{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T21:19:32Z","timestamp":1787779172148,"version":"build-2784847793"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.biomaterials.2026.124451","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T06:39:30Z","timestamp":1783665570000},"page":"124451","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Self-organizing bioceramic granules with wave-dissipating architectures for bone void filling"],"prefix":"10.1016","volume":"336","author":[{"given":"Zhengyi","family":"Xing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puxin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanhong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Grazia","family":"Raucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangdong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Ambrosio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingdong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7248-8218","authenticated-orcid":false,"given":"Xiao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biomaterials.2026.124451_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.pmatsci.2023.101072","article-title":"Design, printing, and engineering of regenerative biomaterials for personalized bone healthcare","volume":"134","author":"Jia","year":"2023","journal-title":"Prog. Mater. Sci."},{"key":"10.1016\/j.biomaterials.2026.124451_bib2","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/s41578-020-0204-2","article-title":"Materials design for bone-tissue engineering","volume":"5","author":"Koons","year":"2020","journal-title":"Nat. Rev. Mater."},{"key":"10.1016\/j.biomaterials.2026.124451_bib3","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.actbio.2022.04.014","article-title":"Personalized 3D printed bone scaffolds: a review","volume":"156","author":"Mirkhalaf","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.biomaterials.2026.124451_bib4","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202403641","article-title":"Recent advances in 3D printing of smart scaffolds for bone tissue engineering and regeneration","volume":"36","author":"Yuan","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.biomaterials.2026.124451_bib5","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.mattod.2015.10.008","article-title":"Calcium phosphates in biomedical applications: materials for the future?","volume":"19","author":"Habraken","year":"2016","journal-title":"Mater. Today"},{"key":"10.1016\/j.biomaterials.2026.124451_bib6","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/S1369-7021(10)70014-6","article-title":"Resorbable biomaterials as bone graft substitutes","volume":"13","author":"Bohner","year":"2010","journal-title":"Mater. Today"},{"key":"10.1016\/j.biomaterials.2026.124451_bib7","doi-asserted-by":"crossref","first-page":"8228","DOI":"10.3390\/ijerph19148228","article-title":"Bone regeneration by multichannel cylindrical granular bone substitute for regeneration of bone in cases of tumor, fracture, and arthroplasty","volume":"19","author":"Jung","year":"2022","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.biomaterials.2026.124451_bib8","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s10047-022-01335-2","article-title":"Unidirectional porous beta-tricalcium phosphate as a potential bone regeneration material for infectious bony cavity without debridement in pyogenic spondylitis","volume":"26","author":"Funayama","year":"2023","journal-title":"J. Artif. Organs"},{"key":"10.1016\/j.biomaterials.2026.124451_bib9","doi-asserted-by":"crossref","first-page":"3973","DOI":"10.1016\/j.biomaterials.2008.06.026","article-title":"The clinical use of enriched bone marrow stem cells combined with porous beta-tricalcium phosphate in posterior spinal fusion","volume":"29","author":"Gan","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2026.124451_bib10","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ijsp.2011.10.001","article-title":"Clinical and radiographic outcomes of extreme lateral approach to interbody fusion with \u03b2-tricalcium phosphate and hydroxyapatite composite for lumbar degenerative conditions","volume":"6","author":"Rodgers","year":"2012","journal-title":"Int. J. Spine Surg."