{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T02:31:06Z","timestamp":1793327466999,"version":"4.5.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,3,1]],"date-time":"2027-03-01T00:00:00Z","timestamp":1803859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,3,1]],"date-time":"2027-03-01T00:00:00Z","timestamp":1803859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,3,1]],"date-time":"2027-03-01T00:00:00Z","timestamp":1803859200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,3,1]],"date-time":"2027-03-01T00:00:00Z","timestamp":1803859200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,3,1]],"date-time":"2027-03-01T00:00:00Z","timestamp":1803859200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,3,1]],"date-time":"2027-03-01T00:00:00Z","timestamp":1803859200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,3,1]],"date-time":"2027-03-01T00:00:00Z","timestamp":1803859200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2026J009051"],"award-info":[{"award-number":["2026J009051"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2025J01087"],"award-info":[{"award-number":["2025J01087"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32501233"],"award-info":[{"award-number":["32501233"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271326"],"award-info":[{"award-number":["82271326"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82571456"],"award-info":[{"award-number":["82571456"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017686","name":"Fujian Provincial Health Technology Project","doi-asserted-by":"publisher","award":["2024CXA017"],"award-info":[{"award-number":["2024CXA017"]}],"id":[{"id":"10.13039\/501100017686","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2027,3]]},"DOI":"10.1016\/j.biomaterials.2026.124649","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:19:58Z","timestamp":1790137198000},"page":"124649","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"PA","title":["Neutrophil membrane-camouflaged ruthenium single-atom nanozymes precisely eliminate neutrophil extracellular traps to reprogram redox-immune microenvironment in intracerebral hemorrhage"],"prefix":"10.1016","volume":"338","author":[{"given":"Weijie","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengjun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingbo","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuting","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senlin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuxin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4747-9130","authenticated-orcid":false,"given":"Yang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanxiang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.biomaterials.2026.124649_bib1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41572-023-00424-7","article-title":"Intracerebral haemorrhage","volume":"9","author":"Puy","year":"2023","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"12","key":"10.1016\/j.biomaterials.2026.124649_bib2","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/s41582-024-01035-w","article-title":"Intracerebral haemorrhage \u2014 mechanisms, diagnosis and prospects for treatment and prevention","volume":"20","author":"Seiffge","year":"2024","journal-title":"Nat. Rev. Neurol."},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124649_bib3","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-54817-7","article-title":"NET formation-mediated in situ protein delivery to the inflamed central nervous system","volume":"15","author":"Wu","year":"2024","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124649_bib4","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1038\/s41467-020-16191-y","article-title":"Neutrophil extracellular traps released by neutrophils impair revascularization and vascular remodeling after stroke","volume":"11","author":"Kang","year":"2020","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124649_bib5","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1182\/blood.2020008913","article-title":"Neutrophil extracellular traps promote tPA-induced brain hemorrhage via cGAS in mice with stroke","volume":"138","author":"Wang","year":"2021","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.biomaterials.2026.124649_bib6","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202519865","article-title":"High-entropy alloy-based artificial enzymes with modulated D-Band center and pH-Controllable ROS biocatalysis for stage-specific treatment of inflammatory and infectious oral diseases","volume":"38","author":"Du","year":"2026","journal-title":"Adv. Mater."},{"issue":"13","key":"10.1016\/j.biomaterials.2026.124649_bib7","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1001\/jama.2019.2413","article-title":"Cerebral intraparenchymal hemorrhage: a review","volume":"321","author":"Gross","year":"2019","journal-title":"JAMA"},{"key":"10.1016\/j.biomaterials.2026.124649_bib8","article-title":"GPR110-Dependent macrophage polarization mediates the therapeutic effect of V-N3P single-atom catalyst in septic intestinal injury","author":"Wang","year":"2026","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124649_bib9","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1186\/s12951-025-03392-0","article-title":"Ultrasmall platinum single-atom enzyme alleviates oxidative stress and macrophage polarization induced by acute kidney ischemia\u2013reperfusion injury through inhibition of cell death storm","volume":"23","author":"Ye","year":"2025","journal-title":"J. Nanobiotechnol."