{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T22:33:06Z","timestamp":1783031586091,"version":"3.54.6"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Deanship of Scientific Research at king Saud University","award":["RG-257-1435-1436"],"award-info":[{"award-number":["RG-257-1435-1436"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.bioorg.2016.07.009","type":"journal-article","created":{"date-parts":[[2016,7,20]],"date-time":"2016-07-20T22:12:17Z","timestamp":1469052737000},"page":"72-79","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"special_numbering":"C","title":["Synthesis of pyrimidine-2,4,6-trione derivatives: Anti-oxidant, anti-cancer, \u03b1-glucosidase, \u03b2-glucuronidase inhibition and their molecular docking studies"],"prefix":"10.1016","volume":"68","author":[{"given":"Assem","family":"Barakat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Shahidul","family":"Islam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah Mohammed","family":"Al-Majid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hazem A.","family":"Ghabbour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sammer","family":"Yousuf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahwish","family":"Ashraf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nimra Naveed","family":"Shaikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Iqbal Choudhary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruqaiya","family":"Khalil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaheer","family":"Ul-Haq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2016.07.009_b0005","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1056\/NEJMoa1008862","volume":"364","author":"Seshasai","year":"2011","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.bioorg.2016.07.009_b0010","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1161\/01.CIR.0000158483.13093.9D","volume":"111","author":"Dandona","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.bioorg.2016.07.009_b0015","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/sj.ijo.0803177","volume":"30","author":"Vincent","year":"2006","journal-title":"Int. J. Obes., (Lond)"},{"key":"10.1016\/j.bioorg.2016.07.009_b0020","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1503\/cmaj.1031414","volume":"172","author":"Cheng","year":"2005","journal-title":"CMAJ"},{"key":"10.1016\/j.bioorg.2016.07.009_b0025","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1365-2362.1994.tb02255.x","volume":"24","author":"Lefebvre","year":"1994","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.bioorg.2016.07.009_b0030","doi-asserted-by":"crossref","first-page":"521","DOI":"10.2165\/00003495-200059030-00012","volume":"59","author":"Scott","year":"2000","journal-title":"Drugs"},{"key":"10.1016\/j.bioorg.2016.07.009_b0035","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.ejmech.2014.07.026","volume":"84","author":"Barakat","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2016.07.009_b0040","doi-asserted-by":"crossref","first-page":"6740","DOI":"10.1016\/j.bmc.2015.09.001","volume":"23","author":"Barakat","year":"2015","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2016.07.009_b0045","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.molstruc.2015.06.037","volume":"1098","author":"Barakat","year":"2015","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.bioorg.2016.07.009_b0050","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1053\/ctrv.2001.0222","volume":"27","author":"Gomez","year":"2001","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.bioorg.2016.07.009_b0055","first-page":"329","volume":"4","author":"\u0139opez-M\u0169noz","year":"2005","journal-title":"Dis. Treat."},{"key":"10.1016\/j.bioorg.2016.07.009_b0060","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1021\/jm00363a004","volume":"26","author":"Andrews","year":"1983","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2016.07.009_b0065","doi-asserted-by":"crossref","first-page":"3991","DOI":"10.1021\/ja808014h","volume":"131","author":"Ruble","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bioorg.2016.07.009_b0070","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1021\/jm201352k","volume":"55","author":"Wang","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2016.07.009_b0075","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1021\/jm101549k","volume":"54","author":"Xia","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2016.07.009_b0080","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.1021\/cg100284r","volume":"10","author":"Ivanova","year":"2010","journal-title":"Cryst. Growth Des."},{"key":"10.1016\/j.bioorg.2016.07.009_b0085","doi-asserted-by":"crossref","first-page":"13004","DOI":"10.1021\/ja0372098","volume":"125","author":"McClenaghan","year":"2003","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bioorg.2016.07.009_b0090","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1021\/ol802363x","volume":"11","author":"Lee","year":"2009","journal-title":"Org. Lett."},{"key":"10.1016\/j.bioorg.2016.07.009_b0095","doi-asserted-by":"crossref","first-page":"5727","DOI":"10.1016\/j.tetlet.2005.06.075","volume":"46","author":"Devi","year":"2005","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.bioorg.2016.07.009_b0100","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1021\/jo991491c","volume":"65","author":"Trost","year":"2000","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bioorg.2016.07.009_b0105","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1016\/S0040-4039(03)00111-4","volume":"44","author":"Jursic","year":"2003","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.bioorg.2016.07.009_b0110","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1002\/jhet.5570430313","volume":"43","author":"Singh","year":"2006","journal-title":"J. Heterocycl. Chem."},{"key":"10.1016\/j.bioorg.2016.07.009_b0115","doi-asserted-by":"crossref","first-page":"7486","DOI":"10.1021\/jo801288s","volume":"73","author":"Volonterio","year":"2008","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bioorg.2016.07.009_b0120","doi-asserted-by":"crossref","first-page":"6984","DOI":"10.1016\/j.tetlet.2015.10.108","volume":"56","author":"Barakat","year":"2015","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.bioorg.2016.07.009_b0125","first-page":"59","volume":"41","author":"Osman","year":"2003","journal-title":"Bull. Fac. Pharm."},{"key":"10.1016\/j.bioorg.2016.07.009_b0130","doi-asserted-by":"crossref","first-page":"4909","DOI":"10.1039\/c3ra46551a","volume":"4","author":"Barakat","year":"2014","journal-title":"RSC Adv."},{"key":"10.1016\/j.bioorg.2016.07.009_b0135","doi-asserted-by":"crossref","first-page":"23762","DOI":"10.3390\/ijms141223762","volume":"14","author":"Al-Majid","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2016.07.009_b0140","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.saa.2015.03.016","volume":"147","author":"Barakat","year":"2015","journal-title":"Spectrochim. Acta"},{"key":"10.1016\/j.bioorg.2016.07.009_b0145","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.molstruc.2014.12.030","volume":"1084","author":"Barakat","year":"2015","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.bioorg.2016.07.009_b0150","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.3390\/molecules19011150","volume":"19","author":"Al-Najjar","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.bioorg.2016.07.009_b0155","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2174\/092986708783330683","volume":"15","author":"Andricopulo","year":"2008","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bioorg.2016.07.009_b0160","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.3390\/md9091554","volume":"9","author":"Liu","year":"2011","journal-title":"Marine drugs"},{"key":"10.1016\/j.bioorg.2016.07.009_b0165","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1093\/nar\/gkg520","volume":"31","author":"Schwede","year":"2003","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.bioorg.2016.07.009_b0170","first-page":"361","author":"Imran","year":"2015","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.bioorg.2016.07.009_b0175","doi-asserted-by":"crossref","first-page":"4420","DOI":"10.1016\/j.bmcl.2010.06.059","volume":"20","author":"Nakamura","year":"2010","journal-title":"Bioorganic Med. Chem. Lett."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206816301328?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206816301328?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T10:50:01Z","timestamp":1536576601000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206816301328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":35,"alternative-id":["S0045206816301328"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2016.07.009","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis of pyrimidine-2,4,6-trione derivatives: Anti-oxidant, anti-cancer, \u03b1-glucosidase, \u03b2-glucuronidase inhibition and their molecular docking studies","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2016.07.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}