{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T19:37:27Z","timestamp":1788377847130,"version":"build-2803163510"},"reference-count":84,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","award":["2016\/22429-7"],"award-info":[{"award-number":["2016\/22429-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","award":["2016\/16312-0"],"award-info":[{"award-number":["2016\/16312-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","award":["2018\/00163-0"],"award-info":[{"award-number":["2018\/00163-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.bioorg.2019.02.010","type":"journal-article","created":{"date-parts":[[2019,2,10]],"date-time":"2019-02-10T18:59:32Z","timestamp":1549825172000},"page":"455-468","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"special_numbering":"C","title":["Novel lawsone-containing ruthenium(II) complexes: Synthesis, characterization and anticancer activity on 2D and 3D spheroid models of prostate cancer cells"],"prefix":"10.1016","volume":"85","author":[{"given":"Rone Aparecido","family":"De Grandis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick Wellington da Silva dos","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia Mara de","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Rita Tomazela","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre Ferro","family":"Aissa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alzir Azevedo","family":"Batista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lus\u00e2nia Maria Greggi","family":"Antunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Rog\u00e9rio","family":"Pavan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2019.02.010_b0005","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.2174\/138161210791209009","article-title":"Novel metals and metal complexes as platforms for cancer therapy","volume":"16","author":"Frezza","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bioorg.2019.02.010_b0010","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.3390\/cancers3011351","article-title":"Cisplatin as an anti-tumor drug: cellular mechanisms of activity, drug resistance and induced side effects","volume":"3","author":"Florea","year":"2011","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.bioorg.2019.02.010_b0015","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/BF00133563","article-title":"Na[trans-RuCl4(DMSO)Im], a metal complex of ruthenium with antimetastatic properties","volume":"10","author":"Sava","year":"1992","journal-title":"Clin. Exp. Metastasis."},{"key":"10.1016\/j.bioorg.2019.02.010_b0020","doi-asserted-by":"crossref","first-page":"3201","DOI":"10.1039\/C5DT03919C","article-title":"Metal-based drugs that break the rules","volume":"45","author":"Allardyce","year":"2016","journal-title":"Dalt. Trans."},{"key":"10.1016\/j.bioorg.2019.02.010_b0025","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.ccr.2010.09.002","article-title":"Metal complexes for DNA-mediated charge transport","volume":"255","author":"Barton","year":"2011","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.bioorg.2019.02.010_b0030","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.ejmech.2018.03.015","article-title":"Detailed account on activation mechanisms of ruthenium coordination complexes and their role as antineoplastic agents","volume":"150","author":"Pal","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.02.010_b0035","first-page":"927","article-title":"Lack of In vitro cytotoxicity, associated to increased G(2)-M cell fraction and inhibition of matrigel invasion, may predict In vivo-selective antimetastasis activity of ruthenium complexes","volume":"295","author":"Zorzet","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bioorg.2019.02.010_b0040","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1595\/003214001X4526269","article-title":"Ruthenium in medicine: Current clinical uses and future prospects","volume":"45","author":"Allardyce","year":"2001","journal-title":"Platin. Met. Rev."},{"key":"10.1016\/j.bioorg.2019.02.010_b0045","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/CAD.0b013e328322fbc5","article-title":"Pharmacokinetics of a novel anticancer ruthenium complex (KP1019, FFC14A) in a phase I dose-escalation study","volume":"20","author":"Lentz","year":"2009","journal-title":"Anticancer. Drugs"},{"key":"10.1016\/j.bioorg.2019.02.010_b0050","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s10637-014-0179-1","article-title":"Phase I\/II study with ruthenium compound NAMI-A and gemcitabine in patients with non-small cell lung cancer after first line therapy","volume":"33","author":"Leijen","year":"2015","journal-title":"Invest. New Drugs."