{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:12:21Z","timestamp":1787314341671,"version":"build-2736575974"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100009571","name":"Universidad Nacional de San Luis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009571","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008478","name":"Instituto Nacional del C\u00e1ncer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.bioorg.2020.104145","type":"journal-article","created":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T21:35:25Z","timestamp":1595885725000},"page":"104145","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Hydroxynaphthalenecarboxamides and substituted piperazinylpropandiols, two new series of BRAF inhibitors. A theoretical and experimental study"],"prefix":"10.1016","volume":"103","author":[{"given":"Ludmila E.","family":"Campos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Garibotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Angelina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiri","family":"Kos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Gonec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavlina","family":"Marvanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Vettorazzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Oravec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabela","family":"Jendrzejewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Jampilek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio E.","family":"Alvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo D.","family":"Enriz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2020.104145_b0005","unstructured":"H. Davies Y et al, Mutations of the BRAF gene in human cancer, Nature, pp. 949-54, 2002."},{"issue":"4","key":"10.1016\/j.bioorg.2020.104145_b0010","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1158\/1535-7163.MCT-15-0643","article-title":"Genomically Driven Tumors and Actionability across Histologies: BRAF-Mutant Cancers as a Paradigm","volume":"15","author":"Turski","year":"2016","journal-title":"Molecular Cancer Therapeutics"},{"key":"10.1016\/j.bioorg.2020.104145_b0015","doi-asserted-by":"crossref","unstructured":"K. Young, A. Minchom, Y.J. Larkin, BRIM-1, -2 and -3 Trials: Improved Survival With Vemurafenib in Metastatic Melanoma Patients With a BRAF(V600E) Mutation, Future Oncol., pp. 499-507, 2012.","DOI":"10.2217\/fon.12.43"},{"key":"10.1016\/j.bioorg.2020.104145_b0020","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nrclinonc.2017.43","article-title":"Targeted agents and immunotherapies: optimizing outcomes in melanoma","author":"Luke","year":"2017","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.bioorg.2020.104145_b0025","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ejca.2016.04.005","article-title":"Resistance to combination BRAF and MEK inhibition in metastatic melanoma: Where to next?","author":"Welsh","year":"2016","journal-title":"European Journal of Cancer"},{"key":"10.1016\/j.bioorg.2020.104145_b0030","first-page":"9","article-title":"BRAF Mutation in Colorectal Cancer: An Update., Biomark","author":"Barras","year":"2015","journal-title":"Cancer."},{"key":"10.1016\/j.bioorg.2020.104145_b0035","doi-asserted-by":"crossref","unstructured":"K. B. Kim, M. E. Cabanillas, A. J. Lazar, Y.S. I. Sherman, Clinical Responses to Vemurafenib in Patients with Metastatic Papillary Thyroid Cancer Harboring BRAFV600E Mutation, Thyroid, p. 1277\u20131283, 2013.","DOI":"10.1089\/thy.2013.0057"},{"key":"10.1016\/j.bioorg.2020.104145_b0040","doi-asserted-by":"crossref","unstructured":"R. Dummer, P. A. Ascierto, H. J. Gogas, A. Arance, Y.K. T. Flaherty, Overall survival in patients with BRAF-mutant melanoma receiving encorafenib plus binimetinib versus vemurafenib or encorafenib (COLUMBUS): a multicentre, open-label, randomised, phase 3 trial, The Lancet Oncology, pp. 1315-1327, 2018.","DOI":"10.1016\/S1470-2045(18)30497-2"},{"issue":"5","key":"10.1016\/j.bioorg.2020.104145_b0045","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S1470-2045(18)30142-6","article-title":"Encorafenib plus binimetinib versus vemurafenib or encorafenib in patients with BRAF -mutant melanoma (COLUMBUS): a multicentre, open-label, randomised phase 3 trial","volume":"19","author":"Dummer","year":"2018","journal-title":"The Lancet Oncology"},{"key":"10.1016\/j.bioorg.2020.104145_b0050","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1038\/nrd4281","article-title":"Targeting