{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T16:57:28Z","timestamp":1793120248336,"version":"4.5.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"T\u00dcB\u0130TAK","award":["117Z293"],"award-info":[{"award-number":["117Z293"]}]},{"name":"In\u00f6n\u00fc University, Turkey","award":["FUA-2018-1101"],"award-info":[{"award-number":["FUA-2018-1101"]}]},{"DOI":"10.13039\/501100004434","name":"Universita\u2018 degli Studi di Firenze, Italy","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004434","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.bioorg.2018.11.003","type":"journal-article","created":{"date-parts":[[2018,11,3]],"date-time":"2018-11-03T12:02:09Z","timestamp":1541246529000},"page":"414-423","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Synthesis and carbonic anhydrase inhibitory properties of novel 4-(2-aminoethyl)benzenesulfonamide-dipeptide conjugates"],"prefix":"10.1016","volume":"83","author":[{"given":"Hasan","family":"K\u00fc\u00e7\u00fckbay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nesrin","family":"Bu\u011fday","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. Zehra","family":"K\u00fc\u00e7\u00fckbay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Berrino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5631-8769","authenticated-orcid":false,"given":"Gianluca","family":"Bartolucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Del Prete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3314-2411","authenticated-orcid":false,"given":"Clemente","family":"Capasso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4262-0323","authenticated-orcid":false,"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2018.11.003_b0005","doi-asserted-by":"crossref","first-page":"58","DOI":"10.5937\/savteh1701058T","article-title":"Antimicrobial sulfonamide drugs","volume":"6","author":"Tacic","year":"2017","journal-title":"Adv. Technol."},{"key":"10.1016\/j.bioorg.2018.11.003_b0010","doi-asserted-by":"crossref","first-page":"818","DOI":"10.2174\/1385272822666180122153839","article-title":"Sulfonamides as potential bioactive scaffolds","volume":"22","author":"Khan","year":"2018","journal-title":"Curr. Org. Chem."},{"key":"10.1016\/j.bioorg.2018.11.003_b0015","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1080\/13543776.2018.1523897","article-title":"Carbonic anhydrase inhibitors and their potential in a range of therapeutic areas","volume":"28","author":"Supuran","year":"2018","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bioorg.2018.11.003_b0020","doi-asserted-by":"crossref","first-page":"160","DOI":"10.2174\/1570193X11310020005","article-title":"Synthetic routes of sulfonamide derivatives: a brief review","volume":"10","author":"Ashfaq","year":"2003","journal-title":"Mini Rev. Org. Chem."},{"key":"10.1016\/j.bioorg.2018.11.003_b0025","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1080\/17460441.2017.1253677","article-title":"Advances in structure-based drug discovery of carbonic anhydrase inhibitors","volume":"12","author":"Supuran","year":"2017","journal-title":"Expert Opin. Drug Discov."},{"key":"10.1016\/j.bioorg.2018.11.003_b0030","doi-asserted-by":"crossref","first-page":"E56","DOI":"10.3390\/metabo7040056","article-title":"An overview of the bacterial carbonic anhydrases","volume":"7","author":"Supuran","year":"2017","journal-title":"Metabolites"},{"key":"10.1016\/j.bioorg.2018.11.003_b0035","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.4155\/fmc.15.71","article-title":"Carbonic anhydrase IX inhibitors in cancer therapy: an update","volume":"7","author":"Supuran","year":"2015","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.bioorg.2018.11.003_b0040","doi-asserted-by":"crossref","first-page":"70","DOI":"10.2174\/138955713804484749","article-title":"Recent advances in medicinal chemistry of sulfonamides. Rational design as anti-tumoral, anti-bacterial and anti-inflammatory agents","volume":"13","author":"Shah","year":"2013","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.11.003_b0045","doi-asserted-by":"crossref","first-page":"925","DOI":"10.2174\/0929867033457647","article-title":"Anticancer and antiviral sulfonamides","volume":"10","author":"Scozzafava","year":"2003","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.11.003_b0050","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrd2467","article-title":"Carbonic anhydrases: novel therapeutic applications for inhibitors and activator","volume":"7","author":"Supuran","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bioorg.2018.11.003_b0055","doi-asserted-by":"crossref","first-page":"3332","DOI":"10.1096\/fj.10-157040","article-title":"High-throughput discovery of broad-spectrum peptide antibiotics","volume":"24","author":"Rathinakumar","year":"2010","journal-title":"FASEB J."},{"key":"10.1016\/j.bioorg.2018.11.003_b0060","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1113\/jphysiol.1938.sp003605","article-title":"The buffering role of muscle in rigor: protein, phosphate and carnosine","volume":"92","author":"Bate-Smith","year":"1938","journal-title":"J. Physiol."