{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:15:48Z","timestamp":1792671348515,"version":"4.5.0"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100016145","name":"Ministerio de Sanidad, Consumo y Bienestar Social","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016145","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.bioorg.2020.104350","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T07:47:03Z","timestamp":1602143223000},"page":"104350","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":90,"special_numbering":"C","title":["Design, green synthesis, molecular docking and anticancer evaluations of diazepam bearing sulfonamide moieties as VEGFR-2 inhibitors"],"prefix":"10.1016","volume":"104","author":[{"given":"Nashwa M.","family":"Saleh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed S.A.","family":"El-Gaby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"El\u2010Adl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nour E.A.","family":"Abd El-Sattar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2020.104350_b0005","doi-asserted-by":"crossref","unstructured":"R. Manchanayakage, Integrating Green and Sustainable Chemistry Principles into Education, 2019, pp. 117\u2013139. https:\/\/doi.org\/10.1016\/B978-0-12-817418-0.00005-X.","DOI":"10.1016\/B978-0-12-817418-0.00005-X"},{"issue":"9","key":"10.1016\/j.bioorg.2020.104350_b0010","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.3390\/molecules25092051","article-title":"An efficient synthetic approach towards Benzo[b]pyrano[2,3-e][1,4]diazepines, and their cytotoxic activity","volume":"25","author":"El Azab","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.bioorg.2020.104350_b0015","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.arabjc.2017.08.005","article-title":"Design, synthesis, computational and biological evaluation of new benzodiazepines as CNS agents","volume":"13","author":"Verma","year":"2020","journal-title":"Arab. J. Chem."},{"key":"10.1016\/j.bioorg.2020.104350_b0020","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.tips.2018.03.006","article-title":"The benzodiazepine binding sites of GABAA receptors","volume":"39","author":"Sigel","year":"2018","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.bioorg.2020.104350_b0025","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1080\/14656566.2018.1472767","article-title":"Comparing the efficacy of benzodiazepines and serotonergic anti-depressants for adults with generalized anxiety disorder: a meta-analytic review","volume":"19","author":"Gomez","year":"2018","journal-title":"Expert Opin. Pharmacother."},{"key":"10.1016\/j.bioorg.2020.104350_b0030","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.neuropharm.2017.08.002","article-title":"Intact blood-brain barrier transport of small molecular drugs in animal models of amyloid beta and alpha-synuclein pathology","volume":"128","author":"Gustafsson","year":"2018","journal-title":"Neuropharmacology"},{"issue":"7","key":"10.1016\/j.bioorg.2020.104350_b0035","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1021\/ol900210h","article-title":"Synthesis and anticancer activity of new hydroxamic acid containing 1,4-benzodiazepines","volume":"11","author":"Tardibono","year":"2009","journal-title":"Org. Lett."},{"key":"10.1016\/j.bioorg.2020.104350_b0040","first-page":"331","article-title":"Synthesis and biological screening of 4-(5-alkyl-2-isoxazolin-3-yl)-2-aryl-2,3-dihydro-1H-1,5-benzodiazepines","volume":"3","author":"Chadha","year":"2011","journal-title":"J. Chem. Pharm. Res."},{"key":"10.1016\/j.bioorg.2020.104350_b0045","first-page":"VE01","article-title":"Alcohol withdrawal syndrome: benzodiazepines and beyond","volume":"9","author":"Sachdeva","year":"2015","journal-title":"J. Clin. Diagn. Res."},{"key":"10.1016\/j.bioorg.2020.104350_b0050","doi-asserted-by":"crossref","first-page":"16500","DOI":"10.3390\/ijms150916500","article-title":"Synthesis, anticonvulsant, sedative and anxiolytic activities of novel annulated pyrrolo[1,4]benzodiazepines","volume":"15","author":"Kumaraswamy","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2020.104350_b0055","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1056\/NEJMra1611832","article-title":"Treatment of benzodiazepine dependence","volume":"376","author":"Soyka","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bioorg.2020.104350_b0060","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.clinph.2017.03.009","article-title":"Sleep architecture in insomniacs with severe benzodiazepine abuse","volume":"128","author":"Manconi","year":"2017","journal-title":"J. Clin. Neurophysiol."