RAS\u2013ERK signalling in","author":"Samatar","year":"2014","journal-title":"Nature Reviews Drug Discovery"},{"key":"10.1016\/j.bioorg.2020.104145_b0055","doi-asserted-by":"crossref","unstructured":"X. Wang, Y.K. Schleicher, Conformation-specific Inhibitors of Raf Kinases, Enzymes, pp. 41-66, 2013.","DOI":"10.1016\/B978-0-12-420146-0.00003-2"},{"key":"10.1016\/j.bioorg.2020.104145_b0060","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/nrm3979","article-title":"Regulation of RAF Protein Kinases in ERK Signalling","author":"Lavoie","year":"2015","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.bioorg.2020.104145_b0065","doi-asserted-by":"crossref","unstructured":"Z. Karoulia, Y. Wu, T. A. Ahmed, Q. Xin, Y.P. I. Poulikakos, Integrated Model of RAF Inhibitor Action Predicts Inhibitor Activity against Oncogenic BRAF Signaling, Cancer Cell, p. 485\u2013498, 2017.","DOI":"10.1016\/j.ccell.2016.06.024"},{"key":"10.1016\/j.bioorg.2020.104145_b0070","doi-asserted-by":"crossref","unstructured":"S.-H. Chen, Y. Zhang, R. D. Van Horn, T. Yin, Y.S.-B. Peng, That Function as Homodimers and Are Sensitive to Inhibition by RAF Dimer Inhibitor LY3009120, Cancer Discovery, p. 300\u2212315, 2016.","DOI":"10.1158\/2159-8290.CD-15-0896"},{"issue":"7","key":"10.1016\/j.bioorg.2020.104145_b0075","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/nchembio.1257","article-title":"Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization","volume":"9","author":"Lavoie","year":"2013","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.bioorg.2020.104145_b0080","doi-asserted-by":"crossref","first-page":"5775","DOI":"10.1021\/acs.jmedchem.7b01306","article-title":"Current Insights of BRAF Inhibitors in Cancer","author":"Agianian","year":"2018","journal-title":"J. Med. Chem."},{"issue":"2","key":"10.1016\/j.bioorg.2020.104145_b0085","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.cell.2009.12.040","article-title":"Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF","volume":"140","author":"Heidorn","year":"2010","journal-title":"Cell"},{"issue":"7287","key":"10.1016\/j.bioorg.2020.104145_b0090","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nature08902","article-title":"RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF","volume":"464","author":"Poulikakos","year":"2010","journal-title":"Nature"},{"issue":"7287","key":"10.1016\/j.bioorg.2020.104145_b0095","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nature08833","article-title":"RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth","volume":"464","author":"Hatzivassiliou","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.bioorg.2020.104145_b0100","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nrc3760","article-title":"Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond","author":"Holderfield","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bioorg.2020.104145_b0105","doi-asserted-by":"crossref","unstructured":"N. Cope, C. Candelora, K. Wong, S. Kumar, Y.Z. Wang, Mechanism of BRAF Activation Through Biochemical Characterization of the Recombinant Full-Length Protein, Chembiochem , pp. 1988-1997, 2018.","DOI":"10.1002\/cbic.201800359"},{"issue":"3","key":"10.1016\/j.bioorg.2020.104145_b0110","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.ccell.2016.08.008","article-title":"An Integrated Model of RAF Inhibitor Action Predicts Inhibitor Activity against Oncogenic BRAF Signaling","volume":"30","author":"Karoulia","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bioorg.2020.104145_b0115","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/nature14982","article-title":"RAF inhibitors that evade paradoxical MAPK pathway activation","volume":"526","author":"Zhang","year":"2015","journal-title":"Nature"},{"issue":"21","key":"10.1016\/j.bioorg.2020.104145_b0120","doi-asserted-by":"crossref","first-page":"30453","DOI":"10.18632\/oncotarget.8351","article-title":"Comparative profiles of BRAF inhibitors: the paradox index as a predictor of clinical toxicity","volume":"7","author":"Adelmann","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.bioorg.2020.104145_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2019.103125","article-title":"Searching New Structural Scaffolds for BRAF Inhibitors. An Integrative Study using theoretical and experimental techniques","author":"Campos","year":"2019","journal-title":"Bioorganic Chemistry"},{"key":"10.1016\/j.bioorg.2020.104145_b0130","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.ejmech.2017.08.017","article-title":"An integrative study to identify novel scaffolds for sphingosine kinase 1 inhibitors, Europ","author":"Vettorazzi","year":"2017","journal-title":"J Med. Chem."