{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T11:47:11Z","timestamp":1773316031214,"version":"3.50.1"},"reference-count":82,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["18-33-20051"],"award-info":[{"award-number":["18-33-20051"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.bioorg.2020.104306","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T08:18:51Z","timestamp":1600935531000},"page":"104306","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Targeting pathogenic fungi, bacteria and fungal-bacterial biofilms by newly synthesized quaternary ammonium derivative of pyridoxine and terbinafine with dual action profile"],"prefix":"10.1016","volume":"104","author":[{"given":"Marsel R.","family":"Garipov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alina E.","family":"Sabirova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman S.","family":"Pavelyev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikita V.","family":"Shtyrlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana A.","family":"Lisovskaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oksana V.","family":"Bondar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandr V.","family":"Laikov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia G.","family":"Romanova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikhail I.","family":"Bogachev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Airat R.","family":"Kayumov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yurii G.","family":"Shtyrlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.bioorg.2020.104306_b0005","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.ijantimicag.2017.08.010","article-title":"Antifungal resistance in mucorales","volume":"50","author":"Dannaoui","year":"2017","journal-title":"Int. J. Antimicrob. Agents"},{"issue":"3","key":"10.1016\/j.bioorg.2020.104306_b0010","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s12275-016-5514-0","article-title":"Interaction of Candida albicans with host cells: virulence factors, host defense, escape strategies, and the microbiota","volume":"54","author":"Hofs","year":"2016","journal-title":"J. Microbiol."},{"key":"10.1016\/j.bioorg.2020.104306_b0015","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1146\/annurev-micro-091014-104330","article-title":"Candida albicans biofilms and human disease","volume":"69","author":"Nobile","year":"2015","journal-title":"Annu. Rev. Microbiol."},{"issue":"1","key":"10.1016\/j.bioorg.2020.104306_b0020","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/nyas.13739","article-title":"New pathogens, new tricks: emerging, drug-resistant fungal pathogens and future prospects for antifungal therapeutics","volume":"1435","author":"Geddes-McAlister","year":"2019","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"4","key":"10.1016\/j.bioorg.2020.104306_b0025","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1080\/13543776.2017.1261113","article-title":"Novel antifungal agents: a patent review (2013-present)","volume":"27","author":"Castelli","year":"2017","journal-title":"Expert Opin. Ther. Pat."},{"issue":"9","key":"10.1016\/j.bioorg.2020.104306_b0030","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1177\/1060028015590838","article-title":"Is fluconazole or an echinocandin the agent of choice for candidemia","volume":"49","author":"Eschenauer","year":"2015","journal-title":"Ann. Pharmacother."},{"issue":"5","key":"10.1016\/j.bioorg.2020.104306_b0035","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01365-16","article-title":"Commensal protection of Staphylococcus aureus against antimicrobials by Candida albicans biofilm matrix","volume":"7","author":"Kong","year":"2016","journal-title":"MBio"},{"issue":"5","key":"10.1016\/j.bioorg.2020.104306_b0040","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.ijantimicag.2017.05.012","article-title":"Molecular basis of antifungal drug resistance in