{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T14:21:48Z","timestamp":1778077308989,"version":"3.51.4"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.bioorg.2019.103033","type":"journal-article","created":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T15:46:37Z","timestamp":1559835997000},"page":"103033","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["N-aryl-N\u2019-ureido-O-sulfamates: Potent and selective inhibitors of the human Carbonic Anhydrase VII isoform with neuropathic pain relieving properties"],"prefix":"10.1016","volume":"89","author":[{"given":"Murat","family":"Bozdag","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulio","family":"Poli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Angeli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Lucarini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziano","family":"Tuccinardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Di Cesare Mannelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Selleri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Ghelardini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Yves","family":"Winum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Carta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2019.103033_b0005","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1016\/j.pain.2011.06.017","article-title":"A new definition of neuropathic pain","volume":"152","author":"Jensen","year":"2011","journal-title":"Pain"},{"key":"10.1016\/j.bioorg.2019.103033_b0010","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1097\/j.pain.0000000000000492","article-title":"Neuropathic pain: an updated grading system for research and clinical practice","volume":"157","author":"Finnerup","year":"2016","journal-title":"Pain"},{"key":"10.1016\/j.bioorg.2019.103033_b0015","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.pain.2009.11.015","article-title":"Acetazolamide and midazolam act synergistically to inhibit neuropathic pain","volume":"148","author":"Asiedu","year":"2010","journal-title":"Pain"},{"key":"10.1016\/j.bioorg.2019.103033_b0020","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.jpain.2014.01.001","article-title":"Inhibition of carbonic anhydrase augments GABAA receptor-mediated analgesia via a spinal mechanism of action","volume":"15","author":"Asiedu","year":"2014","journal-title":"J. Pain"},{"key":"10.1016\/j.bioorg.2019.103033_b0025","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1016\/j.bmc.2015.02.027","article-title":"A class of sulfonamide carbonic anhydrase inhibitors with neuropathic pain modulating effects","volume":"23","author":"Carta","year":"2015","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.103033_b0030","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.ejmech.2018.05.026","article-title":"Design, synthesis and X-Ray crystallography of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects","volume":"154","author":"Angeli","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.103033_b0035","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1080\/14737175.2016.1193009","article-title":"Carbonic Anhydrase inhibition and the management of neuropathic pain","volume":"16","author":"Supuran","year":"2016","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.bioorg.2019.103033_b0040","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrd2467","article-title":"Carbonic Anhydrases: novel therapeutic applications for inhibitors and activators","volume":"7","author":"Supuran","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bioorg.2019.103033_b0045","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1021\/ja809683v","article-title":"Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors","volume":"131","author":"Maresca","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bioorg.2019.103033_b0050","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1021\/jm901287j","article-title":"Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins","volume":"53","author":"Maresca","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.103033_b0055","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1021\/acs.jmedchem.5b01720","article-title":"Thioxocoumarins show an alternative carbonic anhydrase inhibition mechanism compared to coumarins","volume":"59","author":"Ferraroni","year":"2016","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.103033_b0060","doi-asserted-by":"crossref","first-page":"8271","DOI":"10.1021\/jm200983e","article-title":"Glycosyl coumarin Carbonic Anhydrase IX and XII inhibitors strongly attenuate the growth of primary breast tumors","volume":"54","author":"Touisni","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.103033_b0065","doi-asserted-by":"crossref","first-page":"397","DOI":"10.3109\/14756366.2011.650692","article-title":"Metronidazole-coumarin conjugates and 3-cyano-7-hydroxy-coumarin act as isoform-selective Carbonic Anhydrase Inhibitors","volume":"28","author":"Bonneau","year":"2013","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.103033_b0070","doi-asserted-by":"crossref","first-page":"292","DOI":"10.3109\/14756366.2013.777334","article-title":"Novel coumarins and benzocoumarins acting as isoform-selective inhibitors against the tumor-associated Carbonic Anhydrase IX","volume":"29","author":"Sharma","year":"2014","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.103033_b0075","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1021\/jm301625s","article-title":"Sulfocoumarins (1,2-benzoxathiine-2,2-dioxides): a class of potent and isoform-selective inhibitors of tumor-associated Carbonic Anhydrases","volume":"56","author":"Tars","year":"2013","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.103033_b0080","doi-asserted-by":"crossref","first-page":"4502","DOI":"10.1016\/j.bmc.2013.05.032","article-title":"7-Substituted-sulfocoumarins are isoform-selective, potent Carbonic Anhydrase II