{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T05:32:39Z","timestamp":1793770359066,"version":"4.6.1"},"reference-count":172,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,3,1]],"date-time":"2027-03-01T00:00:00Z","timestamp":1803859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,3,1]],"date-time":"2027-03-01T00:00:00Z","timestamp":1803859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2027,3]]},"DOI":"10.1016\/j.biomaterials.2026.124695","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:17:41Z","timestamp":1791818261000},"page":"124695","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"PB","title":["Engineering biomaterials to improve cytokine therapies for wound healing"],"prefix":"10.1016","volume":"338","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5417-8205","authenticated-orcid":false,"given":"Isabella","family":"Horton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3560-9751","authenticated-orcid":false,"given":"Katharina","family":"Maisel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2587-8330","authenticated-orcid":false,"given":"Kaitlyn","family":"Sadtler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biomaterials.2026.124695_bib1","series-title":"Janeway's Immunbiology","first-page":"110","author":"Kenneth Murphy","year":"2022"},{"issue":"10","key":"10.1016\/j.biomaterials.2026.124695_bib2","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/s41573-023-00746-x","article-title":"Strategies to therapeutically modulate cytokine action","volume":"22","author":"Leonard","year":"2023","journal-title":"Nat. Rev. Drug Discov."},{"issue":"9","key":"10.1016\/j.biomaterials.2026.124695_bib3","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.15252\/emmm.201606413","article-title":"IFN\u03bb is a potent anti\u2010influenza therapeutic without the inflammatory side effects of IFN\u03b1 treatment","volume":"8","author":"Davidson","year":"2016","journal-title":"EMBO Mol. Med."},{"issue":"5","key":"10.1016\/j.biomaterials.2026.124695_bib4","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1080\/14712598.2023.2211709","article-title":"Interferon lambda as a potential treatment for COVID-19","volume":"23","author":"McCarthy","year":"2023","journal-title":"Expert Opin. Biol. Ther."},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124695_bib5","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41573-022-00557-6","article-title":"Emerging principles of cytokine pharmacology and therapeutics","volume":"22","author":"Saxton","year":"2023","journal-title":"Nat. Rev. Drug Discov."},{"issue":"5","key":"10.1016\/j.biomaterials.2026.124695_bib6","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/wrr.12205","article-title":"Clinical application of growth factors and cytokines in wound healing","volume":"22","author":"Barrientos","year":"2014","journal-title":"Wound Repair Regen."},{"issue":"16_suppl","key":"10.1016\/j.biomaterials.2026.124695_bib7","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.2022.40.16_suppl.4508","article-title":"Final clinical results of pivotal trial of IL-15R\u03b1Fc superagonist N-803 with BCG in BCG-unresponsive CIS and papillary nonmuscle-invasive bladder cancer (NMIBC)","volume":"40","author":"Chamie","year":"2022","journal-title":"J. Clin. Oncol."},{"issue":"11","key":"10.1016\/j.biomaterials.2026.124695_bib8","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s40264-014-0226-z","article-title":"Side effects of cytokines approved for therapy","volume":"37","author":"Baldo","year":"2014","journal-title":"Drug Saf."},{"issue":"3","key":"10.1016\/j.biomaterials.2026.124695_bib9","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/wrr.12043","article-title":"Interleukin\u201010 reduces scar formation in both animal and human cutaneous wounds: results of two preclinical and phase <scp>II<\/scp> randomized control studies","volume":"21","author":"Kieran","year":"2013","journal-title":"Wound Repair Regen."},{"key":"10.1016\/j.biomaterials.2026.124695_bib138","article-title":"Safety profile for the clinical use of bone morphogenetic proteins in the spine","volume":"27","author":"L","year":"2002","journal-title":"Spine"},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124695_bib139","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1172\/JCI2237","article-title":"Osteogenic protein-1 (bone morphogenetic protein-7) reduces severity of injury after ischemic acute renal failure in rat","volume":"102","author":"Vukicevic","year":"1998","journal-title":"J. Clin. Investig."},{"issue":"10","key":"10.1016\/j.biomaterials.2026.124695_bib140","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1111\/j.1440-1681.1992.tb00402.x","article-title":"Origin of urinary epidermal growth factor in humans: excretion of endogenous EGF and infused [131I]\u2010HUMAN EGF and kidney histochemistry","volume":"19","author":"Lev\u2010Ran","year":"1992","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"issue":"3","key":"10.1016\/j.biomaterials.2026.124695_bib141","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s00228-005-0896-7","article-title":"The pharmacokinetics of erythropoietin in the cerebrospinal fluid after intravenous administration of recombinant human erythropoietin","volume":"61","author":"Xenocostas","year":"2005","journal-title":"Eur. J. Clin. Pharmacol."},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124695_bib142","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-89229-w","article-title":"Half-life modeling of basic fibroblast growth factor released from growth factor-eluting polyelectrolyte multilayers","volume":"11","author":"Ding","year":"2021","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.biomaterials.2026.124695_bib143","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1172\/JCI23606","article-title":"FGF-21 as a novel metabolic regulator","volume":"115","author":"Kharitonenkov","year":"2005","journal-title":"J. Clin. Investig."},{"issue":"6","key":"10.1016\/j.biomaterials.2026.124695_bib144","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.1210\/jc.2006-2865","article-title":"Determination of the elimination half-life of fibroblast growth Factor-23","volume":"92","author":"Khosravi","year":"2007","journal-title":"J. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.biomaterials.2026.124695_bib145","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.jconrel.2022.06.024","article-title":"Development of an extended half-life GM-CSF fusion protein for parkinson's disease","volume":"348","author":"Yeapuri","year":"2022","journal-title":"J. Contr. Release"},{"issue":"5","key":"10.1016\/j.biomaterials.2026.124695_bib146","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/clpt.1984.101","article-title":"Interferon kinetics and adverse reactions after intravenous, intramuscular, and subcutaneous injection","volume":"35","author":"Wills","year":"1984","journal-title":"Clin. Pharmacol. Therapeut."},{"issue":"5","key":"10.1016\/j.biomaterials.2026.124695_bib147","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1002\/j.1552-4604.1987.tb03044.x","article-title":"Pharmacokinetics of interferon \u03b1\u20102b in healthy volunteers","volume":"27","author":"Radwanski","year":"1987","journal-title":"J. Clin. Pharmacol."