{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T10:23:54Z","timestamp":1794565434674,"version":"4.9.1"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52403192"],"award-info":[{"award-number":["52403192"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["347897"],"award-info":[{"award-number":["347897"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.biomaterials.2026.124255","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T11:22:59Z","timestamp":1777461779000},"page":"124255","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Gene-programmed micro-nano metabolic engine drives coupled osteogenic-angiogenic regeneration"],"prefix":"10.1016","volume":"334","author":[{"given":"Wu","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengzhen","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tapani","family":"Viitala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2694-9882","authenticated-orcid":false,"given":"Heemin","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1071-4416","authenticated-orcid":false,"given":"Hongbo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6938-9582","authenticated-orcid":false,"given":"Wenguo","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.biomaterials.2026.124255_bib1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41413-025-00417-0","article-title":"Cell communication and relevant signaling pathways in osteogenesis\u2013angiogenesis coupling","volume":"13","author":"Li","year":"2025","journal-title":"Bone Res."},{"issue":"33","key":"10.1016\/j.biomaterials.2026.124255_bib2","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202302622","article-title":"Exosomal mRNAs for angiogenic\u2013osteogenic coupled bone repair","volume":"10","author":"Ma","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.biomaterials.2026.124255_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122566","article-title":"Synergistic large segmental bone repair by 3D printed bionic scaffolds and engineered ADSC nanovesicles: towards an optimized regenerative microenvironment","volume":"308","author":"Jiang","year":"2024","journal-title":"Biomaterials"},{"issue":"9","key":"10.1016\/j.biomaterials.2026.124255_bib4","doi-asserted-by":"crossref","first-page":"5222","DOI":"10.1021\/acsbiomaterials.3c00609","article-title":"Bioactive materials for bone regeneration: biomolecules and delivery systems","volume":"9","author":"Szwed-Georgiou","year":"2023","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"44","key":"10.1016\/j.biomaterials.2026.124255_bib5","doi-asserted-by":"crossref","first-page":"eadq6700","DOI":"10.1126\/sciadv.adq6700","article-title":"Stem cell\u2013homing biomimetic hydrogel promotes the repair of osteoporotic bone defects through osteogenic and angiogenic coupling","volume":"10","author":"Wei","year":"2024","journal-title":"Sci. Adv."},{"issue":"36","key":"10.1016\/j.biomaterials.2026.124255_bib6","article-title":"Electrosprayed regeneration\u2010enhancer\u2010element microspheres power osteogenesis and angiogenesis coupling","volume":"18","author":"Xu","year":"2022","journal-title":"Small"},{"issue":"9","key":"10.1016\/j.biomaterials.2026.124255_bib7","doi-asserted-by":"crossref","first-page":"4569","DOI":"10.1021\/acsbiomaterials.1c00639","article-title":"Regulation of an antimicrobial peptide GL13K-modified titanium surface on osteogenesis, osteoclastogenesis, and angiogenesis base on osteoimmunology","volume":"7","author":"Zhou","year":"2021","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"6","key":"10.1016\/j.biomaterials.2026.124255_bib8","article-title":"A nanocoating Co\u2010localizing nitric oxide and growth factor onto individual endothelial cells reveals synergistic effects on angiogenesis","volume":"11","author":"Jeong","year":"2022","journal-title":"Adv. Healthcare Mater."},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124255_bib9","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/s13287-016-0442-9","article-title":"Molecular control of nitric oxide synthesis through eNOS and caveolin-1 interaction regulates osteogenic differentiation of adipose-derived stem cells by modulation of Wnt\/\u03b2-catenin signaling","volume":"7","author":"Bandara","year":"2016","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.biomaterials.2026.124255_bib10","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jconrel.2017.07.019","article-title":"Amelioration of atherosclerotic inflammation and plaques via endothelial adrenoceptor-targeted eNOS gene delivery using redox-sensitive polymer bearing l-arginine","volume":"262","author":"Ain","year":"2017","journal-title":"J. Contr. Release"},{"issue":"3","key":"10.1016\/j.biomaterials.2026.124255_bib11","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1021\/acsnano.2c11058","article-title":"Minimalist nanocomplex with dual regulation of endothelial function and inflammation for targeted therapy of inflammatory vascular diseases","volume":"17","author":"Wang","year":"2023","journal-title":"ACS