{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T07:04:49Z","timestamp":1775372689129,"version":"3.50.1"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.bioorg.2020.104253","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T23:23:53Z","timestamp":1599002633000},"page":"104253","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Novel adamantyl retinoid-related molecules with POLA1 inhibitory activity"],"prefix":"10.1016","volume":"104","author":[{"given":"Raffaella","family":"Cincinelli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loana","family":"Musso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario B.","family":"Guglielmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"La Porta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Fucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Egildo","family":"Luca D'Andrea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Cardile","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiana","family":"Colelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giacomo","family":"Signorino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadine","family":"Darwiche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Gervasoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulio","family":"Vistoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Pisano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"Dallavalle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2020.104253_b0005","first-page":"433","article-title":"Retinoid related molecules an emerging class of apoptotic agents with promising therapeutic potential in oncology: pharmacological activity and mechanisms of action","volume":"10","author":"Garattini","year":"2004","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bioorg.2020.104253_b0010","first-page":"3516","article-title":"The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivatives","volume":"113","author":"Wanka","year":"2013","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bioorg.2020.104253_b0015","first-page":"909","article-title":"A novel atypical retinoid endowed with proapoptotic and antitumor activity","volume":"46","author":"Cincinelli","year":"2003","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2020.104253_b0020","first-page":"4931","article-title":"Synthesis and structure\u2212activity relationships of a new series of retinoid-Related biphenyl-4-ylacrylic acid endowed with antiproliferative and proapoptotic activity","volume":"48","author":"Cincinelli","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2020.104253_b0025","first-page":"3518","article-title":"Antagonist aAnalogue of 6-[3\u2018-(1-adamantyl)-4\u2018-hydroxyphenyl]-2-naphthalenecarboxylic acid (AHPN) family of apoptosis inducers that effectively blocks AHPN-induced apoptosis but not cell-cycle arrest","volume":"47","author":"Dawson","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2020.104253_b0030","first-page":"233","volume":"55","author":"Xia","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2020.104253_b0035","first-page":"1625","article-title":"SHP and Sin3A expression are essential for adamantyl-substituted retinoid-related molecule\u2013mediated nuclear factor-\u03baB activation, c-Fos\/c-Jun expression, and cellular apoptosis","volume":"8","author":"Farhana","year":"2009","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.bioorg.2020.104253_b0040","first-page":"154","article-title":"Retinoid-related molecules require caspase 9 for the effective release of Smac and the rapid induction of apoptosis","volume":"11","author":"Lopez-Hernandez","year":"2004","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bioorg.2020.104253_b0045","unstructured":"L. Farhana, M.I. Dawson, J.K Das, F. Murshed, Z. Xia, T.J. Hadden, J. Hatfield, J.A. Fontana, Adamantyl retinoid-related molecules induce apoptosis in pancreatic cancer cells by inhibiting IGF-1R and Wnt\/\u03b2-Catenin pathways, Journal of Oncology 2012 (2012) ID796729. http:\/\/dx.doi.org\/10.1155\/2012\/796729."},{"key":"10.1016\/j.bioorg.2020.104253_b0050","first-page":"2941","article-title":"Atypical retinoids ST1926 and CD437 are S-phase-specific agents causing DNA double-strand breaks: significance for the cytotoxic and antiproliferative activity","volume":"7","author":"Valli","year":"2008","journal-title":"Mol. Cancer Therap."},{"key":"10.1016\/j.bioorg.2020.104253_b0055","first-page":"1246","article-title":"Sensitization of ovarian carcinoma cells to the atypical retinoid ST1926 by the histone deacetylase inhibitor, RC307: enhanced DNA damage response","volume":"126","author":"Zuco","year":"2010","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bioorg.2020.104253_b0060","first-page":"511","article-title":"The anti-tumor toxin CD437 is a direct inhibitor of DNA Polymerase \u03b1","volume":"7","author":"Han","year":"2016","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bioorg.2020.104253_b0065","first-page":"417","article-title":"Eukaryotic DNA Replication Fork","volume":"86","author":"Burgers","year":"2017","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.bioorg.2020.104253_b0070","first-page":"14013","article-title":"Structural basis for inhibition of DNA replication by aphidicolin","volume":"42","author":"Baranovskiy","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bioorg.2020.104253_b0075","first-page":"495","article-title":"DNA polymerase-\u03b1 regulates the activation of type I interferons through cytosolic RNA: DNA