},{"key":"10.1016\/j.bioorg.2019.02.010_b0055","doi-asserted-by":"crossref","first-page":"104367","DOI":"10.18632\/oncotarget.22248","article-title":"Novel piplartine-containing ruthenium complexes: synthesis, cell growth inhibition, apoptosis induction and ROS production on HCT116 cells","volume":"8","author":"D\u2019Sousa","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.bioorg.2019.02.010_b0060","doi-asserted-by":"crossref","first-page":"3064","DOI":"10.1021\/ja017482e","article-title":"Organometallic ruthenium(II) diamine anticancer complexes: Arene-nucleobase stacking and stereospecific hydrogen-bonding in guanine adducts","volume":"124","author":"Chen","year":"2002","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bioorg.2019.02.010_b0065","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.mrgentox.2016.01.007","article-title":"In vitro evaluation of cyto-genotoxic potential of ruthenium(II) SCAR complexes: a promissing class of antituberculosis agents","volume":"798","author":"De Grandis","year":"2016","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen."},{"key":"10.1016\/j.bioorg.2019.02.010_b0070","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1016\/j.ejmech.2011.01.074","article-title":"Synthesis, characterization, antiproliferative and anti-metastatic properties of two ruthenium-DMSO complexes containing 2,2\u2032-biimidazole","volume":"46","author":"Tan","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.02.010_b0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-18639-6","article-title":"A ruthenium-based 5-fluorouracil complex with enhanced cytotoxicity and apoptosis induction action in HCT116 cells","volume":"8","author":"Silva","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioorg.2019.02.010_b0080","doi-asserted-by":"crossref","unstructured":"C. Avenda\u00f1o, J.C. Men\u00e9ndez, Medicinal Chemistry of Anticancer Drugs, Elsevier Science, 2008. http:\/\/doi.org\/10.1016\/B978-0-444-52824-7.00001-9.","DOI":"10.1016\/B978-0-444-52824-7.00001-9"},{"key":"10.1016\/j.bioorg.2019.02.010_b0085","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.mrfmmm.2007.06.009","article-title":"DNA topoisomerase II, genotoxicity, and cancer","volume":"623","author":"McClendon","year":"2007","journal-title":"Mutat. Res. Fundam. Mol. Mech. Mutagen."},{"key":"10.1016\/j.bioorg.2019.02.010_b0090","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.micpath.2018.03.024","article-title":"Antibacterial naphthoquinone derivatives targeting resistant strain Gram-negative bacteria in biofilms","volume":"118","author":"Novais","year":"2018","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.bioorg.2019.02.010_b0095","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.ejmech.2017.12.051","article-title":"Antimalarial naphthoquinones. Synthesis via click chemistry, in vitro activity, docking to PfDHODH and SAR of lapachol-based compounds","volume":"145","author":"Brand\u00e3o","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.02.010_b0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0082504","article-title":"Synthetic 1,4-pyran naphthoquinones are potent inhibitors of dengue virus replication","volume":"8","author":"Da Costa","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bioorg.2019.02.010_b0105","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.ejmech.2014.07.024","article-title":"Synthesis, anticancer activity and QSAR study of 1,4-naphthoquinone derivatives","volume":"84","author":"Prachayasittikul","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.02.010_b0110","doi-asserted-by":"crossref","first-page":"489","DOI":"10.2174\/187152006778226512","article-title":"Anti-cancer activities of 1,4-naphthoquinones: a QSAR Study","volume":"6","author":"Verma","year":"2006","journal-title":"Anticancer. Agents Med. Chem."},{"key":"10.1016\/j.bioorg.2019.02.010_b0115","doi-asserted-by":"crossref","first-page":"6052","DOI":"10.1016\/j.ejmech.2010.10.006","article-title":"Biological evaluation of donor-acceptor aminonaphthoquinones as antitumor agents","volume":"45","author":"Benites","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.02.010_b0120","doi-asserted-by":"crossref","first-page":"248","DOI":"10.17533\/udea.vitae.17322","article-title":"Naphthoquinones: Biological properties and synthesis of lawsone and derivatives - a structured review","volume":"21","author":"L\u00f3pez-L\u00f3pez","year":"2014","journal-title":"Vitae"},{"key":"10.1016\/j.bioorg.2019.02.010_b0125","doi-asserted-by":"crossref","first-page":"112","DOI":"10.7603\/s40730-014-0018-1","article-title":"Lawsonia inermis (L.): a perspective on anticancer potential of Mehndi\/Henna","volume":"1","author":"Singh","year":"2014","journal-title":"Biomed. Res. Ther."