{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:39:46Z","timestamp":1787312386617,"version":"build-2736575974"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.bioorg.2019.01.002","type":"journal-article","created":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T13:36:24Z","timestamp":1546522584000},"page":"198-208","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"special_numbering":"C","title":["Synthesis of novel benzenesulfonamide bearing 1,2,3-triazole linked hydroxy-trifluoromethylpyrazolines and hydrazones as selective carbonic anhydrase isoforms IX and XII inhibitors"],"prefix":"10.1016","volume":"85","author":[{"given":"Vikas","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0107-2682","authenticated-orcid":false,"given":"Silvia","family":"Bua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawan K.","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2019.01.002_b0005","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1016\/j.ejmech.2017.11.005","volume":"143","author":"\u017bo\u0142nowska","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.01.002_b0010","first-page":"6631","article-title":"Carbon dioxide \u201cTrapped\u201d in a \u03b2-carbonic anhydrase","volume":"54","author":"Aggarwal","year":"2015","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2019.01.002_b0015","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/S0223-5234(00)00169-0","article-title":"Carbonic anhydrase inhibitors-Part 94. 1,3,4-Thiadiazole-2-sulfonamide derivatives as antitumor agents","author":"Supuran","year":"2000","journal-title":"Eur. J. Med. Chem. 35"},{"key":"10.1016\/j.bioorg.2019.01.002_h0020","doi-asserted-by":"crossref","first-page":"345","DOI":"10.3109\/14756366.2015.1122001","article-title":"How many carbonic anhydrase inhibition mechanisms exist ?","volume":"31","author":"Supuran","year":"2016","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.01.002_h0025","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1042\/BCJ20160115","article-title":"Structure and function of carbonic anhydrases","volume":"473","author":"Supuran","year":"2016","journal-title":"Biochem. J."},{"key":"10.1016\/j.bioorg.2019.01.002_h0030","doi-asserted-by":"crossref","first-page":"4472","DOI":"10.1016\/j.bmc.2013.05.058","article-title":"Anion inhibition studies of the \u03b1-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease","volume":"21","author":"Pan","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.01.002_h0035","doi-asserted-by":"crossref","first-page":"5773","DOI":"10.1021\/jm400418p","article-title":"A class of sulfonamides with strong inhibitory action against the \u03b1-carbonic anhydrase from Trypanosoma cruzi","volume":"56","author":"G\u00fczel-Akdemir","year":"2013","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.01.002_b0030","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1080\/14756366.2017.1284069","article-title":"Biochemical characterization of the native \u03b1-carbonic anhydrase purified from the mantle of the Mediterranean mussel, Mytilusgalloprovincialis","volume":"32","author":"Perfetto","year":"2017","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.01.002_b0035","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrd2467","article-title":"Carbonic anhydrases: novel therapeutic applications for inhibitors and activators","volume":"7","author":"Supuran","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bioorg.2019.01.002_b0040","doi-asserted-by":"crossref","first-page":"325","DOI":"10.3109\/14756366.2014.910202","article-title":"An overview of the alpha-, beta-and gamma-carbonic anhydrases from Bacteria: can bacterial carbonic anhydrases shed new light on evolution of bacteria?","volume":"30","author":"Capasso","year":"2015","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.01.002_b0045","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1517\/14728222.2014.991312","article-title":"The \u03b7-class carbonic anhydrases as drug targets for antimalarial agents","volume":"19","author":"Supuran","year":"2015","journal-title":"Expert Opin. Ther. Targets."},{"key":"10.1016\/j.bioorg.2019.01.002_b0050","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1080\/14756366.2016.1232254","article-title":"A class of carbonic anhydrase I-selective activators","volume":"32","author":"Licsandru","year":"2017","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.01.002_b0055","doi-asserted-by":"crossref","first-page":"6428","DOI":"10.1021\/acs.jmedchem.7b00766","article-title":"3-Hydroxy-1 H-quinazoline-2, 4-dione as a new scaffold to develop potent and selective inhibitors of the tumor-associated carbonic anhydrases IX and XII","volume":"60","author":"Falsini","year":"2017","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.01.002_b0060","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.ejmech.2017.11.061","article-title":"Inhibitory effects and