{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T04:04:57Z","timestamp":1768881897555,"version":"3.49.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001851","name":"Ministry of Earth Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001851","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.bioorg.2019.103072","type":"journal-article","created":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T16:49:53Z","timestamp":1561135793000},"page":"103072","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Muscle extract of Arothron immaculatus regulates the blood glucose level and the antioxidant system in high-fat diet and streptozotocin induced diabetic rats"],"prefix":"10.1016","volume":"90","author":[{"given":"Karunanidhi","family":"Kaleshkumar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajendran","family":"Rajaram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nambirajan","family":"Gayathri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thilagar","family":"Sivasudha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ganesan","family":"Arun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Govindaraju","family":"Archunan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bal\u00e1zs","family":"Guly\u00e1s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parasuraman","family":"Padmanabhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2019.103072_b0005","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.3390\/md12031512","article-title":"Anti-diabetic effects of CTB-APSL fusion protein in type 2 diabetic mice","volume":"12","author":"Liu","year":"2014","journal-title":"Mar. Drugs."},{"key":"10.1016\/j.bioorg.2019.103072_b0010","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1016\/S0140-6736(16)30507-4","article-title":"Environmental risk factors for type 1 diabetes","volume":"387","author":"Rewers","year":"2016","journal-title":"Lancet."},{"key":"10.1016\/j.bioorg.2019.103072_b0015","doi-asserted-by":"crossref","first-page":"738","DOI":"10.2337\/db08-1372","article-title":"Phenotypic type 2 diabetes in obese youth: insulin sensitivity and secretion in islet cell antibody-negative versus\u2013positive patients","volume":"58","author":"Tfayli","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.bioorg.2019.103072_b0020","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.phymed.2010.07.005","article-title":"Hypoglycemic effect of Belamcanda chinensis leaf extract in normal and STZ-induced diabetic rats and its potential active faction","volume":"18","author":"Wu","year":"2011","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bioorg.2019.103072_b0025","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.jep.2011.03.062","article-title":"Identification of trans-tiliroside as active principle with anti-hyperglycemic, anti-hyperlipidemic and antioxidant effects from Potentilla chinesis","volume":"135","author":"Qiao","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bioorg.2019.103072_b0030","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.2337\/dc07-1144","article-title":"Supplementation of conventional therapy with the novel grain Salba (Salvia hispanica L.) improves major and emerging cardiovascular risk factors in type 2 diabetes: results of a randomized controlled trial","volume":"30","author":"Vuksan","year":"2007","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bioorg.2019.103072_b0035","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1016\/j.foodchem.2010.07.104","article-title":"Protective effect of dietary ginger on antioxidant enzymes and oxidative damage in experimental diabetic rat tissues","volume":"124","author":"Shanmugam","year":"2011","journal-title":"Food Chem."},{"key":"10.1016\/j.bioorg.2019.103072_b0040","doi-asserted-by":"crossref","first-page":"6158","DOI":"10.1021\/jo800837k","article-title":"Glycolipids from sponges. 20. J-coupling analysis for stereochemical assignments in furanosides: Structure elucidation of vesparioside B, a glycosphingolipid from the marine sponge Spheciospongia vesparia","volume":"73","author":"Costantino","year":"2008","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bioorg.2019.103072_b0045","first-page":"65","article-title":"Exploration of anti-diabetic potentials amongst marine species-A mini review","volume":"4","author":"Bhattacharjee","year":"2014","journal-title":"Indo Glob. J. Pharm. Sci."},{"key":"10.1016\/j.bioorg.2019.103072_b0050","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.nut.2010.01.011","article-title":"Beneficial effects of oligopeptides from marine salmon skin in a rat model of type 2 diabetes","volume":"26","author":"Zhu","year":"2010","journal-title":"Nutrition"},{"key":"10.1016\/j.bioorg.2019.103072_b0055","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s10228-014-0444-5","article-title":"Taxonomy and systematics of tetraodontiform fishes: a review focusing primarily on progress in the period from 1980 to 2014","volume":"62","author":"Matsuura","year":"2014","journal-title":"Ichthyol. Res."