{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T23:53:29Z","timestamp":1768262009437,"version":"3.49.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.bioorg.2018.06.013","type":"journal-article","created":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T18:21:16Z","timestamp":1528222876000},"page":"164-173","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Design, synthesis and evaluation of some pyrazolo[3,4-d]pyrimidine derivatives bearing thiazolidinone moiety as anti-inflammatory agents"],"prefix":"10.1016","volume":"80","author":[{"given":"Gina N.","family":"Tageldin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salwa M.","family":"Fahmy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayam M.","family":"Ashour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mounir A.","family":"Khalil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasha A.","family":"Nassra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim M.","family":"Labouta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bioorg.2018.06.013_b0005","doi-asserted-by":"crossref","first-page":"52","DOI":"10.2174\/187152312803476255","article-title":"Clinical pharmacology of non-steroidal anti-inflammatory drugs: a review","volume":"11","author":"Bacchi","year":"2012","journal-title":"Anti-Inflamm. Anti-Allergy Agents Med. Chem. (Formerly Current Med. Chem.-Anti-Inflamm. Anti-Allergy Agents)"},{"issue":"2","key":"10.1016\/j.bioorg.2018.06.013_b0010","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.plefa.2004.10.005","article-title":"COX-3 and the mechanism of action of paracetamol\/acetaminophen","volume":"72","author":"Botting","year":"2005","journal-title":"Prostagl. Leukot. Essent. Fatty Acids"},{"issue":"1","key":"10.1016\/j.bioorg.2018.06.013_b0015","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.ejphar.2004.07.042","article-title":"Mechanisms underlying intestinal injury induced by anti-inflammatory COX inhibitors","volume":"500","author":"Whittle","year":"2004","journal-title":"Eur. J. Pharmacol."},{"issue":"16","key":"10.1016\/j.bioorg.2018.06.013_b0020","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.2174\/092986709788682209","article-title":"Nonsteroidal anti-inflammatory drugs: a critical review on current concepts applied to reduce gastrointestinal toxicity","volume":"16","author":"Abdel-Tawab","year":"2009","journal-title":"Curr. Med. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2018.06.013_b0025","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/bcpt.12117","article-title":"Variability in the response to non-steroidal anti-inflammatory drugs: mechanisms and perspectives","volume":"114","author":"Bruno","year":"2014","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"issue":"9","key":"10.1016\/j.bioorg.2018.06.013_b0030","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1016\/S0149-2918(00)80005-3","article-title":"Celecoxib, a selective cyclooxygenase-2 inhibitor for the treatment of rheumatoid arthritis and osteoarthritis","volume":"21","author":"Goldenberg","year":"1999","journal-title":"Clin. Therap."},{"issue":"16","key":"10.1016\/j.bioorg.2018.06.013_b0035","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1161\/CIRCULATIONAHA.108.764530","article-title":"Cardiovascular risk of celecoxib in 6 randomized placebo-controlled trials the cross trial safety analysis","volume":"117","author":"Solomon","year":"2008","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.bioorg.2018.06.013_b0040","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0223-5234(92)90064-8","article-title":"Synthesis and pharmacological properties of pyrazolotriazolopyrimidine derivatives","volume":"27","author":"Russo","year":"1992","journal-title":"Eur. J. Med. Chem."},{"issue":"5","key":"10.1016\/j.bioorg.2018.06.013_b0045","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/0223-5234(93)90123-V","article-title":"Pyrazolothiazolopyrimidine derivatives as a novel class of anti-inflammatory or antinociceptive agents: synthesis, structural characterization and pharmacological evaluation","volume":"28","author":"Russo","year":"1993","journal-title":"Eur. J. Med. Chem."