{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:46:59Z","timestamp":1786985219702,"version":"build-2736575974"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"DSFP"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.bioorg.2019.01.030","type":"journal-article","created":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T21:56:18Z","timestamp":1547848578000},"page":"39-43","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Benzenesulfonamides incorporating nitrogenous bases show effective inhibition of \u03b2-carbonic anhydrases from the pathogenic fungi Cryptococcus neoformans, Candida glabrata and Malassezia globosa"],"prefix":"10.1016","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0107-2682","authenticated-orcid":false,"given":"Silvia","family":"Bua","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameh M.","family":"Osman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeid","family":"AlOthman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3342-702X","authenticated-orcid":false,"given":"Alessio","family":"Nocentini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2019.01.030_b0005","unstructured":"https:\/\/www.cdc.gov\/fungal\/antifungal-resistance.html."},{"key":"10.1016\/j.bioorg.2019.01.030_b0010","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1128\/CMR.12.4.501","article-title":"Antifungal agents: mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance","volume":"12","author":"Ghannoum","year":"1999","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.bioorg.2019.01.030_b0015","first-page":"85","article-title":"Assessment of antimicrobial and antioxidant activities of Nepeta trachonitica-Analysis of its phenolic compounds using HPLC-MS\/MS","volume":"15","author":"Koksal","year":"2017","journal-title":"Scientia Pharmaceutica"},{"key":"10.1016\/j.bioorg.2019.01.030_b0020","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1080\/13813455.2017.1360914","article-title":"Synthesis of chalcone-imide derivatives and investigation of their anticancer and antimicrobial activities, carbonic anhydrase and acetylcholinesterase enzymes inhibition profiles","volume":"124","author":"Kocyigit","year":"2018","journal-title":"Arch. Physiol. Biochem."},{"key":"10.1016\/j.bioorg.2019.01.030_b0025","doi-asserted-by":"crossref","first-page":"249","DOI":"10.2147\/IDR.S124918","article-title":"Antifungal resistance: current trends and future strategies to combat","volume":"10","author":"Wiederhold","year":"2017","journal-title":"Infect. Drug. Resist."},{"key":"10.1016\/j.bioorg.2019.01.030_b0030","first-page":"2173","article-title":"Azole antifungal resistance in candida albicans and emerging non-albicans candida species","volume":"7","author":"Whaley","year":"2016","journal-title":"Front Microbiol."},{"key":"10.1016\/j.bioorg.2019.01.030_b0035","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1054\/drup.1999.0090","article-title":"Drug resistance in Cryptococcus neoformans","volume":"4","author":"Perfect","year":"1999","journal-title":"Drug. Resist. Updat."},{"key":"10.1016\/j.bioorg.2019.01.030_b0040","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1093\/mmy\/myu010","article-title":"Antifungal susceptibility of Malassezia furfur, Malassezia sympodialis, and Malassezia globosa to azole drugs and amphotericin B evaluated using a broth microdilution method","volume":"52","author":"Rojas","year":"2014","journal-title":"Med. Mycol."},{"key":"10.1016\/j.bioorg.2019.01.030_b0045","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1517\/14728222.2015.1067685","article-title":"Bacterial, fungal and protozoan carbonic anhydrases as drug targets","volume":"19","author":"Capasso","year":"2015","journal-title":"Expert Opin. Ther. Targets."},{"key":"10.1016\/j.bioorg.2019.01.030_b0050","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrd2467","article-title":"Carbonic anhydrases: novel therapeutic applications for inhibitors and activators","volume":"7","author":"Supuran","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bioorg.2019.01.030_b0055","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1021\/jm501573b","article-title":"Synthesis and carbonic anhydrase isoenzymes I, II, IX, and XII inhibitory effects of dimethoxy-bromophenol derivatives incorporating cyclopropane moieties","volume":"58","author":"Boztas","year":"2015","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.01.030_b0060","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.1016\/j.bmc.2014.12.054","article-title":"N-Acylsulfonamides strongly inhibit human carbonic anhydrase isoenzymes I and II","volume":"23","author":"Yildirim","year":"2015","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.01.030_b0065","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.poly.2018.08.026","article-title":"Synthesis, characterization, crystal structure, electrochemical studies and biological evaluation of metal complexes with thiosemicarbazone of glyoxylic acid","volume":"155","author":"Huseynova","year":"2018","journal-title":"Polyhedron"},{"key":"10.1016\/j.bioorg.2019.01.030_b0070","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/j.bmc.2012.05.053","article-title":"Carbonic anhydrase regulation and CO2 sensing in the fungal pathogen Candida glabrata involves a novel Rca1p ortholog","volume":"21","author":"Cottier","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.01.030_b0075","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.jmb.2008.11.037","article-title":"Structure and Inhibition of the CO2-sensing carbonic anhydrase Can2 from the pathogenic fungus Cryptococcus neoformans","volume":"385","author":"Schlicker","year":"2009","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bioorg.2019.01.030_b0080","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.1021\/jm300203r","article-title":"Molecular cloning, characterization, and inhibition studies of a beta-carbonic anhydrase from Malassezia globosa, a potential antidandruff target","volume":"55","author":"Hewitson","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.01.030_b0085","doi-asserted-by":"crossref","first-page":"5194","DOI":"10.1016\/j.bmcl.2015.09.068","article-title":"Anion inhibition studies of the dandruff-producing fungus Malassezia globosa \u03b2-carbonic anhydrase MgCA","volume":"25","author":"Del Prete","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2019.01.030_b0090","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1080\/17460441.2017.1253677","article-title":"Advances in structure-based drug discovery of carbonic anhydrase inhibitors","volume":"12","author":"Supuran","year":"2017","journal-title":"Expert Opin. Drug Discov."