{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:33:36Z","timestamp":1790706816871,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Ataturk University BAP office"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.bioorg.2018.03.027","type":"journal-article","created":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T22:43:59Z","timestamp":1522449839000},"page":"290-297","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"special_numbering":"C","title":["Anticancer effects of new dibenzenesulfonamides by inducing apoptosis and autophagy pathways and their carbonic anhydrase inhibitory effects on hCA I, hCA II, hCA IX, hCA XII isoenzymes"],"prefix":"10.1016","volume":"78","author":[{"given":"Halise Inci","family":"Gul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cem","family":"Yamali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merve","family":"Bulbuller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petek Ballar","family":"Kirmizibayrak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0042-890X","authenticated-orcid":false,"given":"Mustafa","family":"Gul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1470-7192","authenticated-orcid":false,"given":"Andrea","family":"Angeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0107-2682","authenticated-orcid":false,"given":"Silvia","family":"Bua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2018.03.027_b0005","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3322\/caac.20107","article-title":"Global cancer statistics","volume":"61","author":"Jemal","year":"2011","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.bioorg.2018.03.027_b0010","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/978-1-60761-416-6_21","article-title":"Circumventing tumor resistance to chemotherapy by nanotechnology","volume":"596","author":"Liang","year":"2010","journal-title":"Methods Mol. Biol."},{"issue":"4","key":"10.1016\/j.bioorg.2018.03.027_b0015","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1128\/IAI.73.4.1907-1916.2005","article-title":"Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells","volume":"73","author":"Fink","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.bioorg.2018.03.027_b0020","doi-asserted-by":"crossref","first-page":"150845","DOI":"10.1155\/2014\/150845","article-title":"Apoptosis and molecular targeting therapy in cancer","volume":"2014","author":"Hassan","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.bioorg.2018.03.027_b0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.fct.2017.12.028","article-title":"Molecular chemotherapeutic potential of butein: a concise review","volume":"112","author":"Jayasooriya","year":"2017","journal-title":"Food Chem. Toxicol."},{"issue":"4","key":"10.1016\/j.bioorg.2018.03.027_b0030","doi-asserted-by":"crossref","first-page":"a008656","DOI":"10.1101\/cshperspect.a008656","article-title":"Caspase functions in cell death and disease","volume":"5","author":"McIlwain","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"Pt 1","key":"10.1016\/j.bioorg.2018.03.027_b0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BST0360001","article-title":"Caspase activation cascades in apoptosis","volume":"36","author":"Logue","year":"2008","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.bioorg.2018.03.027_b0040","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1478-811X-8-31","article-title":"PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration","volume":"8","author":"Chaitanya","year":"2010","journal-title":"Cell Commun. Signal."},{"issue":"6","key":"10.1016\/j.bioorg.2018.03.027_b0045","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/sj.cdd.4400851","article-title":"Characterization of the necrotic cleavage of poly(ADP-ribose) polymerase (PARP-1): implication of lysosomal proteases","volume":"8","author":"Gobeil","year":"2001","journal-title":"Cell Death Differ."},{"issue":"4","key":"10.1016\/j.bioorg.2018.03.027_b0050","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1023\/A:1016119328968","article-title":"Poly(ADP-ribose) polymerase-1 cleavage during apoptosis: An update","volume":"7","author":"Soldani","year":"2002","journal-title":"Apoptosis"},{"issue":"3","key":"10.1016\/j.bioorg.2018.03.027_b0055","doi-asserted-by":"crossref","first-page":"266","DOI":"10.4161\/auto.3908","article-title":"Maintaining T lymphocyte homeostasis: another duty of autophagy","volume":"3","author":"Pua","year":"2007","journal-title":"Autophagy"},{"key":"10.1016\/j.bioorg.2018.03.027_b0060","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.bcp.2017.11.021","article-title":"Modulating autophagy in cancer therapy: advancements and challenges for cancer cell death sensitization","volume":"147","author":"Bhat","year":"2018","journal-title":"Biochem. Pharmacol."