},{"issue":"8","key":"10.1016\/j.bioorg.2018.06.013_b0050","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1002\/cmdc.201000165","article-title":"Hit identification and biological evaluation of anticancer pyrazolopyrimidines endowed with anti-inflammatory activity","volume":"5","author":"Alcaro","year":"2010","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bioorg.2018.06.013_b0055","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.bioorg.2018.03.032","article-title":"New advances in synthesis and clinical aspects of pyrazolo[3,4-d]pyrimidine scaffolds","volume":"78","author":"Abdellatif","year":"2018","journal-title":"Bioorg. Chem."},{"issue":"6","key":"10.1016\/j.bioorg.2018.06.013_b0060","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/S0968-0896(02)00562-X","article-title":"6-Dimethylamino 1H-pyrazolo [3, 4-d] pyrimidine derivatives as new inhibitors of inflammatory mediators in intact cells","volume":"11","author":"Quintela","year":"2003","journal-title":"Bioorg. Med. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2018.06.013_b0065","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.ejphar.2004.02.015","article-title":"A new pyrazolo pyrimidine derivative inhibitor of cyclooxygenase-2 with anti-angiogenic activity","volume":"488","author":"Devesa","year":"2004","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bioorg.2018.06.013_b0070","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.ejps.2014.05.025","article-title":"Novel pyrazolopyrimidine derivatives targeting COXs and iNOS enzymes; design, synthesis and biological evaluation as potential anti-inflammatory agents","volume":"62","author":"Abdelazeem","year":"2014","journal-title":"Eur. J. Pharm. Sci."},{"issue":"5","key":"10.1016\/j.bioorg.2018.06.013_b0075","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1016\/j.bmc.2010.01.021","article-title":"Synthesis and biological evaluation of novel pyrazolyl-2, 4-thiazolidinediones as anti-inflammatory and neuroprotective agents","volume":"18","author":"Youssef","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.06.013_b0080","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.ejmech.2013.04.010","article-title":"Synthesis and biological evaluation of novel thiazolidinone derivatives as potential anti-inflammatory agents","volume":"64","author":"Hu","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.06.013_b0085","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.ejmech.2013.06.005","article-title":"Novel 2-(2, 4-dioxo-1, 3-thiazolidin-5-yl) acetamides as antioxidant and\/or anti-inflammatory compounds","volume":"66","author":"Koppireddi","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.06.013_b0090","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.ejmech.2013.03.011","article-title":"Novel quinolone substituted thiazolidin-4-ones as anti-inflammatory, anticancer agents: Design, synthesis and biological screening","volume":"63","author":"Suthar","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.06.013_b0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bioorg.2015.11.001","article-title":"Design, synthesis and biological screening of new 4-thiazolidinone derivatives with promising COX-2 selectivity, anti-inflammatory activity and gastric safety profile","volume":"64","author":"Abdellatif","year":"2016","journal-title":"Bioorg. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2018.06.013_b0100","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0014-2999(02)01888-5","article-title":"Modeling and biological evaluation of 3, 3\u2032-(1, 2-ethanediyl) bis [2-(4-methoxyphenyl)-thiazolidin-4-one], a new synthetic cyclooxygenase-2 inhibitor","volume":"448","author":"Ottan\u00e1","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bioorg.2018.06.013_b0105","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ejmech.2012.08.046","article-title":"Molecular modeling, synthesis and screening of some new 4-thiazolidinone derivatives with promising selective COX-2 inhibitory activity","volume":"57","author":"Unsal-Tan","year":"2012","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.06.013_b0110","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.bioorg.2017.03.012","article-title":"El-Hawash SaM. New hybrid molecules combining benzothiophene or benzofuran with rhodanine as dual COX-1\/2 and 5-LOX inhibitors: synthesis, biological evaluation and docking study","volume":"72","author":"El-Miligy","year":"2017","journal-title":"Bioorg. Chem."