synthesis","volume":"17","author":"Starokadomskyy","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bioorg.2020.104253_b0080","first-page":"160","article-title":"Checkpoint-modulating immunotherapies in tumor treatment: targets, drugs, and mechanisms","volume":"67","author":"Sun","year":"2019","journal-title":"International Immunopharmacology"},{"key":"10.1016\/j.bioorg.2020.104253_b0085","first-page":"4863","article-title":"Synthesis and structure-activity relationships of new antiproliferative and proapoptotic retinoid-related biphenyl-4-yl-acrylic acids","volume":"15","author":"Cincinelli","year":"2007","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2020.104253_b0090","first-page":"2405","article-title":"New retinoid derivatives as back-ups of Adarotene","volume":"20","author":"Giannini","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2020.104253_b0095","first-page":"909","volume":"70","author":"Parrella","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bioorg.2020.104253_b0100","first-page":"757","article-title":"Antitumor activities of the synthetic retinoid ST1926 in two-dimensional and three-dimensional human breast cancer models","volume":"28","author":"Aouad","year":"2017","journal-title":"Anticancer drugs"},{"key":"10.1016\/j.bioorg.2020.104253_b0105","first-page":"2047","article-title":"Antitumor effect of the atypical retinoid ST1926 in acute myeloid Leukemia and nanoparticle formulation prolongs lifespan and reduces tumor burden of xenograft mice","volume":"16","author":"El-Houjeiri","year":"2017","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.bioorg.2020.104253_b0110","first-page":"698","article-title":"ST1926, an orally active synthetic retinoid, induces apoptosis in chronic myeloid leukemia cells and prolongs survival in a murine model","volume":"137","author":"Nasr","year":"2015","journal-title":"Int. J. Cancer."},{"key":"10.1016\/j.bioorg.2020.104253_b0115","first-page":"1528","article-title":"The synthetic retinoid ST1926 as a novel therapeutic agent in rhabdomyosarcoma","volume":"138","author":"Basma","year":"2016","journal-title":"Int. J. Cancer."},{"key":"10.1016\/j.bioorg.2020.104253_b0120","first-page":"39","article-title":"Mechanism of action of the atypical retinoid ST1926 in colorectal cancer: DNA damage and DNA polymerase \u03b1","volume":"8","author":"Abdel-Samad","year":"2018","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.bioorg.2020.104253_b0125","first-page":"2622","volume":"50","author":"Dawson","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2020.104253_b0130","first-page":"667","article-title":"Development of resistance to the atypical retinoid, ST1926, in the lung carcinoma cell line H460 is associated with reduced formation of DNA strand breaks and a defective DNA damage response","volume":"7","author":"Zuco","year":"2005","journal-title":"Neoplasia"},{"key":"10.1016\/j.bioorg.2020.104253_b0135","first-page":"1800191","article-title":"Molecular mechanisms of DNA replication and repair machinery: insights from microscopic simulations","volume":"2","author":"Maffeo","year":"2019","journal-title":"Adv Theory Simul."},{"key":"10.1016\/j.bioorg.2020.104253_b0140","first-page":"78","article-title":"Reciprocal carbonyl-carbonyl interactions in small molecules and proteins","volume":"8","author":"Rahim","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioorg.2020.104253_b0145","first-page":"6074","article-title":"Dual inhibitors as a new challenge for cancer multidrug resistance treatment","volume":"26","author":"Stankovi\u0107","year":"2019","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bioorg.2020.104253_b0150","first-page":"251","article-title":"Influence of the adamantyl moiety on the activity of biphenylacrylohydroxamic acid-based HDAC inhibitors Eur","volume":"79","author":"Cincinelli","year":"2014","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2020.104253_b0155","first-page":"243","article-title":"FUGUE: sequence-structure homology recognition using environment-specific substitution tables and structure-dependent gap penalties","volume":"310","author":"Shi","year":"2001","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bioorg.2020.104253_b0160","first-page":"W368","article-title":"H++: a server for estimating pKas and adding missing hydrogens to macromolecules","volume":"33","author":"Gordon","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bioorg.2020.104253_b0165","first-page":"247","article-title":"Automatic atom type and bond type perception in molecular mechanical calculations","volume":"25","author":"Wang","year":"2006","journal-title":"J. Mol. Graphics Model."},{"key":"10.1016\/j.bioorg.2020.104253_b0170","first-page":"727","article-title":"Development and Validation of a Genetic Algorithm for Flexible Docking","volume":"267","author":"Jones","year":"1997","journal-title":"J. Mol. Biol."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206820315510?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206820315510?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T15:33:45Z","timestamp":1763566425000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206820315510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":34,"alternative-id":["S0045206820315510"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2020.104253","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel adamantyl retinoid-related molecules with POLA1 inhibitory activity","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2020.104253","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104253"}}