507","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.biomaterials.2026.124251","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T11:22:51Z","timestamp":1777461771000},"page":"124251","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Cargo-defined engineered vesicles enable targeted miRNA delivery for cardiac repair after myocardial infarction"],"prefix":"10.1016","volume":"334","author":[{"given":"Yameng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6063-0731","authenticated-orcid":false,"given":"Guoyue","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0830-9714","authenticated-orcid":false,"given":"Haoran","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xipeng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenguo","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengling","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanzhe","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1613-4682","authenticated-orcid":false,"given":"Sitong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keqing","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohai","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0718-9128","authenticated-orcid":false,"given":"Jianhua","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingjun","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9524","key":"10.1016\/j.biomaterials.2026.124251_bib1","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1016\/S0140-6736(06)68770-9","article-title":"Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data","volume":"367","author":"Lopez","year":"2006","journal-title":"Lancet"},{"issue":"8","key":"10.1016\/j.biomaterials.2026.124251_bib2","doi-asserted-by":"crossref","first-page":"e93","DOI":"10.1161\/CIR.0000000000001123","article-title":"Heart disease and stroke statistics-2023 update: a report from the American heart association","volume":"147","author":"Tsao","year":"2023","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124251_bib3","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/s41392-022-00925-z","article-title":"Signaling pathways and targeted therapy for myocardial infarction","volume":"7","author":"Zhang","year":"2022","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"44","key":"10.1016\/j.biomaterials.2026.124251_bib4","doi-asserted-by":"crossref","first-page":"3626","DOI":"10.1093\/eurheartj\/ehy600","article-title":"Treatments targeting inotropy","volume":"40","author":"Maack","year":"2019","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.biomaterials.2026.124251_bib5","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jconrel.2021.01.018","article-title":"Co-delivery of curcumin and miRNA-144-3p using heart-targeted extracellular vesicles enhances the therapeutic efficacy for myocardial infarction","volume":"331","author":"Kang","year":"2021","journal-title":"J. Contr. Release"},{"issue":"3","key":"10.1016\/j.biomaterials.2026.124251_bib6","doi-asserted-by":"crossref","first-page":"486","DOI":"10.20517\/evcna.2023.29","article-title":"MicroRNA biogenesis pathway alterations in aging","volume":"4","author":"Sanz-Ros","year":"2023","journal-title":"Extracell. Vesicles Circ. Nucl. Acids"},{"issue":"8","key":"10.1016\/j.biomaterials.2026.124251_bib7","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.7150\/thno.29945","article-title":"Localized injection of miRNA-21-enriched extracellular vesicles effectively restores cardiac function after myocardial infarction","volume":"9","author":"Song","year":"2019","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124251_bib8","doi-asserted-by":"crossref","first-page":"5565","DOI":"10.1038\/s41467-024-49901-x","article-title":"Single dose of intravenous miR199a-5p delivery targeting ischemic heart for long-term repair of myocardial infarction","volume":"15","author":"Chen","year":"2024","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.biomaterials.2026.124251_bib9","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1161\/CIRCULATIONAHA.116.024171","article-title":"Inhibition of MicroRNA-146a and overexpression of its target dihydrolipoyl succinyltransferase protect against pressure overload-induced cardiac hypertrophy and dysfunction","volume":"136","author":"Heggermont","year":"2017","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.biomaterials.2026.124251_bib10","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/nrcardio.2014.207","article-title":"MicroRNAs in myocardial infarction","volume":"12","author":"Boon","year":"2015","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.biomaterials.2026.124251_bib11","article-title":"Cascade nanozyme delivering miRNA to ischemic heart to alleviate myocardial ischemia-reperfusion injury","author":"Chen","year":"2025","journal-title":"Small"},{"issue":"7","key":"10.1016\/j.biomaterials.2026.124251_bib12","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/s41419-018-0805-5","article-title":"MicroRNA-21 prevents excessive inflammation and cardiac dysfunction after myocardial infarction through targeting KBTBD7","volume":"9","author":"Yang","year":"2018","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124251_bib13","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1161\/CIRCRESAHA.120.317244","article-title":"Mir-30d regulates cardiac remodeling by intracellular and paracrine signaling","volume":"128","author":"Li","year":"2021","journal-title":"Circ. Res."