},{"issue":"3","key":"10.1016\/j.bioorg.2018.06.013_b0115","doi-asserted-by":"crossref","first-page":"685","DOI":"10.3390\/molecules23030685","article-title":"Thiazoles and thiazolidinones as COX\/LOX inhibitors","volume":"23","author":"Liaras","year":"2018","journal-title":"Molecules"},{"issue":"18","key":"10.1016\/j.bioorg.2018.06.013_b0120","doi-asserted-by":"crossref","first-page":"6414","DOI":"10.1016\/j.bmc.2006.05.042","article-title":"Synthesis, pulse radiolysis, and in vitro radioprotection studies of melatoninolipoamide, a novel conjugate of melatonin and \u03b1-lipoic acid","volume":"14","author":"Venkatachalam","year":"2006","journal-title":"Bioorg. Med. Chem."},{"issue":"27","key":"10.1016\/j.bioorg.2018.06.013_b0125","doi-asserted-by":"crossref","first-page":"6973","DOI":"10.1021\/jm049637+","article-title":"Drug evolution concept in drug design: 1. Hybridization method","volume":"47","author":"Lazar","year":"2004","journal-title":"J. Med. Chem."},{"issue":"5","key":"10.1016\/j.bioorg.2018.06.013_b0130","doi-asserted-by":"crossref","first-page":"443","DOI":"10.4155\/fmc-2016-0230","article-title":"New benzothiophene derivatives as dual COX-1\/2 and 5-LOX inhibitors: synthesis, biological evaluation and docking study","volume":"9","author":"El-Miligy","year":"2017","journal-title":"Future Med. Chem."},{"issue":"12","key":"10.1016\/j.bioorg.2018.06.013_b0135","doi-asserted-by":"crossref","first-page":"5269","DOI":"10.1007\/s00044-014-1079-9","article-title":"Synthesis, biological evaluation of certain pyrazolo[3,4-d]pyrimidines as novel anti-inflammatory and analgesic agents","volume":"23","author":"Kadry","year":"2014","journal-title":"Med. Chem. Res."},{"issue":"2","key":"10.1016\/j.bioorg.2018.06.013_b0140","first-page":"393","article-title":"Synthesis, anti-inflammatory, and ulcerogenicity studies of novel substituted and fused pyrazolo [3, 4-d] pyrimidin-4-ones","volume":"81","author":"El-Tombary","year":"2013","journal-title":"Sci. Pharmaceut."},{"key":"10.1016\/j.bioorg.2018.06.013_b0145","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.bioorg.2018.03.030","article-title":"Design, synthesis and evaluation of some pyrazolo[3,4-d]pyrimidines as anti-inflammatory agents","volume":"78C","author":"Tageldin","year":"2018","journal-title":"Bioorg. Chem."},{"issue":"5","key":"10.1016\/j.bioorg.2018.06.013_b0150","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S1093-3263(01)00135-8","article-title":"Differential binding mode of diverse cyclooxygenase inhibitors","volume":"20","author":"Llorens","year":"2002","journal-title":"J. Mol. Graph. Model."},{"issue":"1","key":"10.1016\/j.bioorg.2018.06.013_b0155","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0014-827X(98)00109-8","article-title":"Antiinflammatory agents: new series of N-substituted amino acids with complex pyrimidine structures endowed with antiphlogistic activity","volume":"54","author":"Bruno","year":"1999","journal-title":"Il Farmaco"},{"key":"10.1016\/j.bioorg.2018.06.013_b0160","first-page":"1","article-title":"Novel 1, 5-diphenyl-6-substituted 1H-pyrazolo [3, 4-d] pyrimidin-4 (5 H)-ones induced apoptosis in RKO colon cancer cells","author":"Malki","year":"2015","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.06.013_b0165","doi-asserted-by":"crossref","first-page":"77","DOI":"10.15227\/orgsyn.039.0077","volume":"39","author":"Strube","year":"1959","journal-title":"Org. Synth."