},{"key":"10.1016\/j.bioorg.2019.01.030_b0095","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/j.bmc.2016.12.040","article-title":"Dithiocarbamates effectively inhibit the \u03b2-carbonic anhydrase from the dandruff-producing fungus Malassezia globosa","volume":"25","author":"Vullo","year":"2017","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.01.030_b0100","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1080\/14756366.2017.1414808","article-title":"Carbonic anhydrases from Trypanosoma cruzi and Leishmania donovani chagasi are inhibited by benzoxaboroles","volume":"33","author":"Nocentini","year":"2018","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.01.030_b0105","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1016\/j.bmc.2017.03.026","article-title":"Inhibition of Malassezia globosa carbonic anhydrase with phenols","volume":"25","author":"Entezari Heravi","year":"2017","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.01.030_b0110","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1080\/14756366.2017.1355307","article-title":"Inhibition of the \u03b2-carbonic anhydrase from the dandruff-producing fungus Malassezia globosa with monothiocarbamates","volume":"32","author":"Nocentini","year":"2017","journal-title":"J Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.01.030_b0115","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1021\/acsmedchemlett.7b00369","article-title":"Benzoxaboroles as efficient inhibitors of the \u03b2-carbonic anhydrases from pathogenic fungi: activity and modeling study","volume":"8","author":"Nocentini","year":"2017","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2019.01.030_b0120","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1002\/cmdc.201800015","article-title":"Natural polyphenols selectively inhibit \u03b2-carbonic anhydrase from the dandruff-producing fungus Malassezia globosa: activity and modeling studies","volume":"13","author":"Nocentini","year":"2018","journal-title":"ChemMedChem."},{"key":"10.1016\/j.bioorg.2019.01.030_b0125","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1016\/j.bmc.2017.03.017","article-title":"Synthesis and human\/bacterial carbonic anhydrase inhibition with a series of sulfonamides incorporating phthalimido moieties","volume":"25","author":"Mohamed","year":"2017","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.01.030_b0130","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1007\/s11427-017-9116-0","article-title":"Biosynthesis and combinatorial biosynthesis of antifungal nucleoside antibiotics","volume":"60","author":"Niu","year":"2017","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.bioorg.2019.01.030_b0135","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1021\/acsmedchemlett.7b00399","article-title":"Discovery of new sulfonamide carbonic anhydrase IX inhibitors incorporating nitrogenous bases","volume":"8","author":"Nocentini","year":"2017","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2019.01.030_b0140","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1358\/dot.2015.51.12.2421058","article-title":"Triazole antifungals: a review","volume":"51","author":"Peyton","year":"2015","journal-title":"Drugs Today (Barc)."},{"key":"10.1016\/j.bioorg.2019.01.030_b0145","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1016\/S0021-9258(18)62326-9","article-title":"The carbon dioxide hydration activity of carbonic anhydrase","volume":"246","author":"Khalifah","year":"1971","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bioorg.2019.01.030_b0150","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1080\/14756366.2018.1467901","article-title":"Synthesis of novel benzenesulfamide derivatives with inhibitory activity against human cytosolic carbonic anhydrase I and II and Vibrio cholerae \u03b1- and \u03b2-class enzymes","volume":"33","author":"Bua","year":"2018","journal-title":"J. Enzyme. Inhib. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.01.030_b0155","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1080\/14756366.2018.1475371","article-title":"Dioxygen, an unexpected carbonic anhydrase ligand","volume":"33","author":"Ferraroni","year":"2018","journal-title":"J. Enzyme. Inhib. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.01.030_b0160","doi-asserted-by":"crossref","first-page":"9004","DOI":"10.1021\/acs.jmedchem.5b01343","article-title":"Efficient expression and crystallization system of cancer-associated carbonic anhydrase isoform IX","volume":"58","author":"Leitans","year":"2015","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.01.030_b0165","doi-asserted-by":"crossref","DOI":"10.1080\/13543776.2018.1508453","article-title":"Carbonic anhydrase inhibitors as antitumor\/antimetastatic agents: a patent review (2008\u20132018)","author":"Nocentini","year":"2018","journal-title":"Expert. Opin. Ther. Pat."},{"key":"10.1016\/j.bioorg.2019.01.030_b0170","doi-asserted-by":"crossref","first-page":"5380","DOI":"10.1021\/acs.jmedchem.8b00625","article-title":"Discovery of \u03b2-adrenergic receptors blocker-carbonic anhydrase inhibitor hybrids for multitargeted antiglaucoma therapy","volume":"61","author":"Nocentini","year":"2018","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.01.030_b0175","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1016\/j.bmc.2016.12.047","article-title":"Sharma PK Benzenesulfonamide bearing imidazothiadiazole and thiazolotriazole scaffolds as potent tumor associated human carbonic anhydrase IX and XII inhibitors","volume":"25","author":"Kumar","year":"2017","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.01.030_b0180","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1080\/14756366.2018.1450400","article-title":"Mono- and di-thiocarbamate inhibition studies of the \u03b4-carbonic anhydrase TweCA\u03b4 from the marine diatom Thalassiosira weissflogii","volume":"33","author":"Bua","year":"2018","journal-title":"J. Enzyme. Inhib. Med. Chem."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206818311155?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206818311155?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T07:45:53Z","timestamp":1758613553000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206818311155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":36,"alternative-id":["S0045206818311155"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2019.01.030","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Benzenesulfonamides incorporating nitrogenous bases show effective inhibition of \u03b2-carbonic anhydrases from the pathogenic fungi Cryptococcus neoformans, Candida glabrata and Malassezia globosa","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2019.01.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}