{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T10:11:21Z","timestamp":1780567881735,"version":"3.54.1"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21562013"],"award-info":[{"award-number":["21562013"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["20154001"],"award-info":[{"award-number":["20154001"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.bioorg.2018.06.026","type":"journal-article","created":{"date-parts":[[2018,6,20]],"date-time":"2018-06-20T21:53:12Z","timestamp":1529531592000},"page":"433-443","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"special_numbering":"C","title":["Syntheses, antiviral activities and induced resistance mechanisms of novel quinazoline derivatives containing a dithioacetal moiety"],"prefix":"10.1016","volume":"80","author":[{"given":"Dandan","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Awei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangcheng","family":"Zu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuhai","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoan","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deyu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2018.06.026_b0005","doi-asserted-by":"crossref","first-page":"4096","DOI":"10.1016\/j.bmcl.2017.07.038","article-title":"Synthesis, antiviral activity, and molecular docking study of trans-ferulic acid derivatives containing acylhydrazone moiety","volume":"27","author":"Wang","year":"2017","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2018.06.026_b0010","doi-asserted-by":"crossref","first-page":"4270","DOI":"10.1016\/j.bmcl.2017.08.048","article-title":"Novel \u03b1, \u03b2-unsaturated amide derivatives bearing \u03b1-amino phosphonate moiety as potential antiviral agents","volume":"27","author":"Lan","year":"2017","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2018.06.026_b0015","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1080\/10426507.2017.1323895","article-title":"Synthesis and antiviral activity of novel a-aminophosphonates containing 6-fluorobenzothiazole moiety, Phosphorus","volume":"192","author":"Xie","year":"2017","journal-title":"Sulfur Silicon Relat. Elem."},{"key":"10.1016\/j.bioorg.2018.06.026_b0020","doi-asserted-by":"crossref","first-page":"10212","DOI":"10.1021\/jf303550a","article-title":"Design, Synthesis, and anti-tobacco mosaic virus (TMV) activity of phenanthroindolizidines and their analogues","volume":"60","author":"Wang","year":"2012","journal-title":"J. Agric. Food. Chem."},{"key":"10.1016\/j.bioorg.2018.06.026_b0025","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.bioorg.2017.04.009","article-title":"Synthesis, crystal structure determination, biological screening and docking studies of N1-substituted derivatives of 2,3-dihydroquinazolin-4(1H)-one as inhibitors of cholinesterases","volume":"72","author":"Sultana","year":"2017","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2018.06.026_b0030","doi-asserted-by":"crossref","first-page":"9575","DOI":"10.1021\/jf403193q","article-title":"Synthesis and bioactivity evaluation of novel arylimines containing a 3-aminoethyl-2-[(p-trifluoromethoxy) anilino]-4(3H)-quinazolinone moiety","volume":"61","author":"Wang","year":"2013","journal-title":"J. Agric. Food. Chem."},{"key":"10.1016\/j.bioorg.2018.06.026_b0035","doi-asserted-by":"crossref","first-page":"3768","DOI":"10.1016\/j.bmc.2007.03.037","article-title":"Synthesis and antifungal activity of novel s-substituted 6-fluoro-4-alkyl (aryl) thioquinazoline derivatives","volume":"15","author":"Xu","year":"2007","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.06.026_b0040","doi-asserted-by":"crossref","first-page":"3452","DOI":"10.1016\/j.bmcl.2014.05.073","article-title":"Synthesis and anti-TMV activity of novel \u03b2-amino acid ester derivatives containing quinazoline and benzothiazole moieties","volume":"24","author":"Xiao","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.06.026_b0045","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.ejmech.2013.02.035","article-title":"Synthesis and antiviral bioactivity of novel (1E,4E)-1-aryl-5-(2-(quinazoline-4-yloxy)phenyl)-1,4-pentadien-3-one derivatives","volume":"63","author":"Luo","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.06.026_b0050","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.ejmech.2015.08.029","article-title":"Synthesis, anti-tobacco mosaic virus and cucumber mosaic virus activity, and 3D-QSAR study of novel 1, 4-pentadien-3-one derivatives containing 4-thioquinazoline moiety","volume":"102","author":"Long","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.06.026_b0055","doi-asserted-by":"crossref","first-page":"6730","DOI":"10.3390\/ijms13066730","article-title":"Rapid synthesis and antiviral activity of [(quinazolin-4-yl)amino]methyl-phosphonates through microwave irradiation","volume":"13","author":"Luo","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2018.06.026_b0060","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1002\/jhet.2849","article-title":"Design, synthesis, antiviral activities of novel phosphonate derivatives containing quinazoline based on chalone motif","volume":"54","author":"Zhang","year":"2017","journal-title":"J. Heterocyclic Chem."},{"key":"10.1016\/j.bioorg.2018.06.026_b0065","doi-asserted-by":"crossref","first-page":"4643","DOI":"10.1016\/j.bmcl.2017.09.018","article-title":"gem-Dithioacetylated indole derivatives as novel antileishmanial agents","volume":"27","author":"Porwal","year":"2017","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2018.06.026_b0070","doi-asserted-by":"crossref","first-page":"6132","DOI":"10.1021\/acs.orglett.7b03008","article-title":"Sulfur-directed ligand-free C-H borylation by iridium catalysis","volume":"19","author":"Liu","year":"2017","journal-title":"Org. Lett."