},{"key":"10.1016\/j.bioorg.2019.02.010_b0130","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/cbdd.12255","article-title":"Beyond topoisomerase inhibition: antitumor 1,4-naphthoquinones as potential inhibitors of human monoamine oxidase","volume":"83","author":"Coelho-Cerqueira","year":"2014","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.bioorg.2019.02.010_b0135","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1016\/j.bmc.2013.03.002","article-title":"Synthesis and cytotoxic activity of metallic complexes of lawsone","volume":"21","author":"Oramas-Royo","year":"2013","journal-title":"Bioorganic Med. Chem."},{"key":"10.1016\/j.bioorg.2019.02.010_b0140","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jinorgbio.2017.08.019","article-title":"Selective Ru (II)\/lawsone complexes inhibiting tumor cell growth by apoptosis","volume":"176","author":"Oliveira","year":"2017","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.bioorg.2019.02.010_b0145","doi-asserted-by":"crossref","first-page":"3616","DOI":"10.1016\/j.ejmech.2011.04.064","article-title":"A new nitrosyl ruthenium complex: synthesis, chemical characterization, in vitro and in vivo antitumor activities and probable mechanism of action","volume":"46","author":"Heinrich","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.02.010_b0150","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s10534-017-0008-z","article-title":"Human topoisomerase inhibition and DNA\/BSA binding of Ru(II)\u2013SCAR complexes as potential anticancer candidates for oral application","volume":"30","author":"De Grandis","year":"2017","journal-title":"BioMetals"},{"key":"10.1016\/j.bioorg.2019.02.010_b0155","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.poly.2017.04.005","article-title":"Ruthenium (II)\/triphenylphosphine complexes: an effective way to improve the cytotoxicity of lapachol","volume":"130","author":"Oliveira","year":"2017","journal-title":"Polyhedron"},{"key":"10.1016\/j.bioorg.2019.02.010_b0160","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jinorgbio.2016.06.023","article-title":"Ru(II)\/clotrimazole\/diphenylphosphine\/bipyridine complexes: Interaction with DNA, BSA and biological potential against tumor cell lines and Mycobacterium tuberculosis","volume":"162","author":"Colina-Vegas","year":"2016","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.bioorg.2019.02.010_b0165","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1039\/C5MT00227C","article-title":"Inhibition of human DNA topoisomerase IB by nonmutagenic ruthenium(II)-based compounds with antitumoral activity","volume":"8","author":"de Camargo","year":"2016","journal-title":"Metallomics"},{"key":"10.1016\/j.bioorg.2019.02.010_b0170","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-017-0104-6","article-title":"A novel ruthenium complex with xanthoxylin induces S-phase arrest and causes ERK1\/2-mediated apoptosis in HepG2 cells through a p53-independent pathway article","volume":"9","author":"De Carvalho","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bioorg.2019.02.010_b0175","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s11010-017-3129-3","article-title":"Ru(II)\/diphenylphosphine\/pyridine-6-thiolate complexes induce S-180 cell apoptosis through intrinsic mitochondrial pathway involving inhibition of Bcl-2 and p53\/Bax activation","volume":"438","author":"Pires","year":"2018","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.bioorg.2019.02.010_b0180","first-page":"3","article-title":"Lipophilicity - Methods of determination and its role in medicinal chemistry","volume":"70","author":"Rutkowska","year":"2013","journal-title":"Acta Pol. Pharm. Drug Res."},{"key":"10.1016\/j.bioorg.2019.02.010_b0185","first-page":"1","article-title":"for testing os chemicals, Partition coefficient (n-octanol\/water): shake flask method","volume":"107","author":"Guideline","year":"1995","journal-title":"OECD Guidel."},{"key":"10.1016\/j.bioorg.2019.02.010_b0190","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.poly.2014.05.004","article-title":"Synthesis and biological evaluation of ternary silver compounds bearing N, N-chelating ligands and thiourea: X-ray structure of [{Ag(bpy)(\u03bc-tu)}2](NO3)2(bpy = 2,2\u2032-bipyridine; Tu = thiourea)","volume":"79","author":"Segura","year":"2014","journal-title":"Polyhedron"},{"key":"10.1016\/j.bioorg.2019.02.010_b0195","doi-asserted-by":"crossref","first-page":"921","DOI":"10.2174\/187152011797927670","article-title":"Phosphine-gold (I) compounds as anticancer agents: general description and mechanisms of action","volume":"11","author":"Lima","year":"2011","journal-title":"Anticancer. Agents Med. Chem."