Nano"},{"issue":"1\u20132","key":"10.1016\/j.biomaterials.2026.124255_bib12","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ijpharm.2017.02.014","article-title":"A three-dimensional assemblage of gingiva-derived mesenchymal stem cells and NO-releasing microspheres for improved differentiation","volume":"520","author":"Regmi","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.biomaterials.2026.124255_bib13","article-title":"A photothermal responsive system accelerating nitric oxide release to enhance bone repair by promoting osteogenesis and angiogenesis","volume":"28","author":"Cheng","year":"2024","journal-title":"Mater. Today Bio"},{"issue":"3","key":"10.1016\/j.biomaterials.2026.124255_bib14","first-page":"305","article-title":"Nitric oxide delivery using nanostructures and its biomedical applications","volume":"57","author":"Choi","year":"2019","journal-title":"Korean Chemical Engineering Research"},{"issue":"8","key":"10.1016\/j.biomaterials.2026.124255_bib15","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1073\/pnas.0300464101","article-title":"S-nitrosylation of endothelial nitric oxide synthase is associated with monomerization and decreased enzyme activity","volume":"101","author":"Ravi","year":"2004","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124255_bib16","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/1585840","article-title":"Neural peptide \u03b1\u2010CGRP coregulated angiogenesis and osteogenesis via promoting the cross\u2010talk between mesenchymal stem cells and endothelial cells","volume":"2022","author":"Shi","year":"2022","journal-title":"BioMed Res. Int."},{"issue":"3","key":"10.1016\/j.biomaterials.2026.124255_bib17","doi-asserted-by":"crossref","first-page":"R833","DOI":"10.1152\/ajpregu.00534.2009","article-title":"Bmp2 and Bmp4 exert opposing effects in hypoxic pulmonary hypertension","volume":"298","author":"Anderson","year":"2010","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"7","key":"10.1016\/j.biomaterials.2026.124255_bib18","doi-asserted-by":"crossref","first-page":"eabl6242","DOI":"10.1126\/sciadv.abl6242","article-title":"Efficient healing of large osseous segmental defects using optimized chemically modified messenger RNA encoding BMP-2","volume":"8","author":"De La Vega","year":"2022","journal-title":"Sci. Adv."},{"issue":"6","key":"10.1016\/j.biomaterials.2026.124255_bib19","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1016\/j.matt.2022.03.006","article-title":"The roles of polymers in mRNA delivery","volume":"5","author":"Huang","year":"2022","journal-title":"Matter"},{"key":"10.1016\/j.biomaterials.2026.124255_bib20","first-page":"111","article-title":"Transcript-activated collagen matrix for enhanced bone marrow stem cell differentiation and osteochondral repair","volume":"6","author":"Zhong","year":"2025","journal-title":"Eng. Regen."},{"issue":"52","key":"10.1016\/j.biomaterials.2026.124255_bib21","doi-asserted-by":"crossref","first-page":"23374","DOI":"10.1002\/anie.202003545","article-title":"Emerging concepts of nanobiotechnology in mRNA delivery","volume":"59","author":"Wang","year":"2020","journal-title":"Angew. Chem. Int. Ed."},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124255_bib22","doi-asserted-by":"crossref","first-page":"6905","DOI":"10.1038\/s41467-023-42740-2","article-title":"An autocatalytic multicomponent DNAzyme nanomachine for tumor-specific photothermal therapy sensitization in pancreatic cancer","volume":"14","author":"Yan","year":"2023","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124255_bib23","first-page":"1989","article-title":"Utility of amorphous calcium phosphate-based scaffolds in dental\/biomedical applications","volume":"7","author":"Bienek","year":"2017","journal-title":"Biointerface Res. Appl. Chem."},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124255_bib24","doi-asserted-by":"crossref","first-page":"4170","DOI":"10.1038\/s41467-018-06570-x","article-title":"Transformation of amorphous calcium phosphate to bone-like apatite","volume":"9","author":"Lotsari","year":"2018","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.biomaterials.2026.124255_bib25","doi-asserted-by":"crossref","first-page":"4836","DOI":"10.1021\/acsami.1c18727","article-title":"Surface stability and morphology of calcium phosphate tuned by pH values and lactic acid additives: theoretical and experimental study","volume":"14","author":"Chen","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124255_bib26","article-title":"Apatite formation: why it may not work as planned, and how to conclusively identify apatite compounds","volume":"2013","author":"Drouet","year":"2013","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.biomaterials.2026.124255_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.113978","article-title":"In situ construction of ossification micro-units for critical bone regeneration via sustained lifting of epigenetic