},{"key":"10.1016\/j.bioorg.2020.104350_b0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/jcm7020017","article-title":"Benzodiazepines I: upping the care on downers: the evidence of risks, benefits and alternatives","volume":"7","author":"Guina","year":"2018","journal-title":"J. Clin. Med."},{"issue":"1","key":"10.1016\/j.bioorg.2020.104350_b0070","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s11030-019-09940-9","article-title":"Novel fused 1,2,3-triazolo-benzodiazepine derivatives as potent anticonvulsant agents: design, synthesis, in vivo, and in silico evaluations","volume":"24","author":"Shafie","year":"2020","journal-title":"Mol Divers"},{"key":"10.1016\/j.bioorg.2020.104350_b0075","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s11062-013-9389-y","article-title":"Analgesic effects of 3-substituted derivatives of 1,4-benzodiazepines and their possible mechanisms","volume":"45","author":"Pavlovsky","year":"2013","journal-title":"Neurophysiology"},{"key":"10.1016\/j.bioorg.2020.104350_b0080","first-page":"1","article-title":"Anti-inflammatory effects of diazepam on different models of inflammation: roles of peripheral benzodiazepine receptors and genes for corticosterone, nitric oxide and cytokines biosynthesis","volume":"3","author":"Bader","year":"2017","journal-title":"J. Clin. Epigenet."},{"key":"10.1016\/j.bioorg.2020.104350_b0085","doi-asserted-by":"crossref","first-page":"3774","DOI":"10.3892\/etm.2017.4955","article-title":"Antiplatelet drug ticagrelor delays gastric ulcer healing in rats","volume":"14","author":"Jing-Jing","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.bioorg.2020.104350_b0090","first-page":"345","article-title":"Benzodiazepines in combination with antipsychotic drugs for schizophrenia: GABA-ergic targeted therapy","volume":"29","author":"W\u0142odarczyk","year":"2017","journal-title":"Psychiatr Danub."},{"key":"10.1016\/j.bioorg.2020.104350_b0095","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.2174\/1871520619666190308112732","article-title":"The anti-proliferative activity of anisosciadone: a new guaiane sesquiterpene from anisosciadium lanatum","volume":"19","author":"Mahmoud","year":"2019","journal-title":"Anti-Cancer Agents Med. Chem."},{"key":"10.1016\/j.bioorg.2020.104350_b0100","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.ejmech.2018.09.032","article-title":"Pyrazolo[4,3-b]pyrimido[4,5-e] [1,4]diazepine derivatives as new multi-targeted inhibitors of Aurora A\/B and KDR","volume":"5","author":"Zhang","year":"2018","journal-title":"Eur. J. Med. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2020.104350_b0105","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s11060-016-2285-8","article-title":"Alisertib demonstrates significant antitumor activity in bevacizumab resistant, patient derived orthotopic models of glioblastoma","volume":"131","author":"Kurokawa","year":"2017","journal-title":"J. Neurooncol."},{"key":"10.1016\/j.bioorg.2020.104350_b0110","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1021\/ml500409n","article-title":"MLN8054 and alisertib (MLN8237): discovery of selective oral aurora a inhibitors","volume":"6","author":"Sells","year":"2015","journal-title":"ACS Med. Chem. Lett."},{"issue":"2","key":"10.1016\/j.bioorg.2020.104350_b0115","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1248\/bpb.31.255","article-title":"Comparative anticancer effects of flavonoids and diazepam in cultured cancer cells","volume":"31","author":"Kim","year":"2008","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.bioorg.2020.104350_b0120","first-page":"4377","article-title":"Anticancer drug design using scaffolds of B-lactams, sulfonamides, quinoline, quinoxaline and natural products","volume":"19","author":"Balderas-Renteria","year":"2012","journal-title":"Drugs Adv. Clinical Trials. CMC"},{"issue":"10","key":"10.1016\/j.bioorg.2020.104350_b0125","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1080\/10426500802561096","article-title":"Synthesis