{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T18:54:26Z","timestamp":1771008866435,"version":"3.50.1"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.bioorg.2020.104142","type":"journal-article","created":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T21:35:23Z","timestamp":1595885723000},"page":"104142","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Identification and structure\u2013activity relationship (SAR) studies of carvacrol derivatives as potential anti-malarial against Plasmodium falciparum falcipain-2 protease"],"prefix":"10.1016","volume":"103","author":[{"given":"Amad","family":"Uddin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vigyasa","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iram","family":"Irfan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taj","family":"Mohammad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahul","family":"Singh Hada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md","family":"Imtaiyaz Hassan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Abid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shailja","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"22","key":"10.1016\/j.bioorg.2020.104142_b0005","doi-asserted-by":"crossref","first-page":"18364","DOI":"10.1039\/C5RA19673F","article-title":"A structure guided drug-discovery approach towards identification of Plasmodium inhibitors","volume":"6","author":"Aneja","year":"2016","journal-title":"RSC Adv."},{"key":"10.1016\/j.bioorg.2020.104142_b0010","first-page":"1","article-title":"Targeting metacaspase-3 from Plasmodium falciparum towards antimalarial therapy: A combined approach of in-silico and in-vitro investigation","author":"Kumar","year":"2019","journal-title":"Journal of Biomolecular Structure and Dynamics (just-accepted)"},{"issue":"5","key":"10.1016\/j.bioorg.2020.104142_b0015","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.ijpara.2006.02.004","article-title":"Human cerebral malaria and the blood\u2013brain barrier","volume":"36","author":"Medana","year":"2006","journal-title":"Int. J. Parasitol."},{"issue":"1","key":"10.1016\/j.bioorg.2020.104142_b0020","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1186\/s12889-018-5521-7","article-title":"Are we doing enough to prevent poor-quality antimalarial medicines in the developing world?","volume":"18","author":"Walker","year":"2018","journal-title":"BMC public health"},{"issue":"5","key":"10.1016\/j.bioorg.2020.104142_b0025","doi-asserted-by":"crossref","first-page":"377","DOI":"10.2174\/1568026620666200130162347","article-title":"Inhibition of Hemoglobin Degrading Protease Falcipain-2 as a Mechanism for Anti-Malarial Activity of Triazole-Amino Acid Hybrids","volume":"20","author":"Singh","year":"2020","journal-title":"Curr Top Med Chem"},{"key":"10.1016\/j.bioorg.2020.104142_b0030","volume":"2019","author":"Organization","year":"2019","journal-title":"World malaria report"},{"issue":"4","key":"10.1016\/j.bioorg.2020.104142_b0035","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.cbpa.2007.05.038","article-title":"Drug discovery for malaria: a very challenging and timely endeavor","volume":"11","author":"Gelb","year":"2007","journal-title":"Curr. Opin. Chem. Biol."},{"issue":"1","key":"10.1016\/j.bioorg.2020.104142_b0040","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3390\/tropicalmed4010026","article-title":"Resistance to artemisinin combination therapies (ACTs): do not forget the partner drug!","volume":"4","author":"Nsanzabana","year":"2019","journal-title":"Tropical medicine and infectious disease"},{"issue":"5","key":"10.1016\/j.bioorg.2020.104142_b0045","doi-asserted-by":"crossref","first-page":"3484","DOI":"10.1074\/jbc.M310536200","article-title":"Independent intramolecular mediators of folding, activity, and inhibition for the Plasmodium falciparum cysteine protease falcipain-2","volume":"279","author":"Pandey","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"38","key":"10.1016\/j.bioorg.2020.104142_b0050","doi-asserted-by":"crossref","first-page":"25697","DOI":"10.1074\/jbc.M109.014340","article-title":"Vinyl sulfones as antiparasitic agents and a structural basis for drug design","volume":"284","author":"Kerr","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.bioorg.2020.104142_b0055","doi-asserted-by":"crossref","first-page":"2931","DOI":"10.1073\/pnas.87.8.2931","article-title":"Hemoglobin degradation in the malaria parasite Plasmodium falciparum: an ordered process in a unique organelle","volume":"87","author":"Goldberg","year":"1990","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"8","key":"10.1016\/j.bioorg.2020.104142_b0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004336","article-title":"A cysteine protease inhibitor of plasmodium berghei is essential for exo-erythrocytic development","volume":"10","author":"Lehmann","year":"2014","journal-title":"PLoS Pathog."