suppression","volume":"385","author":"Yang","year":"2025","journal-title":"J. Contr. Release : Official Journal of the Controlled Release Society"},{"issue":"7","key":"10.1016\/j.biomaterials.2026.124255_bib28","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.2174\/0109298673278936240107121907","article-title":"Cell-Penetrating peptides as keys to endosomal escape and intracellular trafficking in nanomedicine delivery","volume":"32","author":"Soni","year":"2025","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.biomaterials.2026.124255_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2023.1267912","article-title":"A variable mineralization time and solution concentration intervene in the microstructure of biomimetic mineralized collagen and potential osteogenic microenvironment","volume":"11","author":"Zhu","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"2","key":"10.1016\/j.biomaterials.2026.124255_bib30","doi-asserted-by":"crossref","first-page":"287","DOI":"10.5155\/eurjchem.5.2.287-290.1007","article-title":"Secondary structure investigation of bovine serum albumin (BSA) by fourier transform infrared (FTIR) spectroscopy in the amide III region","volume":"5","author":"Li","year":"2014","journal-title":"Eur. J. Chem."},{"key":"10.1016\/j.biomaterials.2026.124255_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.polymer.2020.122248","article-title":"Alendronate-functionalized poly (amido amine) cryogels of high-toughness for biomedical applications","volume":"190","author":"Guven","year":"2020","journal-title":"Polymer"},{"key":"10.1016\/j.biomaterials.2026.124255_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2019.115635","article-title":"Preparation, characterization and antibacterial properties of 6-deoxy-6-arginine modified chitosan","volume":"230","author":"Su","year":"2020","journal-title":"Carbohydr. Polym."},{"issue":"4","key":"10.1016\/j.biomaterials.2026.124255_bib33","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.molmed.2004.02.001","article-title":"Role of eNOS in neovascularization: NO for endothelial progenitor cells","volume":"10","author":"Duda","year":"2004","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.biomaterials.2026.124255_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-016-0442-9","article-title":"Molecular control of nitric oxide synthesis through eNOS and caveolin-1 interaction regulates osteogenic differentiation of adipose-derived stem cells by modulation of Wnt\/\u03b2-catenin signaling","volume":"7","author":"Bandara","year":"2016","journal-title":"Stem Cell Res. Ther."},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124255_bib35","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s12951-023-01871-w","article-title":"Hydrogel armed with Bmp2 mRNA-enriched exosomes enhances bone regeneration","volume":"21","author":"Yang","year":"2023","journal-title":"J. Nanobiotechnol."},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124255_bib36","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-02931-x","article-title":"mRNA encoding bone morphogenetic protein-2 facilitated peri-implant bone formation of titanium implants placed in rat femurs","volume":"15","author":"Jriyasetapong","year":"2025","journal-title":"Sci. Rep."},{"issue":"15","key":"10.1016\/j.biomaterials.2026.124255_bib37","doi-asserted-by":"crossref","first-page":"8889","DOI":"10.1039\/D2RA00713D","article-title":"A brief review of mRNA therapeutics and delivery for bone tissue engineering","volume":"12","author":"Rajendran","year":"2022","journal-title":"RSC Adv."},{"issue":"51","key":"10.1016\/j.biomaterials.2026.124255_bib38","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202305635","article-title":"Inflammation\u2010regulated auto aggregated hydrogel microspheres via anchoring cartilage deep matrix for genes delivery","volume":"33","author":"Chen","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.biomaterials.2026.124255_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122699","article-title":"3D-printed bone regeneration scaffolds modulate bone metabolic homeostasis through vascularization for osteoporotic bone defects","volume":"311","author":"Yan","year":"2024","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2026.124255_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121214","article-title":"Cell-laden injectable microgels: current status and future prospects for cartilage regeneration","volume":"279","author":"Nguyen","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2026.124255_bib41","doi-asserted-by":"crossref","first-page":"131","DOI":"10.34133\/research.0131","article-title":"In situ sustained macrophage-targeted nanomicelle\u2013hydrogel microspheres for inhibiting osteoarthritis","volume":"6","author":"Li","year":"2023","journal-title":"Research"},{"issue":"5","key":"10.1016\/j.biomaterials.2026.124255_bib42","doi-asserted-by":"crossref","first-page":"321","DOI":"10.5051\/jpis.2203220161","article-title":"Photo-crosslinked gelatin