Inhibitors","volume":"21","author":"Tanc","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.103033_b0085","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1016\/j.bmc.2010.01.076","article-title":"Carbonic Anhydrase Inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids","volume":"18","author":"Innocenti","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.103033_b0090","doi-asserted-by":"crossref","first-page":"5511","DOI":"10.1021\/jm1003667","article-title":"Polyamines inhibit Carbonic Anhydrases by anchoring to the zinc-coordinated water molecule","volume":"53","author":"Carta","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.103033_b0095","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1021\/jm300031j","article-title":"Dithiocarbamates strongly inhibit Carbonic Anhydrases and show antiglaucoma action in vivo","volume":"55","author":"Carta","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.103033_b0100","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1039\/c2cc16395k","article-title":"Dithiocarbamates: a new class of Carbonic Anhydrase Inhibitors. Crystallographic and kinetic investigations","volume":"48","author":"Carta","year":"2012","journal-title":"Chem. Commun. (Camb.)"},{"key":"10.1016\/j.bioorg.2019.103033_b0105","doi-asserted-by":"crossref","first-page":"4691","DOI":"10.1021\/jm400414j","article-title":"Xanthates and trithiocarbonates strongly inhibit Carbonic Anhydrases and show antiglaucoma effects in vivo","volume":"56","author":"Carta","year":"2013","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.103033_b0110","doi-asserted-by":"crossref","first-page":"5857","DOI":"10.1021\/acs.jmedchem.6b00462","article-title":"Monothiocarbamates strongly inhibit Carbonic Anhydrases in vitro and possess intraocular pressure lowering activity in an animal model of glaucoma","volume":"59","author":"Vullo","year":"2016","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.103033_b0115","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1039\/C4CC07320G","article-title":"Out of the active site binding pocket for Carbonic Anhydrase Inhibitors","volume":"51","author":"D\u2019Ambrosio","year":"2015","journal-title":"Chem. Commun. (Camb.)"},{"key":"10.1016\/j.bioorg.2019.103033_b0120","doi-asserted-by":"crossref","first-page":"11983","DOI":"10.1039\/C6CC06399C","article-title":"Benzoxaborole as a new chemotype for Carbonic Anhydrase Inhibition","volume":"52","author":"Alterio","year":"2016","journal-title":"Chem. Commun. (Camb.)"},{"key":"10.1016\/j.bioorg.2019.103033_b0125","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1039\/C8CC08562E","article-title":"Selenols: a new class of Carbonic Anhydrase Inhibitors","volume":"55","author":"Angeli","year":"2019","journal-title":"Chem. Commun. (Camb.)"},{"key":"10.1016\/j.bioorg.2019.103033_b0130","doi-asserted-by":"crossref","first-page":"4316","DOI":"10.1016\/j.bmcl.2006.05.068","article-title":"N-Hydroxyurea\u2013a versatile zinc binding function in the design of metalloenzyme inhibitors","volume":"16","author":"Temperini","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2019.103033_b0135","doi-asserted-by":"crossref","first-page":"8371","DOI":"10.1039\/c0cc02707c","article-title":"Selective hydrophobic pocket binding observed within the Carbonic Anhydrase II active site accommodate different 4-substituted-ureido-benzenesulfonamides and correlate to inhibitor potency","volume":"46","author":"Pacchiano","year":"2010","journal-title":"Chem. Commun. (Camb.)"},{"key":"10.1016\/j.bioorg.2019.103033_b0140","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1021\/jm101541x","article-title":"Ureido-substituted benzenesulfonamides potently inhibit Carbonic Anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis","volume":"54","author":"Pacchiano","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.103033_b0145","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1158\/0008-5472.CAN-10-4261","article-title":"Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel Carbonic Anhydrase IX Inhibitors","volume":"71","author":"Lou","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.bioorg.2019.103033_b0150","unstructured":"A Study of SLC-0111 and Gemcitabine for Metastatic Pancreatic Ductal Cancer in Subjects Positive for CAIX-Full Text View - ClinicalTrials.gov https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03450018 (accessed Jan 24, 2019)."},{"key":"10.1016\/j.bioorg.2019.103033_b0155","doi-asserted-by":"crossref","first-page":"11519","DOI":"10.1039\/C5CC03711E","article-title":"Hydroxylamine-O-sulfonamide is a versatile lead compound for the development of Carbonic Anhydrase Inhibitors","volume":"51","author":"Fiore","year":"2015","journal-title":"Chem. Commun."},{"key":"10.1016\/j.bioorg.2019.103033_b0160","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1146\/annurev.anchem.1.031207.112945","article-title":"High-resolution mass spectrometers","volume":"1","author":"Marshall","year":"2008","journal-title":"Annu. Rev. Anal. Chem."},{"key":"10.1016\/j.bioorg.2019.103033_b0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bioorg.2018.02.029","article-title":"Synthesis of N\u2019-phenyl-N-hydroxyureas and investigation of their inhibitory activities on human Carbonic Anhydrases","volume":"78","author":"Bozdag","year":"2018","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2019.103033_b0170","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1016\/S0021-9258(18)62326-9","article-title":"The carbon dioxide hydration activity of Carbonic Anhydrase. I. Stop-flow kinetic studies on the native human isoenzymes B and C","volume":"246","author":"Khalifah","year":"1971","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bioorg.2019.103033_b0175","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1016\/S0959-8049(01)00300-8","article-title":"Effects of different schedules of oxaliplatin treatment on the peripheral nervous system of the rat","volume":"37","author":"Cavaletti","year":"2001","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.bioorg.2019.103033_b0180","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.neuropharm.2013.10.034","article-title":"Involvement