},{"issue":"2","key":"10.1016\/j.bioorg.2020.104142_b0065","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.parint.2017.12.005","article-title":"Inhibition of Plasmodium falciparum cysteine proteases by the sugarcane cystatin CaneCPI-4","volume":"67","author":"Melo","year":"2018","journal-title":"Parasitol. Int."},{"issue":"23","key":"10.1016\/j.bioorg.2020.104142_b0070","doi-asserted-by":"crossref","first-page":"8840","DOI":"10.1073\/pnas.0601876103","article-title":"Plasmodium falciparum ensures its amino acid supply with multiple acquisition pathways and redundant proteolytic enzyme systems","volume":"103","author":"Liu","year":"2006","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"3","key":"10.1016\/j.bioorg.2020.104142_b0075","first-page":"298","article-title":"In silico design of Plasmodium falciparum cysteine protease falcipain 2 inhibitors with favorable pharmacokinetic profile","volume":"7","author":"Fagnidi","year":"2018","journal-title":"J Anal Pharm Res"},{"issue":"7019","key":"10.1016\/j.bioorg.2020.104142_b0080","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/nature03197","article-title":"Virtual screening of chemical libraries","volume":"432","author":"Shoichet","year":"2004","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.bioorg.2020.104142_b0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1004586","article-title":"AutoDockFR: advances in protein-ligand docking with explicitly specified binding site flexibility","volume":"11","author":"Ravindranath","year":"2015","journal-title":"PLoS Comput. Biol."},{"issue":"3","key":"10.1016\/j.bioorg.2020.104142_b0090","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/cpch.27","article-title":"Overview of methods and strategies for conducting virtual small molecule screening","volume":"9","author":"Fradera","year":"2017","journal-title":"Current protocols Chemical biology"},{"issue":"21","key":"10.1016\/j.bioorg.2020.104142_b0095","doi-asserted-by":"crossref","first-page":"3735","DOI":"10.1242\/jeb.00589","article-title":"Antimalarial drug discovery: old and new approaches","volume":"206","author":"Rosenthal","year":"2003","journal-title":"J. Exp. Biol."},{"issue":"5","key":"10.1016\/j.bioorg.2020.104142_b0100","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1021\/jm0505765","article-title":"Identification of novel parasitic cysteine protease inhibitors by use of virtual screening. 2. The available chemical directory","volume":"49","author":"Desai","year":"2006","journal-title":"J. Med. Chem."},{"issue":"2","key":"10.1016\/j.bioorg.2020.104142_b0105","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.bioorg.2020.104142_b0110","article-title":"Discovery Studio Modeling Environment, release 4.5; Dassault Syst\u00e8mes","author":"Biovia","year":"2015","journal-title":"San Diego"},{"key":"10.1016\/j.bioorg.2020.104142_b0115","series-title":"The PyMOL Molecular Graphics System","author":"DeLano","year":"2002"},{"key":"10.1016\/j.bioorg.2020.104142_b0120","doi-asserted-by":"crossref","first-page":"42717","DOI":"10.1038\/srep42717","article-title":"SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules","volume":"7","author":"Daina","year":"2017","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.bioorg.2020.104142_b0125","first-page":"1","article-title":"CarcinoPred-EL: novel models for predicting the carcinogenicity of chemicals using molecular fingerprints and ensemble learning methods","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.bioorg.2020.104142_b0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1002499","article-title":"Accessible high-throughput virtual screening molecular docking software for students and educators","volume":"8","author":"Jacob","year":"2012","journal-title":"PLoS Comput. Biol."},{"issue":"9","key":"10.1016\/j.bioorg.2020.104142_b0135","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1007\/s00894-018-3791-8","article-title":"M.C. dos Santos Junior, Virtual screening to identify Leishmania braziliensis N-myristoyltransferase inhibitors: pharmacophore models, docking, and molecular dynamics","volume":"24","author":"de Carvalho Gallo","year":"2018","journal-title":"J. Mol. Model."