of thiazolidine and thiophene derivatives for evaluation as anticancer agents","volume":"184","author":"El-Gaby","year":"2009","journal-title":"Phosphorus Sulfur Silicon Related Elements"},{"key":"10.1016\/j.bioorg.2020.104350_b0130","doi-asserted-by":"crossref","first-page":"103262","DOI":"10.1016\/j.bioorg.2019.103262","article-title":"First example of Azo-Sulfa conjugated chromene moieties: synthesis, characterization, antimicrobial assessment, docking simulation as potent class I histone deacetylase inhibitors and antitumor agents","volume":"92","author":"Okasha","year":"2019","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2020.104350_b0135","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.ejmech.2016.08.060","article-title":"Biological evaluation of some new N -(2,6-dimethoxypyrimidinyl) thioureido benzenesulfonamide derivatives as potential antimicrobial and anticancer agents","volume":"124","author":"Ghorab","year":"2016","journal-title":"Eur. J. Med. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2020.104350_b0140","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s00044-017-2035-2","article-title":"Synthesis, structural characterization and anticancer evaluation of pyrazole derivatives","volume":"27","author":"El-Gaby","year":"2018","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.bioorg.2020.104350_b0145","doi-asserted-by":"crossref","first-page":"415","DOI":"10.2478\/v10007-011-0040-4","article-title":"Synthesis, in vitro anticancer screening and radiosensitizing evaluation of some new 4-[3-(substituted)thioureido]-N-(quinoxalin-2-yl)-benzenesulfonamide derivatives","volume":"61","author":"Ghorab","year":"2011","journal-title":"Acta Pharmaceutica"},{"key":"10.1016\/j.bioorg.2020.104350_b0150","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.bioorg.2014.05.010","article-title":"Design, synthesis and biological evaluation of type-II VEGFR-2 inhibitors based on quinoxaline scaffold","volume":"56","author":"Shahin","year":"2014","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2020.104350_b0155","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/ardp.201500468","article-title":"Quinoxaline-based scaffolds targeting tyrosine kinases and their potential anticancer activity","volume":"349","author":"El Newahie","year":"2016","journal-title":"Arch. Pharm. Chem. Life Sci."},{"key":"10.1016\/j.bioorg.2020.104350_b0160","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.clinbiochem.2004.05.006","article-title":"Tyrosine kinase inhibitors in cancer therapy","volume":"37","author":"Madhusudan","year":"2004","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.bioorg.2020.104350_b0165","doi-asserted-by":"crossref","first-page":"6899","DOI":"10.1016\/S0040-4020(01)80432-4","article-title":"Reactions of hydroxyglycines. New synthetic routes to 4-phenylquinazoline derivatives","volume":"49","author":"Hoefnagel","year":"1993","journal-title":"Tetrahedron"},{"issue":"13","key":"10.1016\/j.bioorg.2020.104350_b0170","doi-asserted-by":"crossref","first-page":"3774","DOI":"10.1016\/j.bmcl.2007.04.006","article-title":"The crystal structures of copper(II), manganese(II), and nickel(II) complexes of a (Z)-2-hydroxy-N\u2032-(2-oxoindolin-3-ylidene) benzohydrazide\u2014potential antitumor agents","volume":"17","author":"Zhong","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"3","key":"10.1016\/j.bioorg.2020.104350_b0175","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1002\/jhet.5570450343","article-title":"Convenient syntheses of 5-[(2-methyl-5-nitro-1H-imidazol-1-yl) methyl]-1, 3, 4-oxadiazole-2 (3H) thione and N-substituted 2-amino-5-[(2-methyl-5-nitro-1H-imidazol-1-yl) methyl]-1, 3, 4-thiadiazoles","volume":"45","author":"Mirzaei","year":"2008","journal-title":"J. Heterocyclic Chem."},{"issue":"7","key":"10.1016\/j.bioorg.2020.104350_b0180","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.ctrv.2012.04.006","article-title":"Role of angiogenesis in the pathogenesis of cancer","volume":"38","author":"Hoff","year":"2012","journal-title":"Cancer Treat. Rev."},{"issue":"3","key":"10.1016\/j.bioorg.2020.104350_b0185","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.bcmd.2006.12.003","article-title":"Vascular endothelial growth factor family of ligands and receptors","volume":"38","author":"Otrock","year":"2007","journal-title":"Blood Cells Mol. Dis."