{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:30:48Z","timestamp":1790706648399,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.bioorg.2018.01.021","type":"journal-article","created":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T20:22:05Z","timestamp":1516134125000},"page":"411-419","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":142,"special_numbering":"C","title":["New anticancer drug candidates sulfonamides as selective hCA IX or hCA XII inhibitors"],"prefix":"10.1016","volume":"77","author":[{"given":"Halise Inci","family":"Gul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cem","family":"Yamali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Sakagami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Angeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janis","family":"Leitans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andris","family":"Kazaks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaspars","family":"Tars","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilan Ozmen","family":"Ozgun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2018.01.021_b0005","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3390\/molecules21030271","article-title":"Biological validation of novel polysubstituted pyrazole candidates with in vitro anticancer activities","volume":"21","author":"Fahmy","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.bioorg.2018.01.021_b0010","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/35077213","article-title":"Proliferation, cell cycle and apoptosis in cancer","volume":"411","author":"Evan","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.bioorg.2018.01.021_b0015","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s00044-017-1781-5","article-title":"Design, synthesis and molecular docking of novel structural hybrids of substituted isatin based pyrazoline and thiadiazoline as antitumor agents","volume":"26","author":"Gangarapu","year":"2017","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.bioorg.2018.01.021_b0020","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1517\/13543776.2013.778246","article-title":"Carbonic anhydrase inhibitors: an editorial","volume":"23","author":"Supuran","year":"2013","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bioorg.2018.01.021_b0025","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1517\/13543776.2013.798648","article-title":"Anticancer carbonic anhydrase inhibitors: a patent review (2008\u20132013)","volume":"23","author":"Monti","year":"2013","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bioorg.2018.01.021_b0030","doi-asserted-by":"crossref","first-page":"6494","DOI":"10.1158\/0008-5472.CAN-13-1110","article-title":"Antitumor efficacy of a monoclonal antibody that inhibits the activity of cancer-associated carbonic anhydrase XII","volume":"73","author":"Gondi","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.bioorg.2018.01.021_b0035","doi-asserted-by":"crossref","first-page":"345","DOI":"10.3109\/14756366.2015.1122001","article-title":"How many carbonic anhydrase inhibition mechanisms exist?","volume":"31","author":"Supuran","year":"2016","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.01.021_b0040","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1042\/BCJ20160115","article-title":"Structure and function of carbonic anhydrases","volume":"473","author":"Supuran","year":"2016","journal-title":"Biochem. J."},{"key":"10.1016\/j.bioorg.2018.01.021_b0045","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrd2467","article-title":"Carbonic anhydrases: novel therapeutic applications for inhibitors and activators","volume":"7","author":"Supuran","year":"2008","journal-title":"Nat. Rev. Drug. Discov."},{"key":"10.1016\/j.bioorg.2018.01.021_b0050","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1016\/j.bmc.2012.08.019","article-title":"Insights towards sulfonamide drug specificity in alpha-carbonic anhydrases","volume":"21","author":"Aggarwal","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.01.021_b0055","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.bioorg.2018.01.021_b0060","first-page":"7075","article-title":"Hypoxia-inducible expression of tumor-associated carbonic anhydrases","volume":"60","author":"Wykoff","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.bioorg.2018.01.021_b0065","doi-asserted-by":"crossref","first-page":"e33952","DOI":"10.1371\/journal.pone.0033952","article-title":"CAXII is a sero-diagnostic marker for lung cancer","volume":"7","author":"Kobayashi","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bioorg.2018.01.021_b0070","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1158\/1078-0432.CCR-11-0238","article-title":"Noninvasive detection of breast cancer lymph node metastasis using carbonic anhydrases IX and XII targeted imaging probes","volume":"18","author":"Tafreshi","year":"2012","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bioorg.2018.01.021_b0075","doi-asserted-by":"crossref","first-page":"13815","DOI":"10.1074\/jbc.M111.219899","article-title":"Dual role of CO2\/HCO3(-) buffer in the regulation of intracellular pH of three-dimensional tumor growths","volume":"286","author":"Hulikova","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bioorg.2018.01.021_b0080","first-page":"6449","article-title":"Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review","volume":"49","author":"Vaupel","year":"1989","journal-title":"Cancer Res."