yeasts","volume":"50","author":"Morio","year":"2017","journal-title":"Int. J. Antimicrob. Agents"},{"issue":"6","key":"10.1016\/j.bioorg.2020.104306_b0045","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1093\/jac\/dkm095","article-title":"Acquired resistance to echinocandins in Candida albicans: case report and review","volume":"59","author":"Baixench","year":"2007","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.bioorg.2020.104306_b0050","doi-asserted-by":"crossref","first-page":"249","DOI":"10.2147\/IDR.S124918","article-title":"Antifungal resistance: current trends and future strategies to combat","volume":"10","author":"Wiederhold","year":"2017","journal-title":"Infect. Drug Resistance"},{"key":"10.1016\/j.bioorg.2020.104306_b0055","doi-asserted-by":"crossref","DOI":"10.1038\/srep26860","article-title":"Exploring ecological modelling to investigate factors governing the colonization success in nosocomial environment of Candida albicans and other pathogenic yeasts","volume":"6","author":"Corte","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioorg.2020.104306_b0060","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2018.00028","article-title":"Candida biofilms: threats, challenges, and promising strategies","volume":"5","author":"Cavalheiro","year":"2018","journal-title":"Front. Med."},{"issue":"8","key":"10.1016\/j.bioorg.2020.104306_b0065","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1099\/jmm.0.46569-0","article-title":"Biofilm matrix of Candida albicans and Candida tropicalis: chemical composition and role in drug resistance","volume":"55","author":"Al-Fattani","year":"2006","journal-title":"J. Med. Microbiol."},{"issue":"3","key":"10.1016\/j.bioorg.2020.104306_b0070","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1439-0507.2011.02076.x","article-title":"Antifungal susceptibility of Candida albicans in biofilms","volume":"55","author":"Tobudic","year":"2012","journal-title":"Mycoses"},{"issue":"4","key":"10.1016\/j.bioorg.2020.104306_b0075","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1128\/EC.4.4.633-638.2005","article-title":"Candida biofilms: an update","volume":"4","author":"Ramage","year":"2005","journal-title":"Eukaryot. Cell"},{"issue":"1","key":"10.1016\/j.bioorg.2020.104306_b0080","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S0966-842X(02)00002-1","article-title":"Candida biofilms and their role in infection","volume":"11","author":"Douglas","year":"2003","journal-title":"Trends Microbiol."},{"issue":"10","key":"10.1016\/j.bioorg.2020.104306_b0085","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.2217\/fmb.13.101","article-title":"Mechanisms of Candida biofilm drug resistance","volume":"8","author":"Taff","year":"2013","journal-title":"Future Microbiol."},{"key":"10.1016\/j.bioorg.2020.104306_b0090","doi-asserted-by":"crossref","unstructured":"H. Carolus, K. Van Dyck, P. Van Dijck, and, Front Microbiol 10 (2019) 2162.","DOI":"10.3389\/fmicb.2019.02162"},{"issue":"4","key":"10.1016\/j.bioorg.2020.104306_b0095","doi-asserted-by":"crossref","DOI":"10.1093\/femspd\/ftw018","article-title":"Pathogenesis of Candida albicans biofilm","volume":"74","author":"Tsui","year":"2016","journal-title":"Pathog. Dis."},{"issue":"4","key":"10.1016\/j.bioorg.2020.104306_b0100","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1099\/0022-1317-51-4-344","article-title":"Mixed species biofilms of Candida albicans and Staphylococcus epidermidis","volume":"51","author":"Adam","year":"2002","journal-title":"J. Med. Microbiol."},{"issue":"3","key":"10.1016\/j.bioorg.2020.104306_b0105","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.burns.2004.11.012","article-title":"Interactions between bacteria and Candida in the burn wound","volume":"31","author":"Gupta","year":"2005","journal-title":"Burns"},{"issue":"2","key":"10.1016\/j.bioorg.2020.104306_b0110","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jcf.2007.06.006","article-title":"Prevalence and antimicrobial susceptibility of microorganisms isolated from sputa of patients with cystic fibrosis","volume":"7","author":"Valenza","year":"2008","journal-title":"J. Cyst. Fibros."