{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:39:51Z","timestamp":1793392791576,"version":"4.5.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"University Grant Commission"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.bioorg.2019.03.071","type":"journal-article","created":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T12:12:15Z","timestamp":1553861535000},"page":"667-678","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"special_numbering":"C","title":["Unveiling novel diphenyl-1H-pyrazole based acrylates tethered to 1,2,3-triazole as promising apoptosis inducing cytotoxic and anti-inflammatory agents"],"prefix":"10.1016","volume":"87","author":[{"given":"Mohemmed Faraz","family":"Khan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarique","family":"Anwer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afroz","family":"Bakht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garima","family":"Verma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wasim","family":"Akhtar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Mumtaz","family":"Alam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moshahid Alam","family":"Rizvi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4380-3965","authenticated-orcid":false,"given":"Mymoona","family":"Akhter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Shaquiquzzaman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2019.03.071_b0005","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.cclet.2016.10.020","article-title":"Morpholine hydrazone scaffold: synthesis, anticancer activity and docking studies","volume":"28","author":"Taha","year":"2017","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.bioorg.2019.03.071_b0010","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ejmech.2016.03.009","article-title":"Synthesis, cytotoxic activity evaluation and HQSAR study of novel isosteviol derivatives as potential anticancer agents","volume":"15","author":"Liu","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.03.071_b0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejmech.2015.01.056","article-title":"Synthesis and anticancer activities of ceritinib analogs modified in the terminal piperidine ring","volume":"93","author":"Wang","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.03.071_b0020","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.ejmech.2016.07.024","article-title":"Design, synthesis, anticancer, antimicrobial activities and molecular docking studies of theophyhlline containing 1,2,3-triazoles with variant nucleoside derivatives","volume":"123","author":"Ruddarraju","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.03.071_b0025","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.ejmech.2014.10.015","article-title":"Synthesis and biological evaluation of new oxadiazoline-substituted naphthlenyl acetates s anticancer agents","volume":"87","author":"Chaaban","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.03.071_b0030","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.semcancer.2017.08.006","article-title":"Inflammation fires up cancer metastasis","volume":"47","author":"Qian","year":"2017","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.bioorg.2019.03.071_b0035","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.canlet.2013.08.025","article-title":"Inflammation and gastrointestinal cancer: an overview","volume":"345","author":"Marusawa","year":"2014","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bioorg.2019.03.071_b0040","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1016\/j.freeradbiomed.2012.02.035","article-title":"Emerging venues linking inflammation and cancer","volume":"52","author":"Kundu","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bioorg.2019.03.071_b0045","first-page":"401","article-title":"Novel natural product therapeutics targeting both inflammation and cancer","volume":"15","author":"Qin","year":"2017","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.bioorg.2019.03.071_b0050","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1016\/j.bcp.2006.06.029","article-title":"Inflammation and cancer: how hot is the link?","volume":"72","author":"Aggarwal","year":"2006","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bioorg.2019.03.071_b0055","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.mrrev.2008.03.002","article-title":"Inflammation: gearing the journey to cancer","volume":"659","author":"Kundu","year":"2008","journal-title":"Mutat. Res."},{"key":"10.1016\/j.bioorg.2019.03.071_b0060","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/10552","article-title":"Mice deficient in tumor necrosis factor-a are resistant to skin carcinogenesis","volume":"5","author":"Moore","year":"1999","journal-title":"Nat. Med."},{"key":"10.1016\/j.bioorg.2019.03.071_b0065","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.4161\/cc.8.20.9699","article-title":"Inflammation: a driving force speeds cancer metastasis","volume":"8","author":"Wu","year":"2009","journal-title":"Cell Cycle"},{"key":"10.1016\/j.bioorg.2019.03.071_b0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2010\/520258","article-title":"The role of exercise-induced myokines in muscle homeostasis and the defense against chronic diseases","volume":"2010","author":"Brandt","year":"2010","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.bioorg.2019.03.071_b0075","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/aje\/kwq135","article-title":"Circulating C-reactive protein concentrations and risks of colon and rectal cancer: a nested case-control study within the European prospective investigation into cancer and nutrition","volume":"172","author":"Aleksandrova","year":"2010","journal-title":"A. J. Epidemiol."