},{"issue":"4","key":"10.1016\/j.biomaterials.2026.124251_bib14","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.ymthe.2018.11.018","article-title":"mRNA-based protein replacement therapy for the heart","volume":"27","author":"Magadum","year":"2019","journal-title":"Mol. Ther."},{"issue":"30","key":"10.1016\/j.biomaterials.2026.124251_bib15","first-page":"19470","article-title":"Nanoparticle\u2013patch system for localized, effective, and sustained miRNA administration into infarcted myocardium to alleviate myocardial ischemia\u2013reperfusion injury","volume":"18","author":"Chen","year":"2024","journal-title":"ACS Nano"},{"issue":"11","key":"10.1016\/j.biomaterials.2026.124251_bib16","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.tibtech.2014.09.002","article-title":"Drug target miRNAs: chances and challenges","volume":"32","author":"Schmidt","year":"2014","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.biomaterials.2026.124251_bib17","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.addr.2014.05.009","article-title":"In vivo delivery of miRNAs for cancer therapy: challenges and strategies","volume":"81","author":"Chen","year":"2015","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124251_bib18","doi-asserted-by":"crossref","first-page":"165","DOI":"10.20517\/evcna.2025.161","article-title":"80 years of extracellular vesicles: from discovery to clinical translation","volume":"7","author":"Li","year":"2026","journal-title":"Extracell. Vesicles Circ. Nucl. Acids"},{"key":"10.1016\/j.biomaterials.2026.124251_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.05.011","article-title":"Extracellular vesicles as a drug delivery system: a systematic review of preclinical studies","volume":"175","author":"Escud\u00e9 Martinez de Castilla","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"5","key":"10.1016\/j.biomaterials.2026.124251_bib20","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1161\/CIRCULATIONAHA.122.063759","article-title":"Extracellular vesicle-encapsulated adeno-associated viruses for therapeutic gene delivery to the heart","volume":"148","author":"Li","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.biomaterials.2026.124251_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122976","article-title":"Myocardial delivery of miR30d with peptide-functionalized milk-derived extracellular vesicles for targeted treatment of hypertrophic heart failure","volume":"316","author":"Tong","year":"2025","journal-title":"Biomaterials"},{"issue":"6","key":"10.1016\/j.biomaterials.2026.124251_bib22","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12466","article-title":"Gut-liver axis: potential mechanisms of action of food-derived extracellular vesicles","volume":"13","author":"Zhang","year":"2024","journal-title":"J. Extracell. Vesicles"},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124251_bib23","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1186\/s12951-024-02631-0","article-title":"Targeting delivery of miR-146a via IMTP modified milk exosomes exerted cardioprotective effects by inhibiting NF-\u03baB signaling pathway after myocardial ischemia-reperfusion injury","volume":"22","author":"Meng","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.biomaterials.2026.124251_bib24","article-title":"Orally administered milk-derived extracellular vesicles alleviate hepatic metabolic dysfunction by targeting hepatocytes and modulating ER stress","volume":"522","author":"Zhang","year":"2025","journal-title":"Chem. Eng. J."},{"issue":"3","key":"10.1016\/j.biomaterials.2026.124251_bib25","doi-asserted-by":"crossref","first-page":"339","DOI":"10.20517\/evcna.2023.25","article-title":"Milk-borne small extracellular vesicles: kinetics and mechanisms of transport, distribution, and elimination","volume":"4","author":"Ngu","year":"2023","journal-title":"Extracell. Vesicles Circ. Nucl. Acids"},{"key":"10.1016\/j.biomaterials.2026.124251_bib26","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s12986-019-0412-1","article-title":"Milk exosomal miRNAs: potential drivers of AMPK-to-mTORC1 switching in \u03b2-cell de-differentiation of type 2 diabetes mellitus","volume":"16","author":"Melnik","year":"2019","journal-title":"Nutr. Metab."},{"key":"10.1016\/j.biomaterials.2026.124251_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.concog.2023.103477","article-title":"What is autonomous sensory meridian response (ASMR)? A narrative review and comparative analysis of related phenomena","volume":"109","author":"Mahady","year":"2023","journal-title":"Conscious. Cognit."