},{"issue":"6245","key":"10.1016\/j.biomaterials.2026.124649_bib10","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1126\/science.aac7801","article-title":"Neutrophil-macrophage communication in inflammation and atherosclerosis","volume":"349","author":"Nahrendorf","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.biomaterials.2026.124649_bib11","article-title":"Microenvironment-responsive nanozyme for all stages of infectious chronic wound management through macrophage reprogramming","author":"Wu","year":"2026","journal-title":"Adv. Funct. Mater."},{"issue":"6","key":"10.1016\/j.biomaterials.2026.124649_bib12","doi-asserted-by":"crossref","first-page":"4357","DOI":"10.1021\/acs.chemrev.8b00672","article-title":"Nanozymes: classification, catalytic mechanisms, activity regulation, and applications","volume":"119","author":"Huang","year":"2019","journal-title":"Chem. Rev."},{"issue":"14","key":"10.1016\/j.biomaterials.2026.124649_bib13","doi-asserted-by":"crossref","first-page":"3683","DOI":"10.1039\/C8CS00718G","article-title":"Nanozyme: new horizons for responsive biomedical applications","volume":"48","author":"Jiang","year":"2019","journal-title":"Chem. Soc. Rev."},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124649_bib14","doi-asserted-by":"crossref","first-page":"7127","DOI":"10.1038\/s41467-023-42889-w","article-title":"Bioinspired porous three-coordinated single-atom Fe nanozyme with oxidase-like activity for tumor visual identification via glutathione","volume":"14","author":"Chen","year":"2023","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124649_bib15","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/s41467-023-44463-w","article-title":"A natural biogenic nanozyme for scavenging superoxide radicals","volume":"15","author":"Ma","year":"2024","journal-title":"Nat. Commun."},{"issue":"16","key":"10.1016\/j.biomaterials.2026.124649_bib16","doi-asserted-by":"crossref","first-page":"13424","DOI":"10.1021\/jacs.5c00100","article-title":"Enzyme-mimic activities of RuCo bimetallic nanosheets for inflammatory bowel disease treatment","volume":"147","author":"Chen","year":"2025","journal-title":"J. Am. Chem. Soc."},{"issue":"36","key":"10.1016\/j.biomaterials.2026.124649_bib17","article-title":"Ultrasmall coordination polymer nanodots Fe-Quer nanozymes for preventing and delaying the development and progression of diabetic retinopathy","volume":"33","author":"Gui","year":"2023","journal-title":"Adv. Funct. Mater."},{"issue":"42","key":"10.1016\/j.biomaterials.2026.124649_bib18","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202002439","article-title":"GSH-depleted nanozymes with hyperthermia-enhanced dual enzyme-mimic activities for tumor nanocatalytic therapy","volume":"32","author":"Dong","year":"2020","journal-title":"Adv. Mater."},{"issue":"6","key":"10.1016\/j.biomaterials.2026.124649_bib19","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202409840","article-title":"Engineering mild-photothermal responsive and NO donor prussian blue nanozymes using mild synthesis for inflammation regulation and bacterial eradication in periodontal disease","volume":"37","author":"Li","year":"2025","journal-title":"Adv. Mater."},{"issue":"2","key":"10.1016\/j.biomaterials.2026.124649_bib20","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202308477","article-title":"A cardiac-targeted nanozyme interrupts the inflammation-free radical cycle in myocardial infarction","volume":"36","author":"Liu","year":"2024","journal-title":"Adv. Mater."},{"issue":"30","key":"10.1016\/j.biomaterials.2026.124649_bib21","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202419673","article-title":"Engineered nanozymes with asymmetric mn\u2500o\u2500ce sites for intratumorally leveraged multimode therapy","volume":"37","author":"Ye","year":"2025","journal-title":"Adv. Mater."},{"issue":"10","key":"10.1016\/j.biomaterials.2026.124649_bib22","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202210848","article-title":"Machine-learning-assisted nanozyme design: lessons from materials and engineered enzymes","volume":"36","author":"Zhuang","year":"2024","journal-title":"Adv. Mater."},{"issue":"36","key":"10.1016\/j.biomaterials.2026.124649_bib23","doi-asserted-by":"crossref","first-page":"12624","DOI":"10.1002\/anie.201904751","article-title":"A nanozyme with photo-enhanced dual enzyme-like activities for deep pancreatic cancer therapy","volume":"58","author":"Li","year":"2019","journal-title":"Angew. Chem. Int. Ed."},{"issue":"4","key":"10.1016\/j.biomaterials.2026.124649_bib24","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202416686","article-title":"Mn\u2212Ce symbiosis: nanozymes with multiple active sites facilitate scavenging of Reactive Oxygen Species (ROS) based on electron transfer and confinement anchoring","volume":"64","author":"Zhang","year":"2025","journal-title":"Angew. Chem. Int. Ed."},{"issue":"7","key":"10.1016\/j.biomaterials.2026.124649_bib25","doi-asserted-by":"crossref","first-page":"7515","DOI":"10.1021\/jacs.5c20880","article-title":"Radio-activable gold-single-atom-based artificial enzymes with Cascade biocatalysis and enhanced radiosensitization to prevent metastasis and recurrence in malignancies","volume":"148","author":"Zhu","year":"2026","journal-title":"J. Am. Chem. Soc."