},{"key":"10.1016\/j.bioorg.2020.104142_b0140","doi-asserted-by":"crossref","unstructured":"E. Lindahl, B. Hess, D. Van Der Spoel, GROMACS 3.0: a package for molecular simulation and trajectory analysis, Molecular modeling annual 7(8) (2001) 306-317.","DOI":"10.1007\/s008940100045"},{"key":"10.1016\/j.bioorg.2020.104142_b0145","unstructured":"M. Sobol, Drug-like properties: Concepts, structure design and methods from ADME to toxicity optimization [Book Review], Chemistry in Australia (Jul\/Aug 2018) (2018) 28."},{"issue":"1","key":"10.1016\/j.bioorg.2020.104142_b0150","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0959-440X(02)00283-X","article-title":"Unraveling hot spots in binding interfaces: progress and challenges","volume":"12","author":"DeLano","year":"2002","journal-title":"Curr. Opin. Struct. Biol."},{"issue":"16","key":"10.1016\/j.bioorg.2020.104142_b0155","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.bioorg.2020.104142_b0160","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1016\/j.ijbiomac.2017.10.143","article-title":"Investigation of molecular mechanism of recognition between citral and MARK4: A newer therapeutic approach to attenuate cancer cell progression","volume":"107","author":"Naz","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"issue":"6","key":"10.1016\/j.bioorg.2020.104142_b0165","doi-asserted-by":"crossref","first-page":"6912","DOI":"10.1021\/acsomega.8b00582","article-title":"Natural product-based 1, 2, 3-triazole\/sulfonate analogues as potential chemotherapeutic agents for bacterial infections","volume":"3","author":"Aneja","year":"2018","journal-title":"ACS Omega"},{"issue":"9","key":"10.1016\/j.bioorg.2020.104142_b0170","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1016\/j.bmcl.2017.03.049","article-title":"Anti-leishmanial and cytotoxic activities of amino acid-triazole hybrids: Synthesis, biological evaluation, molecular docking and in silico physico-chemical properties","volume":"27","author":"Masood","year":"2017","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"9","key":"10.1016\/j.bioorg.2020.104142_b0175","doi-asserted-by":"crossref","first-page":"2638","DOI":"10.1002\/slct.201702913","article-title":"N-Substituted 1, 2, 3-Triazolyl-Appended Indole-Chalcone Hybrids as Potential DNA Intercalators Endowed with Antioxidant and Anticancer Properties","volume":"3","author":"Aneja","year":"2018","journal-title":"ChemistrySelect"},{"issue":"2","key":"10.1016\/j.bioorg.2020.104142_b0180","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1042\/bj3600481","article-title":"Expression and characterization of the Plasmodium falciparum haemoglobinase falcipain-3","volume":"360","author":"Sijwali","year":"2001","journal-title":"Biochem. J"},{"issue":"11","key":"10.1016\/j.bioorg.2020.104142_b0185","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.1021\/jm070735f","article-title":"A prodomain peptide of Plasmodium falciparum cysteine protease (falcipain-2) inhibits malaria parasite development","volume":"51","author":"Korde","year":"2008","journal-title":"J. Med. Chem."},{"issue":"2","key":"10.1016\/j.bioorg.2020.104142_b0190","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.exppara.2011.02.015","article-title":"Plasmodium vivax: collaborative roles for plasmepsin 4 and vivapains in hemoglobin hydrolysis","volume":"128","author":"Moon","year":"2011","journal-title":"Exp. Parasitol."},{"issue":"1","key":"10.1016\/j.bioorg.2020.104142_b0195","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1186\/1475-2875-11-272","article-title":"A simple and inexpensive haemozoin-based colorimetric method to evaluate anti-malarial drug activity","volume":"11","author":"Men","year":"2012","journal-title":"Malar. J."},{"key":"10.1016\/j.bioorg.2020.104142_b0200","doi-asserted-by":"crossref","unstructured":"F.A. Mphande, U. Ribacke, O. Kaneko, F. Kironde, G. Winter, M. Wahlgren, SURFIN 4.1, a schizont-merozoite associated protein in the SURFIN family of Plasmodium falciparum, Malaria journal 7(1) (2008) 116.","DOI":"10.1186\/1475-2875-7-116"},{"issue":"6","key":"10.1016\/j.bioorg.2020.104142_b0205","doi-asserted-by":"crossref","first-page":"739","DOI":"10.4269\/ajtmh.1993.48.739","article-title":"Parasite lactate dehydrogenase as an assay for Plasmodium falciparum drug sensitivity","volume":"48","author":"Makler","year":"1993","journal-title":"The American journal of tropical medicine and hygiene"},{"issue":"16","key":"10.1016\/j.bioorg.2020.104142_b0210","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1111\/j.1742-4658.2011.08220.x","article-title":"Multi-targeted activity of maslinic acid as an antimalarial natural compound","volume":"278","author":"Moneriz","year":"2011","journal-title":"The FEBS