{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T21:08:33Z","timestamp":1785186513072,"version":"3.55.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education, Malaysia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004530","name":"Universiti Putra Malaysia","doi-asserted-by":"publisher","award":["9301700"],"award-info":[{"award-number":["9301700"]}],"id":[{"id":"10.13039\/501100004530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004530","name":"Universiti Putra Malaysia","doi-asserted-by":"publisher","award":["9480700"],"award-info":[{"award-number":["9480700"]}],"id":[{"id":"10.13039\/501100004530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007208","name":"Malaysia Toray Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007208","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.bioorg.2019.103376","type":"journal-article","created":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T19:53:34Z","timestamp":1571946814000},"page":"103376","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Inhibition of nitric oxide and prostaglandin E2 production by pyrrolylated-chalcones: Synthesis, biological activity, crystal structure analysis, and molecular docking studies"],"prefix":"10.1016","volume":"94","author":[{"given":"Siti Munirah","family":"Mohd Faudzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam Aisyah","family":"Abdullah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd Rashidi","family":"Abdull Manap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad Zaidi","family":"Ismail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamal","family":"Rullah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd Fadhlizil Fasihi","family":"Mohd Aluwi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aizi Nor","family":"Mazila Ramli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faridah","family":"Abas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nordin H.","family":"Lajis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2019.103376_b0005","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/bja\/77.1.11","volume":"77","author":"Galley","year":"1996","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.bioorg.2019.103376_b0010","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1172\/JCI11914","volume":"107","author":"Yamamoto","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bioorg.2019.103376_b0015","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.intimp.2007.12.017","volume":"8","author":"Cho","year":"2008","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bioorg.2019.103376_b0020","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.1749-6632.2001.tb05662.x","volume":"928","author":"Chung","year":"2001","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bioorg.2019.103376_b0025","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/j.bcp.2003.12.016","volume":"67","author":"Ban","year":"2004","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bioorg.2019.103376_b0030","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/S0223-5234(02)01387-9","volume":"37","author":"Rojas","year":"2002","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.103376_b0035","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.niox.2008.04.006","volume":"19","author":"Ridnour","year":"2008","journal-title":"Nitric Oxide-Biol Ch."},{"key":"10.1016\/j.bioorg.2019.103376_b0040","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1248\/bpb.34.1170","volume":"34","author":"Kawabata","year":"2011","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.bioorg.2019.103376_b0045","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1016\/S0968-0896(02)00094-9","volume":"10","author":"Lin","year":"2002","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.103376_b0050","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ejmech.2006.09.019","volume":"42","author":"Nowakowska","year":"2007","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.103376_b0055","doi-asserted-by":"crossref","first-page":"3695","DOI":"10.1016\/j.bmc.2013.04.031","volume":"21","author":"Battilocchio","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.103376_b0060","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3390\/molecules22030461","volume":"22","author":"Fatahala","year":"2017","journal-title":"Melecules"},{"key":"10.1016\/j.bioorg.2019.103376_b0065","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.ejmech.2013.03.029","volume":"63","author":"Rane","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.103376_b0070","doi-asserted-by":"crossref","first-page":"3683","DOI":"10.1016\/j.bmcl.2017.07.010","volume":"27","author":"Williams","year":"2017","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2019.103376_b0075","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1039\/b909172f","volume":"33","author":"Smith","year":"2009","journal-title":"New J. Chem."