},{"issue":"6","key":"10.1016\/j.bioorg.2018.06.013_b0170","first-page":"640","article-title":"Synthesis and anticancer activity in vitro of some 2-thioxo-4-thiazolidone derivatives","volume":"55","author":"Roman","year":"2007","journal-title":"FARMACIA-BUCURESTI-"},{"issue":"7","key":"10.1016\/j.bioorg.2018.06.013_b0175","doi-asserted-by":"crossref","first-page":"3714","DOI":"10.1016\/j.bmc.2008.02.001","article-title":"2-Heteroarylimino-5-benzylidene-4-thiazolidinones analogues of 2-thiazolylimino-5-benzylidene-4-thiazolidinones with antimicrobial activity: synthesis and structure\u2013activity relationship","volume":"16","author":"Vicini","year":"2008","journal-title":"Bioorg. Med. Chem."},{"issue":"3","key":"10.1016\/j.bioorg.2018.06.013_b0180","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/s00706-015-1549-x","article-title":"Synthesis and pharmacological evaluation of new pyrazolyl benzenesulfonamides linked to polysubstituted pyrazoles and thiazolidinones as anti-inflammatory and analgesic agents","volume":"147","author":"Ashour","year":"2016","journal-title":"Monatsh. Chem.\u2013 Chem. Monthly"},{"issue":"2","key":"10.1016\/j.bioorg.2018.06.013_b0185","doi-asserted-by":"crossref","first-page":"125","DOI":"10.4103\/0973-8258.155062","article-title":"Evaluation of anti-inflammatory and analgesic activities of methanolic leaf extract of the endangered tree species, Hildegardia populifolia (Roxb.) Schott and Endl","volume":"9","author":"Subramanium","year":"2015","journal-title":"Int. J. Green Pharm. (IJGP)"},{"key":"10.1016\/j.bioorg.2018.06.013_b0190","first-page":"153","article-title":"Evaluation of anti-nociceptive and anti-inflammatory activities of novel chalcone derivatives","volume":"12","author":"Razmi","year":"2013","journal-title":"Iran. J. Pharm. Res."},{"issue":"6","key":"10.1016\/j.bioorg.2018.06.013_b0195","article-title":"Screening of anti-inflammatory activity and dose selection of Mollugo pentaphylla by using cotton pellet induced","volume":"2","author":"Mishra","year":"2011","journal-title":"Int. J. Pharm. Life Sci."},{"issue":"1","key":"10.1016\/j.bioorg.2018.06.013_b0200","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S1043-6618(05)80109-4","article-title":"Protection against gastric ulcer by verapamil","volume":"23","author":"Srivastava","year":"1991","journal-title":"Pharm. Res."},{"issue":"5","key":"10.1016\/j.bioorg.2018.06.013_b0205","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s13659-014-0034-2","article-title":"A new gastroprotective effect of limonoid compounds xyloccensins x and y from xylocarpus molluccensis in rats","volume":"4","author":"Lakshmi","year":"2014","journal-title":"Natl. Prod. Bioprospect."},{"key":"10.1016\/j.bioorg.2018.06.013_b0210","unstructured":"https:\/\/www.caymanchem.com\/product\/760111 (accessed 12th October 2017)."},{"issue":"4","key":"10.1016\/j.bioorg.2018.06.013_b0215","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/0090-6980(83)90025-4","article-title":"Requirements for hydroperoxide by the cyclooxygenase and peroxidase activities of prostaglandin H synthase","volume":"25","author":"Kulmacz","year":"1983","journal-title":"Prostaglandins"},{"key":"10.1016\/j.bioorg.2018.06.013_b0220","series-title":"Encyclopedia of statistical sciences","author":"Kotz","year":"2006"},{"key":"10.1016\/j.bioorg.2018.06.013_b0225","unstructured":"Kirkpatrick La, Bc. F. A simple guide to IBM SPSS statistics for version 20.0. Student ed. Wadsworth, Cengage Learning, Belmont, Calif., 2013."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206818304000?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206818304000?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T07:45:29Z","timestamp":1758613529000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206818304000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":45,"alternative-id":["S0045206818304000"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2018.06.013","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, synthesis and evaluation of some pyrazolo[3,4-d]pyrimidine derivatives bearing thiazolidinone moiety as anti-inflammatory agents","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2018.06.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}