journal"},{"key":"10.1016\/j.bioorg.2020.104142_b0215","doi-asserted-by":"crossref","unstructured":"B.C. Evans, C.E. Nelson, S.Y. Shann, K.R. Beavers, A.J. Kim, H. Li, H.M. Nelson, T.D. Giorgio, C.L. Duvall, Ex vivo red blood cell hemolysis assay for the evaluation of pH-responsive endosomolytic agents for cytosolic delivery of biomacromolecular drugs, JoVE (Journal of Visualized Experiments) (73) (2013) e50166.","DOI":"10.3791\/50166-v"},{"key":"10.1016\/j.bioorg.2020.104142_b0220","doi-asserted-by":"crossref","unstructured":"F.A. Wani, Amaduddin, B. Aneja, G. Sheehan, K. Kavanagh, R. Ahmad, M. Abid, R. Patel, Synthesis of Novel Benzimidazolium Gemini Surfactants and Evaluation of Their Anti-Candida Activity, ACS omega 4(7) (2019) 11871-11879.","DOI":"10.1021\/acsomega.9b01056"},{"issue":"4","key":"10.1016\/j.bioorg.2020.104142_b0225","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1080\/00034983.1980.11687360","article-title":"The antimalarial activity of N-benzyloxydihydrotriazines: I. The activity of clociguanil (BRL 50216) against rodent malaria, and studies on its mode of action","volume":"74","author":"Knight","year":"1980","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"10.1016\/j.bioorg.2020.104142_b0230","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/5464519","article-title":"Antimalarial Activity of Tinospora baenzigeri against Plasmodium berghei-Infected Mice","volume":"2019","author":"Ounjaijean","year":"2019","journal-title":"Journal of tropical medicine"},{"issue":"3","key":"10.1016\/j.bioorg.2020.104142_b0235","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.bbrc.2009.10.014","article-title":"Insight into the molecular switch mechanism of human Rab5a from molecular dynamics simulations","volume":"390","author":"Wang","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"7","key":"10.1016\/j.bioorg.2020.104142_b0240","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1080\/07391102.2018.1468282","article-title":"Identification and evaluation of bioactive natural products as potential inhibitors of human microtubule affinity-regulating kinase 4 (MARK4)","volume":"37","author":"Mohammad","year":"2019","journal-title":"J. Biomol. Struct. Dyn."},{"issue":"8","key":"10.1016\/j.bioorg.2020.104142_b0245","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1080\/07391102.2015.1089186","article-title":"Cloning, expression, and molecular dynamics simulations of a xylosidase obtained from Thermomyces lanuginosus","volume":"34","author":"Gramany","year":"2016","journal-title":"J. Biomol. Struct. Dyn."},{"issue":"1","key":"10.1016\/j.bioorg.2020.104142_b0250","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.gene.2015.09.062","article-title":"Large scale analysis of the mutational landscape in \u03b2-glucuronidase: a major player of mucopolysaccharidosis type VII","volume":"576","author":"Khan","year":"2016","journal-title":"Gene"},{"issue":"9","key":"10.1016\/j.bioorg.2020.104142_b0255","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/s00894-015-2772-4","article-title":"A comparative molecular dynamics study of thermophilic and mesophilic \u03b2-fructosidase enzymes","volume":"21","author":"Mazola","year":"2015","journal-title":"J. Mol. Model."},{"key":"10.1016\/j.bioorg.2020.104142_b0260","doi-asserted-by":"crossref","unstructured":"R.E. Hubbard, M. Kamran Haider, Hydrogen bonds in proteins: role and strength, e LS (2001).","DOI":"10.1038\/npg.els.0003011"},{"issue":"1","key":"10.1016\/j.bioorg.2020.104142_b0265","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/med.20163","article-title":"Falcipain-2 inhibitors","volume":"30","author":"Ettari","year":"2010","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bioorg.2020.104142_b0270","series-title":"Falcipains and other cysteine proteases of malaria parasites","first-page":"30","author":"Rosenthal","year":"2011"},{"key":"10.1016\/j.bioorg.2020.104142_b0275","article-title":"Use of selected amino acid-zinc complexes as anti-malarials","author":"Malhotra","year":"2005","journal-title":"Google Patents"},{"key":"10.1016\/j.bioorg.2020.104142_b0280","doi-asserted-by":"crossref","DOI":"10.1017\/S1462399409001082","article-title":"Adhesion of Plasmodium falciparum-infected erythrocytes to human cells: molecular mechanisms and therapeutic implications","volume":"11","author":"Rowe","year":"2009","journal-title":"Expert Rev. Mol. Med."},{"issue":"2","key":"10.1016\/j.bioorg.2020.104142_b0285","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.molbiopara.2004.11.009","article-title":"Biosynthesis, localization, and processing of falcipain cysteine proteases of Plasmodium falciparum","volume":"139","author":"Dahl","year":"2005","journal-title":"Mol. Biochem. Parasitol."