},{"key":"10.1016\/j.bioorg.2020.104145_b0135","doi-asserted-by":"crossref","unstructured":"P. Marvanova, T. Padrtova, T. Pekarek, J. Brus, Y.J. Jampilek, Synthesis and characterization of new 3-(4-arylpiperazin-1-yl)-2-hydroxypropyl 4-propoxybenzoates and their hydrochloride salts, Molecules, pp. 4-7, 2016a.","DOI":"10.3390\/molecules21060707"},{"key":"10.1016\/j.bioorg.2020.104145_b0140","doi-asserted-by":"crossref","unstructured":"P. Marvanova, T. Padrtova, K. Odehnalova, O. Hosik, Y.P. Mokry, Synthesis and determination of physicochemical properties of new 3-(4-arylpiperazin-1-yl)-2-hydroxypropyl 4-alkoxyethoxy-benzoates., Molecules, pp. 1682-1688, 2016b.","DOI":"10.3390\/molecules21121682"},{"key":"10.1016\/j.bioorg.2020.104145_b0145","doi-asserted-by":"crossref","unstructured":"T. Gonec, J. Kos, E. Nevin, R. Govender, Y.J. Jampilek, Preparation and biological properties of ring-substituted naphthalene-1-carboxanilides., Molecules, p. 9\u201311, 2014.","DOI":"10.3390\/molecules190710386"},{"key":"10.1016\/j.bioorg.2020.104145_b0150","doi-asserted-by":"crossref","unstructured":"T. Gonec, J. Kos, I. Zadrazilova, M. Pesko, Y.J. Jampilek, Antibacterial and herbicidal activity of ring-substituted 2-hydroxynaphthalene-1-carboxanilides, Molecules, pp. 9397-9419, 2013.","DOI":"10.3390\/molecules18089397"},{"key":"10.1016\/j.bioorg.2020.104145_b0155","doi-asserted-by":"crossref","unstructured":"T. Gonec, J. Kos, M. Pesko, J. Dohanosova, Y.J. Jampilek, Halogenated 1-hydroxynaphthalene-2-carboxanilides affecting photosynthetic electron transport in photosystem II, Molecules, pp. 15-17, 2017.","DOI":"10.3390\/molecules22101709"},{"key":"10.1016\/j.bioorg.2020.104145_b0160","doi-asserted-by":"crossref","unstructured":"J. Kos, I. Zadrazilova, M. Pesko, S. Keltosova, Y.J. Jampilek, Antibacterial and herbicidal activity of ring-substituted 3-hydroxynaphthalene-2-carboxanilides, Molecules, pp. 7977-7997, 2013.","DOI":"10.3390\/molecules18077977"},{"key":"10.1016\/j.bioorg.2020.104145_b0165","first-page":"20","article-title":"Synthesis and antimycobacterial properties of ring-substituted 6-hydroxynaphthalene- 2-carboxanilides","author":"Kos","year":"2015","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2020.104145_b0170","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.bioorg.2020.104145_b0175","unstructured":"AMBER 2014, 2014."},{"key":"10.1016\/j.bioorg.2020.104145_b0180","doi-asserted-by":"crossref","unstructured":"K. Lindorff-Larsen, S. Piana, K. Palmo, P. Maragakis, Y.D. E. Shaw, Improved Side-Chain Torsion Potentials for the Amber ff99SB Protein Force Field, Proteins, p. 1950\u20131958, 2010.","DOI":"10.1002\/prot.22711"},{"key":"10.1016\/j.bioorg.2020.104145_b0185","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1002\/jcc.20035","article-title":"Development and Testing of a General Amber Force Field","author":"Wang","year":"2004","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.bioorg.2020.104145_b0190","doi-asserted-by":"crossref","first-page":"5648","DOI":"10.1063\/1.464913","article-title":"Density-functional Thermochemistry. III. The Role of Exact Exchange","author":"Becke","year":"1993","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.bioorg.2020.104145_b0195","doi-asserted-by":"crossref","DOI":"10.1063\/1.470117","article-title":"Smooth Particle Mesh Ewald Method","author":"Essmann","year":"1995","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.bioorg.2020.104145_b0200","doi-asserted-by":"crossref","unstructured":"D. R. Roe, Y.T. E. Cheatham, PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data, J. Chem. Theory Comput., p. 3084\u20133095, 2013.","DOI":"10.1021\/ct400341p"},{"key":"10.1016\/j.bioorg.2020.104145_b0205","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1517\/17460441.2015.1032936","article-title":"The MM\/PBSA and MM\/GBSA Methods to Estimate Ligand-Binding Affinities","author":"Genheden","year":"2015","journal-title":"Expert Opin. Drug Discov."},{"key":"10.1016\/j.bioorg.2020.104145_b0210","doi-asserted-by":"crossref","first-page":"9747","DOI":"10.1021\/j100024a016","article-title":"Characterization of C-H-O Hydrogen Bonds on the Basis of the Charge Density","author":"Koch","year":"1995","journal-title":"J. Phys. Chem."