},{"key":"10.1016\/j.bioorg.2019.02.010_b0200","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.1021\/acs.inorgchem.6b02419","article-title":"Copper(I)-phosphine polypyridyl complexes: synthesis, characterization, DNA\/HSA binding study, and antiproliferative activity","volume":"56","author":"Villarreal","year":"2017","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.bioorg.2019.02.010_b0205","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.jinorgbio.2007.09.003","article-title":"In vitro antitumour and hepatotoxicity profiles of Au(I) and Ag(I) bidentate pyridyl phosphine complexes and relationships to cellular uptake","volume":"102","author":"Liu","year":"2008","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.bioorg.2019.02.010_b0210","doi-asserted-by":"crossref","first-page":"16589","DOI":"10.1039\/C7DT03385K","article-title":"Tuning the cytotoxicity of ruthenium(II) para-cymene complexes by mono-substitution at a triphenylphosphine\/phenoxydiphenylphosphine ligand","volume":"46","author":"Biancalana","year":"2017","journal-title":"Dalt. Trans."},{"key":"10.1016\/j.bioorg.2019.02.010_b0215","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1038\/nprot.2006.339","article-title":"Clonogenic assay of cells in vitro","volume":"1","author":"Franken","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bioorg.2019.02.010_b0220","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1038\/cdd.2009.44","article-title":"Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes","volume":"16","author":"Galluzzi","year":"2009","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bioorg.2019.02.010_b0225","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/mc.21844","article-title":"In vitro three-dimensional (3D) models in cancer research: an update","volume":"52","author":"Kimlin","year":"2013","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.bioorg.2019.02.010_b0230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphar.2018.00006","article-title":"Three-dimensional in vitro cell culture models in drug discovery and drug repositioning","volume":"9","author":"Langhans","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bioorg.2019.02.010_b0235","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nrd3144","article-title":"Anticancer drug development: the grand challenges","volume":"9","author":"Hait","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bioorg.2019.02.010_b0240","first-page":"2993","article-title":"Three-dimensional cell culture models for anticancer drug screening: Worth the effort?","author":"Doijen","year":"2017","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bioorg.2019.02.010_b0245","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.jconrel.2012.04.045","article-title":"Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy","volume":"164","author":"Mehta","year":"2012","journal-title":"J. Control. Release."},{"key":"10.1016\/j.bioorg.2019.02.010_b0250","first-page":"1","article-title":"Enhanced anti-metastatic and anti-tumorigenic efficacy of Berbamine loaded lipid nanoparticles in vivo","author":"Parhi","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioorg.2019.02.010_b0255","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.cbi.2017.09.013","article-title":"cis-[RuCl(BzCN)(bipy)(dppe)]PF6 induces anti-angiogenesis and apoptosis by a mechanism of caspase-dependent involving DNA damage, PARP activation, and Tp53 induction in Ehrlich tumor cells","volume":"278","author":"Magalh\u00e3es","year":"2017","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.bioorg.2019.02.010_b0260","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1083\/jcb.201102147","article-title":"The extracellular matrix: A dynamic niche in cancer progression","volume":"196","author":"Lu","year":"2012","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bioorg.2019.02.010_b0265","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1038\/sj.bjc.6600176","article-title":"Inhibition of endothelial cell functions and of angiogenesis by the metastasis inhibitor NAMI-A","volume":"4","author":"Vacca","year":"2002","journal-title":"Br. J. Cancer."},{"key":"10.1016\/j.bioorg.2019.02.010_b0270","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1002\/cam4.826","article-title":"Antimetastatic activity of novel ruthenium (III) pyridine complexes","volume":"5","author":"Gu","year":"2016","journal-title":"Cancer Med."