},{"issue":"27","key":"10.1016\/j.biomaterials.2026.124695_bib148","doi-asserted-by":"crossref","first-page":"16139","DOI":"10.1074\/jbc.271.27.16139","article-title":"Heparin decreases the blood clearance of Interferon-\u03b3 and increases its activity by limiting the processing of its carboxyl-terminal sequence","volume":"271","author":"Lortat-Jacob","year":"1996","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.biomaterials.2026.124695_bib149","first-page":"753","article-title":"Insulin-like growth factors I and II in healthy man","volume":"121","author":"Guler","year":"1989","journal-title":"Acta Endocrinol."},{"issue":"2","key":"10.1016\/j.biomaterials.2026.124695_bib150","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0009-9236(97)90065-5","article-title":"Pharmacodynamics of subcutaneous recombinant human interleukin-10 in healthy volunteers","volume":"62","author":"Huhn","year":"1997","journal-title":"Clin. Pharmacol. Therapeut."},{"issue":"2","key":"10.1016\/j.biomaterials.2026.124695_bib151","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0168-8278(00)80078-1","article-title":"A phase I\/II study of recombinant human interleukin-12 in patients with chronic hepatitis B","volume":"32","author":"Carre\u00f1o","year":"2000","journal-title":"J. Hepatol."},{"issue":"3","key":"10.1016\/j.biomaterials.2026.124695_bib152","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.immuni.2016.02.007","article-title":"Intestinal Interleukin-17 receptor signaling mediates reciprocal control of the Gut Microbiota and autoimmune inflammation","volume":"44","author":"Kumar","year":"2016","journal-title":"Immunity"},{"issue":"4","key":"10.1016\/j.biomaterials.2026.124695_bib153","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1128\/CDLI.9.4.777-783.2002","article-title":"Interleukin-18 induces acute biphasic reduction in the levels of circulating leukocytes in mice","volume":"9","author":"Hosohara","year":"2002","journal-title":"Clin. Vaccine Immunol."},{"issue":"7","key":"10.1016\/j.biomaterials.2026.124695_bib154","first-page":"2009","article-title":"Pharmacokinetics of Recombinant Interleukin 2 in Humans","volume":"50","author":"Konrad","year":"1990","journal-title":"Cancer Res."},{"issue":"12","key":"10.1016\/j.biomaterials.2026.124695_bib155","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1200\/JCO.2007.14.5193","article-title":"Phase I Study of recombinant Interleukin-21 in patients with metastatic Melanoma and renal cell carcinoma","volume":"26","author":"Thompson","year":"2008","journal-title":"J. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124695_bib156","first-page":"31","article-title":"Interleukin-4 (B-cell stimulatory factor-1) augments the in vivo generation of cytotoxic cells in immunosuppressed animals","volume":"1","author":"Conlon","year":"1989","journal-title":"Biotechnol. Therapeut."},{"issue":"2","key":"10.1016\/j.biomaterials.2026.124695_bib157","doi-asserted-by":"crossref","first-page":"80","DOI":"10.5625\/lar.2018.34.2.80","article-title":"Elimination half-lives of interleukin-6 and cytokine-induced neutrophil chemoattractant-1 synthesized in response to inflammatory stimulation in rats","volume":"34","author":"Kuribayashi","year":"2018","journal-title":"Laboratory Animal Research"},{"issue":"2","key":"10.1016\/j.biomaterials.2026.124695_bib158","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1158\/1078-0432.CCR-09-1303","article-title":"Phase I study of recombinant human Interleukin-7 administration in subjects with refractory malignancy","volume":"16","author":"Sport\u00e8s","year":"2010","journal-title":"Clin. Cancer Res."},{"issue":"3","key":"10.1016\/j.biomaterials.2026.124695_bib159","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1002\/jcp.1041480315","article-title":"Clearance and fate of leukemia\u2010inhibitory factor (LIF) after injection into mice","volume":"148","author":"Hilton","year":"1991","journal-title":"J. Cell. Physiol."},{"issue":"6","key":"10.1016\/j.biomaterials.2026.124695_bib160","doi-asserted-by":"crossref","first-page":"963","DOI":"10.2967\/jnumed.107.050054","article-title":"Quantitation of CXCR4 expression in myocardial infarction using 99mTc-Labeled SDF-1\u03b1","volume":"49","author":"Misra","year":"2008","journal-title":"J. Nucl. Med."},{"issue":"3","key":"10.1016\/j.biomaterials.2026.124695_bib161","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1172\/JCI113130","article-title":"Hepatic processing of transforming growth factor beta in the rat. Uptake, metabolism, and biliary excretion","volume":"80","author":"Coffey","year":"1987","journal-title":"J. Clin. Investig."},{"issue":"9","key":"10.1016\/j.biomaterials.2026.124695_bib162","first-page":"1180","article-title":"Pharmacokinetics of tumor necrosis factor alpha after intravenous administration in rats. Dose dependence and influence of tumor necrosis factor beta","volume":"39","author":"Zahn","year":"1989","journal-title":"Arzneimittelforschung"},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124695_bib163","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1067\/mcp.2002.126179","article-title":"A target\u2010mediated model to describe the pharmacokinetics and hemodynamic effects of recombinant human vascular endothelial growth factor in humans","volume":"72","author":"Eppler","year":"2002","journal-title":"Clin. Pharmacol. Therapeut."},{"key":"10.1016\/j.biomaterials.2026.124695_bib10","series-title":"Multifarious Determinants of Cytokine Receptor Signaling Specificity","first-page":"1","author":"Moraga","year":"2014"},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124695_bib11","doi-asserted-by":"crossref","first-page":"13","DOI":"10.4062\/biomolther.2023.196","article-title":"Current development status of cytokines for cancer immunotherapy","volume":"32","author":"Song","year":"2024","journal-title":"Biomol Ther (Seoul)"},{"issue":"6515","key":"10.1016\/j.biomaterials.2026.124695_bib12","doi-asserted-by":"crossref","DOI":"10.1126\/science.abd4585","article-title":"Autoantibodies against type I IFNs in patients with life-threatening COVID-19","volume":"370","author":"Bastard","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.biomaterials.2026.124695_bib13","series-title":"Guardians at the Gate: Unraveling Type I Interferon's Role and Challenges Posed by Anti-interferon Antibodies in COVID-19","first-page":"135","author":"Aljabali","year":"2025"},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124695_bib14","doi-asserted-by":"crossref","DOI":"10.1186\/s12985-023-01989-1","article-title":"The detectable anti-interferon-\u03b3 autoantibodies in COVID-19 patients may be associated with disease severity","volume":"20","author":"Chen","year":"2023","journal-title":"Virol. J."},{"issue":"4","key":"10.1016\/j.biomaterials.2026.124695_bib15","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/s44222-023-00030-y","article-title":"Engineering cytokine therapeutics","volume":"1","author":"Deckers","year":"2023","journal-title":"Nat. Rev. Bioeng."},{"issue":"8","key":"10.1016\/j.biomaterials.2026.124695_bib16","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a041234","article-title":"Growth factor and cytokine delivery systems for wound healing","volume":"14","author":"Legrand","year":"2022","journal-title":"Cold Spring Harbor Perspect. Biol."