},{"issue":"6","key":"10.1016\/j.bioorg.2020.104350_b0190","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s10517-010-1043-8","article-title":"Vascular endothelial growth factor and its type 2 receptor in hepatocellular carcinoma","volume":"149","author":"Gershtein","year":"2010","journal-title":"Bull. Exp. Biol. Med."},{"issue":"14","key":"10.1016\/j.bioorg.2020.104350_b0195","doi-asserted-by":"crossref","first-page":"3548","DOI":"10.1158\/1078-0432.CCR-09-2797","article-title":"Vascular endothelial growth factor receptors VEGFR-2 and VEGFR-3 are localized primarily to the vasculature in human primary solid cancers","volume":"16","author":"Smith","year":"2010","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bioorg.2020.104350_b0200","doi-asserted-by":"crossref","first-page":"111552","DOI":"10.1016\/j.ejmech.2019.07.055","article-title":"Design, synthesis and biological evaluation of novel 4-anilinoquinazoline derivatives as hypoxia-selective EGFR and VEGFR-2 dual inhibitors","volume":"181","author":"Wei","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2020.104350_b0205","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.ejmech.2017.04.068","article-title":"Design, synthesis, molecular docking and cytotoxic evaluation of novel 2-furybenzimidazoles as VEGFR-2 inhibitors","volume":"136","author":"Abdullaziz","year":"2017","journal-title":"Eur. J. Med. Chem."},{"issue":"14","key":"10.1016\/j.bioorg.2020.104350_b0210","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.4155\/fmc.12.121","article-title":"Development and strategies of VEGFR-2\/KDR inhibitors","volume":"4","author":"Huang","year":"2012","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.bioorg.2020.104350_b0215","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s11523-015-0416-3","article-title":"Lenvatinib: a review in refractory thyroid cancer","volume":"11","author":"Frampton","year":"2016","journal-title":"Target. Oncol."},{"issue":"12","key":"10.1016\/j.bioorg.2020.104350_b0220","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1248\/bpb.34.1785","article-title":"Vascular endothelial growth factor (VEGF), VEGF receptors and their inhibitors for antiangiogenic tumor therapy","volume":"34","author":"Takahashi","year":"2011","journal-title":"Biol. Pharm. Bull."},{"issue":"2","key":"10.1016\/j.bioorg.2020.104350_b0225","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1111\/j.1476-5381.2011.01801.x","article-title":"A combinatorial in silico and cellular approach to identify a new class of compounds that target VEGFR2 receptor tyrosine kinase activity and angiogenesis","volume":"166","author":"Kankanala","year":"2012","journal-title":"British J. Pharmacol."},{"issue":"7","key":"10.1016\/j.bioorg.2020.104350_b0230","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.tips.2015.04.005","article-title":"FDA-approved small-molecule kinase inhibitors","volume":"36","author":"Wu","year":"2015","journal-title":"Trends Pharmacol. Sci."},{"issue":"10","key":"10.1016\/j.bioorg.2020.104350_b0235","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/nrd2130","article-title":"Discovery and development of sorafenib: a multikinase inhibitor for treating cancer","volume":"5","author":"Wilhelm","year":"2006","journal-title":"Nat. Rev. Drug Discov."},{"issue":"10","key":"10.1016\/j.bioorg.2020.104350_b0240","doi-asserted-by":"crossref","first-page":"7077","DOI":"10.3390\/ijms12107077","article-title":"Biomarkers in tumor angiogenesis and anti-angiogenic therapy","volume":"12","author":"Pircher","year":"2011","journal-title":"Int. J. Mole. Sci."},{"key":"10.1016\/j.bioorg.2020.104350_b0245","doi-asserted-by":"crossref","first-page":"104059","DOI":"10.1016\/j.bioorg.2020.104059","article-title":"Design, synthesis, molecular docking and anticancer evaluations of 5-benzylidenethiazolidine-2,4-dione derivatives targeting VEGFR-2 enzyme","volume":"102","author":"El-Adl","year":"2020","journal-title":"Bioorg. Chem."},{"issue":"12","key":"10.1016\/j.bioorg.2020.104350_b0250","doi-asserted-by":"crossref","first-page":"1900178","DOI":"10.1002\/ardp.201900178","article-title":"Benzoxazole\/benzothiazole\u2010derived VEGFR\u20102 inhibitors: design, synthesis, molecular docking, and anticancer evaluations","volume":"352","author":"El\u2010Helby","year":"2019","journal-title":"Arch. Pharm. Chem. Life Sci."