},{"issue":"6","key":"10.1016\/j.bioorg.2018.03.027_b0065","doi-asserted-by":"crossref","first-page":"542","DOI":"10.4161\/auto.4600","article-title":"How to interpret LC3 immunoblotting","volume":"3","author":"Mizushima","year":"2007","journal-title":"Autophagy"},{"key":"10.1016\/j.bioorg.2018.03.027_b0070","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0076-6879(08)03612-4","article-title":"Monitoring autophagic degradation of p62\/SQSTM1","volume":"452","author":"Bjorkoy","year":"2009","journal-title":"Methods Enzymol."},{"issue":"4","key":"10.1016\/j.bioorg.2018.03.027_b0075","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s00281-010-0220-1","article-title":"Selective degradation of p62 by autophagy","volume":"32","author":"Ichimura","year":"2010","journal-title":"Semin. Immunopathol."},{"issue":"1","key":"10.1016\/j.bioorg.2018.03.027_b0080","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1080\/17460441.2017.1253677","article-title":"Advances in structure-based drug discovery of carbonic anhydrase inhibitors","volume":"12","author":"Supuran","year":"2017","journal-title":"Expert. Opin. Drug Discov."},{"issue":"6","key":"10.1016\/j.bioorg.2018.03.027_b0085","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1517\/13543776.2013.778246","article-title":"Carbonic anhydrase inhibitors: an editorial","volume":"23","author":"Supuran","year":"2013","journal-title":"Expert. Opin. Ther. Pat."},{"issue":"1","key":"10.1016\/j.bioorg.2018.03.027_b0090","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1080\/14756366.2016.1243536","article-title":"Designing, synthesis and bioactivities of 4-[3-(4-hydroxyphenyl)-5-aryl-4,5-dihydro-pyrazol-1-yl]benzenesulfonamides","volume":"32","author":"Gul","year":"2017","journal-title":"J. Enzyme Inhib. Med. Chem."},{"issue":"3","key":"10.1016\/j.bioorg.2018.03.027_b0095","doi-asserted-by":"crossref","DOI":"10.3390\/metabo7030048","article-title":"Carbonic Anhydrase inhibition and the management of hypoxic tumors","volume":"7","author":"Supuran","year":"2017","journal-title":"Metabolites"},{"issue":"6","key":"10.1016\/j.bioorg.2018.03.027_b0100","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1517\/13543776.2013.798648","article-title":"Anticancer carbonic anhydrase inhibitors: a patent review (2008\u20132013)","volume":"23","author":"Monti","year":"2013","journal-title":"Expert. Opin. Ther. Pat."},{"issue":"29","key":"10.1016\/j.bioorg.2018.03.027_b0105","doi-asserted-by":"crossref","first-page":"3246","DOI":"10.2174\/138161210793429841","article-title":"Recent advances in structural studies of the carbonic anhydrase family: the crystal structure of human CA IX and CA XIII","volume":"16","author":"Supuran","year":"2010","journal-title":"Curr. Pharm. Des."},{"issue":"10","key":"10.1016\/j.bioorg.2018.03.027_b0110","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.4155\/fmc.14.68","article-title":"Sulfonamides and their isosters as carbonic anhydrase inhibitors","volume":"6","author":"Carta","year":"2014","journal-title":"Future Med. Chem."},{"issue":"6","key":"10.1016\/j.bioorg.2018.03.027_b0115","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.3109\/14756366.2016.1160077","article-title":"Synthesis and bioactivity studies on new 4-(3-(4-substitutedphenyl)-3a,4-dihydro-3H-indeno[1,2-c]pyrazol-2-yl) benzenesulfonamides","volume":"31","author":"Gul","year":"2016","journal-title":"J. Enzyme Inhib. Med. Chem."},{"issue":"sup4","key":"10.1016\/j.bioorg.2018.03.027_b0120","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1080\/14756366.2016.1217852","article-title":"Synthesis, cytotoxicity and carbonic anhydrase inhibitory activities of new pyrazolines","volume":"31","author":"Kucukoglu","year":"2016","journal-title":"J. Enzyme Inhib. Med. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2018.03.027_b0125","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1080\/14756366.2016.1244533","article-title":"Synthesis, carbonic anhydrase I and II inhibition studies of the 1,3,5-trisubstituted-pyrazolines","volume":"32","author":"Gul","year":"2017","journal-title":"J. Enzyme Inhib. Med. Chem."