},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124695_bib17","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/imr.13234","article-title":"Spatiotemporally programming cytokine immunotherapies through protein engineering","volume":"320","author":"Santollani","year":"2023","journal-title":"Immunol. Rev."},{"issue":"8","key":"10.1016\/j.biomaterials.2026.124695_bib18","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1039\/D4BM01051E","article-title":"Development of a VEGF-activated scaffold with enhanced angiogenic and neurogenic properties for chronic wound healing applications","volume":"13","author":"Palomeque Ch\u00e1vez","year":"2025","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.biomaterials.2026.124695_bib19","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jconrel.2018.05.035","article-title":"Lipid nanoparticles with minimum burst release of TNF-\u03b1 siRNA show strong activity against rheumatoid arthritis unresponsive to methotrexate","volume":"283","author":"Aldayel","year":"2018","journal-title":"J. Contr. Release"},{"issue":"8","key":"10.1016\/j.biomaterials.2026.124695_bib20","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1016\/j.ymthe.2019.05.002","article-title":"Lipidoid-siRNA nanoparticle-mediated IL-1\u03b2 gene silencing for systemic arthritis therapy in a mouse model","volume":"27","author":"Song","year":"2019","journal-title":"Mol. Ther."},{"key":"10.1016\/j.biomaterials.2026.124695_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.111164","article-title":"Biomimetic nanoparticles of platelet membranes carrying bFGF and VEGFA genes promote deep burn wound healing","volume":"125","author":"Wang","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.biomaterials.2026.124695_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123869","article-title":"Macrophage cell therapy enabled by interleukin-4 mRNA-loaded lipid nanoparticles to sustain a pro-reparative phenotype in inflammatory injuries","volume":"328","author":"O'Brien","year":"2026","journal-title":"Biomaterials"},{"issue":"5","key":"10.1016\/j.biomaterials.2026.124695_bib23","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1177\/0883911511420700","article-title":"Encapsulation of adipose-derived stem cells and transforming growth factor-\u03b21 in carrageenan-based hydrogels for cartilage tissue engineering","volume":"26","author":"Rocha","year":"2011","journal-title":"J. Bioact. Compat Polym."},{"issue":"11","key":"10.1016\/j.biomaterials.2026.124695_bib24","doi-asserted-by":"crossref","first-page":"2902","DOI":"10.3390\/biomedicines10112902","article-title":"PLGA\/Gelatin\/Hyaluronic acid fibrous membrane scaffold for therapeutic delivery of adipose-derived stem cells to promote wound healing","volume":"10","author":"Hsieh","year":"2022","journal-title":"Biomedicines"},{"issue":"5","key":"10.1016\/j.biomaterials.2026.124695_bib25","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.jcyt.2025.01.001","article-title":"Effects of a PDGF-stem cell-hydrogel compound on skin wound healing in mice","volume":"27","author":"Lin","year":"2025","journal-title":"Cytotherapy"},{"issue":"11","key":"10.1016\/j.biomaterials.2026.124695_bib26","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1089\/wound.2020.1183","article-title":"Advancements in the delivery of growth factors and cytokines for the treatment of cutaneous wound indications","volume":"10","author":"Berry-Kilgour","year":"2021","journal-title":"Adv. Wound Care"},{"key":"10.1016\/j.biomaterials.2026.124695_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2022.114541","article-title":"Cytokine conjugates to elastin-like polypeptides","volume":"190","author":"Gong","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"2","key":"10.1016\/j.biomaterials.2026.124695_bib28","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1097\/01.BCR.0000111766.97335.34","article-title":"Cytokines and wound healing: the role of cytokine and anticytokine therapy in the repair response","volume":"25","author":"Efron","year":"2004","journal-title":"J. Burn Care Rehabil."},{"key":"10.1016\/j.biomaterials.2026.124695_bib29","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.addr.2018.04.008","article-title":"Drug delivery systems and materials for wound healing applications","volume":"127","author":"Saghazadeh","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.biomaterials.2026.124695_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2023.154528","article-title":"Cytokine sustained delivery for cancer therapy; special focus on stem cell- and biomaterial- based delivery methods","volume":"247","author":"Mehralizadeh","year":"2023","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.biomaterials.2026.124695_bib31","series-title":"Annual Review of Cancer Biology","article-title":"Natural and engineered cytokines as cancer therapeutics","author":"O'Neal","year":"2025"},{"key":"10.1016\/j.biomaterials.2026.124695_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2022.114112","article-title":"Engineering interferons and interleukins for cancer immunotherapy","volume":"182","author":"Holder","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"8","key":"10.1016\/j.biomaterials.2026.124695_bib33","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/nbt.4181","article-title":"Enhancing T cell therapy through TCR-signaling-responsive nanoparticle drug delivery","volume":"36","author":"Tang","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.biomaterials.2026.124695_bib34","article-title":"siRNA-based nanotherapeutic approaches for targeted delivery in rheumatoid arthritis","volume":"168","author":"Sawan","year":"2025","journal-title":"Biomater. Adv."},{"issue":"7","key":"10.1016\/j.biomaterials.2026.124695_bib35","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201703178","article-title":"Cytokine secreting microparticles engineer the fate and the effector functions of t\u2010cells","volume":"30","author":"Majedi","year":"2018","journal-title":"Adv. Mater."},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124695_bib36","doi-asserted-by":"crossref","DOI":"10.1186\/s40360-025-00937-9","article-title":"The safety, tolerability, pharmacokinetics, and pharmacodynamics of nebulized pegylated interferon \u03b1-2b in healthy adults: a randomized phase 1 trial","volume":"26","author":"Huang","year":"2025","journal-title":"BMC Pharmacology and Toxicology"},{"issue":"20","key":"10.1016\/j.biomaterials.2026.124695_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/app10207098","article-title":"Nanotechnology solutions for controlled cytokine delivery: an applied perspective","volume":"10","author":"Goncalves","year":"2020","journal-title":"Appl. Sci."},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124695_bib38","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1023\/A:1007514424253","article-title":"Liposomes containing interferon-gamma as adjuvant in tumor cell vaccines","volume":"17","author":"Van Slooten","year":"2000","journal-title":"Pharm. Res."