},{"key":"10.1016\/j.bioorg.2018.06.026_b0075","doi-asserted-by":"crossref","first-page":"3659","DOI":"10.1021\/acs.joc.7b00170","article-title":"Indium-catalyzed reductive dithioacetalization of carboxylic acids with dithiols: Scope, limitations, and application to oxidative desulfurization","volume":"82","author":"Nishino","year":"2017","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bioorg.2018.06.026_b0080","doi-asserted-by":"crossref","first-page":"4582","DOI":"10.1021\/acs.jafc.7b01035","article-title":"Facile synthesis of novel vanillin derivatives incorporating a bis(2-hydroxyethyl) dithioacetal moiety as antiviral agents","volume":"65","author":"Zhang","year":"2017","journal-title":"J. Agric. Food. Chem."},{"key":"10.1016\/j.bioorg.2018.06.026_b0085","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1002\/jccs.200600157","article-title":"A novel chemoselective reaction of aldehydes with 2-mercaptoethanol catalyzed by SiO2-NaHSO4 under solvent-free condition","volume":"53","author":"Azarifar","year":"2006","journal-title":"J. Chin. Chem. Soc-TaiP."},{"key":"10.1016\/j.bioorg.2018.06.026_b0090","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1016\/j.bmcl.2014.04.101","article-title":"Design, synthesis, antiviral activity, and SARs of 13a-substituted phenanthroindolizidine alkaloid derivatives","volume":"24","author":"Su","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2018.06.026_b0095","first-page":"1889","article-title":"Effect of intercropped garlic (Allium sativum) on chlorophyll contents, photosynthesis and antioxidant enzymes in pepper","volume":"45","author":"Ahmad","year":"2013","journal-title":"Pak. J. Bot."},{"key":"10.1016\/j.bioorg.2018.06.026_b0100","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1146\/annurev.bi.49.070180.004305","article-title":"Enzyme-catalyzed phosphoryl transfer reactions","volume":"49","author":"Knowles","year":"1980","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.bioorg.2018.06.026_b0105","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1023\/A:1006445810996","article-title":"Rapid evolutionary divergence of Photosystem I core subunits PsaA and PsaB in the marine prokaryote Prochlorococcus","volume":"65","author":"Staay","year":"2000","journal-title":"Photosynth. Res."},{"key":"10.1016\/j.bioorg.2018.06.026_b0110","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0005-2728(01)00196-7","article-title":"Role of subunits in eukaryotic photosystem I","volume":"1507","author":"Scheller","year":"2001","journal-title":"Biochim. Biophys. Acta."},{"key":"10.1016\/j.bioorg.2018.06.026_b0115","doi-asserted-by":"crossref","first-page":"31211","DOI":"10.1074\/jbc.M002933200","article-title":"Down-regulation of the PSI-F subunit of photosystem I (PSI) in Arabidopsis thaliana. The PSI-F subunit is essential for photoautotrophic growth and contributes to antenna function","volume":"275","author":"Haldrup","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bioorg.2018.06.026_b0120","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1046\/j.1365-313X.1999.00419.x","article-title":"The interaction between plastocyanin and photosystem I is inefficient in transgenic Arabidopsis plants lacking the PSI-N subunit of photosystem I","volume":"17","author":"Haldrup","year":"1999","journal-title":"Plant. J."},{"key":"10.1016\/j.bioorg.2018.06.026_b0125","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S1672-6308(13)60133-X","article-title":"Positive regulation of phytochrome B on chlorophyll biosynthesis and chloroplast development in rice","volume":"20","author":"Zhao","year":"2013","journal-title":"Rice Science"},{"key":"10.1016\/j.bioorg.2018.06.026_b0130","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2-\u25b3\u25b3CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.bioorg.2018.06.026_b0135","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/pmic.200390014","article-title":"Proteins induced by Xanthomonas axonopodis pv. passif lorae with leaf extract of the host plant (Passif lorae edulis)","volume":"3","author":"Tahara","year":"2003","journal-title":"Proteomics"},{"key":"10.1016\/j.bioorg.2018.06.026_b0140","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.1021\/pr4001543","article-title":"Proteomic analysis reveals novel extracellular virulence-associated proteins and functions regulated by the diffusible signal factor (DSF) in Xanthomonas oryzae pv. Oryzicola","volume":"12","author":"Qian","year":"2013","journal-title":"J. Proteome. Res"},{"key":"10.1016\/j.bioorg.2018.06.026_b0145","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1007\/s13361-011-0142-8","article-title":"Software lock mass by two-dimensional minimization of peptide mass errors","volume":"22","author":"Cox","year":"2011","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.bioorg.2018.06.026_b0150","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.immuni.2010.01.013","article-title":"Quantitative proteomics reveals subset-specific viral recognition in dendritic cells","volume":"32","author":"Luber","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.bioorg.2018.06.026_b0155","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1093\/nar\/gkh036","article-title":"The gene ontology (GO) database and informatics resource","volume":"32","author":"Harris","year":"2004","journal-title":"Nucleic Acids Res."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004520681830292X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004520681830292X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T07:48:38Z","timestamp":1758613718000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004520681830292X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":31,"alternative-id":["S004520681830292X"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2018.06.026","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Syntheses, antiviral activities and induced resistance mechanisms of novel quinazoline derivatives containing a dithioacetal moiety","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2018.06.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}