},{"key":"10.1016\/j.bioorg.2020.104145_b0215","first-page":"563","article-title":"Extended Weak Bonding Interactions in DNA: \u03c0-Stacking (Base\u2212Base), Base\u2212Backbone, and Backbone\u2212Backbone Interactions","author":"Matta","year":"2005","journal-title":"J. Phys. Chem."},{"key":"10.1016\/j.bioorg.2020.104145_b0220","doi-asserted-by":"crossref","unstructured":"R. A. Mosquera, M. J. Moa, L. Estev\u0301ez, M. Mandado, Y.A. M. Gra\u00f1a, An Electron Density\u2010Based Approach to the Origin of Stacking Interactions, de Quantum Biochemistry, Weinheim, Germany, Ed. WILEY-VCH Verlag GmbH & Co, 2010, pp. 365-387.","DOI":"10.1002\/9783527629213.ch11"},{"key":"10.1016\/j.bioorg.2020.104145_b0225","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1021\/ar00109a003","article-title":"Atoms in molecules","author":"Bader","year":"1985","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.bioorg.2020.104145_b0230","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1021\/cr00005a013","article-title":"A quantum theory of molecular structure and its applications","author":"Bader","year":"1991","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bioorg.2020.104145_b0235","doi-asserted-by":"crossref","unstructured":"R. F. Bader, The Quantum Mechanical Basis of Conceptual Chemistry, Monatshefte f\u00fcr Chemie, p. 819\u2013854, 2005.","DOI":"10.1007\/s00706-005-0307-x"},{"key":"10.1016\/j.bioorg.2020.104145_b0240","article-title":"Atoms in Molecules, Encycl","author":"Bader","year":"1998","journal-title":"Comput. Chem."},{"key":"10.1016\/j.bioorg.2020.104145_b0245","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1021\/ci2004225","article-title":"Searching the \u201cBiologically Relevant\u201dConformation of Dopamine: A Computational Approach","author":"Andujar","year":"2012","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.bioorg.2020.104145_b0250","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1021\/ci400178h","article-title":"Molecular Modeling Study of Dihydrofolate Reductase Inhibitors. Molecular Dynamics Simulations, Quantum Mechanical Calculations, and Experimental Corroboration","author":"Tosso","year":"2013","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.bioorg.2020.104145_b0255","doi-asserted-by":"crossref","unstructured":"F. Chen, Multiwfn: A multifunctional wavefunction analyzer, J. Comput., pp. 580-592, 2012.","DOI":"10.1002\/jcc.22885"},{"key":"10.1016\/j.bioorg.2020.104145_b0260","unstructured":"T. A. Keith, T. G. S. AIMAll (Version 19.02.13), Overl. Park KS, USA, 2019."},{"key":"10.1016\/j.bioorg.2020.104145_b0265","unstructured":"M. J. Frisch, G. W. Trucks, H. B. Schlegel, G. E. Scuseria, Y.D. J. Fox, Gaussian 16, Revision B.01. 2016, Wallingford CT, 2016."},{"key":"10.1016\/j.bioorg.2020.104145_b0270","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1103\/PhysRevB.37.785","article-title":"Development of the Colle-Salvetti Correlation-Energy Formula into a Functional of the Electron Density","author":"Lee","year":"1988","journal-title":"Phys. Rev. B. Condens. Matter"},{"key":"10.1016\/j.bioorg.2020.104145_b0275","article-title":"Self\u2014Consistent Molecular Orbital Methods. XII. Further Extensions of Gaussian\u2014Type Basis Sets for Use in Molecular Orbital Studies of Organic Molecules","author":"Hehre","year":"1972","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.bioorg.2020.104145_b0280","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1002\/jcc.20495","article-title":"Semiempirical GGA-Type Density Functional Constructed with a Long-Range Dispersion Correction","author":"Grimme","year":"2006","journal-title":"J. Comput. Chem."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206820314425?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206820314425?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T08:06:15Z","timestamp":1758614775000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206820314425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":56,"alternative-id":["S0045206820314425"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2020.104145","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hydroxynaphthalenecarboxamides and substituted piperazinylpropandiols, two new series of BRAF inhibitors. A theoretical and experimental study","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2020.104145","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104145"}}