},{"issue":"6","key":"10.1016\/j.biomaterials.2026.124695_bib39","doi-asserted-by":"crossref","first-page":"709","DOI":"10.3390\/pharmaceutics17060709","article-title":"A pH-Responsive poly beta-amino ester nanoparticulate thermo-responsive PEG-PCL-PEG hydrogel dispersed system for the delivery of interferon alpha to the ocular surface","volume":"17","author":"Abdalla","year":"2025","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.biomaterials.2026.124695_bib40","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/s41563-025-02390-9","article-title":"IL-12-releasing nanoparticles for effective immunotherapy of metastatic ovarian cancer","volume":"25","author":"Pires","year":"2025","journal-title":"Nat. Mater."},{"key":"10.1016\/j.biomaterials.2026.124695_bib41","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.biomaterials.2015.03.044","article-title":"Myelin repair in vivo is increased by targeting oligodendrocyte precursor cells with nanoparticles encapsulating leukaemia inhibitory factor (LIF)","volume":"56","author":"Rittchen","year":"2015","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124695_bib42","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1021\/mp100203a","article-title":"Modulation of CD4+ T lymphocyte lineage outcomes with targeted, nanoparticle-mediated cytokine delivery","volume":"8","author":"Park","year":"2011","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.biomaterials.2026.124695_bib43","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2025.1508172","article-title":"Severe soft tissue injuries in multiple trauma patients\u2014a challenge we can meet? A matched-pair analysis from the TraumaRegister DGU\u00ae","volume":"12","author":"Kirsten","year":"2025","journal-title":"Front. Med."},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124695_bib44","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/s41563-023-01689-9","article-title":"Pro-regenerative biomaterials recruit immunoregulatory dendritic cells after traumatic injury","volume":"23","author":"Lokwani","year":"2024","journal-title":"Nat. Mater."},{"key":"10.1016\/j.biomaterials.2026.124695_bib49","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.01059","article-title":"Origin and evolution of dendritic epidermal T cells","volume":"9","author":"Sutoh","year":"2018","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.biomaterials.2026.124695_bib45","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/s41590-018-0064-8","article-title":"Innate immune responses to trauma","volume":"19","author":"Huber-Lang","year":"2018","journal-title":"Nat. Immunol."},{"issue":"5","key":"10.1016\/j.biomaterials.2026.124695_bib46","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1177\/147323000903700531","article-title":"The wound healing process: an overview of the cellular and molecular mechanisms","volume":"37","author":"Velnar","year":"2009","journal-title":"J. Int. Med. Res."},{"issue":"2","key":"10.1016\/j.biomaterials.2026.124695_bib47","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1089\/wound.2014.0608","article-title":"The innate immune system in acute and chronic wounds","volume":"5","author":"MacLeod","year":"2016","journal-title":"Adv. Wound Care"},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124695_bib48","doi-asserted-by":"crossref","DOI":"10.1038\/s41392-023-01653-8","article-title":"\u03b3\u03b4 T cells: origin and fate, subsets, diseases and immunotherapy","volume":"8","author":"Hu","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"2","key":"10.1016\/j.biomaterials.2026.124695_bib50","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/exd.13115","article-title":"IL-17A promotes neutrophilic inflammation and disturbs acute wound healing in skin","volume":"26","author":"Takagi","year":"2017","journal-title":"Exp. Dermatol."},{"issue":"15","key":"10.1016\/j.biomaterials.2026.124695_bib51","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1042\/CS20220531","article-title":"M1\/M2 macrophages and their overlaps \u2013 myth or reality?","volume":"137","author":"Strizova","year":"2023","journal-title":"Clin. Sci."},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124695_bib52","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","article-title":"Macrophage activation and polarization: nomenclature and experimental guidelines","volume":"41","author":"Peter","year":"2014","journal-title":"Immunity"},{"issue":"6","key":"10.1016\/j.biomaterials.2026.124695_bib53","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/cr.2015.58","article-title":"Combination of inflammation-related cytokines promotes long-term muscle stem cell expansion","volume":"25","author":"Fu","year":"2015","journal-title":"Cell Res."},{"key":"10.1016\/j.biomaterials.2026.124695_bib54","doi-asserted-by":"crossref","first-page":"233","DOI":"10.37349\/ei.2023.00100","article-title":"Immune response: the achilles' heel of the stem cell-based regenerative therapies","author":"Oliveira","year":"2023","journal-title":"Exploration of Immunology"},{"issue":"7","key":"10.1016\/j.biomaterials.2026.124695_bib55","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1089\/wound.2017.0761","article-title":"Immune regulation of skin wound healing: mechanisms and novel therapeutic targets","volume":"7","author":"Larouche","year":"2018","journal-title":"Adv. Wound Care"},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124695_bib56","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-08398-4","article-title":"Anti-inflammatory effects of mesenchymal stem cell-conditioned media inhibited macrophages activation in vitro","volume":"12","author":"Jin","year":"2022","journal-title":"Sci. Rep."},{"issue":"16","key":"10.1016\/j.biomaterials.2026.124695_bib57","doi-asserted-by":"crossref","first-page":"3932","DOI":"10.3390\/ijms20163932","article-title":"Interleukin 4 moderately affects competence of pluripotent stem cells for myogenic conversion","volume":"20","author":"\u015awierczek-Lasek","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.biomaterials.2026.124695_bib58","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1016\/j.jaci.2011.01.049","article-title":"IL-4 induces differentiation of human embryonic stem cells into fibrogenic fibroblast-like cells","volume":"127","author":"Sato","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"issue":"7","key":"10.1016\/j.biomaterials.2026.124695_bib59","doi-asserted-by":"crossref","DOI":"10.1096\/fj.201901024RR","article-title":"IL\u201010 promotes endothelial progenitor cell infiltration and wound healing via STAT3","volume":"36","author":"Short","year":"2022","journal-title":"FASEB J."},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124695_bib60","article-title":"Overexpression of IL\u201010 in adipose mesenchymal stem cells promotes wound healing in diabetic mice","volume":"2026","author":"Zhao","year":"2026","journal-title":"Stem Cell. Int."},{"issue":"2","key":"10.1016\/j.biomaterials.2026.124695_bib61","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/wrr.12398","article-title":"Transforming growth factor beta (TGF-\u03b2) isoforms in wound healing and fibrosis","volume":"24","author":"Lichtman","year":"2016","journal-title":"Wound Repair Regen."