{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:46:47Z","timestamp":1786985207724,"version":"build-2736575974"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100006377","name":"Purdue University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006377","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.bioorg.2020.104183","type":"journal-article","created":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T21:46:58Z","timestamp":1598564818000},"page":"104183","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["\u03b2,\u03b3-Diaryl \u03b1-methylene-\u03b3-butyrolactones as potent antibacterials against methicillin-resistant Staphylococcus aureus"],"prefix":"10.1016","volume":"104","author":[{"given":"Henry J.","family":"Hamann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nader S.","family":"Abutaleb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rusha","family":"Pal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed N.","family":"Seleem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Veeraraghavan","family":"Ramachandran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2020.104183_b0005","unstructured":"CDC, Antibiotic Resistance Threats in the United States, 2013. Centers for Disease Control and Prevention. p. 1-114.; 2013."},{"key":"10.1016\/j.bioorg.2020.104183_b0010","unstructured":"CDC, Antibiotic Resistance Threats in the United States, 2015. Centers for Disease Control and Prevention. Updated report; 2015."},{"key":"10.1016\/j.bioorg.2020.104183_b0015","article-title":"Antimicrobial resistance -","author":"Review","year":"2017","journal-title":"Global strategic direction"},{"issue":"3","key":"10.1016\/j.bioorg.2020.104183_b0020","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.ijantimicag.2006.10.007","volume":"29","author":"Abb","year":"2007","journal-title":"Int. J. Antimicrob. Agents"},{"issue":"11","key":"10.1016\/j.bioorg.2020.104183_b0025","first-page":"1863","volume":"64","author":"Manzella","year":"2001","journal-title":"Am. Fam. Physician"},{"issue":"2","key":"10.1016\/j.bioorg.2020.104183_b0030","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/anie.198500941","volume":"24","author":"Hoffmann","year":"1985","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.bioorg.2020.104183_b0035","doi-asserted-by":"crossref","unstructured":"Kagan, H. B.; Miller, H. E.; Renold, W.; V., L. M.; Tether, L. R.; Herz, W.; Mabry, T. J. J. Org. Chem. 1966, 31 (5), 1629-1632.","DOI":"10.1021\/jo01343a072"},{"issue":"5","key":"10.1016\/j.bioorg.2020.104183_b0040","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1248\/cpb.55.766","volume":"55","author":"Wang","year":"2007","journal-title":"Chem. Pharm. Bull."},{"issue":"24","key":"10.1016\/j.bioorg.2020.104183_b0045","doi-asserted-by":"crossref","first-page":"5517","DOI":"10.1021\/ol802249z","volume":"10","author":"Wang","year":"2008","journal-title":"Org. Lett."},{"issue":"23","key":"10.1016\/j.bioorg.2020.104183_b0050","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.1016\/j.phytochem.2004.08.040","volume":"65","author":"Yamada","year":"2004","journal-title":"Phytochemistry"},{"issue":"3929","key":"10.1016\/j.bioorg.2020.104183_b0055","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1126\/science.168.3929.376","volume":"168","author":"Kupchan","year":"1970","journal-title":"Science"},{"issue":"50","key":"10.1016\/j.bioorg.2020.104183_b0060","doi-asserted-by":"crossref","first-page":"9426","DOI":"10.1002\/anie.200903108","volume":"48","author":"Kitson","year":"2009","journal-title":"Angew. Chem. Int. Ed."},{"issue":"17\u201318","key":"10.1016\/j.bioorg.2020.104183_b0065","first-page":"894","article-title":"Drug Discov","volume":"18","author":"Ghantous","year":"2013","journal-title":"Today"},{"issue":"2","key":"10.1016\/j.bioorg.2020.104183_b0070","first-page":"183","article-title":"Physiol","volume":"15","author":"Blakeman","year":"1979","journal-title":"Plant Pathol."},{"issue":"11","key":"10.1016\/j.bioorg.2020.104183_b0075","doi-asserted-by":"crossref","first-page":"3724","DOI":"10.1021\/ja01191a052","volume":"70","author":"Cavallito","year":"1948","journal-title":"J. Am. Chem. Soc."