methacryloyl hydrogel strengthened with calcium phosphate-based nanoparticles for early healing of rabbit calvarial defects","volume":"53","author":"Lee","year":"2023","journal-title":"Journal of Periodontal & Implant Science"},{"issue":"21","key":"10.1016\/j.biomaterials.2026.124255_bib43","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202201457","article-title":"Physiology\u2010inspired multilayer nanofibrous membranes modulating endogenous stem cell recruitment and osteo\u2010differentiation for staged bone regeneration","volume":"11","author":"Mao","year":"2022","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.biomaterials.2026.124255_bib44","series-title":"Exploration","first-page":"20230149","article-title":"Piezoelectric stimulation enhances bone regeneration in alveolar bone defects through metabolic reprogramming of macrophages","author":"Sui","year":"2024"},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124255_bib45","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41413-025-00424-1","article-title":"Bone-derived factors mediate crosstalk between skeletal and extra-skeletal organs","volume":"13","author":"He","year":"2025","journal-title":"Bone Res."},{"issue":"6","key":"10.1016\/j.biomaterials.2026.124255_bib46","doi-asserted-by":"crossref","DOI":"10.1002\/smsc.202300357","article-title":"Bioinspired bone seed 3D\u2010Printed scaffold via trapping black phosphorus nanosheet for bone regeneration","volume":"4","author":"Cai","year":"2024","journal-title":"Small Sci."},{"key":"10.1016\/j.biomaterials.2026.124255_bib47","first-page":"1","article-title":"Bioactive glass-reinforced hybrid microfibrous spheres promote bone defect repair via stem cell delivery","author":"Chen","year":"2024","journal-title":"Adv. Fiber Mater."},{"issue":"12","key":"10.1016\/j.biomaterials.2026.124255_bib48","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1016\/j.scib.2024.04.002","article-title":"Piezocatalytically-induced controllable mineralization scaffold with bone-like microenvironment to achieve endogenous bone regeneration","volume":"69","author":"Cui","year":"2024","journal-title":"Sci. Bull."},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124255_bib49","doi-asserted-by":"crossref","DOI":"10.1088\/2752-5724\/ad9e09","article-title":"Functionalized bio-spinning silk fiber scaffolds containing Mg2+ with osteoimmunomodulatory and osteogenesis abilities for critical-sized bone defect regeneration","volume":"4","author":"Xu","year":"2025","journal-title":"Materials Futures"},{"key":"10.1016\/j.biomaterials.2026.124255_bib50","doi-asserted-by":"crossref","first-page":"RP98612","DOI":"10.7554\/eLife.98612","article-title":"Combined forces of hydrostatic pressure and actin polymerization drive endothelial tip cell migration and sprouting angiogenesis","volume":"13","author":"Kondrychyn","year":"2025","journal-title":"eLife"},{"issue":"3","key":"10.1016\/j.biomaterials.2026.124255_bib51","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.ymthe.2022.01.012","article-title":"Targeting circular RNA-MET for anti-angiogenesis treatment via inhibiting endothelial tip cell specialization","volume":"30","author":"Yao","year":"2022","journal-title":"Mol. Ther."},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124255_bib52","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s42003-024-07431-8","article-title":"Endothelial tip-cell position, filopodia formation and biomechanics require BMPR2 expression and signaling","volume":"8","author":"Hiepen","year":"2025","journal-title":"Commun. Biol."},{"key":"10.1016\/j.biomaterials.2026.124255_bib53","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.jconrel.2025.02.002","article-title":"Injectable mineralized hydrogel microspheres for accelerated osteocyte network reconstruction and intelligent bone regeneration","volume":"380","author":"Xiao","year":"2025","journal-title":"J. Contr. Release"},{"issue":"6","key":"10.1016\/j.biomaterials.2026.124255_bib54","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202205336","article-title":"Nitric oxide\u2010releasing bioinspired scaffold for exquisite regeneration of osteoporotic bone via regulation of homeostasis","volume":"10","author":"Lee","year":"2023","journal-title":"Adv. Sci."}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961226002796?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961226002796?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T09:30:57Z","timestamp":1794562257000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961226002796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":54,"alternative-id":["S0142961226002796"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2026.124255","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gene-programmed micro-nano metabolic engine drives coupled osteogenic-angiogenic regeneration","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2026.124255","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"124255"}}