},{"issue":"12","key":"10.1016\/j.biomaterials.2026.124695_bib62","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.addr.2012.03.004","article-title":"Growth factor delivery: how surface interactions modulate release in vitro and in vivo","volume":"64","author":"King","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.biomaterials.2026.124695_bib63","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.matbio.2024.08.006","article-title":"Collagen VIII in vascular diseases","volume":"133","author":"Li","year":"2024","journal-title":"Matrix Biol."},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124695_bib64","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1089\/wound.2014.0595","article-title":"Topical collagen-based biomaterials for chronic wounds: rationale and clinical application","volume":"5","author":"Gould","year":"2016","journal-title":"Adv. Wound Care"},{"issue":"4","key":"10.1016\/j.biomaterials.2026.124695_bib65","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0032875","article-title":"Skin regeneration in adult axolotls: a blueprint for scar-free healing in vertebrates","volume":"7","author":"Seifert","year":"2012","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.biomaterials.2026.124695_bib66","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1002\/jmor.20155","article-title":"Skin wound healing in different aged Xenopus laevis","volume":"274","author":"Bertolotti","year":"2013","journal-title":"J. Morphol."},{"issue":"7","key":"10.1016\/j.biomaterials.2026.124695_bib67","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1002\/dvdy.178","article-title":"Wound healing across the animal kingdom: crosstalk between the immune system and the extracellular matrix","volume":"249","author":"Arenas G\u00f3mez","year":"2020","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.biomaterials.2026.124695_bib68","doi-asserted-by":"crossref","unstructured":"L. Qi, C. Zhang, B. Wang, J. Yin, S. Yan, Progress in hydrogels for skin wound repair, Macromol. Biosci. 22(7).","DOI":"10.1002\/mabi.202100475"},{"key":"10.1016\/j.biomaterials.2026.124695_bib69","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.cobme.2019.04.004","article-title":"Engineering biomimetic and instructive materials for wound healing and regeneration","volume":"10","author":"Chantre","year":"2019","journal-title":"Current Opinion in Biomedical Engineering"},{"key":"10.1016\/j.biomaterials.2026.124695_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122141","article-title":"Snail-inspired AFG\/GelMA hydrogel accelerates diabetic wound healing via inflammatory cytokines suppression and macrophage polarization","volume":"299","author":"Zhou","year":"2023","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.biomaterials.2026.124695_bib71","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1524-475X.2007.00211.x","article-title":"Release of basic fibroblast growth factor from a crosslinked glycosaminoglycan hydrogel promotes wound healing","volume":"15","author":"Liu","year":"2007","journal-title":"Wound Repair Regen."},{"issue":"31","key":"10.1016\/j.biomaterials.2026.124695_bib72","doi-asserted-by":"crossref","first-page":"7985","DOI":"10.1016\/j.biomaterials.2010.07.021","article-title":"FGF-2 and VEGF functionalization of starPEG\u2013heparin hydrogels to modulate biomolecular and physical cues of angiogenesis","volume":"31","author":"Zieris","year":"2010","journal-title":"Biomaterials"},{"issue":"19","key":"10.1016\/j.biomaterials.2026.124695_bib73","doi-asserted-by":"crossref","first-page":"4792","DOI":"10.1016\/j.biomaterials.2012.03.039","article-title":"Sustained delivery of SDF-1\u03b1 from heparin-based hydrogels to attract circulating pro-angiogenic cells - ScienceDirect","volume":"33","author":"Prokoph","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2026.124695_bib74","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.actbio.2015.07.036","article-title":"TGF\u03b2 functionalized starPEG-heparin hydrogels modulate human dermal fibroblast growth and differentiation","volume":"25","author":"Watarai","year":"2015","journal-title":"Acta Biomater."},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124695_bib75","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-23482-5","article-title":"Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing","volume":"12","author":"Atcha","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biomaterials.2026.124695_bib76","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119828","article-title":"Carrageenan-based physically crosslinked injectable hydrogel for wound healing and tissue repairing applications","volume":"589","author":"Pettinelli","year":"2020","journal-title":"Int. J. Pharm."},{"issue":"10","key":"10.1016\/j.biomaterials.2026.124695_bib77","article-title":"Fibronectin binding modulates CXCL11 activity and facilitates wound healing","volume":"8","author":"P","year":"2013","journal-title":"PLoS One"},{"issue":"19","key":"10.1016\/j.biomaterials.2026.124695_bib78","doi-asserted-by":"crossref","first-page":"6952","DOI":"10.1073\/pnas.1404605111","article-title":"Long-lasting fibrin matrices ensure stable and functional angiogenesis by highly tunable, sustained delivery of recombinant VEGF164 | PNAS","volume":"111","author":"Veronica Sacchi","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"3","key":"10.1016\/j.biomaterials.2026.124695_bib79","doi-asserted-by":"crossref","DOI":"10.1021\/acs.chemmater.8b04486","article-title":"Assembly of bifunctional aptamer\u2013fibrinogen macromer for VEGF delivery and skin wound healing ACS","volume":"31","author":"Zhao","year":"2019","journal-title":"Chem. Mater."},{"issue":"8","key":"10.1016\/j.biomaterials.2026.124695_bib80","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.3390\/molecules22081259","article-title":"Advanced growth factor delivery systems in wound management and skin regeneration","volume":"22","author":"Park","year":"2017","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124695_bib81","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/jcmm.13952","article-title":"Fibroblast growth factor 21 facilitates peripheral nerve regeneration through suppressing oxidative damage and autophagic cell death","volume":"23","author":"Lu","year":"2019","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.biomaterials.2026.124695_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123609","article-title":"Local release of fibroblast growth factor 21 and cannabidiol promoting spinal cord nerve injury repair through activation of cannabinoid receptor 2","volume":"325","author":"Zhang","year":"2026","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124695_bib83","doi-asserted-by":"crossref","DOI":"10.1038\/s42004-025-01739-0","article-title":"Hydration-induced lipid redistribution in swelling of controlled release liquid crystalline depots","volume":"8","author":"Engstedt","year":"2025","journal-title":"Commun. Chem."},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124695_bib84","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-10756-x","article-title":"SDF-1\u03b1 loaded lipid liquid crystalline hydrogel accelerates diabetic wound healing in in vitro and in vivo models","volume":"15","author":"Sadri","year":"2025","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.biomaterials.2026.124695_bib85","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1177\/08853282251321943","article-title":"Injectable ADM temperature-sensitive hydrogel loaded with bFGF in diabetic rat wound healing study","volume":"39","author":"Chen","year":"2025","journal-title":"J. Biomater. Appl."