},{"key":"10.1016\/j.biomaterials.2026.124451_bib11","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1016\/j.msec.2012.12.041","article-title":"Clinical evaluation of \u03b2-TCP in the treatment of lacunar bone defects: a prospective, randomized controlled study","volume":"33","author":"Wang","year":"2013","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.biomaterials.2026.124451_bib12","first-page":"197","article-title":"Granular tricalcium phosphate grafting of cavitary lesions in human bone","volume":"306","author":"Nicholas","year":"1994","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.biomaterials.2026.124451_bib13","doi-asserted-by":"crossref","first-page":"169","DOI":"10.4103\/0019-5413.39588","article-title":"Calcium phosphate ceramics as bone graft substitutes in filling bone tumor defects","volume":"42","author":"Saikia","year":"2008","journal-title":"Indian J. Orthop."},{"key":"10.1016\/j.biomaterials.2026.124451_bib14","article-title":"Stabilization of Bio-Oss\u00ae particulates using photocurable hydrogel to enhance bone regeneration by regulating macrophage polarization","volume":"11","author":"Wang","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.biomaterials.2026.124451_bib15","article-title":"Transformable carbonate apatite chains as a novel type of bone graft","volume":"13","author":"Hayashi","year":"2024","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.biomaterials.2026.124451_bib16","doi-asserted-by":"crossref","first-page":"487","DOI":"10.4103\/jisp.jisp_656_18","article-title":"The long-term risks and complications of bovine-derived xenografts: a case series","volume":"23","author":"Rodriguez","year":"2019","journal-title":"J. Indian Soc. Periodontol."},{"key":"10.1016\/j.biomaterials.2026.124451_bib17","doi-asserted-by":"crossref","first-page":"178","DOI":"10.4103\/jisp.jisp_494_20","article-title":"The migration of the bovine-derived xenograft particles: a case series","volume":"26","author":"Nowzari","year":"2022","journal-title":"J. Indian Soc. Periodontol."},{"key":"10.1016\/j.biomaterials.2026.124451_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.150401","article-title":"3D printing novel porous granule-type bioceramics via magnesium tuning biological performances beneficial for implantation and clinical translation","volume":"486","author":"Yue","year":"2024","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.biomaterials.2026.124451_bib19","doi-asserted-by":"crossref","DOI":"10.1093\/rb\/rbab077","article-title":"Integrating pore architectures to evaluate vascularization efficacy in silicate-based bioceramic scaffolds","volume":"9","author":"Wu","year":"2022","journal-title":"Regen. Biomater."},{"key":"10.1016\/j.biomaterials.2026.124451_bib20","first-page":"68","article-title":"Historical overview of the structural integrity of concrete armour units","volume":"1","author":"Scaravaglione","year":"2022","journal-title":"COASTAL AND OFFSHORE SCIENCE AND ENGINEERING"},{"key":"10.1016\/j.biomaterials.2026.124451_bib21","series-title":"Proceedings of 6th International Short Course\/Conference on Applied Coastal Research","article-title":"Hydraulic stability of tetrapod armour layers. Physical model study","author":"Fabi\u00e3o","year":"2013"},{"key":"10.1016\/j.biomaterials.2026.124451_bib22","series-title":"Recent Advances in Civil Engineering: Select Proceedings of CTCS 2021","first-page":"775","article-title":"Review of literature on design of rubble mound breakwaters","author":"Akarsh","year":"2023"},{"key":"10.1016\/j.biomaterials.2026.124451_bib23","doi-asserted-by":"crossref","first-page":"960","DOI":"10.3390\/nano8110960","article-title":"Scaffold structural microenvironmental cues to guide tissue regeneration in bone tissue applications","volume":"8","author":"Chen","year":"2018","journal-title":"Nanomaterials"},{"key":"10.1016\/j.biomaterials.2026.124451_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123348","article-title":"Optimal structural characteristics of osteoinductivity in bioceramics derived from a novel high-throughput screening plus machine learning approach","volume":"321","author":"Liu","year":"2025","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2026.124451_bib25","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.msec.2015.12.087","article-title":"Role of pore size and morphology in musculo-skeletal tissue regeneration","volume":"61","author":"Perez","year":"2016","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.biomaterials.2026.124451_bib26","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202214726","article-title":"Structural and functional adaptive artificial bone: materials, fabrications, and properties","volume":"33","author":"Feng","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.biomaterials.2026.124451_bib27","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1016\/j.actbio.2009.10.023","article-title":"Comparative study on bone regeneration by synthetic octacalcium phosphate with various granule sizes","volume":"6","author":"Murakami","year":"2010","journal-title":"Acta Biomater."