structural insights for a novel series of coumarin-based compounds that selectively target human CA IX and CA XII carbonic anhydrases","volume":"143","author":"De Luca","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.01.002_b0065","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ejmech.2014.06.074","article-title":"Synthesis of a new series of N 4-substituted 4-(2-aminoethyl)benzenesulfonamides and their inhibitory effect on human carbonic anhydrase cytosolic isozymes I and II and transmembrane tumor-associated isozymes IX and XII","volume":"84","author":"Slawinski","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.01.002_b0070","doi-asserted-by":"crossref","first-page":"825","DOI":"10.2174\/156802607780636690","article-title":"Carbonic anhydrases as drug targets-an overview","volume":"7","author":"Supuran","year":"2007","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.01.002_b0075","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.ejmech.2017.03.026","article-title":"Structure activity study of carbonic anhydrase IX: Selective inhibition with ureido-substituted benzenesulfonamides","volume":"132","author":"Mboge","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.01.002_b0080","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/nrd3554","article-title":"Interfering with pH regulation in tumours as a therapeutic strategy","volume":"10","author":"Neri","year":"2011","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bioorg.2019.01.002_b0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejmech.2017.03.023","article-title":"Dual-tail approach to discovery of novel carbonic anhydrase IX inhibitors by simultaneously matching the hydrophobic and hydrophilic halves of the active site","volume":"132","author":"Hou","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.01.002_h0100","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.4155\/fmc.11.69","article-title":"Carbonic anhydrase inhibitors and activators for novel therapeutic applications","volume":"3","author":"Supuran","year":"2011","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.bioorg.2019.01.002_h0105","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1517\/13543776.2013.794788","article-title":"Antiglaucoma carbonic anhydrase inhibitors: a patent review","volume":"23","author":"Masini","year":"2013","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bioorg.2019.01.002_b0095","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0960-894X(03)00091-X","article-title":"Carbonic anhydrase inhibitors. Inhibition of the tumor associated isozyme IX with aromatic and heterocyclic sulfonamides","volume":"13","author":"Vullo","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2019.01.002_h0115","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1080\/13543776.2018.1523897","article-title":"Carbonic anhydrase inhibitors and their potential in a range of therapeutic areas","volume":"28","author":"Supuran","year":"2018","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bioorg.2019.01.002_h0120","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1080\/13543776.2018.1519023","article-title":"Applications of carbonic anhydrases inhibitors in renal and central nervous system diseases","volume":"28","author":"Supuran","year":"2018","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bioorg.2019.01.002_b0105","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1080\/13543776.2018.1508453","article-title":"Carbonic anhydrase inhibitors as antitumor\/antimetastatic agents: a patent review (2008\u20132018)","volume":"28","author":"Nocentini","year":"2018","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bioorg.2019.01.002_b0110","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1021\/bi00280a011","article-title":"Roberts, Nitrogen-15 nuclear magnetic resonance study of benzenesulfonamide and cyanate binding to carbonic anhydrase","volume":"22","author":"Kanamori","year":"1983","journal-title":"Biochemistry"},{"key":"10.1016\/j.bioorg.2019.01.002_b0115","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.ejmech.2014.08.010","article-title":"Design and synthesis of novel 1,2,3-triazole-pyrimidine hybrids as potential anticancer agents","volume":"86","author":"Ma","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.01.002_b0120","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/j.bmcl.2014.01.076","article-title":"6-Triazolyl-substituted sulfocoumarins are potent, selective inhibitors of the tumor-associated carbonic anhydrases IX and XII","volume":"24","author":"Grandane","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2019.01.002_b0125","doi-asserted-by":"crossref","first-page":"3698","DOI":"10.1016\/j.bmcl.2017.07.008","article-title":"Synthesis and biological evaluation of novel 1,2,3-triazole derivatives as anti-tubercular