},{"key":"10.1016\/j.biomaterials.2026.124695_bib86","doi-asserted-by":"crossref","unstructured":"M.A. Barajaa, T. Otsuka, D. Ghosh, H.-M. Kan, C.T. Laurencin, Development of porcine skeletal muscle extracellular matrix\u2013derived hydrogels with improved properties and low immunogenicity, Proc. Natl. Acad. Sci. U. S. A. 121(19) e2322822121.","DOI":"10.1073\/pnas.2322822121"},{"issue":"9","key":"10.1016\/j.biomaterials.2026.124695_bib87","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1039\/D4BM01623H","article-title":"Long-term interleukin-4 release from 3D printable affinity hydrogels promotes M2-like macrophage polarisation in vitro","volume":"13","author":"Loxley","year":"2025","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.biomaterials.2026.124695_bib88","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.ijbiomac.2020.03.248","article-title":"Bioinspired sodium alginate based thermosensitive hydrogel membranes for accelerated wound healing","volume":"155","author":"Abbasi","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"issue":"7","key":"10.1016\/j.biomaterials.2026.124695_bib89","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1021\/bm100318z","article-title":"Injectable pH- and temperature-responsive Poly(N-isopropylacrylamide-co-propylacrylic acid) copolymers for delivery of angiogenic growth factors","volume":"11","author":"Garbern","year":"2010","journal-title":"Biomacromolecules"},{"issue":"6","key":"10.1016\/j.biomaterials.2026.124695_bib90","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1177\/193229680900300617","article-title":"Blood glucose control in the trauma patient","volume":"3","author":"Eakins","year":"2009","journal-title":"J. Diabetes Sci. Technol."},{"key":"10.1016\/j.biomaterials.2026.124695_bib91","doi-asserted-by":"crossref","DOI":"10.1016\/j.matdes.2025.114558","article-title":"pH and glucose dual-responsive hydrogels for IL-4 and salvianolic acid A delivery to enhance diabetic wound healing","volume":"258","author":"Xie","year":"2025","journal-title":"Mater. Des."},{"issue":"19","key":"10.1016\/j.biomaterials.2026.124695_bib92","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201700344","article-title":"Liposomes with silk fibroin hydrogel core to stabilize bFGF and promote the wound healing of mice with deep second\u2010degree scald","volume":"6","author":"Xu","year":"2017","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.biomaterials.2026.124695_bib93","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jconrel.2014.10.033","article-title":"The topical administration of rhEGF-loaded nanostructured lipid carriers (rhEGF-NLC) improves healing in a porcine full-thickness excisional wound model","volume":"197","author":"Gainza","year":"2015","journal-title":"J. Contr. Release"},{"issue":"11","key":"10.1016\/j.biomaterials.2026.124695_bib94","doi-asserted-by":"crossref","first-page":"4482","DOI":"10.1039\/C9BM00772E","article-title":"Dual-functional gold nanoparticles with antimicrobial and proangiogenic activities improve the healing of multidrug-resistant bacteria-infected wounds in diabetic mice","volume":"7","author":"Wei","year":"2019","journal-title":"Biomater. Sci."},{"issue":"11","key":"10.1016\/j.biomaterials.2026.124695_bib95","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1007\/s11427-008-0126-5","article-title":"Repair effect of diabetic ulcers with recombinant human epidermal growth factor loaded by sustained-release microspheres","volume":"51","author":"Dong","year":"2008","journal-title":"Sci. China C Life Sci."},{"key":"10.1016\/j.biomaterials.2026.124695_bib96","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jconrel.2019.10.018","article-title":"Glycosaminoglycan-based biomaterials for growth factor and cytokine delivery: making the right choices","volume":"313","author":"Hachim","year":"2019","journal-title":"J. Contr. Release"},{"issue":"25","key":"10.1016\/j.biomaterials.2026.124695_bib97","doi-asserted-by":"crossref","first-page":"7228","DOI":"10.1016\/j.biomaterials.2014.05.011","article-title":"Heparin microparticle effects on presentation and bioactivity of bone morphogenetic protein-2","volume":"35","author":"Hettiaratchi","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2026.124695_bib98","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122095","article-title":"Effects of Interleukin-4 (IL-4)-releasing microparticles and adoptive transfer of macrophages on immunomodulation and angiogenesis","volume":"296","author":"Risser","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2026.124695_bib99","first-page":"499","article-title":"Adaptive immunity of materials: implications for tissue healing and regeneration","volume":"41","author":"Lee","year":"2024","journal-title":"Bioact. Mater."},{"issue":"1\u20132","key":"10.1016\/j.biomaterials.2026.124695_bib100","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1089\/ten.tea.2023.0128","article-title":"Bone marrow mobilization and local stromal cell-derived Factor-1\u03b1 delivery enhances nascent supraspinatus muscle fiber growth","volume":"30","author":"Anderson","year":"2024","journal-title":"Tissue Eng."},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124695_bib101","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-024-03038-7","article-title":"Novel cocktail therapy based on multifunctional supramolecular hydrogel targeting immune-angiogenesis-nerve network for enhanced diabetic wound healing","volume":"22","author":"Zeng","year":"2024","journal-title":"J. Nanobiotechnol."},{"issue":"3","key":"10.1016\/j.biomaterials.2026.124695_bib102","doi-asserted-by":"crossref","DOI":"10.1111\/iwj.70858","article-title":"A systematic review of the cost\u2010effectiveness of interventions for chronic wounds","volume":"23","author":"Mare\u0161ov\u00e1","year":"2026","journal-title":"Int. Wound J."},{"issue":"7","key":"10.1016\/j.biomaterials.2026.124695_bib103","article-title":"Apligraf as an alternative to skin grafting in the pediatric population","volume":"13","author":"Eudy","year":"2021","journal-title":"Cureus"},{"issue":"3","key":"10.1016\/j.biomaterials.2026.124695_bib104","first-page":"A248","article-title":"Comparative cost-effectiveness of becaplermin gel on wound healing and amputation in patients with diabetic foot ulcer","volume":"17","author":"Gilligan","year":"2014","journal-title":"Value Health"},{"key":"10.1016\/j.biomaterials.2026.124695_bib105","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.reth.2025.04.017","article-title":"Bioactive and biodegradable hydrogel based on the dermal matrix loaded with microspheres containing vascular endothelial growth factor (VEGF) and interleukin (IL)-10 accelerated the healing of diabetic wounds in rats","volume":"29","author":"Wang","year":"2025","journal-title":"Regen. Ther."