},{"issue":"1","key":"10.1016\/j.bioorg.2020.104306_b0115","first-page":"20","article-title":"Prevalence of Staphylococcus spp and Candida spp in the oral cavity and periodontal pockets of periodontal disease patients","volume":"23","author":"Cuesta","year":"2010","journal-title":"Acta Odontol Latinoam"},{"issue":"12","key":"10.1016\/j.bioorg.2020.104306_b0120","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/nrmicro.2017.99","article-title":"Targeting microbial biofilms: current and prospective therapeutic strategies","volume":"15","author":"Koo","year":"2017","journal-title":"Nat. Rev. Microbiol."},{"issue":"2","key":"10.1016\/j.bioorg.2020.104306_b0125","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1021\/acsinfecdis.7b00170","article-title":"New Perspectives in Biofilm Eradication","volume":"4","author":"Wolfmeier","year":"2018","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.bioorg.2020.104306_b0130","doi-asserted-by":"crossref","DOI":"10.1038\/s41429-020-0299-0","article-title":"Antibiofilm activities of ceragenins and antimicrobial peptides against fungal-bacterial mono and multispecies biofilms","author":"Hacioglu","year":"2020","journal-title":"J. Antibiot. (Tokyo)"},{"issue":"1","key":"10.1016\/j.bioorg.2020.104306_b0135","doi-asserted-by":"crossref","first-page":"e0211366","DOI":"10.1371\/journal.pone.0211366","article-title":"Metagenomic quorum quenching enzymes affect biofilm formation of Candida albicans and Staphylococcus epidermidis","volume":"14","author":"Weiland-Br\u00e4uer","year":"2019","journal-title":"PLoS ONE"},{"issue":"3","key":"10.1016\/j.bioorg.2020.104306_b0140","article-title":"Increasing susceptibility of drug-resistant","volume":"25","author":"Sharafutdinov","year":"2020","journal-title":"Molecules"},{"issue":"25","key":"10.1016\/j.bioorg.2020.104306_b0145","doi-asserted-by":"crossref","first-page":"3559","DOI":"10.1016\/j.tet.2016.01.014","article-title":"From antimicrobial activity to mechanism of resistance: the multifaceted role of simple quaternary ammonium compounds in bacterial eradication","volume":"72","author":"Minbiole","year":"2016","journal-title":"Tetrahedron"},{"issue":"10","key":"10.1016\/j.bioorg.2020.104306_b0150","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.micres.2013.06.001","article-title":"Antifungal activity of gemini quaternary ammonium salts","volume":"168","author":"Oblak","year":"2013","journal-title":"Microbiol. Res."},{"issue":"1","key":"10.1016\/j.bioorg.2020.104306_b0155","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1093\/jac\/dkl153","article-title":"Lipid-covered drug particles: combined action of dioctadecyldimethylammonium bromide and amphotericin B or miconazole","volume":"58","author":"Lincopan","year":"2006","journal-title":"J. Antimicrob. Chemother."},{"issue":"2","key":"10.1016\/j.bioorg.2020.104306_b0160","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1021\/jm0508843","article-title":"Correlation of antifungal activity with fungal phospholipase inhibition using a series of bisquaternary ammonium salts","volume":"49","author":"Ng","year":"2006","journal-title":"J. Med. Chem."},{"issue":"2","key":"10.1016\/j.bioorg.2020.104306_b0165","doi-asserted-by":"crossref","first-page":"215","DOI":"10.2478\/s11658-010-0002-8","article-title":"The physiological and morphological phenotype of a yeast mutant resistant to the quaternary ammonium salt N-(dodecyloxycarboxymethyl)-N, N, N-trimethyl ammonium chloride","volume":"15","author":"Oblak","year":"2010","journal-title":"Cellular Molecular Biol. Lett."},{"issue":"6","key":"10.1016\/j.bioorg.2020.104306_b0170","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1080\/10601325.2014.906270","article-title":"Synthesis of quaternized amine-terminated polyacrylonitrile and their antimicrobial assessment","volume":"51","author":"El-Newehy","year":"2014","journal-title":"J. Macromol. Sci. Part a-Pure Appl. Chem."