},{"key":"10.1016\/j.bioorg.2018.01.021_b0085","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1517\/13543776.2012.698264","article-title":"Sulfonamides: a patent review (2008\u20132012)","volume":"22","author":"Carta","year":"2012","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bioorg.2018.01.021_b0090","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S0021-9258(19)51331-X","article-title":"The inhibition of carbonic anhydrase by thiophen-2-sulfonamide and sulfanilamide","volume":"158","author":"Davenport","year":"1945","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bioorg.2018.01.021_b0095","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1080\/14756360500141960","article-title":"Carbonic anhydrase inhibitors. Inhibition of red blood cell ostrich (Struthio camelus) carbonic anhydrase with a series of aromatic and heterocyclic sulfonamides","volume":"20","author":"Ozensoy","year":"2005","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.01.021_b0100","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0960-894X(03)00091-X","article-title":"Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides","volume":"13","author":"Vullo","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2018.01.021_b0105","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1080\/14756366.2016.1254207","article-title":"Microwave-assisted synthesis and bioevaluation of new sulfonamides","volume":"32","author":"Gul","year":"2017","journal-title":"J. Enzyme Inhib. Med. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2018.01.021_b0110","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1080\/14756366.2016.1244533","article-title":"Synthesis, carbonic anhydrase I and II inhibition studies of the 1,3,5-trisubstituted-pyrazolines","volume":"32","author":"Gul","year":"2017","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.01.021_b0115","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1080\/14756366.2016.1243536","article-title":"Designing, synthesis and bioactivities of 4-[3-(4-hydroxyphenyl)-5-aryl-4,5-dihydro-pyrazol-1-yl]benzenesulfonamides","volume":"32","author":"Gul","year":"2017","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.01.021_b0120","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1016\/j.bmc.2017.03.027","article-title":"Synthesis and carbonic anhydrase inhibition of a series of SLC-0111 analogs","volume":"25","author":"Carta","year":"2017","journal-title":"Bioorg. Med. Chem."},{"issue":"3","key":"10.1016\/j.bioorg.2018.01.021_b0125","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1124\/dmd.30.3.331","article-title":"Glutathione and mercapturic acid conjugates of sulofenur and their activity against a human colon cancer cell line","volume":"30","author":"Guan","year":"2002","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.bioorg.2018.01.021_b0130","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1007\/s00280-012-1844-8","article-title":"Therapeutic potential and molecular mechanism of a novel sulfonamide anticancer drug, indisulam (E7070) in combination with CPT-11 for cancer treatment","volume":"69","author":"Ozawa","year":"2012","journal-title":"Cancer Chemother. Pharmacol."},{"issue":"4","key":"10.1016\/j.bioorg.2018.01.021_b0135","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s11523-017-0511-8","article-title":"Pazopanib: a review in advanced renal cell carcinoma","volume":"12","author":"Frampton","year":"2017","journal-title":"Target Oncol."},{"key":"10.1016\/j.bioorg.2018.01.021_b0140","unstructured":"T.P. Lehmann, J. Kujawski, J. Kruk, K. Czaja, M.K. Bernard, P.P. Jagodzinski, Cell-specific cytotoxic effect of pyrazole derivatives on breast cancer cell lines MCF7 and MDA-MB-231, J. Physiol. Pharmacol. 68 (2017) 201\u2013207."},{"key":"10.1016\/j.bioorg.2018.01.021_b0145","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jphotobiol.2017.02.003","article-title":"Synthesis, DNA binding and in-vitro cytotoxicity studies on novel bis-pyrazoles","volume":"168","author":"Indrasena Reddy","year":"2017","journal-title":"J. Photochem. Photobiol. B"},{"key":"10.1016\/j.bioorg.2018.01.021_b0150","doi-asserted-by":"crossref","first-page":"75","DOI":"10.2174\/1871520616666160620074534","article-title":"Synthesis, in vitro antiproliferative and antiinflammatory activities, and kinase \u0131nhibitory effects of new 1,3,4-triarylpyrazole derivatives","volume":"17","author":"El-Gamal","year":"2017","journal-title":"Anticancer Agents Med. Chem."},{"issue":"sup4","key":"10.1016\/j.bioorg.2018.01.021_b0155","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1080\/14756366.2016.1217852","article-title":"Synthesis, cytotoxicity and carbonic anhydrase inhibitory activities of new pyrazolines","volume":"31","author":"Kucukoglu","year":"2016","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.01.021_b0160","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.3109\/14756366.2016.1160077","article-title":"Synthesis and bioactivity studies on new 4-(3-(4-substitutedphenyl)-3a,4-dihydro-3H-indeno[1,2-c]pyrazol-2-yl)benzenesulfonamides","volume":"31","author":"Gul","year":"2016","journal-title":"J. Enzyme Inhib. Med. Chem."