{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:01:33Z","timestamp":1790017293004,"version":"4.0.1"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council\u00a0of\u00a0Scientific and Industrial Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004507","name":"Central Drug Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004507","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.bioorg.2018.06.012","type":"journal-article","created":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T17:52:25Z","timestamp":1528221145000},"page":"204-211","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"special_numbering":"C","title":["Design, synthesis and antiplasmodial activity of novel imidazole derivatives based on 7-chloro-4-aminoquinoline"],"prefix":"10.1016","volume":"80","author":[{"given":"Srinivasarao","family":"Kondaparla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashan","family":"Manhas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasantha Rao","family":"Dola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumkum","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil K.","family":"Puri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.B.","family":"Katti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2018.06.012_b0005","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1021\/jm061232x","article-title":"Synthesis and antimalarial activity of new isotebuquine analogues","volume":"50","author":"Miroshnikova","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.06.012_b0010","unstructured":"World Malaria Report World Health Organization: Geneva 27 Switzerland, 2016."},{"key":"10.1016\/j.bioorg.2018.06.012_b0015","doi-asserted-by":"crossref","first-page":"3216","DOI":"10.1021\/jm201676t","article-title":"Design, synthesis, and in vitro activity of novel 2'-O-substituted 15-membered azalides","volume":"55","author":"Pesic","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.06.012_b0020","doi-asserted-by":"crossref","first-page":"10387","DOI":"10.1021\/jm300831b","article-title":"Mimicking the intramolecular hydrogen bond: synthesis, biological evaluation, and molecular modeling of benzoxazines and quinazolines as potential antimalarial agents","volume":"55","author":"Gemma","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.06.012_b0025","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1021\/jm301076q","article-title":"Incorporation of a 3-(2,2,2-trifluoroethyl)-gamma-hydroxy-gamma-lactam motif in the side chain of 4-aminoquinolines. Syntheses and antimalarial activities","volume":"56","author":"Cornut","year":"2013","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.06.012_b0030","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ejmech.2013.05.023","article-title":"Synthesis and bioevaluation of novel 4-aminoquinoline-tetrazole derivatives as potent antimalarial agents","volume":"66","author":"Pandey","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.06.012_b0035","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/374269a0","article-title":"Malarial haemozoin\/beta-haematin supports haem polymerization in the absence of protein","volume":"374","author":"Dorn","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.bioorg.2018.06.012_b0040","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1021\/jm301654b","article-title":"N-cinnamoylated chloroquine analogues as dual-stage antimalarial leads","volume":"56","author":"Perez","year":"2013","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.06.012_b0045","doi-asserted-by":"crossref","first-page":"3685","DOI":"10.1021\/jm100057h","article-title":"Development of a new generation of 4-aminoquinoline antimalarial compounds using predictive pharmacokinetic and toxicology models","volume":"53","author":"Ray","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.06.012_b0050","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1021\/ml3000808","article-title":"Novel 4-aminoquinoline-pyrimidine based hybrids with improved in vitro and in vivo antimalarial activity","volume":"3","author":"Manohar","year":"2012","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2018.06.012_b0055","doi-asserted-by":"crossref","first-page":"3637","DOI":"10.1021\/jm200149e","article-title":"Enone- and chalcone-chloroquinoline hybrid analogues: in silico guided design, synthesis, antiplasmodial activity, in vitro metabolism, and mechanistic studies","volume":"54","author":"Guantai","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.06.012_b0060","doi-asserted-by":"crossref","first-page":"6601","DOI":"10.1039\/c2cc32760k","article-title":"Efficient catalytic cyclizations of three and two imine assemblies: direct access to tetrahydroimidazo[1,5-c]imidazol-7-ones and imidazoles","volume":"48","author":"Saima","year":"2012","journal-title":"Chem. Commun."},{"issue":"2","key":"10.1016\/j.bioorg.2018.06.012_b0065","first-page":"237","article-title":"Review on: synthesis, chemistry and therapeutic approaches of imidazole derivatives","volume":"23","author":"Ghosh","year":"2013","journal-title":"Int. J. Pharm. Sci. Rev. Res."},{"key":"10.1016\/j.bioorg.2018.06.012_b0070","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1021\/jm701247k","article-title":"Clotrimazole scaffold as an innovative pharmacophore towards potent antimalarial agents: design, synthesis, and biological and structure-activity relationship studies","volume":"51","author":"Gemma","year":"2008","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.06.012_b0075","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1021\/jm801352s","article-title":"Combining 4-aminoquinoline- and clotrimazole-based pharmacophores toward innovative and potent hybrid antimalarials","volume":"52","author":"Gemma","year":"2009","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.06.012_b0080","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1021\/jm061002i","article-title":"Synthesis and antimalarial activity of side chain modified 4-aminoquinoline derivatives","volume":"50","author":"Solomon","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.06.012_b0085","doi-asserted-by":"crossref","first-page":"5950","DOI":"10.1016\/j.bmc.2014.09.009","article-title":"Synthesis of chiral chloroquine and its analogues as antimalarial agents","volume":"22","author":"Sinha","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.06.012_b0090","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.bioorg.2016.11.010","article-title":"Antimalarial activity of novel 4-aminoquinolines active against drug resistant strains","volume":"70","author":"Kondaparla","year":"2017","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2018.06.012_b0095","doi-asserted-by":"crossref","first-page":"105676","DOI":"10.1039\/C6RA14016E","article-title":"Synthesis and antimalarial activity of new 4-aminoquinolines active against drug resistant strains","volume":"6","author":"Kondaparla","year":"2017","journal-title":"RSC Adv."},{"key":"10.1016\/j.bioorg.2018.06.012_b0100","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.bmc.2014.05.024","article-title":"Antiplasmodial activity of new 4-aminoquinoline derivatives against chloroquine resistant strain","volume":"22","author":"Sinha","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.06.012_b0105","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1021\/jm990437l","article-title":"Structure-function relationships in aminoquinolines: effect of amino and chloro groups on quinoline-hematin complex formation, inhibition of beta-hematin formation, and antiplasmodial activity","volume":"43","author":"Egan","year":"2000","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.06.012_b0110","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1111\/cbdd.12914","article-title":"Design, synthesis and in vitro antiplasmodial activity of some bisquinolines against chloroquine-resistant strain","volume":"89","author":"Kondaparla","year":"2017","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.bioorg.2018.06.012_b0115","first-page":"37","article-title":"Recent developments in plasmodium falciparum in vitro model for drug discovery","volume":"79","author":"Srivastava","year":"2009","journal-title":"Proc. Natl. Acad. Sci. India"},{"key":"10.1016\/j.bioorg.2018.06.012_b0120","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.bioorg.2018.06.012_b0125","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0162-0134(97)00086-X","article-title":"Thermodynamic factors controlling the interaction of quinoline antimalarial drugs with ferriprotoporphyrin IX","volume":"68","author":"Egan","year":"1997","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.bioorg.2018.06.012_b0130","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ab.2003.10.016","article-title":"Spectrophotometric determination of de novo hemozoin\/beta-hematin formation in an in vitro assay","volume":"325","author":"Tripathi","year":"2004","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bioorg.2018.06.012_b0135","unstructured":"GraphPad Prism, Version 3.0, GraphPad Software, 10855 Sorrento Valley Rd. #203, San Diego, CA 92121, 1999."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206818302396?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206818302396?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T07:45:46Z","timestamp":1758613546000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206818302396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":27,"alternative-id":["S0045206818302396"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2018.06.012","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, synthesis and antiplasmodial activity of novel imidazole derivatives based on 7-chloro-4-aminoquinoline","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2018.06.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}