},{"key":"10.1016\/j.bioorg.2018.11.003_b0065","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1007\/s00726-018-2592-9","article-title":"Carnosine and advanced glycation end products: a systematic review","volume":"50","author":"Ghodsi","year":"2018","journal-title":"Amino Acids"},{"key":"10.1016\/j.bioorg.2018.11.003_b0070","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1093\/chemse\/bjv045","article-title":"Characterization of the binding site of aspartame in the human sweet taste receptor","volume":"40","author":"Maillet","year":"2015","journal-title":"Chem. Senses"},{"key":"10.1016\/j.bioorg.2018.11.003_b0075","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.3109\/14756366.2016.1147438","article-title":"Synthesis and carbonic anhydrase I, II, IV and XII inhibitory properties of amino acid \u2013 sulfonamide conjugates","volume":"31","author":"K\u00fc\u00e7\u00fckbay","year":"2016","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.11.003_b0080","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.bioorg.2018.08.032","article-title":"Synthesis of novel dipeptide sulfonamide conjugates with effective carbonic anhydrase I, II, IX, and XII inhibitory properties","volume":"81","author":"Bu\u011fday","year":"2018","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2018.11.003_b0085","first-page":"2645","article-title":"Highly diasteroselective peptide chain extension of unprotected amino acids with N-(Z-\u03b1aminoacyl)benzotriazoles","volume":"16","author":"Suzuki","year":"2004","journal-title":"Synthesis"},{"key":"10.1016\/j.bioorg.2018.11.003_b0090","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1055\/s-0029-1217827","article-title":"Chiral acylation with N-(protected a- aminoacyl)benzotriazoles for advantageous syntheses of peptides and peptide conjugates","author":"Katritzky","year":"2009","journal-title":"Synlett"},{"key":"10.1016\/j.bioorg.2018.11.003_b0095","doi-asserted-by":"crossref","first-page":"9492","DOI":"10.1039\/C5OB01400J","article-title":"Macrocyclic peptidomimetics with antimicrobial activity: synthesis, bioassay, and molecular modeling studies","volume":"13","author":"Ibrahim","year":"2015","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.bioorg.2018.11.003_b0100","doi-asserted-by":"crossref","first-page":"198","DOI":"10.2174\/1570178614666170203093406","article-title":"Synthesis and evaluation of novel benzimidazole conjugates incorporating amino acids and dipeptide moieties","volume":"14","author":"Bu\u011fday","year":"2017","journal-title":"Lett. Org. Chem."},{"key":"10.1016\/j.bioorg.2018.11.003_b0105","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/cbdd.12134","article-title":"Synthesis and antimalarial bioassay of quinine-peptide conjugates","volume":"82","author":"Panda","year":"2013","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.bioorg.2018.11.003_b0110","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.3109\/14756366.2015.1114931","article-title":"Synthesis, characterization and carbonic anhydrase inhibitory activity of novel benzothiazole derivatives","volume":"31","author":"K\u00fc\u00e7\u00fckbay","year":"2016","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.11.003_b0115","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.3109\/14756366.2015.1113173","article-title":"Synthesis and carbonic anhydrase inhibitory properties of amino acid\u2013coumarin\/quinolinone conjugates incorporating glycine, alanine and phenylalanine moieties","volume":"31","author":"K\u00fc\u00e7\u00fckbay","year":"2016","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.11.003_b0120","doi-asserted-by":"crossref","first-page":"3747","DOI":"10.1016\/j.bmcl.2003.08.017","article-title":"QSAR study on antibacterial activity of sulfonamides and derived Mannich bases","volume":"13","author":"Joshi","year":"2003","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.11.003_b0125","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1016\/j.bmc.2012.12.037","article-title":"C.T. O- Benzenedisulfonimido-sulfonamides are potent inhibitors of the tumor-associated carbonicanhydrase isoforms CA IX and CA XII","volume":"21","author":"Guzel-Akdemir","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.11.003_b0130","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.bmcl.2004.12.053","article-title":"Carbonic anhydrase inhibitors. Inhibition of the transmebrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?","volume":"15","author":"Vullo","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2018.11.003_b0135","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1021\/jm030912m","article-title":"Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition","volume":"47","author":"Weber","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.11.003_b0140","doi-asserted-by":"crossref","first-page":"5311","DOI":"10.1016\/j.bmc.2015.07.066","article-title":"Exploring new probenecid-based carbonic anhydrase inhibitors: synthesis, biological evaluation and docking