},{"issue":"sup4","key":"10.1016\/j.bioorg.2018.01.021_b0165","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1080\/14756366.2016.1221825","article-title":"Synthesis and bioactivities of halogen bearing phenolic chalcones and their corresponding bis Mannich bases","volume":"31","author":"Yamali","year":"2016","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.01.021_b0170","doi-asserted-by":"crossref","first-page":"383","DOI":"10.3109\/14756366.2014.940934","article-title":"Synthesis and biological evaluation of 1,5-bis(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one and its aminomethyl derivatives","volume":"30","author":"Yerdelen","year":"2015","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.01.021_b0175","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1016\/j.bmcl.2017.02.016","article-title":"6-Benzylidene-2-[4-(pyridin-3-ylcarboxy)benzylidene]cyclohexanones: a novel cluster of tumour-selective cytotoxins","volume":"27","author":"Panda","year":"2017","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2018.01.021_b0180","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1007\/s00044-017-1911-0","article-title":"Synthesis and structure elucidation of 1-(2,5\/3,5-difluorophenyl)-3-(2,3\/2,4\/2,5\/3,4-dimethoxyphenyl)-2-propen-1-ones as anticancer agents","volume":"26","author":"Yamali","year":"2017","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.bioorg.2018.01.021_b0185","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.2174\/1871520617666170327123909","article-title":"Synthesis and cytotoxic activities of difluoro-dimethoxy chalcones","volume":"17","author":"Yamali","year":"2017","journal-title":"Anticancer Agents Med. Chem."},{"key":"10.1016\/j.bioorg.2018.01.021_b0190","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s13402-016-0272-x","article-title":"A novel curcumin-like dienone induces apoptosis in triple-negative breast cancer cells","volume":"39","author":"Robles-Escajeda","year":"2016","journal-title":"Cell Oncol. (Dordr)."},{"key":"10.1016\/j.bioorg.2018.01.021_b0195","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1021\/acs.jmedchem.5b01706","article-title":"3,5-Bis(3-alkylaminomethyl-4-hydroxybenzylidene)-4-piperidones: a novel class of potent tumor-selective cytotoxins","volume":"59","author":"Karki","year":"2016","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.01.021_b0200","doi-asserted-by":"crossref","first-page":"974","DOI":"10.3109\/14756366.2012.700927","article-title":"1-(3-Aminomethyl-4-hydroxyphenyl)-3-pyridinyl-2-propen-1-ones: a novel group of tumour-selective cytotoxins","volume":"28","author":"Bilginer","year":"2013","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.01.021_b0205","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1021\/jm500255y","article-title":"Cyclic secondary sulfonamides: unusually good inhibitors of cancer-related carbonic anhydrase enzymes","volume":"57","author":"Moeker","year":"2014","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.01.021_b0210","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1016\/j.bmc.2016.12.047","article-title":"Benzenesulfonamide bearing imidazothiadiazole and thiazolotriazole scaffolds as potent tumor associated human carbonic anhydrase IX and XII inhibitors","volume":"25","author":"Kumar","year":"2017","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.01.021_b0215","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.3109\/14756366.2016.1140755","article-title":"Carbonic anhydrase inhibition and cytotoxicity studies of Mannich base derivatives of thymol","volume":"31","author":"Gul","year":"2016","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.01.021_b0220","unstructured":"A.S. McDowell, R.E. Sammelson, L.A. Sklar, M.K. Haynes, Methods for treating bacterial infection, United States Patent Application Publication, 2015, US 2015\/0190408 Al 1-27."},{"key":"10.1016\/j.bioorg.2018.01.021_b0225","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.bioorg.2016.11.008","article-title":"Design, synthesis, cyclooxygenase inhibition and biological evaluation of new 1,3,5-triaryl-4,5-dihydro-1H-pyrazole derivatives possessing amino\/methanesulfonyl pharmacophore","volume":"70","author":"Abdellatif","year":"2017","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2018.01.021_b0230","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.bmcl.2015.11.105","article-title":"Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of new 1,3,5-triarylpyrazoline and 1,5-diarylpyrazole derivatives as selective COX-2 inhibitors","volume":"26","author":"Khaled","year":"2016","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2018.01.021_b0235","doi-asserted-by":"crossref","first-page":"100","DOI":"10.5794\/jjoms.20.100","article-title":"A new human cell line derived from human carcinoma of the gingiva. I. Its establishment and morphological studies","volume":"20","author":"Horikoshi","year":"1974","journal-title":"Jpn. J. Oral. Maxillofac. Surg."},{"key":"10.1016\/j.bioorg.2018.01.021_b0240","first-page":"843","article-title":"Hormetic and anti-radiation effects of tropolone-related compounds","volume":"24","author":"Kantoh","year":"2010","journal-title":"In Vivo"}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206817309185?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206817309185?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T07:48:56Z","timestamp":1758613736000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206817309185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":48,"alternative-id":["S0045206817309185"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2018.01.021","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"New anticancer drug candidates sulfonamides as selective hCA IX or hCA XII inhibitors","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2018.01.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}