},{"key":"10.1016\/j.bioorg.2020.104306_b0175","doi-asserted-by":"crossref","first-page":"104072","DOI":"10.1016\/j.micpath.2020.104072","article-title":"Antibacterial activity profile of miramistin in in vitro and in vivo models","volume":"142","author":"Agafonova","year":"2020","journal-title":"Microb. Pathog."},{"issue":"7","key":"10.1016\/j.bioorg.2020.104306_b0180","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.archoralbio.2012.01.015","article-title":"The effect of various topical peri-implantitis antiseptics on Staphylococcus epidermidis, Candida albicans, and Streptococcus sanguinis","volume":"57","author":"B\u00fcrgers","year":"2012","journal-title":"Arch. Oral Biol."},{"issue":"5","key":"10.1016\/j.bioorg.2020.104306_b0185","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1093\/jac\/46.5.853","article-title":"An in vitro investigation of the antimicrobial activity of oxifulvic acid","volume":"46","author":"van Rensburg","year":"2000","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.bioorg.2020.104306_b0190","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3389\/fmicb.2012.00116","article-title":"Carbohydrate derived fulvic acid: an in vitro investigation of a novel membrane active antiseptic agent against Candida albicans biofilms","volume":"3","author":"Sherry","year":"2012","journal-title":"Front. Microbiol."},{"issue":"11","key":"10.1016\/j.bioorg.2020.104306_b0195","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1111\/myc.12699","article-title":"In vitro efficacy of disinfectants utilised for skin decolonisation and environmental decontamination during a hospital outbreak with Candida auris","volume":"60","author":"Abdolrasouli","year":"2017","journal-title":"Mycoses"},{"issue":"23","key":"10.1016\/j.bioorg.2020.104306_b0200","doi-asserted-by":"crossref","first-page":"7330","DOI":"10.1016\/j.bmc.2013.09.056","article-title":"Bis-phosphonium salts of pyridoxine: The relationship between structure and antibacterial activity","volume":"21","author":"Pugachev","year":"2013","journal-title":"Bioorg. Med. Chem."},{"issue":"14","key":"10.1016\/j.bioorg.2020.104306_b0205","doi-asserted-by":"crossref","first-page":"4388","DOI":"10.1016\/j.bmc.2013.04.051","article-title":"Synthesis and antibacterial activity of novel phosphonium salts on the basis of pyridoxine","volume":"21","author":"Pugachev","year":"2013","journal-title":"Bioorg. Med. Chem."},{"issue":"7","key":"10.1016\/j.bioorg.2020.104306_b0210","doi-asserted-by":"crossref","first-page":"656","DOI":"10.2174\/1573406411666150504122930","article-title":"Synthesis and antibacterial activity of novel quaternary ammonium pyridoxine derivatives","volume":"11","author":"Shtyrlin","year":"2015","journal-title":"Med. Chem."},{"key":"10.1016\/j.bioorg.2020.104306_b0215","first-page":"10","article-title":"New derivatives of pyridoxine exhibit high antibacterial activity against biofilm-embedded Staphylococcus cells","author":"Kayumov","year":"2015","journal-title":"Biomed Res. Int."},{"issue":"12","key":"10.1016\/j.bioorg.2020.104306_b0220","doi-asserted-by":"crossref","first-page":"3188","DOI":"10.1007\/s00044-017-2012-9","article-title":"New quaternary ammonium pyridoxine derivatives: synthesis and antibacterial activity","volume":"26","author":"Sapozhnikov","year":"2017","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.bioorg.2020.104306_b0225","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/4761650","article-title":"Fluconazole-pyridoxine bis-triazolium compounds with potent activity against pathogenic bacteria and fungi including their biofilm-embedded forms","author":"Garipov","year":"2017","journal-title":"J. Chem."},{"issue":"9","key":"10.1016\/j.bioorg.2020.104306_b0230","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/sj.embor.embor914","article-title":"A genomic overview of pyridoxal-phosphate-dependent enzymes","volume":"4","author":"Percudani","year":"2003","journal-title":"EMBO Rep."},{"issue":"1\u20132","key":"10.1016\/j.bioorg.2020.104306_b0235","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0027-5107(00)00064-6","article-title":"The Ames Salmonella\/microsome mutagenicity assay","volume":"455","author":"Mortelmans","year":"2000","journal-title":"Mutation Res.