},{"issue":"5","key":"10.1016\/j.bioorg.2020.104183_b0080","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/0031-9422(90)80102-M","volume":"29","author":"Goren","year":"1990","journal-title":"Phytochemistry"},{"issue":"6","key":"10.1016\/j.bioorg.2020.104183_b0085","doi-asserted-by":"crossref","first-page":"751","DOI":"10.7164\/antibiotics.41.751","volume":"41","author":"Park","year":"1988","journal-title":"J. Antibiot."},{"issue":"3","key":"10.1016\/j.bioorg.2020.104183_b0090","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0305-1978(86)90101-8","volume":"14","author":"Picman","year":"1986","journal-title":"Biochem. Syst. Ecol."},{"issue":"2","key":"10.1016\/j.bioorg.2020.104183_b0095","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1021\/np9004129","volume":"73","author":"Saroglou","year":"2010","journal-title":"J. Nat. Prod."},{"issue":"22","key":"10.1016\/j.bioorg.2020.104183_b0100","doi-asserted-by":"crossref","first-page":"6620","DOI":"10.1016\/j.bmcl.2010.09.022","volume":"20","author":"Ramachandran","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"19","key":"10.1016\/j.bioorg.2020.104183_b0105","doi-asserted-by":"crossref","first-page":"4270","DOI":"10.1016\/j.bmcl.2015.07.087","volume":"25","author":"Ramachandran","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"96","key":"10.1016\/j.bioorg.2020.104183_b0110","doi-asserted-by":"crossref","first-page":"15216","DOI":"10.1039\/C4CC05765A","volume":"50","author":"Ramachandran","year":"2014","journal-title":"Chem. Comm."},{"issue":"4","key":"10.1016\/j.bioorg.2020.104183_b0115","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1021\/ol035952z","volume":"6","author":"Ramachandran","year":"2004","journal-title":"Org. Lett."},{"issue":"24","key":"10.1016\/j.bioorg.2020.104183_b0120","doi-asserted-by":"crossref","first-page":"9310","DOI":"10.1021\/jo034954u","volume":"68","author":"Ramachandran","year":"2003","journal-title":"J. Org. Chem."},{"issue":"43","key":"10.1016\/j.bioorg.2020.104183_b0125","doi-asserted-by":"crossref","first-page":"7325","DOI":"10.1016\/j.tetlet.2005.08.140","volume":"46","author":"Kabalka","year":"2005","journal-title":"Tetrahedron Lett."},{"issue":"5","key":"10.1016\/j.bioorg.2020.104183_b0130","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.5012\/bkcs.2009.30.5.1012","volume":"30","author":"Kim","year":"2009","journal-title":"Bull. Korean Chem. Soc."},{"issue":"3\u20134","key":"10.1016\/j.bioorg.2020.104183_b0135","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/1615-4169(200206)344:3\/4<303::AID-ADSC303>3.0.CO;2-J","volume":"344","author":"Mendez-Andino","year":"2002","journal-title":"Adv. Synth. Catal."},{"issue":"25","key":"10.1016\/j.bioorg.2020.104183_b0140","doi-asserted-by":"crossref","first-page":"4187","DOI":"10.1016\/j.tetlet.2006.04.063","volume":"47","author":"Kabalka","year":"2006","journal-title":"Tetrahedron Lett."},{"issue":"11","key":"10.1016\/j.bioorg.2020.104183_b0145","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1021\/ol0705806","volume":"9","author":"Ramachandran","year":"2007","journal-title":"Org. Lett."},{"issue":"17","key":"10.1016\/j.bioorg.2020.104183_b0150","doi-asserted-by":"crossref","first-page":"3877","DOI":"10.1021\/ol061566g","volume":"8","author":"Ramachandran","year":"2006","journal-title":"Org. Lett."},{"issue":"50","key":"10.1016\/j.bioorg.2020.104183_b0155","doi-asserted-by":"crossref","first-page":"6568","DOI":"10.1016\/j.tetlet.2010.10.077","volume":"51","author":"Park","year":"2010","journal-title":"Tetrahedron Lett."},{"issue":"2","key":"10.1016\/j.bioorg.2020.104183_b0160","first-page":"1","article-title":"David M","volume":"6","author":"Alam","year":"2015","journal-title":"Z. mBio"},{"issue":"5418","key":"10.1016\/j.bioorg.2020.104183_b0165","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1126\/science.284.5418.1318","volume":"284","author":"Costerton","year":"1999","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.bioorg.2020.104183_b0170","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/nrmicro2182","volume":"7","author":"Otto","year":"2009","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.bioorg.2020.104183_b0175","unstructured":"CDC, Antibiotic Resistance Threats in the United States, 2019. Centers for Disease Control and Prevention. p. 1-148; 2019."