},{"issue":"4","key":"10.1016\/j.bioorg.2018.03.027_b0130","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1111\/cbdd.13149","article-title":"Synthesis, molecular modeling, and biological evaluation of 4-[5-aryl-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl] benzenesulfonamides toward acetylcholinesterase, carbonic anhydrase I and II enzymes","volume":"91","author":"Yamali","year":"2018","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.bioorg.2018.03.027_b0135","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.bioorg.2018.01.021","article-title":"New anticancer drug candidates sulfonamides as selective hCA IX or hCA XII inhibitors","volume":"77","author":"Gul","year":"2018","journal-title":"Bioorg. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2018.03.027_b0140","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1080\/14756366.2016.1254207","article-title":"Microwave-assisted synthesis and bioevaluation of new sulfonamides","volume":"32","author":"Gul","year":"2017","journal-title":"J. Enzyme Inhib. Med. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2018.03.027_b0145","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4103\/0975-7406.171694","article-title":"Current status of pyrazole and its biological activities","volume":"8","author":"Naim","year":"2016","journal-title":"J. Pharm. Bioallied Sci."},{"issue":"14","key":"10.1016\/j.bioorg.2018.03.027_b0150","doi-asserted-by":"crossref","first-page":"3911","DOI":"10.1016\/j.bmc.2004.04.045","article-title":"Cinnamoyl nitrogen mustard derivatives of pyrazole analogues of tallimustine modified at the amidino moiety: design, synthesis, molecular modeling and antitumor activity studies","volume":"12","author":"Baraldi","year":"2004","journal-title":"Bioorg. Med. Chem."},{"issue":"7","key":"10.1016\/j.bioorg.2018.03.027_b0155","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1016\/j.bmc.2010.03.006","article-title":"Pyrazolone-fused combretastatins and their precursors: synthesis, cytotoxicity, antitubulin activity and molecular modeling studies","volume":"18","author":"Burja","year":"2010","journal-title":"Bioorg. Med. Chem."},{"issue":"7","key":"10.1016\/j.bioorg.2018.03.027_b0160","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1248\/cpb.51.838","article-title":"Synthesis of novel 1,3,4-trisubstituted pyrazole derivatives and their evaluation as antitumor and antiangiogenic agents","volume":"51","author":"Abadi","year":"2003","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"issue":"16","key":"10.1016\/j.bioorg.2018.03.027_b0165","doi-asserted-by":"crossref","first-page":"4766","DOI":"10.1016\/j.bmcl.2010.06.121","article-title":"Synthesis of novel oxime-containing pyrazole derivatives and discovery of regulators for apoptosis and autophagy in A549 lung cancer cells","volume":"20","author":"Zheng","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"13","key":"10.1016\/j.bioorg.2018.03.027_b0170","doi-asserted-by":"crossref","first-page":"3367","DOI":"10.1021\/jm031145u","article-title":"3-Aminopyrazole inhibitors of CDK2\/cyclin A as antitumor agents. 1. Lead finding","volume":"47","author":"Pevarello","year":"2004","journal-title":"J. Med. Chem."},{"issue":"13","key":"10.1016\/j.bioorg.2018.03.027_b0175","doi-asserted-by":"crossref","first-page":"4080","DOI":"10.1158\/1078-0432.CCR-05-1964","article-title":"PHA-680632, a novel Aurora kinase inhibitor with potent antitumoral activity","volume":"12","author":"Soncini","year":"2006","journal-title":"Clin. Cancer Res."},{"issue":"14","key":"10.1016\/j.bioorg.2018.03.027_b0180","doi-asserted-by":"crossref","first-page":"3338","DOI":"10.1016\/j.bmcl.2005.05.046","article-title":"The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors","volume":"15","author":"Cheung","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"5","key":"10.1016\/j.bioorg.2018.03.027_b0185","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1111\/cbdd.12451","article-title":"4-Substituted-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine derivatives: design, synthesis, antitumor and EGFR tyrosine kinase inhibitory activity","volume":"85","author":"Abbas","year":"2015","journal-title":"Chem. Biol. Drug Des."