},{"key":"10.1016\/j.bioorg.2019.03.071_b0080","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.prostaglandins.2015.06.001","article-title":"NSAIDS and gastrointestinal cancer","volume":"120","author":"Piazuelo","year":"2015","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"10.1016\/j.bioorg.2019.03.071_b0085","doi-asserted-by":"crossref","first-page":"5891","DOI":"10.1016\/j.bmc.2017.09.035","article-title":"Recently reported biological activities of pyrazole compounds","volume":"25","author":"Faria","year":"2017","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.03.071_b0090","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.ejmech.2016.04.077","article-title":"The therapeutic voyage of pyrazole and its analogs: a review","volume":"120","author":"Khan","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.03.071_b0095","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.bioorg.2017.01.010","article-title":"Medicinal attributes of 1,2,3-triazoles: current developments","volume":"71","author":"Dheer","year":"2017","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2019.03.071_b0100","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1007\/s00044-012-0072-4","article-title":"Synthesis and evaluation of analgesic, anti-inflammatory, and anticancer activities of new pyrazole-3(5)-carboxylic acid derivatives","volume":"22","author":"Caliskan","year":"2013","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.bioorg.2019.03.071_b0105","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1007\/s00044-011-9850-7","article-title":"Synthesis anti-inflammatory and anticancer activity evaluation of some pyrazole and oxadiazole derivatives","volume":"21","author":"Sondhi","year":"2012","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.bioorg.2019.03.071_b0110","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.ejmech.2014.04.052","article-title":"Synthesis of novel 1,2,3-triazole substituted-N-alkyl\/aryl nitrone derivatives, their anti-inflammatory and anticancer activity","volume":"80","author":"Rao","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.03.071_b0115","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.ejmech.2014.05.012","article-title":"Synthesis of novel 2-mercaptobenzoxazole based 1,2,3-triazoles as inhibitors of proinflammatory cytokines and suppressors of COX-2 gene expression","volume":"81","author":"Haider","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.03.071_b0120","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ejmech.2016.03.051","article-title":"Synthesis of (Z)-1-(1,3-diphenyl-1H-pyrazol-4-yl)-3-(phenylamino)prop-2-en-1-one derivatives as potential anticancer and apoptosis inducing agents","volume":"117","author":"Reddy","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.03.071_b0125","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1016\/j.bmcl.2013.02.105","article-title":"PEG mediated synthesis and pharmacological evaluation of some fluoro substituted pyrazoline derivatives as antiinflammatory and analgesic agents","volume":"23","author":"Jadhav","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2019.03.071_b0130","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ejmech.2016.09.060","article-title":"Design and synthesis of imidazo[2,1-b]thiazole linked triazole conjugates: microtubule-destabilizing agents","volume":"126","author":"Shaik","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.03.071_b0135","doi-asserted-by":"crossref","first-page":"10136","DOI":"10.1039\/C5OB00842E","article-title":"Synthesis and biological evaluation of pyrazolo-triazole hybrids as cytotoxic and apoptosis inducing agents","volume":"13","author":"Reddy","year":"2015","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.bioorg.2019.03.071_b0140","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.ejmech.2016.06.011","article-title":"Design, synthesis and biological evaluation of N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)-1,3-diphenyl-1H-pyrazole-4-carboxamides as CDK1\/Cdc2 inhibitors","volume":"122","author":"Reddy","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.03.071_b0145","doi-asserted-by":"crossref","first-page":"5678","DOI":"10.1016\/j.bmc.2017.08.042","article-title":"Synthesis, pharmacological activities and molecular docking studies of pyrazolyltriazoles as anti-bacterial and anti-inflammatory agents","volume":"25","author":"Dayakar","year":"2017","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.03.071_b0150","doi-asserted-by":"crossref","first-page":"4714","DOI":"10.1039\/C5OB00007F","article-title":"Synthesis, antitumor activity, and mechanism of action of 6-acrylic phenethyl ester-2-pyranone derivatives","volume":"13","author":"Fang","year":"2015","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.bioorg.2019.03.071_b0155","unstructured":"K.S. Joshi, M. Sivakumar, V.S. Aware, V.S. Wagh, A. Deshpande, A. G. Sarde, S. Sharma, Anti cancer use of caffeic acid and derivatives, EP 2061452 B1, Oct 26, 2011."