agents","volume":"27","author":"Ali","year":"2017","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.01.002_b0130","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.ejmech.2015.07.002","article-title":"Kerkar, Design and synthesis of some new pyrazolyl-pyrazolines as potential anti-inflammatory, analgesic and antibacterial agents","volume":"101","author":"Viveka","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.01.002_b0135","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ejmech.2016.02.041","article-title":"Synthesis of newer 1,2,3-triazole linked chalcone and flavone hybrid compounds and evaluation of their antimicrobial and cytotoxic activities","volume":"113","author":"Kant","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.01.002_b0140","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ejmech.2018.06.055","article-title":"Synthesis of pyrazolo[3,4-d]pyrimidin-4(5H)-ones tethered to 1,2,3-triazoles and their evaluation as potential anticancer agents","volume":"156","author":"Allam","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.01.002_b0145","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.ejmech.2015.05.029","article-title":"Synthesis by microwave assisted 1,3-dipolar cycloaddition of 1,2,3-triazole 1\u2032-homo-3\u2032-isoazanucleosides and evaluation of their anticancer activity","volume":"98","author":"da Costa","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.01.002_b0150","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1080\/14756366.2017.1344982","article-title":"Synthesis and biological evaluation of novel 7-hydroxy-4-phenylchromen-2-one\u2013linked to triazole moieties as potent cytotoxic agents","volume":"32","author":"Liu","year":"2017","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.01.002_b0155","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.ejmech.2014.12.055","article-title":"A novel series of thiazolyl-pyrazoline derivatives: synthesis and evaluation of antifungal activity, cytotoxicity and genotoxicity","volume":"92","author":"Alt\u0131ntop","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.01.002_b0160","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.ejmech.2016.10.022","article-title":"Design, synthesis and biological evaluation of [1,2,3]triazolo[4,5-d]pyrimidine derivatives possessing a hydrazone moiety as antiproliferative agents","volume":"124","author":"Li","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.01.002_b0165","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.ejmech.2015.10.019","article-title":"A click chemistry approach for the synthesis of mono and bisaryloxy linked coumarinyl triazoles as anti-tubercular agents","volume":"105","author":"Anand","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.01.002_b0170","doi-asserted-by":"crossref","first-page":"3208","DOI":"10.1016\/j.bmcl.2015.05.096","article-title":"Sulfonamide bearing pyrazolylpyrazolines as potent inhibitors of carbonic anhydrase isoforms I, II, IX and XII","volume":"25","author":"Khloya","year":"2015","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.01.002_b0175","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.ejmech.2018.03.030","article-title":"Synthesis of novel 4-functionalized 1,5-diaryl-1,2,3-triazolescontaining benzenesulfonamide moiety as carbonic anhydrase I, II, IV and IX inhibitors","volume":"150","author":"Vats","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.01.002_b0180","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.ejmech.2018.06.021","article-title":"Design and synthesis of novel benzenesulfonamide containing 1, 2, 3-triazoles as potent human carbonic anhydrase isoforms I, II, IV and IX inhibitors","volume":"155","author":"Kumar","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.01.002_b0185","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1080\/14756366.2017.1367775","article-title":"Synthesis and biological evaluation of benzenesulphonamide-bearing 1,4,5-trisubstituted-1,2,3-triazoles possessing human carbonic anhydrase I, II, IV, and IX inhibitory activity","volume":"32","author":"Kumar","year":"2017","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.01.002_b0190","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1016\/j.bmc.2014.01.055","article-title":"Benzenesulfonamide bearing 1,2,4-triazole scaffolds as potent inhibitors of tumor associated carbonic anhydrase isoforms hCA IX and hCA XII","volume":"22","author":"Ram","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.01.002_b0195","doi-asserted-by":"crossref","first-page":"10609","DOI":"10.1016\/0040-4020(96)00609-6","article-title":"Synthetic studies on virantmycin. 1. Total synthesis of (\u00b1)-virantmycin and determination of its relative stereochemistry","author":"Morimoto","year":"1996","journal-title":"Tetrahedron 52"},{"key":"10.1016\/j.bioorg.2019.01.002_b0200","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0022-1139(02)00221-X","article-title":"Synthesis of fluorinated heterocycles","volume":"118","author":"Sloop","year":"2002","journal-title":"J. Fluor. Chem."