},{"key":"10.1016\/j.biomaterials.2026.124451_bib28","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1177\/0885328218768605","article-title":"Bone regeneration strategy by different sized multichanneled biphasic calcium phosphate granules: in vivo evaluation in rabbit model","volume":"32","author":"Taz","year":"2018","journal-title":"J. Biomater. Appl."},{"key":"10.1016\/j.biomaterials.2026.124451_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2017.01.076","article-title":"Biphasic calcium phosphate ceramics for bone reconstruction: a review of biological response","volume":"53","author":"Bouler","year":"2017","journal-title":"Acta Biomater."},{"key":"10.1016\/j.biomaterials.2026.124451_bib30","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1744-7402.2005.02020.x","article-title":"Bioceramic bone graft substitutes: influence of porosity and chemistry","volume":"2","author":"Hing","year":"2005","journal-title":"Int. J. Appl. Ceram. Technol."},{"key":"10.1016\/j.biomaterials.2026.124451_bib31","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1007\/s41779-023-00880-0","article-title":"A comprehensive review of the effects of porosity and macro- and micropore formations in porous \u03b2-TCP scaffolds on cell responses","volume":"59","author":"Mohammed Mohammed","year":"2023","journal-title":"J. Aust. Ceram. Soc."},{"key":"10.1016\/j.biomaterials.2026.124451_bib32","article-title":"Granular honeycomb scaffolds composed of carbonate apatite for simultaneous intra- and inter-granular osteogenesis and angiogenesis","volume":"14","author":"Hayashi","year":"2022","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.biomaterials.2026.124451_bib33","doi-asserted-by":"crossref","first-page":"4956","DOI":"10.1016\/j.actbio.2012.09.035","article-title":"Inflammatory cell response to calcium phosphate biomaterial particles: an overview","volume":"9","author":"Velard","year":"2013","journal-title":"Acta Biomater."},{"key":"10.1016\/j.biomaterials.2026.124451_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2022.03.057","article-title":"Sustained local ionic homeostatic imbalance caused by calcification modulates inflammation to trigger heterotopic ossification","volume":"145","author":"Bohner","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.biomaterials.2026.124451_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.compositesb.2023.110727","article-title":"Flow channel performance in 3D printed hydroxyapatite scaffolds to improve metabolism and tissue ingrowth in flat bone repair","volume":"259","author":"Mao","year":"2023","journal-title":"Compos. B Eng."},{"key":"10.1016\/j.biomaterials.2026.124451_bib36","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.actbio.2024.07.008","article-title":"3D printing calcium phosphate ceramics with high osteoinductivity through pore architecture optimization","volume":"185","author":"Wu","year":"2024","journal-title":"Acta Biomater."},{"key":"10.1016\/j.biomaterials.2026.124451_bib37","doi-asserted-by":"crossref","first-page":"3722","DOI":"10.1021\/acsami.8b18525","article-title":"Osteoinductivity of porous biphasic calcium phosphate ceramic spheres with nanocrystalline and their efficacy in guiding bone regeneration","volume":"11","author":"Li","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.biomaterials.2026.124451_bib38","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1007\/s41779-022-00806-2","article-title":"A review on the behavioral responses of osteoclast and osteoblast cells on the near-surface of the bioceramic coating: roles of ions released, solubility, and pH","volume":"58","author":"Mohammed Mohammed","year":"2022","journal-title":"J. Aust. Ceram. Soc."},{"key":"10.1016\/j.biomaterials.2026.124451_bib39","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.actbio.2016.08.025","article-title":"Micropore-induced capillarity enhances bone distribution in vivo in biphasic calcium phosphate scaffolds","volume":"44","author":"Rustom","year":"2016","journal-title":"Acta Biomater."