},{"key":"10.1016\/j.biomaterials.2026.124251_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123282","article-title":"Development of an innovative extracellular vesicle mimetic delivery platform for efficient miRNA delivery to tumours","volume":"321","author":"Chen","year":"2025","journal-title":"Biomaterials"},{"issue":"20","key":"10.1016\/j.biomaterials.2026.124251_bib29","doi-asserted-by":"crossref","first-page":"19613","DOI":"10.1021\/acsnano.3c01534","article-title":"Customized loading of microRNA-126 to small extracellular vesicle-derived vehicles improves cardiac function after myocardial infarction","volume":"17","author":"Bheri","year":"2023","journal-title":"ACS Nano"},{"issue":"15","key":"10.1016\/j.biomaterials.2026.124251_bib30","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.008737","article-title":"Engineered exosomes with ischemic myocardium-targeting peptide for targeted therapy in myocardial infarction","volume":"7","author":"Wang","year":"2018","journal-title":"J. Am. Heart Assoc."},{"issue":"11","key":"10.1016\/j.biomaterials.2026.124251_bib31","doi-asserted-by":"crossref","DOI":"10.1172\/JCI159179","article-title":"MicroRNAs as therapeutic targets in cardiovascular disease","volume":"132","author":"Laggerbauer","year":"2022","journal-title":"J. Clin. Investig."},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124251_bib32","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41392-024-01735-1","article-title":"Extracellular vesicles as tools and targets in therapy for diseases","volume":"9","author":"Kumar","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"19","key":"10.1016\/j.biomaterials.2026.124251_bib33","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1161\/CIRCULATIONAHA.108.788331","article-title":"Cardiac-specific overexpression of caveolin-3 induces endogenous cardiac protection by mimicking ischemic preconditioning","volume":"118","author":"Tsutsumi","year":"2008","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.biomaterials.2026.124251_bib34","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12044","article-title":"Comprehensive evaluation of methods for small extracellular vesicles separation from human plasma, urine and cell culture medium","volume":"10","author":"Dong","year":"2020","journal-title":"J. Extracell. Vesicles"},{"issue":"20","key":"10.1016\/j.biomaterials.2026.124251_bib35","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1161\/CIRCULATIONAHA.120.050812","article-title":"LARP7 protects against heart failure by enhancing mitochondrial biogenesis","volume":"143","author":"Yu","year":"2021","journal-title":"Circulation"},{"issue":"14","key":"10.1016\/j.biomaterials.2026.124251_bib36","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1161\/CIRCULATIONAHA.124.070286","article-title":"Nrf3-Mediated mitochondrial superoxide promotes cardiomyocyte apoptosis and impairs cardiac functions by suppressing Pitx2","volume":"151","author":"Chen","year":"2025","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.biomaterials.2026.124251_bib37","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1093\/cvr\/cvn335","article-title":"Oxidative stress and left ventricular remodelling after myocardial infarction","volume":"81","author":"Hori","year":"2009","journal-title":"Cardiovasc. Res."},{"issue":"17","key":"10.1016\/j.biomaterials.2026.124251_bib38","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1016\/j.jacc.2020.03.020","article-title":"Extracellular matrix in ischemic heart disease, part 4\/4: JACC focus seminar","volume":"75","author":"Frangogiannis","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124251_bib39","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1161\/CIRCRESAHA.119.311148","article-title":"The extracellular matrix in ischemic and nonischemic heart failure","volume":"125","author":"Frangogiannis","year":"2019","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124251_bib40","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13045-017-0390-6","article-title":"Thrombospondin-2 promotes prostate cancer bone metastasis by the up-regulation of matrix metalloproteinase-2 through down-regulating miR-376c expression","volume":"10","author":"Chen","year":"2017","journal-title":"J. Hematol. Oncol."