},{"key":"10.1016\/j.bioorg.2019.02.010_b0275","doi-asserted-by":"crossref","first-page":"2848","DOI":"10.1016\/j.ccr.2013.02.023","article-title":"DNA-binding of nickel(II), copper(II) and zinc(II) complexes: structure-affinity relationships","volume":"257","author":"Barone","year":"2013","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.bioorg.2019.02.010_b0280","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep06476","article-title":"A thiazole coumarin (TC) turn-on fluorescence probe for AT-base pair detection and multipurpose applications in different biological systems","volume":"4","author":"Narayanaswamy","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioorg.2019.02.010_b0285","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1039\/C4MB00636D","article-title":"Multi-spectroscopic and molecular modelling studies on the interaction of esculetin with calf thymus DNA","volume":"11","author":"Sarwar","year":"2015","journal-title":"Mol. Biosyst."},{"key":"10.1016\/j.bioorg.2019.02.010_b0295","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","article-title":"The hallmarks of cancer","volume":"100","author":"Hanahan","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.bioorg.2019.02.010_b0300","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.bioorg.2019.02.010_b0305","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0022-1759(95)00072-I","article-title":"A novel assay for apoptosis Flow cytometric detection of phosphatidylserine early apoptotic cells using fluorescein labelled expression on Annexin V","volume":"184","author":"Vermes","year":"1995","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.bioorg.2019.02.010_b0310","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/1010428317695933","article-title":"Antitumor effectiveness and mechanism of action of Ru(II)\/amino acid\/diphosphine complexes in the peritoneal carcinomatosis progression","volume":"39","author":"Mello-Andrade","year":"2017","journal-title":"Tumor Biol."},{"key":"10.1016\/j.bioorg.2019.02.010_b0315","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.biomaterials.2017.03.017","article-title":"Ruthenium complexes with phenylterpyridine derivatives target cell membrane and trigger death receptors-mediated apoptosis in cancer cells","volume":"129","author":"Deng","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioorg.2019.02.010_b0320","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/sj.cdd.4400453","article-title":"An elevated BAX\/BCL-2 ratio corresponds with the onset of prostate epithelial cell apoptosis","volume":"6","author":"Perlman","year":"1999","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bioorg.2019.02.010_b0325","first-page":"22","article-title":"ROS-inducing agents for cancer chemotherapy","volume":"1","author":"Kasiappan","year":"2016","journal-title":"React. Oxyg. Species"},{"key":"10.1016\/j.bioorg.2019.02.010_b0330","doi-asserted-by":"crossref","first-page":"20309","DOI":"10.1039\/C4RA13547D","article-title":"Understanding cancer and the anticancer activities of naphthoquinones \u2013 a review","volume":"5","author":"Wellington","year":"2015","journal-title":"RSC Adv."},{"key":"10.1016\/j.bioorg.2019.02.010_b0335","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1042\/BJ20130282","article-title":"ROS inhibitor N -acetyl-L-cysteine antagonizes the activity of proteasome inhibitors","volume":"454","author":"Halasi","year":"2013","journal-title":"Biochem. J."},{"key":"10.1016\/j.bioorg.2019.02.010_b0340","doi-asserted-by":"crossref","first-page":"14902","DOI":"10.3390\/molecules190914902","article-title":"1,4-naphthoquinones: From oxidative damage to cellular and inter-cellular signaling","volume":"19","author":"Klotz","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.bioorg.2019.02.010_b0345","doi-asserted-by":"crossref","first-page":"8818","DOI":"10.1039\/C5CS00134J","article-title":"Linking the future of anticancer metal-complexes to the therapy of tumour metastases","volume":"44","author":"Bergamo","year":"2015","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.bioorg.2019.02.010_b0350","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jinorgbio.2017.06.002","article-title":"Recent development of transition metal complexes with in vivo antitumor activity","volume":"177","author":"Liang","year":"2017","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.bioorg.2019.02.010_b0355","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/859730","article-title":"Anticancer activities of mononuclear ruthenium(II) coordination complexes","volume":"2015","author":"Motswainyana","year":"2015","journal-title":"Adv. Chem."