},{"key":"10.1016\/j.biomaterials.2026.124451_bib40","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.actbio.2018.11.003","article-title":"Mineralization in micropores of calcium phosphate scaffolds","volume":"83","author":"Rustom","year":"2019","journal-title":"Acta Biomater."},{"key":"10.1016\/j.biomaterials.2026.124451_bib41","doi-asserted-by":"crossref","first-page":"37232","DOI":"10.1021\/acsami.3c06430","article-title":"Efficient osteogenic activity of PEEK surfaces achieved by femtosecond laser\u2013hydroxylation","volume":"15","author":"Luo","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.biomaterials.2026.124451_bib42","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.actbio.2025.04.048","article-title":"Low-temperature plasma effect-induced enhancement of osteogenic activity in calcium phosphate ceramics","volume":"200","author":"Luo","year":"2025","journal-title":"Acta Biomater."},{"key":"10.1016\/j.biomaterials.2026.124451_bib43","article-title":"Macrophage fusion event as one prerequisite for inorganic nanoparticle-induced antitumor response","volume":"9","author":"Chen","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.biomaterials.2026.124451_bib44","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The molecular signatures database hallmark gene set collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst."},{"key":"10.1016\/j.biomaterials.2026.124451_bib45","doi-asserted-by":"crossref","first-page":"7591","DOI":"10.1039\/D4TB01335B","article-title":"PI3K\/AKT\/mTOR signaling regulates BCP ceramic-induced osteogenesis","volume":"12","author":"Tan","year":"2024","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.biomaterials.2026.124451_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1021\/acsbiomaterials.7b00615","article-title":"Fabrication aspects of porous biomaterials in orthopedic applications: a review","volume":"4","author":"Babaie","year":"2018","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.biomaterials.2026.124451_bib47","doi-asserted-by":"crossref","DOI":"10.1002\/adem.202100463","article-title":"How does scaffold porosity conduct bone tissue regeneration?","volume":"23","author":"Mohammadi","year":"2021","journal-title":"Adv. Eng. Mater."},{"key":"10.1016\/j.biomaterials.2026.124451_bib48","article-title":"HtrA3-Mediated endothelial cell\u2013extracellular matrix crosstalk regulates tip cell specification","volume":"31","author":"Guo","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.biomaterials.2026.124451_bib49","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1186\/s12951-022-01655-8","article-title":"Exosomal miR-140-5p inhibits osteogenesis by targeting IGF1R and regulating the mTOR pathway in ossification of the posterior longitudinal ligament","volume":"20","author":"Tang","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.biomaterials.2026.124451_bib50","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13036-023-00354-8","article-title":"PLGA\/BGP\/Nef porous composite restrains osteoclasts by inhibiting the NF-\u03baB pathway, enhances IGF-1-mediated osteogenic differentiation and promotes bone regeneration","volume":"17","author":"Wu","year":"2023","journal-title":"J. Biol. Eng."},{"key":"10.1016\/j.biomaterials.2026.124451_bib51","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s40364-017-0097-4","article-title":"Bone biomarker for the clinical assessment of osteoporosis: recent developments and future perspectives","volume":"5","author":"Kuo","year":"2017","journal-title":"Biomarker Res."},{"key":"10.1016\/j.biomaterials.2026.124451_bib52","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1210\/endrev\/bnac031","article-title":"Bone turnover markers: basic biology to clinical applications","volume":"44","author":"Schini","year":"2023","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.biomaterials.2026.124451_bib53","doi-asserted-by":"crossref","first-page":"7513","DOI":"10.3390\/ijms21207513","article-title":"Functions of osteocalcin in bone, pancreas, testis, and muscle","volume":"21","author":"Komori","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biomaterials.2026.124451_bib54","article-title":"Engineered cell\u2010laden armor unit\u2010mimicking bioceramic granules for bone regeneration","volume":"34","author":"Wu","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.biomaterials.2026.124451_bib55","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1177\/03635465980260031201","article-title":"Evaluation of the intraosseous and extraosseous blood supply to the distal femoral condyles","volume":"26","author":"Reddy","year":"1998","journal-title":"Am. J. Sports Med."