studies","volume":"23","author":"Mollica","year":"2015","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.11.003_b0145","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1016\/S0021-9258(18)62326-9","article-title":"The carbon dioxide hydration activity of carbonic anhydrase. I. Stop-flow kinetic studies on the native human isoenzymes B and C","volume":"246","author":"Khalifah","year":"1971","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bioorg.2018.11.003_b0150","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1016\/S0968-0896(99)00190-X","article-title":"Carbonic anhydrase inhibitors: synthesis of water-soluble, topically effective intraocular pressure lowering aromatic\/heterocyclic sulfonamides containing 8-quinoline-sulfonyl moieties: is the tail more important than the ring?","volume":"7","author":"Borras","year":"1999","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.11.003_b0155","doi-asserted-by":"crossref","first-page":"3690","DOI":"10.1021\/jm9901879","article-title":"Carbonic anhydrase inhibitors: synthesis of water-soluble, aminoacyl\/dipeptidyl sulfonamides possessing long-lasting intraocular pressure-lowering properties via the topical route","volume":"42","author":"Scozzafava","year":"1999","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.11.003_b0160","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1042\/BCJ20160115","article-title":"Structure and function of carbonic anhydrases","volume":"473","author":"Supuran","year":"2016","journal-title":"Biochem. J."},{"key":"10.1016\/j.bioorg.2018.11.003_b0165","doi-asserted-by":"crossref","first-page":"4421","DOI":"10.1021\/cr200176r","article-title":"Multiple binding modes of inhibitors to carbonic anhydrases: how to design specific drugs targeting 15 different isoforms?","volume":"112","author":"Alterio","year":"2012","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bioorg.2018.11.003_b0170","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1039\/c1md00130b","article-title":"Solution-phase synthesis of chiral o-acyl isodipeptides","volume":"2","author":"El Khatib","year":"2011","journal-title":"Med. Chem. Comm."},{"key":"10.1016\/j.bioorg.2018.11.003_b0175","doi-asserted-by":"crossref","first-page":"4884","DOI":"10.1021\/jm001051+","article-title":"Carbonic anhydrase inhibitors: water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects","volume":"43","author":"Casini","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.11.003_b0180","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1080\/14756366.2018.1428572","article-title":"Carbon-versus sulphur-based zinc binding groups for carbonic anhydrase inhibitors?","volume":"33","author":"Supuran","year":"2018","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.11.003_b0185","doi-asserted-by":"crossref","first-page":"388","DOI":"10.3109\/14756366.2011.649268","article-title":"Inhibition of the alpha- and beta- carbonic anhydrases from the gastric pathogen Helycobacter pylori with anions","volume":"28","author":"Maresca","year":"2013","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.11.003_b0190","doi-asserted-by":"crossref","first-page":"392","DOI":"10.3109\/14756366.2011.650168","article-title":"Inhibition of the beta- class carbonic anhydrases from Mycobacterium tuberculosis with carboxylic acids","volume":"28","author":"Maresca","year":"2013","journal-title":"J. Enzyme Inhib. Med. Chem."},{"issue":"sup4","key":"10.1016\/j.bioorg.2018.11.003_b0195","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1080\/14756366.2016.1217857","article-title":"Overexpression of the transmembrane carbonic anhydrase isoforms IX and XII in the inflamed synovium","volume":"31","author":"Margheri","year":"2016","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.11.003_b0200","doi-asserted-by":"crossref","first-page":"345","DOI":"10.3109\/14756366.2015.1122001","article-title":"How many carbonic anhydrase inhibition mechanisms exist?","volume":"31","author":"Supuran","year":"2016","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bioorg.2018.11.003_b0205","doi-asserted-by":"crossref","first-page":"9673","DOI":"10.1021\/jm501497m","article-title":"A class of 4-sulfamoylphenyl-\u03c9-aminoalkyl ethers with effective carbonic anhydrase inhibitory action and antiglaucoma effects","volume":"57","author":"Bozda\u011f","year":"2014","journal-title":"J. Med. Chem."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206818310745?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206818310745?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T07:46:15Z","timestamp":1758613575000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206818310745"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":41,"alternative-id":["S0045206818310745"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2018.11.003","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and carbonic anhydrase inhibitory properties of novel 4-(2-aminoethyl)benzenesulfonamide-dipeptide conjugates","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2018.11.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}