},{"key":"10.1016\/j.biomaterials.2026.124695_bib106","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2025.102877","article-title":"Collagen-based hydrogel encapsulated with SDF-1\u03b1 microspheres accelerate diabetic wound healing in rats","volume":"95","author":"Suliman","year":"2025","journal-title":"Tissue Cell"},{"key":"10.1016\/j.biomaterials.2026.124695_bib107","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122848","article-title":"Immunomodulatory hydrogel orchestrates pro-regenerative response of macrophages and angiogenesis for chronic wound healing","volume":"314","author":"Kuan","year":"2025","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2026.124695_bib108","doi-asserted-by":"crossref","first-page":"97","DOI":"10.2147\/IJN.S72998","article-title":"Effect of the protein corona on nanoparticles for modulating cytotoxicity and immunotoxicity","author":"Khang","year":"2014","journal-title":"Int. J. Nanomed."},{"issue":"34","key":"10.1016\/j.biomaterials.2026.124695_bib109","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202402935","article-title":"Concepts and approaches to reduce or avoid protein Corona formation on nanoparticles: challenges and opportunities","volume":"11","author":"Barz","year":"2024","journal-title":"Adv. Sci."},{"issue":"16","key":"10.1016\/j.biomaterials.2026.124695_bib110","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1080\/17435889.2025.2535277","article-title":"Bioengineered nanoparticles for targeted topical delivery in wound healing: advances and future outlook","volume":"20","author":"Sood","year":"2025","journal-title":"Nanomedicine"},{"key":"10.1016\/j.biomaterials.2026.124695_bib111","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2024.149614","article-title":"Integrated GelMA and interleukin 8-loaded liposome composite scaffold for endogenous BMSCs recruitment in bone repair","volume":"703","author":"Wang","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biomaterials.2026.124695_bib112","article-title":"Dual cytokine release from microsphere-containing decellularized extracellular matrix immune regulation promotes bone repair and regeneration","volume":"40","author":"Dang","year":"2024","journal-title":"Appl. Mater. Today"},{"issue":"3","key":"10.1016\/j.biomaterials.2026.124695_bib113","doi-asserted-by":"crossref","first-page":"5998","DOI":"10.1021\/acsami.5c23172","article-title":"IL-4\/Nanohydroxyapatite codelivery in a dual-bionic scaffold: design and immunomodulatory endogenous osteogenesis mechanism","volume":"18","author":"Wang","year":"2026","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"42","key":"10.1016\/j.biomaterials.2026.124695_bib114","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adz5302","article-title":"Spatiotemporally controlled delivery of biological effectors from nanofiber scaffolds accelerates skin wound healing in porcine models","volume":"11","author":"Zhang","year":"2025","journal-title":"Sci. Adv."},{"issue":"8","key":"10.1016\/j.biomaterials.2026.124695_bib115","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1080\/09205063.2012.731375","article-title":"Wound dressing composed of hyaluronic acid and collagen containing EGF or bFGF: comparative culture study","volume":"24","author":"Yu","year":"2013","journal-title":"J. Biomater. Sci. Polym. Ed."},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124695_bib116","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/jbm.a.10396","article-title":"Effect of chitosan film containing basic fibroblast growth factor on wound healing in genetically diabetic mice","volume":"64A","author":"Mizuno","year":"2003","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.biomaterials.2026.124695_bib117","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.113943","article-title":"Affinity-based controlled release of interleukin-4 from scaffolds via biotin-streptavidin interactions for immunomodulation","volume":"384","author":"Nash","year":"2025","journal-title":"J. Contr. Release"},{"issue":"8","key":"10.1016\/j.biomaterials.2026.124695_bib118","article-title":"Matrix\u2010rigidity cooperates with biochemical cues in M2 macrophage activation through increased nuclear deformation and chromatin accessibility","volume":"12","author":"Shin","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.biomaterials.2026.124695_bib119","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.biomaterials.2018.11.002","article-title":"Divergent immune responses to synthetic and biological scaffolds","volume":"192","author":"Sadtler","year":"2019","journal-title":"Biomaterials"},{"issue":"4","key":"10.1016\/j.biomaterials.2026.124695_bib120","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1021\/acsabm.8b00769","article-title":"Stabilized Interleukin-4-Loaded poly(lactic-co-glycolic) acid films shift proinflammatory macrophages toward a regenerative Phenotypein Vitro","volume":"2","author":"Ziemba","year":"2019","journal-title":"ACS Appl. Bio Mater."},{"issue":"11","key":"10.1016\/j.biomaterials.2026.124695_bib121","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1038\/s41565-021-01001-3","article-title":"The role and impact of polyethylene glycol on anaphylactic reactions to COVID-19 nano-vaccines","volume":"16","author":"Bigini","year":"2021","journal-title":"Nat. Nanotechnol."},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124695_bib164","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/jbm.a.31588","article-title":"Investigation of epidermal growth factor containing liposome formulation effects on burn wound healing","volume":"85A","author":"Alemdaro\u011flu","year":"2008","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.biomaterials.2026.124695_bib165","doi-asserted-by":"crossref","first-page":"3417","DOI":"10.2147\/IJN.S82091","article-title":"Novel stable cytokine delivery system& nbsp;in physiological pH solution: chitosan oligosaccharide\/heparin nanoparticles","author":"Tang","year":"2015","journal-title":"Int. J. Nanomed."},{"issue":"2","key":"10.1016\/j.biomaterials.2026.124695_bib166","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s40883-018-0052-4","article-title":"Localized SDF-1\u03b1 delivery increases pro-healing bone marrow-derived cells in the supraspinatus muscle following severe rotator cuff injury","volume":"4","author":"Tellier","year":"2018","journal-title":"Regener. Eng. Transl. Med."},{"issue":"7","key":"10.1016\/j.biomaterials.2026.124695_bib167","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1016\/j.actbio.2008.12.013","article-title":"Biofunctionalized electrospun silk mats as a topical bioactive dressing for accelerated wound healing","volume":"5","author":"Schneider","year":"2009","journal-title":"Acta Biomater."},{"key":"10.1016\/j.biomaterials.2026.124695_bib122","first-page":"1","article-title":"World's first clinical case of gene-activated bone substitute application","volume":"2016","author":"Bozo","year":"2016","journal-title":"Case Rep. Dent."