-Fundamental Molecular Mech. Mutagenesis"},{"issue":"5","key":"10.1016\/j.bioorg.2020.104306_b0240","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/ja.2014.143","article-title":"Inhibition of biofilm formation in Bacillus subtilis by new halogenated furanones","volume":"68","author":"Kayumov","year":"2015","journal-title":"J. Antibiot."},{"issue":"2","key":"10.1016\/j.bioorg.2020.104306_b0245","doi-asserted-by":"crossref","first-page":"102","DOI":"10.32607\/20758251-2015-7-2-102-107","article-title":"Thio derivatives of 2(5H)-furanone as inhibitors against Bacillus subtilis biofilms","volume":"7","author":"Trizna","year":"2015","journal-title":"Acta Naturae"},{"key":"10.1016\/j.bioorg.2020.104306_b0250","doi-asserted-by":"crossref","DOI":"10.1038\/srep46068","article-title":"Targeting microbial biofilms using Ficin, a nonspecific plant protease","volume":"7","author":"Baidamshina","year":"2017","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.bioorg.2020.104306_b0255","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1469-0691.2011.03703.x","article-title":"EUCAST expert rules in antimicrobial susceptibility testing","volume":"19","author":"Leclercq","year":"2013","journal-title":"Clin. Microbiol. Infect."},{"issue":"2","key":"10.1016\/j.bioorg.2020.104306_b0260","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0167-7012(00)00241-4","article-title":"How to optimize the drop plate method for enumerating bacteria","volume":"44","author":"Herigstad","year":"2001","journal-title":"J. Microbiol. Methods"},{"key":"10.1016\/j.bioorg.2020.104306_b0265","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2017.02246","article-title":"Antimicrobial effects of sulfonyl derivative of 2(5H)-furanone against planktonic and biofilm associated methicillin-resistant and -Susceptible Staphylococcus aureus","volume":"8","author":"Sharafutdinov","year":"2017","journal-title":"Front. Microbiol."},{"issue":"11","key":"10.1016\/j.bioorg.2020.104306_b0270","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1093\/jac\/dks276","article-title":"In vitro evaluation of the potential for resistance development to ceragenin CSA-13","volume":"67","author":"Pollard","year":"2012","journal-title":"J. Antimicrob. Chemother."},{"issue":"3","key":"10.1016\/j.bioorg.2020.104306_b0275","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20030694","article-title":"Unraveling the Molecular Mechanism of Selective Antimicrobial Activity of 2(5H)-Furanone Derivative against Staphylococcus aureus","volume":"20","author":"Sharafutdinov","year":"2019","journal-title":"Int. J. Mol. sciences"},{"key":"10.1016\/j.bioorg.2020.104306_b0280","doi-asserted-by":"crossref","unstructured":"U.K. Laemmli, CLEAVAGE OF STRUCTURAL PROTEINS DURING ASSEMBLY OF HEAD OF BACTERIOPHAGE-T4, Nature 227(5259) (1970) 680-+.","DOI":"10.1038\/227680a0"},{"issue":"5","key":"10.1016\/j.bioorg.2020.104306_b0285","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nmeth.1318","article-title":"Enzymatic assembly of DNA molecules up to several hundred kilobases","volume":"6","author":"Gibson","year":"2009","journal-title":"Nat. Methods"},{"issue":"7","key":"10.1016\/j.bioorg.2020.104306_b0290","doi-asserted-by":"crossref","first-page":"3483","DOI":"10.1074\/jbc.M115.680991","article-title":"The molecular basis of TnrA control by glutamine synthetase in Bacillus subtilis","volume":"291","author":"Hauf","year":"2016","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.bioorg.2020.104306_b0295","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1111\/j.1742-4658.2011.08102.x","article-title":"Interaction of the general transcription factor TnrA with the PII-like protein GlnK and glutamine synthetase in Bacillus subtilis","volume":"278","author":"Kayumov","year":"2011","journal-title":"FEBS J."