},{"key":"10.1016\/j.bioorg.2019.103072_b0060","article-title":"Economic analysis on the change of the target puffer fishes","author":"Kawata","year":"2003","journal-title":"J. Fisheries Econ. (Japan)"},{"key":"10.1016\/j.bioorg.2019.103072_b0065","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.toxrep.2017.06.004","article-title":"First report on distribution of heavy metals and proximate analysis in marine edible puffer fishes collected from Gulf of Mannar Marine Biosphere Reserve, South India","volume":"4","author":"Kaleshkumar","year":"2017","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.bioorg.2019.103072_b0070","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/S0891-5849(98)00315-3","article-title":"Antioxidant activity applying an improved ABTS radical cation decolorization assay","volume":"26","author":"Re","year":"1999","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bioorg.2019.103072_b0075","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1021\/jf049320i","article-title":"Antioxidant activity of commercial soft and hard wheat (Triticum aestivum L.) as affected by gastric pH conditions","volume":"53","author":"Liyana-Pathirana","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bioorg.2019.103072_b0080","doi-asserted-by":"crossref","first-page":"307","DOI":"10.5264\/eiyogakuzashi.44.307","article-title":"Antioxidative activities of browning reaction prepared from glucosamine","volume":"44","author":"Oyaizu","year":"1986","journal-title":"Jpn. J. Nutr. Dietet."},{"key":"10.1016\/j.bioorg.2019.103072_b0085","doi-asserted-by":"crossref","first-page":"3155","DOI":"10.1021\/ac062215i","article-title":"Analysis of pharmaceuticals in fish using liquid chromatography-tandem mass spectrometry","volume":"79","author":"Ramirez","year":"2007","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bioorg.2019.103072_b0090","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.foodchem.2014.08.010","article-title":"Impact of processing on the phenolic profiles of small millets: Evaluation of their antioxidant and enzyme inhibitory properties associated with hyperglycemia","volume":"169","author":"Pradeep","year":"2015","journal-title":"Food Chem."},{"key":"10.1016\/j.bioorg.2019.103072_b0095","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.foodchem.2015.12.025","article-title":"Distribution of phenolic antioxidants in whole and milled fractions of quinoa and their inhibitory effects on \u03b1-amylase and \u03b1-glucosidase activities","volume":"199","author":"Hemalatha","year":"2016","journal-title":"Food Chem."},{"key":"10.1016\/j.bioorg.2019.103072_b0100","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/j.biopha.2018.10.007","article-title":"Evaluation of antidiabetic activity of bud and flower of Avaram Senna (Cassia auriculata L.) In high fat diet and streptozotocin induced diabetic rats","volume":"108","author":"Gayathri","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bioorg.2019.103072_b0105","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jff.2014.02.018","article-title":"Mulberry leaf extract intake reduces hyperglycaemia in streptozotocin (STZ)-induced diabetic rats fed high-fat diet","volume":"8","author":"Jeszka-Skowron","year":"2014","journal-title":"J. Funct. Foods."},{"key":"10.1016\/j.bioorg.2019.103072_b0110","first-page":"130","article-title":"A modified spectrophotometric assay of superoxide dismutase","volume":"21","author":"Kakkar","year":"1984","journal-title":"Indian J. Biochem. Biophys."},{"key":"10.1016\/j.bioorg.2019.103072_b0115","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0304-4165(79)90289-7","article-title":"Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver","volume":"582","author":"Moron","year":"1979","journal-title":"Biochim. Biophys. Acta."},{"key":"10.1016\/j.bioorg.2019.103072_b0120","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1126\/science.179.4073.588","article-title":"Selenium: biochemical role as a component of glutathione peroxidise","volume":"179","author":"Rotruck","year":"1973","journal-title":"Science"},{"key":"10.1016\/j.bioorg.2019.103072_b0125","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bioorg.2019.103072_b0130","doi-asserted-by":"crossref","first-page":"220","DOI":"10.3390\/md14120220","article-title":"Marine organisms with anti-diabetes properties","volume":"14","author":"Lauritano","year":"2016","journal-title":"Mar. Drugs."},{"key":"10.1016\/j.bioorg.2019.103072_b0135","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2174\/157015909787602823","article-title":"Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options","volume":"7","author":"Uttara","year":"2009","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.bioorg.2019.103072_b0140","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1002\/jsfa.2616","article-title":"Antioxidants in foods and health: problems and fallacies in the field","volume":"86","author":"Frankel","year":"2006","journal-title":"J. Sci. Food Agric."},{"key":"10.1016\/j.bioorg.2019.103072_b0145","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/jfbc.12257","article-title":"In vitro antidiabetic and antioxidant potential of the ethanolic extract of skipjack tuna (K atsuwonus Pelamis) heart","volume":"40","author":"Ali","year":"2016","journal-title":"J. Food Biochem."},{"key":"10.1016\/j.bioorg.2019.103072_b0150","unstructured":"G.S. Centenaro, M.S. Centenaro, C.P. Hernandez, Antioxidant activity of protein hydrolysates of fish and chicken bones, (2011)."},{"key":"10.1016\/j.bioorg.2019.103072_b0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3945\/an.111.000893","article-title":"Omega-3 fatty acids EPA and DHA: health benefits throughout life","volume":"3","author":"Swanson","year":"2012","journal-title":"Adv. Nut."},{"key":"10.1016\/j.bioorg.2019.103072_b0160","first-page":"3021","article-title":"Docosahexaenoic acid has an anti-diabetic effect in streptozotocin-induced diabetic micem","volume":"7","author":"Li","year":"2014","journal-title":"Int J Clin Exp Med."},{"key":"10.1016\/j.bioorg.2019.103072_b0165","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jfoodeng.2011.10.011","article-title":"Supercritical fluid extraction of fish oil from fish by-products: A comparison with other extraction methods","volume":"109","author":"Rubio-Rodr\u00edguez","year":"2012","journal-title":"J. Food Eng."