},{"key":"10.1016\/j.bioorg.2020.104183_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.111593","volume":"182","author":"Elsebaei","year":"2019","journal-title":"Eur. J. Med. Chem."},{"issue":"10","key":"10.1016\/j.bioorg.2020.104183_b0185","doi-asserted-by":"crossref","first-page":"4495","DOI":"10.1128\/AAC.00237-09","article-title":"Antimicrob","volume":"53","author":"Singh","year":"2009","journal-title":"Agents Chemother."},{"issue":"11","key":"10.1016\/j.bioorg.2020.104183_b0190","first-page":"1820","article-title":"ACS Infect","volume":"5","author":"Dayal","year":"2019","journal-title":"Dis"},{"issue":"1","key":"10.1016\/j.bioorg.2020.104183_b0195","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0001409","volume":"3","author":"Kubica","year":"2008","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.bioorg.2020.104183_b0200","first-page":"1679","article-title":"ACS Infect","volume":"4","author":"Hagras","year":"2018","journal-title":"Dis"},{"issue":"5","key":"10.1016\/j.bioorg.2020.104183_b0205","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0012-3692(15)33412-7","volume":"124","author":"Wunderink","year":"2003","journal-title":"Chest"},{"issue":"17","key":"10.1016\/j.bioorg.2020.104183_b0210","doi-asserted-by":"crossref","first-page":"7998","DOI":"10.1021\/acs.jmedchem.9b00720","volume":"62","author":"Hammad","year":"2019","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2020.104183_b0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.111830","volume":"185","author":"Hosny","year":"2020","journal-title":"Eur. J. Med. Chem."},{"issue":"5","key":"10.1016\/j.bioorg.2020.104183_b0220","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.coph.2009.07.009","volume":"9","author":"Kobayashi","year":"2009","journal-title":"Curr. Opin. Pharmacol."},{"issue":"14","key":"10.1016\/j.bioorg.2020.104183_b0225","doi-asserted-by":"crossref","first-page":"5883","DOI":"10.1073\/pnas.0900743106","volume":"106","author":"Li","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"4","key":"10.1016\/j.bioorg.2020.104183_b0230","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1086\/590157","volume":"198","author":"Montgomery","year":"2008","journal-title":"J. Infect. Dis."},{"issue":"3","key":"10.1016\/j.bioorg.2020.104183_b0235","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1128\/IAI.69.3.1521-1527.2001","volume":"69","author":"Reed","year":"2001","journal-title":"Infect Immun"},{"key":"10.1016\/j.bioorg.2020.104183_b0240","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1099\/mic.0.26634-0","volume":"150","author":"Shaw","year":"2004","journal-title":"Microbiol. SGM"},{"issue":"44","key":"10.1016\/j.bioorg.2020.104183_b0245","doi-asserted-by":"crossref","first-page":"41770","DOI":"10.1074\/jbc.M207162200","volume":"277","author":"Massimi","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.bioorg.2020.104183_b0250","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0165-2478(92)90124-7","volume":"31","author":"Prokesova","year":"1992","journal-title":"Immunol. Lett."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206820314802?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206820314802?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T15:36:23Z","timestamp":1763566583000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206820314802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":50,"alternative-id":["S0045206820314802"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2020.104183","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"\u03b2,\u03b3-Diaryl \u03b1-methylene-\u03b3-butyrolactones as potent antibacterials against methicillin-resistant Staphylococcus aureus","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2020.104183","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104183"}}