},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124251_bib41","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s00395-023-00999-y","article-title":"Matrix metalloproteinase-2 proteolyzes mitofusin-2 and impairs mitochondrial function during myocardial ischemia-reperfusion injury","volume":"118","author":"Bassiouni","year":"2023","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.biomaterials.2026.124251_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104108","article-title":"Targeting miR-30d reverses pathological cardiac hypertrophy","volume":"81","author":"Li","year":"2022","journal-title":"EBioMedicine"},{"issue":"19","key":"10.1016\/j.biomaterials.2026.124251_bib43","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.3390\/cells12192369","article-title":"MicroRNA-30d-5p-A potential new therapeutic target for prevention of ischemic cardiomyopathy after myocardial infarction","volume":"12","author":"Boxhammer","year":"2023","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124251_bib44","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12967-018-1760-8","article-title":"Exosomes of pasteurized milk: potential pathogens of Western diseases","volume":"17","author":"Melnik","year":"2019","journal-title":"J. Transl. Med."},{"issue":"40","key":"10.1016\/j.biomaterials.2026.124251_bib45","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202301763","article-title":"Standardization approaches for extracellular vesicle loading with oligonucleotides and biologics","volume":"19","author":"Roerig","year":"2023","journal-title":"Small"},{"key":"10.1016\/j.biomaterials.2026.124251_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.vesic.2024.100052","article-title":"Ultrasonication outperforms electroporation for extracellular vesicle cargo depletion","volume":"4","author":"Chen","year":"2024","journal-title":"Extracell. Vesicle."},{"issue":"28","key":"10.1016\/j.biomaterials.2026.124251_bib47","doi-asserted-by":"crossref","first-page":"23615","DOI":"10.1074\/jbc.M112.379164","article-title":"Central role of mitofusin 2 in autophagosome-lysosome fusion in cardiomyocytes","volume":"287","author":"Zhao","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124251_bib48","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2174\/1573403X15666190509090832","article-title":"Regulation of myocardial extracellular matrix dynamic changes in myocardial infarction and postinfarct remodeling","volume":"16","author":"Ushakov","year":"2020","journal-title":"Curr. Cardiol. Rev."},{"issue":"24","key":"10.1016\/j.biomaterials.2026.124251_bib49","doi-asserted-by":"crossref","first-page":"9739","DOI":"10.3390\/ijms21249739","article-title":"The roles of matrix metalloproteinases and their inhibitors in human diseases","volume":"21","author":"Cabral-Pacheco","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124251_bib50","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1002\/imo2.18","article-title":"Cohort profile: a longitudinal multi-omics cohort of patients with acute coronary syndrome","volume":"1","author":"Huang","year":"2024","journal-title":"iMetaOmics"},{"issue":"14","key":"10.1016\/j.biomaterials.2026.124251_bib51","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1093\/eurheartj\/ehaa575","article-title":"2020 ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation","volume":"42","author":"Collet","year":"2021","journal-title":"Eur. Heart J."},{"issue":"15","key":"10.1016\/j.biomaterials.2026.124251_bib52","doi-asserted-by":"crossref","first-page":"eade5041","DOI":"10.1126\/sciadv.ade5041","article-title":"Milk-derived extracellular vesicles protect intestinal barrier integrity in the gut-liver axis","volume":"9","author":"Tong","year":"2023","journal-title":"Sci. Adv."},{"issue":"17","key":"10.1016\/j.biomaterials.2026.124251_bib53","doi-asserted-by":"crossref","first-page":"8570","DOI":"10.7150\/thno.62046","article-title":"Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the gut microbiota","volume":"11","author":"Tong","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.biomaterials.2026.124251_bib54","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.ymeth.2021.12.006","article-title":"Measuring hypertrophy in neonatal rat primary cardiomyocytes and human iPSC-derived cardiomyocytes","volume":"203","author":"Bourque","year":"2022","journal-title":"Methods"},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124251_bib55","doi-asserted-by":"crossref","first-page":"4416","DOI":"10.1038\/s41467-020-18165-6","article-title":"Mitochondrial CaMKII causes adverse metabolic reprogramming and dilated cardiomyopathy","volume":"11","author":"Luczak","year":"2020","journal-title":"Nat. Commun."}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961226002759?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961226002759?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T09:30:05Z","timestamp":1794562205000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961226002759"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":55,"alternative-id":["S0142961226002759"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2026.124251","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cargo-defined engineered vesicles enable targeted miRNA delivery for cardiac repair after myocardial infarction","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2026.124251","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"124251"}}