},{"key":"10.1016\/j.biomaterials.2026.124451_bib56","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s10456-017-9541-1","article-title":"The role of vasculature in bone development, regeneration and proper systemic functioning","volume":"20","author":"Filipowska","year":"2017","journal-title":"Angiogenesis"},{"key":"10.1016\/j.biomaterials.2026.124451_bib57","doi-asserted-by":"crossref","first-page":"311","DOI":"10.4248\/BR201304002","article-title":"Skeletal blood flow in bone repair and maintenance","volume":"1","author":"Tomlinson","year":"2013","journal-title":"Bone Res."},{"key":"10.1016\/j.biomaterials.2026.124451_bib58","doi-asserted-by":"crossref","first-page":"357","DOI":"10.17816\/vto466576","article-title":"Clinical and pathogenetic significance of the microvascular component of bone tissue","volume":"30","author":"Agafonova","year":"2023","journal-title":"N.N. Priorov Journal of Traumatology and Orthopedics"},{"key":"10.1016\/j.biomaterials.2026.124451_bib59","doi-asserted-by":"crossref","first-page":"45","DOI":"10.17816\/vto99987","article-title":"Influence of distraction bone regenerate on blood circulation in limbs (experimental study)","volume":"9","author":"Shevtsov","year":"2002","journal-title":"N.N. Priorov Journal of Traumatology and Orthopedics"},{"key":"10.1016\/j.biomaterials.2026.124451_bib60","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abc4704","article-title":"A biomimetically hierarchical polyetherketoneketone scaffold for osteoporotic bone repair","volume":"6","author":"Yuan","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.biomaterials.2026.124451_bib61","first-page":"379","article-title":"Osteoporotic bone recovery by a bamboo-structured bioceramic with controlled release of hydroxyapatite nanoparticles","volume":"17","author":"Zhao","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.biomaterials.2026.124451_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118234","article-title":"Hai-Honghua medicinal liquor is a reliable remedy for fracture by promotion of osteogenic differentiation via activation of PI3K\/Akt pathway","volume":"330","author":"Qian","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biomaterials.2026.124451_bib63","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1146\/annurev-physiol-021119-034332","article-title":"The osteocyte: new insights","volume":"82","author":"Robling","year":"2020","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.biomaterials.2026.124451_bib64","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.actbio.2015.11.013","article-title":"3D printed Ti6Al4V implant surface promotes bone maturation and retains a higher density of less aged osteocytes at the bone-implant interface","volume":"30","author":"Shah","year":"2016","journal-title":"Acta Biomater."},{"key":"10.1016\/j.biomaterials.2026.124451_bib65","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1177\/0022034518778033","article-title":"A review of the impact of implant biomaterials on osteocytes","volume":"97","author":"Shah","year":"2018","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.biomaterials.2026.124451_bib66","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s10856-018-6124-7","article-title":"Immunohistochemical evaluation after Sr-enriched biphasic ceramic implantation in rabbits femoral neck: comparison of seven different bone conditions","volume":"29","author":"Zarins","year":"2018","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"10.1016\/j.biomaterials.2026.124451_bib67","first-page":"90","article-title":"Enhanced bone regenerative properties of calcium phosphate ceramic granules in rabbit posterolateral spinal fusion through a reduction of grain size","volume":"11","author":"Li","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.biomaterials.2026.124451_bib68","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1016\/j.actbio.2012.02.019","article-title":"Development and evaluation of tetrapod-shaped granular artificial bones","volume":"8","author":"Choi","year":"2012","journal-title":"Acta Biomater."