},{"key":"10.1016\/j.bioorg.2019.03.071_b0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/729754","article-title":"Anti-inflammatory and gastroprotective evaluation of prodrugs of piroxicam","volume":"2014","author":"Redasani","year":"2014","journal-title":"Ulcers"},{"key":"10.1016\/j.bioorg.2019.03.071_b0165","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.bioorg.2018.01.007","article-title":"Synthesis of pyrazole acrylic acid based oxadiazole and amide derivatives as antimalarial and anticancer agents","volume":"77","author":"Verma","year":"2018","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2019.03.071_b0170","doi-asserted-by":"crossref","first-page":"5371","DOI":"10.1021\/jo00339a023","article-title":"Applications of the Vilsmeier reaction. 13. Vilsmeier approach to polycyclic aromatic hydrocarbons","volume":"46","author":"Reddy","year":"1981","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bioorg.2019.03.071_b0175","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1590\/S0100-40422006000500035","article-title":"On the application of Knoevenagel condensation for the synthesis of benzylidene benzothiazine compounds and structural study","volume":"29","author":"Souza","year":"2006","journal-title":"Quim Nova."},{"key":"10.1016\/j.bioorg.2019.03.071_b0180","doi-asserted-by":"crossref","first-page":"A304","DOI":"10.1021\/ed067pA304","article-title":"One step synthesis of cinnamic acids using malonic acid: the Verley-Doebner modification of the Knoevenagel condensation","author":"Kolb","year":"1990","journal-title":"J. Chem. Edu."},{"key":"10.1016\/j.bioorg.2019.03.071_b0185","doi-asserted-by":"crossref","first-page":"e115457","DOI":"10.1371\/journal.pone.0115457","article-title":"A Convenient method for the synthesis of (Prop-2-Ynyloxy)benzene derivatives via reaction with propargyl bromide, their optimization, scope and biological evaluation","volume":"9","author":"Batool","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bioorg.2019.03.071_b0190","doi-asserted-by":"crossref","first-page":"2706","DOI":"10.1055\/s-0033-1339648","article-title":"A simple and effective synthesis of aryl azides via arenediazonium tosylates","volume":"45","author":"Kutonova","year":"2013","journal-title":"Synthesis"},{"key":"10.1016\/j.bioorg.2019.03.071_b0195","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1021\/jm901265h","article-title":"Synthesis, biological activity, and molecular modeling studies of 1H\u20131,2,3-triazole derivatives of carbohydrates as \u03b1-glucosidases inhibitors","volume":"53","author":"Ferreira","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.03.071_b0200","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1038\/nprot.2006.339","article-title":"Clonogenic assay of cells in vitro","volume":"1","author":"Franken","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bioorg.2019.03.071_b0205","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.molimm.2007.07.032","article-title":"Granzyme H induces apoptosis of target tumor cells characterized by DNA fragmentation and Bid-dependent mitochondrial damage","volume":"45","author":"Hou","year":"2008","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.bioorg.2019.03.071_b0210","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.bioorg.2017.05.007","article-title":"Synthesis, molecular docking and anti-diabetic evaluation of 2,4-thiazolidinedione based amide derivatives","volume":"73","author":"Naim","year":"2017","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2019.03.071_b0215","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1155\/2009\/247209","article-title":"Synthesis, spectral and microbial studies of some novel Schiff base derivatives of 4-methylpyridin-2-amine","volume":"6","author":"Vora","year":"2009","journal-title":"J. Chem."},{"key":"10.1016\/j.bioorg.2019.03.071_b0220","first-page":"39","article-title":"Sulforhodamine B assay and chemosensitivity","volume":"110","author":"Voigt","year":"2005","journal-title":"Methods Mol. Med."},{"key":"10.1016\/j.bioorg.2019.03.071_b0225","doi-asserted-by":"crossref","first-page":"46265","DOI":"10.1074\/jbc.M207135200","article-title":"Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor","volume":"277","author":"Stamos","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bioorg.2019.03.071_b0230","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s10822-013-9644-8","article-title":"Protein and ligand preparation: parameters, protocols and influence on virtual screening enrichments","volume":"27","author":"Sastry","year":"2013","journal-title":"J. Comput. Aided Mol. Des."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206818313105?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206818313105?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T07:53:51Z","timestamp":1758614031000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206818313105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":46,"alternative-id":["S0045206818313105"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2019.03.071","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unveiling novel diphenyl-1H-pyrazole based acrylates tethered to 1,2,3-triazole as promising apoptosis inducing cytotoxic and anti-inflammatory agents","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2019.03.071","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}