},{"issue":"13","key":"10.1016\/j.bioorg.2018.03.027_b0190","doi-asserted-by":"crossref","first-page":"3581","DOI":"10.1016\/j.bmcl.2004.04.007","article-title":"Synthesis and activity of new aryl- and heteroaryl-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain","volume":"14","author":"Sawyer","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"1","key":"10.1016\/j.bioorg.2018.03.027_b0195","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2174\/1568009023334060","article-title":"Sulfonamides and sulfonylated derivatives as anticancer agents","volume":"2","author":"Casini","year":"2002","journal-title":"Curr. Cancer Drug Targets"},{"issue":"2","key":"10.1016\/j.bioorg.2018.03.027_b0200","doi-asserted-by":"crossref","first-page":"3289","DOI":"10.18632\/oncotarget.13753","article-title":"Pazopanib, a novel multi-kinase inhibitor, shows potent antitumor activity in colon cancer through PUMA-mediated apoptosis","volume":"8","author":"Zhang","year":"2017","journal-title":"Oncotarget"},{"issue":"2","key":"10.1016\/j.bioorg.2018.03.027_b0205","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s002800050795","article-title":"Phase I study of E7010","volume":"42","author":"Yamamoto","year":"1998","journal-title":"Cancer Chemother. Pharmacol."},{"issue":"4","key":"10.1016\/j.bioorg.2018.03.027_b0210","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/sj.bjc.6603606","article-title":"A phase I and pharmacokinetic study of indisulam in combination with carboplatin","volume":"96","author":"Dittrich","year":"2007","journal-title":"Br. J. Cancer"},{"issue":"16","key":"10.1016\/j.bioorg.2018.03.027_b0215","doi-asserted-by":"crossref","first-page":"3208","DOI":"10.1016\/j.bmcl.2015.05.096","article-title":"Sulfonamide bearing pyrazolylpyrazolines as potent inhibitors of carbonic anhydrase isoforms I, II, IX and XII","volume":"25","author":"Khloya","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"3","key":"10.1016\/j.bioorg.2018.03.027_b0220","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.bmc.2013.12.031","article-title":"7-Azaindole-1-carboxamides as a new class of PARP-1 inhibitors","volume":"22","author":"Cincinelli","year":"2014","journal-title":"Bioorg. Med. Chem."},{"issue":"8","key":"10.1016\/j.bioorg.2018.03.027_b0225","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1002\/bies.20085","article-title":"The PARP superfamily","volume":"26","author":"Ame","year":"2004","journal-title":"Bioessays"},{"issue":"4","key":"10.1016\/j.bioorg.2018.03.027_b0230","doi-asserted-by":"crossref","first-page":"495","DOI":"10.3109\/14756366.2013.806497","article-title":"Carbonic anhydrase inhibitors. Phenols incorporating 2- or 3-pyridyl-ethenylcarbonyl and tertiary amine moieties strongly inhibit Saccharomyces cerevisiae beta-carbonic anhydrase","volume":"29","author":"Bilginer","year":"2014","journal-title":"J. Enzyme Inhib. Med. Chem."},{"issue":"Suppl. 3","key":"10.1016\/j.bioorg.2018.03.027_b0235","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/14756366.2016.1209495","article-title":"Synthesis and bioactivity studies of 1-aryl-3-(2-hydroxyethylthio)-1-propanones","volume":"31","author":"Unluer","year":"2016","journal-title":"J. Enzyme Inhib. Med. Chem."},{"issue":"Suppl. 4","key":"10.1016\/j.bioorg.2018.03.027_b0240","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1080\/14756366.2016.1221825","article-title":"Synthesis and bioactivities of halogen bearing phenolic chalcones and their corresponding bis Mannich bases","volume":"31","author":"Yamali","year":"2016","journal-title":"J. Enzyme Inhib. Med. Chem."},{"issue":"6","key":"10.1016\/j.bioorg.2018.03.027_b0245","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.3109\/14756366.2015.1126715","article-title":"The inhibitory effects of phenolic Mannich bases on carbonic anhydrase I and II isoenzymes","volume":"31","author":"Yamali","year":"2016","journal-title":"J Enzyme Inhib Med Chem."},{"issue":"6","key":"10.1016\/j.bioorg.2018.03.027_b0250","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.3109\/14756366.2016.1140755","article-title":"Carbonic anhydrase inhibition and cytotoxicity studies of Mannich base derivatives of thymol","volume":"31","author":"Gul","year":"2016","journal-title":"J. Enzyme Inhib. Med. Chem."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004520681830155X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004520681830155X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T21:31:52Z","timestamp":1693603912000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004520681830155X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":50,"alternative-id":["S004520681830155X"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2018.03.027","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anticancer effects of new dibenzenesulfonamides by inducing apoptosis and autophagy pathways and their carbonic anhydrase inhibitory effects on hCA I, hCA II, hCA IX, hCA XII isoenzymes","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2018.03.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}