},{"key":"10.1016\/j.biomaterials.2026.124451_bib69","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1021\/acsbiomaterials.7b00232","article-title":"Fabrication and properties of Ca-P bioceramic spherical granules with interconnected porous structure","volume":"3","author":"Li","year":"2017","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.biomaterials.2026.124451_bib70","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3390\/biomimetics9070409","article-title":"Fabrication strategies for bioceramic scaffolds in bone tissue engineering with generative design applications","volume":"9","author":"Cinici","year":"2024","journal-title":"Biomimetics"},{"key":"10.1016\/j.biomaterials.2026.124451_bib71","doi-asserted-by":"crossref","first-page":"11755","DOI":"10.1021\/acsnano.2c03776","article-title":"Effects of scaffold shape on bone regeneration: tiny shape differences affect the entire system","volume":"16","author":"Hayashi","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.biomaterials.2026.124451_bib72","doi-asserted-by":"crossref","DOI":"10.1093\/rb\/rbac005","article-title":"Fabrication and biological evaluation of 3D-printed calcium phosphate ceramic scaffolds with distinct macroporous geometries through digital light processing technology","volume":"9","author":"Wang","year":"2022","journal-title":"Regen. Biomater."},{"key":"10.1016\/j.biomaterials.2026.124451_bib73","doi-asserted-by":"crossref","first-page":"420","DOI":"10.4028\/www.scientific.net\/KEM.631.420","article-title":"A histological and radiological study of bone formation around porous resorbable \u03b2-Tricalcium phosphate used as bone defect filling","volume":"631","author":"Strnadov\u00e1","year":"2014","journal-title":"KEM"},{"key":"10.1016\/j.biomaterials.2026.124451_bib74","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1111\/clr.14421","article-title":"Comparison of two different sizes of deproteinized bovine bone mineral particles in lateral sinus floor elevation with simultaneous implant placement: a radiographic study","volume":"36","author":"Qin","year":"2025","journal-title":"Clin. Oral Implants Res."},{"key":"10.1016\/j.biomaterials.2026.124451_bib75","doi-asserted-by":"crossref","first-page":"10","DOI":"10.2214\/AJR.19.21280","article-title":"Doppler flow measurement of lower extremity arteries adjusted by pulsatility index","volume":"214","author":"Liang","year":"2020","journal-title":"Am. J. Roentgenol."},{"key":"10.1016\/j.biomaterials.2026.124451_bib76","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmpb.2023.107823","article-title":"Modelling blood flow in coronary arteries: newtonian or shear-thinning non-newtonian rheology?","volume":"242","author":"De Nisco","year":"2023","journal-title":"Comput. Methods Progr. Biomed."},{"key":"10.1016\/j.biomaterials.2026.124451_bib77","article-title":"clusterProfiler 4.0: a universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation"},{"key":"10.1016\/j.biomaterials.2026.124451_bib78","doi-asserted-by":"crossref","DOI":"10.1093\/bioinformatics\/btad672","article-title":"aPEAR : an R package for autonomous visualization of pathway enrichment networks","volume":"39","author":"Kerseviciute","year":"2023","journal-title":"Bioinformatics"},{"key":"10.1016\/j.biomaterials.2026.124451_bib79","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0021800","article-title":"REVIGO summarizes and visualizes long lists of gene ontology terms","volume":"6","author":"Supek","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.biomaterials.2026.124451_bib80","first-page":"241","article-title":"Effects of the Non-Newtonian viscosity of blood on flows in a diseased arterial vessel. Part 1: steady flows","volume":"28","author":"Cho","year":"1991","journal-title":"BIRDING"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961226004758?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961226004758?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:40:03Z","timestamp":1787776803000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961226004758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":80,"alternative-id":["S0142961226004758"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2026.124451","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Self-organizing bioceramic granules with wave-dissipating architectures for bone void filling","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2026.124451","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"124451"}}