},{"key":"10.1016\/j.bioorg.2019.103376_b0080","doi-asserted-by":"crossref","first-page":"3969","DOI":"10.1007\/s00044-012-0401-7","volume":"22","author":"Sharma","year":"2013","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.bioorg.2019.103376_b0085","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1039\/C4MD00541D","volume":"6","author":"Mohd Faudzi","year":"2015","journal-title":"MedChemComm"},{"key":"10.1016\/j.bioorg.2019.103376_b0090","doi-asserted-by":"crossref","first-page":"3826","DOI":"10.1016\/j.bmcl.2014.06.061","volume":"24","author":"Rullah","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2019.103376_h0095","doi-asserted-by":"crossref","first-page":"3330","DOI":"10.1016\/j.bmcl.2015.05.056","volume":"25","author":"Leong","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2019.103376_h0100","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1016\/j.bmcl.2016.03.092","volume":"26","author":"Mohd Aluwi","year":"2016","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2019.103376_b0100","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1007\/s00044-011-9706-1","volume":"21","author":"Lam","year":"2012","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.bioorg.2019.103376_b0105","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1248\/bpb.30.1450","volume":"30","author":"Kim","year":"2007","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.bioorg.2019.103376_b0110","doi-asserted-by":"crossref","first-page":"8260","DOI":"10.1021\/jm1004545","volume":"53","author":"Qiu","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.103376_b0115","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00281-012-0342-8","volume":"35","author":"Nakanishi","year":"2013","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.bioorg.2019.103376_b0120","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1016\/j.bmc.2005.11.035","volume":"14","author":"Weber","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.103376_b0125","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/S1359644602025722","volume":"8","author":"Rishton","year":"2003","journal-title":"Drug Disc. Today."},{"key":"10.1016\/j.bioorg.2019.103376_b0130","doi-asserted-by":"crossref","first-page":"9606","DOI":"10.1021\/ja802977h","volume":"130","author":"Coan","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bioorg.2019.103376_b0135","doi-asserted-by":"crossref","first-page":"3658","DOI":"10.1093\/bioinformatics\/btx491","volume":"33","author":"Lagorce","year":"2017","journal-title":"Bioinform."},{"key":"10.1016\/j.bioorg.2019.103376_b0140","doi-asserted-by":"crossref","first-page":"7076","DOI":"10.1021\/acs.jmedchem.5b01105","volume":"58","author":"Irwin","year":"2015","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.103376_b0145","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1021\/jm020017n","volume":"45","author":"Veber","year":"2002","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.103376_b0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.imu.2016.09.004","volume":"5","author":"Gurung","year":"2016","journal-title":"Inform. Med. Unlocked."},{"key":"10.1016\/j.bioorg.2019.103376_b0155","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1107\/S205698901500047X","volume":"71","author":"V\u00e1zquez-Vuelvas","year":"2015","journal-title":"Acta Cryst. E."},{"key":"10.1016\/j.bioorg.2019.103376_b0160","doi-asserted-by":"crossref","first-page":"o2641","DOI":"10.1107\/S1600536809037805","volume":"65","author":"Jasinski","year":"2009","journal-title":"Acta Cryst. E."},{"key":"10.1016\/j.bioorg.2019.103376_b0165","doi-asserted-by":"crossref","first-page":"3969","DOI":"10.1007\/s00044-012-0401-7","volume":"22","author":"Sharma","year":"2013","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.bioorg.2019.103376_b0170","doi-asserted-by":"crossref","first-page":"4727","DOI":"10.1021\/acs.jmedchem.5b00330","volume":"58","author":"Luz","year":"2015","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2019.103376_b0175","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jsb.2008.05.002","volume":"164","author":"Rastelli","year":"2008","journal-title":"J. Struct. Biol."},{"key":"10.1016\/j.bioorg.2019.103376_b0180","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1107\/S0021889808042726","volume":"42","author":"Dolomanov","year":"2009","journal-title":"J. Appl. Cryst."},{"key":"10.1016\/j.bioorg.2019.103376_b0185","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1107\/S0108767307043930","volume":"64","author":"Sheldrick","year":"2008","journal-title":"Acta Cryst. A."},{"key":"10.1016\/j.bioorg.2019.103376_b0190","doi-asserted-by":"crossref","first-page":"W296","DOI":"10.1093\/nar\/gky427","volume":"46","author":"Waterhouse","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bioorg.2019.103376_b0195","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.bioorg.2019.103376_b0200","unstructured":"Accelrys Software Inc., Discovery Studio Modeling Environment, Release 3.5, Accelrys Software Inc., San Diego, 2012."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206819315214?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206819315214?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T07:54:22Z","timestamp":1758614062000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206819315214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":41,"alternative-id":["S0045206819315214"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2019.103376","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of nitric oxide and prostaglandin E2 production by pyrrolylated-chalcones: Synthesis, biological activity, crystal structure analysis, and molecular docking studies","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2019.103376","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103376"}}