},{"issue":"3","key":"10.1016\/j.bioorg.2020.104306_b0300","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.enzmictec.2011.06.007","article-title":"A high-throughput colorimetric assay to measure the activity of glutamate decarboxylase","volume":"49","author":"Yu","year":"2011","journal-title":"Enzyme Microb. Technol."},{"key":"10.1016\/j.bioorg.2020.104306_b0305","first-page":"228","article-title":"Transcription factor TnrA inhibits the biosynthetic activity of glutamine synthetase in Bacillus subtilis","volume":"280","author":"Fedorova","year":"2013","journal-title":"FEBS J."},{"issue":"5","key":"10.1016\/j.bioorg.2020.104306_b0310","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0193267","article-title":"Fast and simple tool for the quantification of biofilm-embedded cells sub-populations from fluorescent microscopic images","volume":"13","author":"Bogachev","year":"2018","journal-title":"PLoS ONE"},{"issue":"12","key":"10.1016\/j.bioorg.2020.104306_b0315","first-page":"3277","article-title":"Polymeric and dendrimeric pyridoxal enzyme mimics","volume":"12","author":"Liu","year":"2004","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2020.104306_b0320","doi-asserted-by":"crossref","unstructured":"N. Shtyrlin, A. Dobrynin, T. Madzhidov, M. Pugachev, L. Sysoeva, R. Musin, I. Litvinov, E.S. Klimovitskii, Yurii, Experimental and theoretical study on 6-substituted pyridoxine derivatives. Synthesis of Cyclic 2,4,5,6-Tetrakis-(hydroxymethyl)pyridin-3-ol Acetonides, Russian J. Org. Chem. 47(1) (2011) 100-108.","DOI":"10.1134\/S107042801101012X"},{"key":"10.1016\/j.bioorg.2020.104306_b0325","doi-asserted-by":"crossref","unstructured":"R. Jones, Pyridine Syntheses. IV. The Preparation of Some Vitamin B6 Analogs, J. Am. Chem. Soc. 74(6) (1952) 1489-1491.","DOI":"10.1021\/ja01126a040"},{"issue":"MAY28","key":"10.1016\/j.bioorg.2020.104306_b0330","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1749-6632.1976.tb23086.x","article-title":"Simple method for detecting environmental carcinogens as mutagens","volume":"271","author":"McCann","year":"1976","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"5","key":"10.1016\/j.bioorg.2020.104306_b0335","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0165-1161(85)90062-7","article-title":"Evaluation of the new system (UMU-test) for the detection of environmental mutagens and carcinogens","volume":"147","author":"Oda","year":"1985","journal-title":"Mutat. Res."},{"issue":"1","key":"10.1016\/j.bioorg.2020.104306_b0340","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ijantimicag.2004.07.016","article-title":"Mechanisms of resistance in Salmonella enterica adapted to erythromycin, benzalkonium chloride and triclosan","volume":"25","author":"Braoudaki","year":"2005","journal-title":"Int. J. Antimicrob. Agents"},{"issue":"18","key":"10.1016\/j.bioorg.2020.104306_b0345","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20184584","article-title":"Intestinal microbiota: a novel target to improve anti-tumor treatment?","volume":"20","author":"Villeger","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.bioorg.2020.104306_b0350","doi-asserted-by":"crossref","DOI":"10.3390\/jof5020037","article-title":"Candida\/Staphylococcal polymicrobial intra-abdominal infection: pathogenesis and perspectives for a novel form of trained innate immunity","volume":"5","author":"Esher","year":"2019","journal-title":"J. Fungi"},{"issue":"1","key":"10.1016\/j.bioorg.2020.104306_b0355","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.cmi.2015.09.018","article-title":"Biofilm formation is a risk factor for mortality in patients with Candida albicans bloodstream infection-Scotland, 2012\u20132013","volume":"22","author":"Rajendran","year":"2016","journal-title":"Clin. Microbiol. Infect."},{"issue":"6","key":"10.1016\/j.bioorg.2020.104306_b0360","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1093\/mmy\/myx111","article-title":"Oral fungal-bacterial biofilm models in vitro: a review","volume":"56","author":"Chevalier","year":"2018","journal-title":"Med. Mycol."