of \u03917 NAChR subtype in rat oxaliplatin-induced neuropathy: effects of selective activation","volume":"79","author":"Di Cesare Mannelli","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bioorg.2019.103033_b0185","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.neuropharm.2015.05.037","article-title":"Oxaliplatin evokes P2X7-dependent glutamate release in the cerebral cortex: a pain mechanismmediated by Pannexin 1","volume":"97","author":"Di Cesare Mannelli","year":"2015","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bioorg.2019.103033_b0190","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1021\/acs.jmedchem.6b01607","article-title":"Design and synthesis of novel nonsteroidal anti-inflammatory drugs and Carbonic Anhydrase Inhibitors hybrids (NSAIDs-CAIs) for the treatment of rheumatoid arthritis","volume":"60","author":"Bua","year":"2017","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.103033_b0195","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1016\/j.bmcl.2012.01.129","article-title":"New chemotypes acting as isozyme-selective Carbonic Anhydrase Inhibitors with low affinity for the offtarget cytosolic isoform II","volume":"22","author":"Carta","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2019.103033_b0200","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","article-title":"The protein data bank","volume":"28","author":"Berman","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bioorg.2019.103033_b0205","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.bioorg.2019.103033_b0210","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1021\/ci500209e","article-title":"AutoDock4Zn: an improved autodock force field for small-molecule docking to zinc metalloproteins","volume":"54","author":"Santos-Martins","year":"2014","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.bioorg.2019.103033_b0215","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ejmech.2018.12.049","article-title":"Continued exploration of 1,2,4-oxadiazole periphery for Carbonic Anhydrase-targeting primary arene sulfonamides: discovery of subnanomolar inhibitors of membrane-bound HCA IX isoform that selectively kill cancer cells in hypoxic environment","volume":"164","author":"Krasavin","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.103033_b0220","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1021\/acs.jnatprod.6b00627","article-title":"Drug affinity responsive target stability (DARTS) identifies laurifolioside as a new clathrin heavy chain modulator","volume":"79","author":"Dal Piaz","year":"2016","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bioorg.2019.103033_b0225","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.fitote.2018.09.010","article-title":"New diterpenes from salvia pseudorosmarinus and their activity as inhibitors of monoacylglycerol lipase (MAGL)","volume":"130","author":"De Leo","year":"2018","journal-title":"Fitoterapia"},{"key":"10.1016\/j.bioorg.2019.103033_b0230","unstructured":"D.A. Case, J.T. Berryman, R.M. Betz, D.S. Cerutti, Darden, R.E. Duke, T.J. Giese, H. Gohlke, A.W. Goetz, N. Homeyer, S. Izadi, P. Janowski, J. Kaus, A. Kovalenko, T.S. Lee, S. LeGrand, P. Li, T. Luchko, R. Luo, B. Madej, K.M. Merz, G. Monard, P. Needham, H. Nguyen, H.T. Nguyen, I. Omelyan, A. Onufriev, D.R. Roe, A. Roitberg, R. Salomon-Ferrer, C.L. Simmerling, W. Smith, J. Swails, R.C. Walker, J. Wang, R.M. Wolf, X. Wu, D.M. York, P.A. Kollman, AMBER, Version 16, University of California, San Francisco, CA, 2016."},{"key":"10.1016\/j.bioorg.2019.103033_b0235","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.ejmech.2018.06.033","article-title":"Discovery and development of novel salicylate synthase (MbtI) furanic inhibitors as antitubercular agents","volume":"155","author":"Chiarelli","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.103033_b0240","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1111\/bph.12955","article-title":"Implementing guidelines on reporting research using animals (ARRIVE Etc.): new requirements for publication in BJP","volume":"172","author":"McGrath","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bioorg.2019.103033_b0245","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1016\/j.jpain.2013.08.002","article-title":"Morphologic features and glial activation in rat oxaliplatin-dependent neuropathic pain","volume":"14","author":"Di Cesare Mannelli","year":"2013","journal-title":"J. Pain"},{"key":"10.1016\/j.bioorg.2019.103033_b0250","doi-asserted-by":"crossref","first-page":"905360","DOI":"10.1155\/2013\/905360","article-title":"Therapeutic effects of the superoxide dismutase mimetic compound MnIIMe2DO2A on experimental articular pain in rats","volume":"2013","author":"Di Cesare Mannelli","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.bioorg.2019.103033_b0255","doi-asserted-by":"crossref","first-page":"7273","DOI":"10.1021\/jm901298x","article-title":"A novel manganese complex effective as superoxide anion scavenger and therapeutic agent against cell and tissue oxidative injury","volume":"52","author":"Failli","year":"2009","journal-title":"J. Med. Chem."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206819305383?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206819305383?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T18:28:58Z","timestamp":1663612138000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206819305383"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":51,"alternative-id":["S0045206819305383"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2019.103033","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"N-aryl-N\u2019-ureido-O-sulfamates: Potent and selective inhibitors of the human Carbonic Anhydrase VII isoform with neuropathic pain relieving properties","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2019.103033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103033"}}