},{"issue":"1","key":"10.1016\/j.biomaterials.2026.124695_bib168","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-026-40440-7","article-title":"Efficacy of topical erythropoietin gel and mouthwash for recurrent aphthous stomatitis in a randomized clinical trial","volume":"16","author":"Elgendi","year":"2026","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.biomaterials.2026.124695_bib169","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1111\/jcpe.14187","article-title":"Efficacy of recombinant human epidermal growth factor on healing of palatal donor sites: a randomised, controlled, double\u2010blinded, single\u2010centre clinical trial (<scp>EGF TRIAL<\/scp>)","volume":"52","author":"Reddy","year":"2025","journal-title":"J. Clin. Periodontol."},{"issue":"6","key":"10.1016\/j.biomaterials.2026.124695_bib170","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1111\/wrr.12969","article-title":"<scp>Effectiveness of<\/scp> a <scp>synthetic human recombinant epidermal growth factor in diabetic patients wound healing<\/scp> : <scp>pilot<\/scp>","volume":"29","author":"Oliveira","year":"2021","journal-title":"Wound Repair Regen."},{"issue":"3","key":"10.1016\/j.biomaterials.2026.124695_bib171","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1093\/jbcr\/iraa019","article-title":"The effects of recombinant human granulocyte\u2013macrophage colony-stimulating factor gel on third-degree frostbite wounds in Northeastern China: a randomized controlled trial","volume":"44","author":"Zhang","year":"2023","journal-title":"J. Burn Care Res."},{"issue":"4","key":"10.1016\/j.biomaterials.2026.124695_bib172","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1089\/rej.2020.2397","article-title":"Topical erythropoietin accelerates wound closure in patients with diabetic foot ulcers: a prospective, multicenter, Single-Blind, randomized, controlled trial","volume":"24","author":"Hamed","year":"2021","journal-title":"Rejuvenation Res."},{"issue":"3","key":"10.1016\/j.biomaterials.2026.124695_bib173","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.tjog.2021.03.014","article-title":"Microencapsulated rhEGF to facilitate epithelial healing and prevent scar formation of cesarean wound: a randomized controlled trial","volume":"60","author":"Kao","year":"2021","journal-title":"Taiwan. J. Obstet. Gynecol."},{"issue":"12","key":"10.1016\/j.biomaterials.2026.124695_bib124","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0113840","article-title":"Residual endotoxin contaminations in recombinant proteins are sufficient to activate human CD1c+ dendritic cells","volume":"9","author":"Schwarz","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.biomaterials.2026.124695_bib125","series-title":"Office of Combination Products: Guidance Document","article-title":"Early development considerations for innovative combination products","year":"2006"},{"key":"10.1016\/j.biomaterials.2026.124695_bib126","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.20982","article-title":"Biomaterials in personalized drug delivery: innovations, challenges, and future directions","volume":"14","author":"Hrapovi\u0107","year":"2026","journal-title":"PeerJ"},{"key":"10.1016\/j.biomaterials.2026.124695_bib127","series-title":"Electronic Health Record Mining Reveals Effects of Patient Immune Status on Clinical Outcomes of Biomaterial Implantation Following Skeletal Muscle Damage, Openrxiv","author":"Sharma","year":"2025"},{"issue":"2","key":"10.1016\/j.biomaterials.2026.124695_bib128","doi-asserted-by":"crossref","DOI":"10.31083\/FBL27113","article-title":"Uncovering sex-related differences in skin macrophage polarization during wound healing in diabetic mice","volume":"30","author":"Huang","year":"2025","journal-title":"Frontiers in Bioscience-Landmark"},{"issue":"9","key":"10.1016\/j.biomaterials.2026.124695_bib129","doi-asserted-by":"crossref","first-page":"5131","DOI":"10.1021\/acsbiomaterials.5c00342","article-title":"Toward sex-specific biomaterials innovation: a perspective","volume":"11","author":"Koons","year":"2025","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"3","key":"10.1016\/j.biomaterials.2026.124695_bib130","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1093\/bjd\/ljae457","article-title":"Tailored bioengineering and nanomedicine strategies for sex-specific healing of chronic wounds","volume":"192","author":"Mahmoudi","year":"2025","journal-title":"Br. J. Dermatol."},{"issue":"10","key":"10.1016\/j.biomaterials.2026.124695_bib131","doi-asserted-by":"crossref","first-page":"5682","DOI":"10.1021\/acsbiomaterials.5c00996","article-title":"The importance of sex-based comparisons in preclinical nanomedicine and regenerative chronic wound therapies","volume":"11","author":"Mahmoudi","year":"2025","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"Suppl 1","key":"10.1016\/j.biomaterials.2026.124695_bib132","doi-asserted-by":"crossref","first-page":"21S","DOI":"10.1097\/PRS.0b013e3181fbe291","article-title":"Biomarkers to predict wound healing: the future of complex war wound management","volume":"127","author":"Hahm","year":"2011","journal-title":"Plast. Reconstr. Surg."},{"issue":"23","key":"10.1016\/j.biomaterials.2026.124695_bib133","doi-asserted-by":"crossref","first-page":"9415","DOI":"10.1073\/pnas.1300290110","article-title":"Macrophages are required for adult salamander limb regeneration","volume":"110","author":"Godwin","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"6","key":"10.1016\/j.biomaterials.2026.124695_bib134","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1097\/SLA.0b013e3181b248d9","article-title":"Inflammatory biomarkers in combat wound healing","volume":"250","author":"Hawksworth","year":"2009","journal-title":"Ann. Surg."},{"key":"10.1016\/j.biomaterials.2026.124695_bib135","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.actbio.2024.06.013","article-title":"Conserved and tissue-specific immune responses to biologic scaffold implantation","volume":"184","author":"Destefano","year":"2024","journal-title":"Acta Biomater."},{"issue":"2","key":"10.1016\/j.biomaterials.2026.124695_bib136","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jbiosc.2024.10.011","article-title":"Topical delivery of gel-in-oil emulsion cocktail with growth factors for the treatment of diabetic pressure ulcers","volume":"139","author":"Zhang","year":"2025","journal-title":"J. Biosci. Bioeng."},{"key":"10.1016\/j.biomaterials.2026.124695_bib137","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.actbio.2017.01.071","article-title":"Generation of anti-inflammatory macrophages for implants and regenerative medicine using self-standing release systems with a phenotype-fixing cytokine cocktail formulation","volume":"53","author":"Riabov","year":"2017","journal-title":"Acta Biomater."}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961226007192?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961226007192?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T05:23:35Z","timestamp":1793769815000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961226007192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,3]]},"references-count":172,"alternative-id":["S0142961226007192"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2026.124695","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2027,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Engineering biomaterials to improve cytokine therapies for wound healing","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2026.124695","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"124695"}}