},{"issue":"16","key":"10.1016\/j.bioorg.2020.104306_b0365","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1517\/14656560903307462","article-title":"Terbinafine: a pharmacological and clinical review","volume":"10","author":"Krishnan-Natesan","year":"2009","journal-title":"Expert Opin. Pharmacother."},{"issue":"1","key":"10.1016\/j.bioorg.2020.104306_b0370","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/tpj.12195","article-title":"Recycling of pyridoxine (vitamin B6) by PUP1 in Arabidopsis","volume":"75","author":"Szydlowski","year":"2013","journal-title":"Plant J."},{"issue":"44","key":"10.1016\/j.bioorg.2020.104306_b0375","doi-asserted-by":"crossref","first-page":"30407","DOI":"10.1021\/acsami.6b08958","article-title":"Vitamin B6 tethered endosomal pH responsive lipid nanoparticles for triggered intracellular release of doxorubicin","volume":"8","author":"Sharma","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bioorg.2020.104306_b0380","doi-asserted-by":"crossref","unstructured":"Patrick Vandeputte, Selene, Ferrari, A.T. Coste., AntifungalResistanceand New Strategies to Control Fungal Infections, in: A.R. and, N.S.t.C.F. Infections (Eds.), International Journal of Microbiology, 2012, p. 26.","DOI":"10.1155\/2012\/713687"},{"key":"10.1016\/j.bioorg.2020.104306_b0385","doi-asserted-by":"crossref","unstructured":"M. Tischer, G. Pradel, K., Ohlsen, U. Holzgrabe, \u201cQuaternary ammonium salts and their antimicrobial potential: Targets or nonspecific interactions?\u201d, in: M. Tischer (Ed.) ChemMedChem, 2012, pp. 22-31.","DOI":"10.1002\/cmdc.201100404"},{"issue":"6","key":"10.1016\/j.bioorg.2020.104306_b0390","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.jmii.2014.03.010","article-title":"In vitro interactions between fluconazole and minocycline against mixed cultures of Candida albicans and Staphylococcus aureus","volume":"48","author":"Li","year":"2015","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"10.1016\/j.bioorg.2020.104306_b0395","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2016.01366","article-title":"Interspecific bacterial interactions are reflected in multispecies biofilm spatial organization","volume":"7","author":"Liu","year":"2016","journal-title":"Front. Microbiol."},{"issue":"1","key":"10.1016\/j.bioorg.2020.104306_b0400","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s11274-015-1969-0","article-title":"Antibacterial effects of quaternary bis-phosphonium and ammonium salts of pyridoxine on Staphylococcus aureus cells: a single base hitting two distinct targets?","volume":"32","author":"Nikitina","year":"2016","journal-title":"World J. Microbiol. Biotechnol."},{"issue":"11","key":"10.1016\/j.bioorg.2020.104306_b0405","doi-asserted-by":"crossref","first-page":"5010","DOI":"10.1128\/AAC.05062-11","article-title":"Survival of adhering staphylococci during exposure to a quaternary ammonium compound evaluated by using atomic force microscopy imaging","volume":"55","author":"Crismaru","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"issue":"3","key":"10.1016\/j.bioorg.2020.104306_b0410","doi-asserted-by":"crossref","first-page":"e91935","DOI":"10.1371\/journal.pone.0091935","article-title":"Influence of calcium in extracellular DNA mediated bacterial aggregation and biofilm formation","volume":"9","author":"Das","year":"2014","journal-title":"PLoS ONE"}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206820316047?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206820316047?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T15:34:57Z","timestamp":1763566497000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206820316047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":82,"alternative-id":["S0045206820316047"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2020.104306","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting pathogenic fungi, bacteria and fungal-bacterial biofilms by newly synthesized quaternary ammonium derivative of pyridoxine and terbinafine with dual action profile","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2020.104306","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104306"}}