},{"key":"10.1016\/j.bioorg.2019.02.010_b0360","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/slct.201600009","article-title":"Gold-NHC complexes as potent bioactive compounds","volume":"1","author":"Al-Majid","year":"2016","journal-title":"ChemistrySelect"},{"key":"10.1016\/j.bioorg.2019.02.010_b0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.arabjc.2017.09.003","article-title":"In vitro antitumor activity of water-soluble copper(I) complexes with diimine and monodentate phosphine ligands","author":"Porchia","year":"2017","journal-title":"Arab. J. Chem."},{"key":"10.1016\/j.bioorg.2019.02.010_b0370","doi-asserted-by":"crossref","DOI":"10.1098\/rsos.171340","article-title":"Using phosphine ligands with a biological role to modulate reactivity in novel platinum complexes","volume":"5","author":"Echeverri","year":"2018","journal-title":"R. Soc. Open Sci."},{"key":"10.1016\/j.bioorg.2019.02.010_b0375","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s002800000166","article-title":"Role of lipophilicity in determining cellular uptake and antitumour activity of gold phosphine complexes","volume":"46","author":"McKeage","year":"2000","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.bioorg.2019.02.010_b0380","first-page":"1","article-title":"Guidance on good cell culture practice (GCCP)","author":"Bal-Price","year":"2011","journal-title":"Cell Cult Tech."},{"key":"10.1016\/j.bioorg.2019.02.010_b0385","doi-asserted-by":"crossref","first-page":"3334","DOI":"10.1021\/ic50190a006","article-title":"Mixed phosphine 2,2\u2019-bipyridine complexes of ruthenium","volume":"17","author":"Sullivan","year":"1978","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.bioorg.2019.02.010_b0390","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1016\/S0277-5387(01)00744-6","article-title":"Electrochemical and spectroscopic studies on RuCl2(PPh3)2(N)2 and RuCl2(PPh3)2(N\u2013N) complexes (N=pyridine derivatives and N-N=phenanthroline or bipyridine derivatives). X-ray structure of RuCl2(PPh3)2(phen)","volume":"20","author":"Batista","year":"2001","journal-title":"Polyhedron"},{"key":"10.1016\/j.bioorg.2019.02.010_b0395","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.jpba.2007.10.030","article-title":"Study of equilibrium solubility measurement by saturation shake-flask method using hydrochlorothiazide as model compound","volume":"46","author":"Baka","year":"2008","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.bioorg.2019.02.010_b0400","article-title":"Ruthenium compounds as anticancer agents","volume":"26\u201329","author":"Page","year":"2012","journal-title":"Educ. Chem."},{"key":"10.1016\/j.bioorg.2019.02.010_b0405","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nprot.2008.226","article-title":"Spheroid-based drug screen: considerations and practical approach","volume":"4","author":"Friedrich","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bioorg.2019.02.010_b0410","doi-asserted-by":"crossref","first-page":"IN1-218","DOI":"10.1016\/S0022-2836(61)80047-8","article-title":"A procedure for the isolation of deoxyribonucleic acid from micro-organisms","volume":"3","author":"Marmur","year":"1961","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bioorg.2019.02.010_b0415","first-page":"1","article-title":"Measurement of cell death in mammalian cells","volume":"1","author":"Cummings","year":"2004","journal-title":"Curr. Protoc. Phamacol."},{"key":"10.1016\/j.bioorg.2019.02.010_b0420","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bioorg.2019.02.010_b0425","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/S0891-5849(99)00107-0","article-title":"Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader","volume":"27","author":"Wang","year":"1999","journal-title":"Free Radic. Biol. Med."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206818310198?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206818310198?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T17:51:55Z","timestamp":1720979515000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206818310198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":84,"alternative-id":["S0045206818310198"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2019.02.010","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel lawsone-containing ruthenium(II) complexes: Synthesis, characterization and anticancer activity on 2D and 3D spheroid models of prostate cancer cells","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2019.02.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}