},{"key":"10.1016\/j.bioorg.2019.103072_b0170","doi-asserted-by":"crossref","first-page":"243","DOI":"10.2152\/jmi.54.243","article-title":"Relationship between serum concentrations of saturated fatty acids and unsaturated fatty acids and the homeostasis model insulin resistance index in Japanese patients with type 2 diabetes mellitus","volume":"54","author":"Kusunoki","year":"2007","journal-title":"J. Med. Invest."},{"key":"10.1016\/j.bioorg.2019.103072_b0175","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/biof.1219","article-title":"Screening alpha-glucosidase and alpha-amylase inhibitors from natural compounds by molecular docking in silico","volume":"41","author":"Jhong","year":"2015","journal-title":"BioFactors"},{"key":"10.1016\/j.bioorg.2019.103072_b0180","first-page":"262","article-title":"Bioactive potential of Fusinus nicobaricus from Gulf of Mannar","volume":"4","author":"Janaki","year":"2015","journal-title":"Int. J. Pharm. Bio Sci."},{"key":"10.1016\/j.bioorg.2019.103072_b0185","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1517\/14728222.2012.664134","article-title":"Antidiabetic effects of natural plant extracts via inhibition of carbohydrate hydrolysis enzymes with emphasis on pancreatic alpha amylase","volume":"16","author":"Etxeberria","year":"2012","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.bioorg.2019.103072_b0190","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.biopha.2017.08.098","article-title":"A practical guide for induction of type-2 diabetes in rat: incorporating a high-fat diet and streptozotocin","volume":"95","author":"Gheibi","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bioorg.2019.103072_b0195","first-page":"99","article-title":"Effect of the duration of high-fat diet and the dosage of streptozotocin on establishing experimental animal model of type 2 diabetes mellitus","volume":"40","author":"Wang","year":"2011","journal-title":"Wei sheng yanjiu= J. Hygiene Res."},{"key":"10.1016\/j.bioorg.2019.103072_b0200","first-page":"1081","article-title":"Increased degradation of dermal collagen in diabetic rats","volume":"29","author":"Rajkumar","year":"1991","journal-title":"Indian J. Exp. Bio."},{"key":"10.1016\/j.bioorg.2019.103072_b0205","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0895-3988(10)60040-2","article-title":"Effect of marine collagen peptides on markers of metabolic nuclear receptors in type 2 diabetic patients with\/without hypertension","volume":"23","author":"Cui-Feng","year":"2010","journal-title":"Biomed. Environ. Sci."},{"key":"10.1016\/j.bioorg.2019.103072_b0210","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1211\/jpp.57.12.0007","article-title":"Antidiabetic effect of a new peptide from Squalus mitsukurii liver (S-8300) in streptozocin-induced diabetic mice","volume":"57","author":"Huang","year":"2005","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.bioorg.2019.103072_b0215","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.metabol.2014.08.010","article-title":"Diabetic dyslipidemia","volume":"63","author":"Wu","year":"2014","journal-title":"Metabolism"},{"key":"10.1016\/j.bioorg.2019.103072_b0220","doi-asserted-by":"crossref","first-page":"581","DOI":"10.4196\/kjpp.2016.20.6.581","article-title":"Evaluation of fish oil-rich in MUFAs for anti-diabetic and anti-inflammation potential in experimental type 2 diabetic rats","volume":"20","author":"Keapai","year":"2016","journal-title":"Korean J. Physiol. Pharmacol."},{"key":"10.1016\/j.bioorg.2019.103072_b0225","article-title":"Altered liver morphology and enzymes in streptozotocin induced diabetic rats","volume":"27","author":"Zafar","year":"2009","journal-title":"Int. J. Morphol."},{"key":"10.1016\/j.bioorg.2019.103072_b0230","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0009-9120(99)00075-2","article-title":"Antioxidant enzymes and human diseases","volume":"32","author":"Mat\u00e9s","year":"1999","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.bioorg.2019.103072_b0235","first-page":"1024","article-title":"An enzyme-based theory of obligate 648 anaero-biosis: the physiological function of superoxide dismutase","volume":"649","author":"Mc Cord","year":"1976","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bioorg.2019.103072_b0240","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0026-0495(00)80082-7","article-title":"Oxidative stress and glycemic regulation","volume":"49","author":"Ceriello","year":"2000","journal-title":"Metabolism"},{"issue":"2004","key":"10.1016\/j.bioorg.2019.103072_b0245","first-page":"17","article-title":"Protective effect of peptide S-8300 from shark liver on acute liver injury in mice","volume":"23","author":"Huang","year":"2004","journal-title":"Chinese J. Marine Drugs"}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206819306510?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206819306510?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T07:53:21Z","timestamp":1758614001000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206819306510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":49,"alternative-id":["S0045206819306510"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2019.103072","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Muscle extract of Arothron immaculatus regulates the blood glucose level and the antioxidant system in high-fat diet and streptozotocin induced diabetic rats","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2019.103072","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103072"}}