},{"key":"10.1016\/j.bioorg.2019.01.002_b0205","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0022-1139(01)00454-7","article-title":"Regioselective synthesis of fluorinated pyrazole derivatives from trifluoromethyl-1,3-diketone","volume":"111","author":"Song","year":"2001","journal-title":"J. Fluor. Chem."},{"key":"10.1016\/j.bioorg.2019.01.002_b0210","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0022-1139(96)03570-1","article-title":"Reaction of hydrazinoquinolines with trifluoromethyl-\u03b2-diketones: structural and mechanistic studies","volume":"83","author":"Singh","year":"1997","journal-title":"J. Fluor. Chem."},{"key":"10.1016\/j.bioorg.2019.01.002_b0215","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0022-1139(99)00011-1","article-title":"Formation and dehydration of a series of 5-hydroxy-5-trifluoromethyl-4,5-dihydropyrazoles","volume":"94","author":"Singh","year":"1999","journal-title":"J. Fluor. Chem."},{"key":"10.1016\/j.bioorg.2019.01.002_b0220","doi-asserted-by":"crossref","first-page":"3757","DOI":"10.1007\/s00044-011-9898-4","article-title":"Heteroaromatic analogues of 1,5-diarylpyrazole classas anti-inflammatory agents","volume":"21","author":"Sharma","year":"2012","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.bioorg.2019.01.002_b0225","doi-asserted-by":"crossref","first-page":"5297","DOI":"10.1021\/jo900768c","article-title":"Discovery and development of the covalent hydrates of trifluoromethylated pyrazoles as riboflavin synthase inhibitors with antibiotic activity against mycobacterium tuberculosis","volume":"74","author":"Zhao","year":"2009","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bioorg.2019.01.002_b0230","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1039\/C4OB02155J","article-title":"6-Substituted 1,2-benzoxathiine-2,2-dioxides are isoform-selective inhibitors of human carbonic anhydrases IX, XII and VA","volume":"13","author":"Tanc","year":"2015","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.bioorg.2019.01.002_b0235","article-title":"Synthesis and carbonic anhydrase inhibitory properties of novel 4-(2- aminoethyl)benzenesulfonamide-dipeptide conjugates","author":"K\u00fc\u00e7\u00fckbay","year":"2018","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2019.01.002_h0260","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1080\/14756366.2017.1386660","article-title":"Synthesis and biological evaluation of histamine Schiff bases as carbonic anhydrase I, II, IV, VII, and IX activators","volume":"32","author":"Akocak","year":"2017","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.01.002_h0265","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1111\/j.1747-0285.2011.01104.x","article-title":"In vitro inhibition of human carbonic anhydrase I and II isozymes with natural phenolic compounds","volume":"77","author":"Senturk","year":"2011","journal-title":"Chem. Biol. Drug. Des."},{"key":"10.1016\/j.bioorg.2019.01.002_h0270","doi-asserted-by":"crossref","first-page":"4231","DOI":"10.1002\/anie.201310709","article-title":"A small molecule drug conjugate for the treatment of carbonic anhydrase IX expressing tumors","volume":"53","author":"Krall","year":"2014","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.bioorg.2019.01.002_h0275","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1080\/14756366.2017.1349764","article-title":"Insights into the binding mode of sulphamates and sulphamides to hCA II: crystallographic studies and binding free energy calculations","volume":"32","author":"De","year":"2017","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.01.002_b0245","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1016\/S0968-0896(99)00190-X","article-title":"Carbonic anhydrase inhibitors: synthesis of water-soluble, topically effective intraocular pressure lowering aromatic\/heterocyclic sulfonamides containing 8-quinoline-sulfonyl moieties: is the tail more important than the ring?","volume":"7","author":"Borras","year":"1999","journal-title":"Bioorg. Med. Chem."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206818312677?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206818312677?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T23:35:08Z","timestamp":1553643308000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206818312677"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":56,"alternative-id":["S0045206818312677"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2019.01.002","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis of novel benzenesulfonamide bearing 1,2,3-triazole linked hydroxy-trifluoromethylpyrazolines and hydrazones as selective carbonic anhydrase isoforms IX and XII inhibitors","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2019.01.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}