},{"issue":"2","key":"10.1016\/j.biomaterials.2026.124649_bib26","article-title":"Enzyme-reaction-system inspired nanobiocatalysts for bioadaptively eradicating primary and metastatic cancers","volume":"2","author":"Xiao","year":"2026","journal-title":"Cell Biomater"},{"issue":"30","key":"10.1016\/j.biomaterials.2026.124649_bib27","doi-asserted-by":"crossref","first-page":"16835","DOI":"10.1021\/jacs.3c05162","article-title":"Dimensionality engineering of single-atom nanozyme for efficient peroxidase-mimicking","volume":"145","author":"Li","year":"2023","journal-title":"J. Am. Chem. Soc."},{"issue":"48","key":"10.1016\/j.biomaterials.2026.124649_bib28","doi-asserted-by":"crossref","first-page":"33239","DOI":"10.1021\/jacs.4c13335","article-title":"Axial chlorination engineering of single-atom nanozyme: Fe-N4Cl catalytic sites for efficient peroxidase-mimicking","volume":"146","author":"Wei","year":"2024","journal-title":"J. Am. Chem. Soc."},{"issue":"36","key":"10.1016\/j.biomaterials.2026.124649_bib29","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202002246","article-title":"Bioinspired copper single-atom catalysts for tumor parallel catalytic therapy","volume":"32","author":"Lu","year":"2020","journal-title":"Adv. Mater."},{"issue":"15","key":"10.1016\/j.biomaterials.2026.124649_bib30","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202107088","article-title":"A bioinspired five-coordinated single-atom iron nanozyme for tumor catalytic therapy","volume":"34","author":"Xu","year":"2022","journal-title":"Adv. Mater."},{"issue":"13","key":"10.1016\/j.biomaterials.2026.124649_bib31","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202312024","article-title":"Engineering atomically dispersed Cu\u2013N1S2 sites via chemical vapor deposition to boost enzyme-like activity for efficient tumor therapy","volume":"36","author":"Xu","year":"2024","journal-title":"Adv. Mater."},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124649_bib32","doi-asserted-by":"crossref","first-page":"4744","DOI":"10.1038\/s41467-022-32411-z","article-title":"Single-atom nanozymes catalytically surpassing naturally occurring enzymes as sustained stitching for brain trauma","volume":"13","author":"Zhang","year":"2022","journal-title":"Nat. Commun."},{"issue":"21","key":"10.1016\/j.biomaterials.2026.124649_bib33","doi-asserted-by":"crossref","first-page":"15449","DOI":"10.1021\/acsnano.6c03635","article-title":"Asymmetrically coordinated Cu single-atom nanozyme to accelerate inflammation and immune homeostasis modulation in acute myocardial infarction","volume":"20","author":"Lin","year":"2026","journal-title":"ACS Nano"},{"issue":"5","key":"10.1016\/j.biomaterials.2026.124649_bib34","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/s41929-021-00609-x","article-title":"Matching the kinetics of natural enzymes with a single-atom iron nanozyme","volume":"4","author":"Ji","year":"2021","journal-title":"Nat. Catal."},{"issue":"7","key":"10.1016\/j.biomaterials.2026.124649_bib35","doi-asserted-by":"crossref","first-page":"4279","DOI":"10.1021\/jacs.2c13597","article-title":"Coordination-driven self-assembly strategy-activated Cu single-atom nanozymes for catalytic tumor-specific therapy","volume":"145","author":"Zhou","year":"2023","journal-title":"J. Am. Chem. Soc."},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124649_bib36","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/s41467-019-14199-7","article-title":"Self-assembled single-atom nanozyme for enhanced photodynamic therapy treatment of tumor","volume":"11","author":"Wang","year":"2020","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124649_bib37","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-54868-w","article-title":"A bioinspired sulfur\u2013Fe\u2013heme nanozyme with selective peroxidase-like activity for enhanced tumor chemotherapy","volume":"15","author":"Zhang","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biomaterials.2026.124649_bib38","article-title":"Microglial membranes wrapped ultrasmall medium-entropy Ru single-atom nanozyme: enhanced catalysis for accelerating inflammation\/redox microenvironment regulation in intracerebral hemorrhage","author":"Li","year":"2026","journal-title":"Adv. Sci."},{"key":"10.1016\/j.biomaterials.2026.124649_bib39","article-title":"Targeting gasdermin D-Mediated pyroptosis with microglial membrane-coated single-atom nanozymes for immune microenvironment reprogramming and early brain injury mitigation after subarachnoid hemorrhage","author":"Hu","year":"2026","journal-title":"Adv. Functi. Mater."},{"key":"10.1016\/j.biomaterials.2026.124649_bib40","article-title":"Oxygen vacancy-enriched platinum single-atom nanozyme wrapped in nanoislands: unlocking catalytic activity and reprogramming redox microenvironment for osteonecrosis repair","author":"Zhu","year":"2026","journal-title":"Adv. Sci."}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961226006733?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961226006733?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T01:39:19Z","timestamp":1793324359000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961226006733"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,3]]},"references-count":40,"alternative-id":["S0142961226006733"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2026.124649","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2027,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neutrophil membrane-camouflaged ruthenium single-atom nanozymes precisely eliminate neutrophil extracellular traps to reprogram redox-immune microenvironment in intracerebral hemorrhage","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2026.124649","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"124649"}}