},{"issue":"20","key":"10.1016\/j.bioorg.2020.104142_b0290","doi-asserted-by":"crossref","first-page":"8298","DOI":"10.1021\/acs.jmedchem.7b00089","article-title":"Exploring heme and hemoglobin binding regions of plasmodium heme detoxification protein for new antimalarial discovery","volume":"60","author":"Gupta","year":"2017","journal-title":"J. Med. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2020.104142_b0295","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.molbiopara.2005.01.015","article-title":"Cysteine-protease activity elicited by Ca2+ stimulus in Plasmodium","volume":"141","author":"Farias","year":"2005","journal-title":"Mol. Biochem. Parasitol."},{"issue":"26","key":"10.1016\/j.bioorg.2020.104142_b0300","doi-asserted-by":"crossref","first-page":"9138","DOI":"10.1073\/pnas.0502368102","article-title":"The Plasmodium falciparum cysteine protease falcipain-2 captures its substrate, hemoglobin, via a unique motif","volume":"102","author":"Pandey","year":"2005","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"5","key":"10.1016\/j.bioorg.2020.104142_b0305","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007031","article-title":"Plasmodium falciparum dipeptidyl aminopeptidase 3 activity is important for efficient erythrocyte invasion by the malaria parasite","volume":"14","author":"Lehmann","year":"2018","journal-title":"PLoS Pathog."},{"issue":"9","key":"10.1016\/j.bioorg.2020.104142_b0310","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1128\/AAC.42.9.2254","article-title":"Antimalarial synergy of cysteine and aspartic protease inhibitors","volume":"42","author":"Semenov","year":"1998","journal-title":"Antimicrob. Agents Chemother."},{"issue":"7","key":"10.1016\/j.bioorg.2020.104142_b0315","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0070025","article-title":"Phospholipid membrane-mediated hemozoin formation: the effects of physical properties and evidence of membrane surrounding hemozoin","volume":"8","author":"Huy","year":"2013","journal-title":"PLoS ONE"},{"issue":"1","key":"10.1016\/j.bioorg.2020.104142_b0320","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1128\/AAC.01709-12","article-title":"Cytostatic versus cytocidal activities of chloroquine analogues and inhibition of hemozoin crystal growth","volume":"57","author":"Gorka","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"issue":"6","key":"10.1016\/j.bioorg.2020.104142_b0325","doi-asserted-by":"crossref","first-page":"4152","DOI":"10.1074\/jbc.M107285200","article-title":"Clotrimazole Binds to Heme and Enhances Heme-dependent Hemolysis PROPOSED ANTIMALARIAL MECHANISM OF CLOTRIMAZOLE","volume":"277","author":"Huy","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bioorg.2020.104142_b0330","doi-asserted-by":"crossref","unstructured":"S.E. Francis, D.J. Sullivan Jr, Goldberg, D. E, Hemoglobin metabolism in the malaria parasite Plasmodium falciparum, Annual Reviews in Microbiology 51(1) (1997) 97-123.","DOI":"10.1146\/annurev.micro.51.1.97"},{"issue":"1","key":"10.1016\/j.bioorg.2020.104142_b0335","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2174\/1386207053328101","article-title":"Targeting the hemozoin synthesis pathway for new antimalarial drug discovery: technologies for in vitro \u03b2-hematin formation assay","volume":"8","author":"Tekwani","year":"2005","journal-title":"Comb. Chem. High Throughput Screening"},{"issue":"7","key":"10.1016\/j.bioorg.2020.104142_b0340","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1021\/ml3000808","article-title":"Novel 4-aminoquinoline-pyrimidine based hybrids with improved in vitro and in vivo antimalarial activity","volume":"3","author":"Manohar","year":"2012","journal-title":"ACS Med. Chem. Lett."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206820314395?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206820314395?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T08:05:19Z","timestamp":1758614719000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206820314395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":68,"alternative-id":["S0045206820314395"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2020.104142","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification and structure\u2013activity relationship (SAR) studies of carvacrol derivatives as potential anti-malarial against Plasmodium falciparum falcipain-2 protease","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2020.104142","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104142"}}