},{"key":"10.1016\/j.bioorg.2020.104350_b0255","doi-asserted-by":"crossref","first-page":"103422","DOI":"10.1016\/j.bioorg.2019.103422","article-title":"Design, synthesis, molecular modeling, in vivo studies and anticancer evaluation of quinazolin-4 (3H)-one derivatives as potential VEGFR-2 inhibitors and apoptosis inducers","volume":"94","author":"Mahdy","year":"2020","journal-title":"Bioorg. Chem."},{"issue":"10","key":"10.1016\/j.bioorg.2020.104350_b0260","doi-asserted-by":"crossref","first-page":"1900113","DOI":"10.1002\/ardp.201900113","article-title":"Design, synthesis, molecular docking, and anticancer activity of benzoxazole derivatives as VEGFR\u20102 inhibitors","volume":"352","author":"El\u2010Helby","year":"2019","journal-title":"Arch. Pharm. Chem. Life Sci."},{"issue":"8","key":"10.1016\/j.bioorg.2020.104350_b0265","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.2174\/1871520618666180412123833","article-title":"Design, synthesis, in vitro anti-cancer activity, ADMET profile and molecular docking of novel triazolo [3, 4-a] phthalazine derivatives targeting VEGFR-2 enzyme","volume":"18","author":"El-Helby","year":"2018","journal-title":"Anti-Cancer Agents Med. Chem. (Form. Curr. Med. Chem.-Anti-Cancer Agents)"},{"issue":"12","key":"10.1016\/j.bioorg.2020.104350_b0270","doi-asserted-by":"crossref","first-page":"1700240","DOI":"10.1002\/ardp.201700240","article-title":"Design, synthesis, molecular docking, and anticancer activity of phthalazine derivatives as VEGFR-2 inhibitors: phthalazine derivatives as VEGFR-2 inhibitors","volume":"350","author":"El-Helby","year":"2017","journal-title":"Arch. Pharm. Chem. Life Sci."},{"issue":"1","key":"10.1016\/j.bioorg.2020.104350_b0275","doi-asserted-by":"crossref","first-page":"137","DOI":"10.4103\/0973-1482.172109","article-title":"Synthesis of sulfadimethoxine based surfactants and their evaluation as antitumor agents","volume":"12","author":"Khowdiary","year":"2016","journal-title":"J. Cancer Res. Ther."},{"key":"10.1016\/j.bioorg.2020.104350_b0280","doi-asserted-by":"crossref","first-page":"917","DOI":"10.3389\/fchem.2019.00917","article-title":"Novel anticancer fused pyrazole derivatives as EGFR and VEGFR-2 dual TK inhibitors","volume":"7","author":"Saleh","year":"2020","journal-title":"Front. Chem."},{"issue":"6","key":"10.1016\/j.bioorg.2020.104350_b0285","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.jmgm.2008.11.008","article-title":"Pharmacophore modeling studies of type I and type II kinase inhibitors of Tie2","volume":"27","author":"Xie","year":"2009","journal-title":"J. Mol. Graph. Model."},{"issue":"11","key":"10.1016\/j.bioorg.2020.104350_b0290","doi-asserted-by":"crossref","first-page":"5420","DOI":"10.1016\/j.ejmech.2010.09.002","article-title":"Pharmacophore modeling and virtual screening studies for new VEGFR-2 kinase inhibitors","volume":"45","author":"Lee","year":"2010","journal-title":"Eur. J. Med. Chem."},{"issue":"19","key":"10.1016\/j.bioorg.2020.104350_b0295","doi-asserted-by":"crossref","first-page":"6497","DOI":"10.1016\/j.bmc.2015.08.010","article-title":"Synthesis, antiangiogenesis evaluation and molecular docking studies of 1-aryl-3-[(thieno[3,2-b]pyridin-7-ylthio)phenyl]ureas: discovery of a new substitution pattern for type II VEGFR-2 Tyr kinase inhibitors","volume":"23","author":"Machado","year":"2015","journal-title":"Bioorg. Med. Chem."},{"issue":"7","key":"10.1016\/j.bioorg.2020.104350_b0300","article-title":"Dietary compound isoliquiritigenin inhibits breast cancer neoangiogenesis via VEGF\/VEGFR-2 signaling pathway","volume":"8","author":"Wang","year":"2013","journal-title":"PloS One"},{"issue":"15","key":"10.1016\/j.bioorg.2020.104350_b0305","doi-asserted-by":"crossref","first-page":"5738","DOI":"10.1016\/j.bmc.2010.05.063","article-title":"The design, synthesis, and evaluation of 8 hybrid DFG-out allosteric kinase inhibitors: a structural analysis of the binding interactions of Gleevec\u00ae, Nexavar\u00ae, and BIRB-796","volume":"18","author":"Dietrich","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2020.104350_b0310","first-page":"1","article-title":"Synthesis of some novel C3 substituted new diazo-[1,4]- benzodiazepine-2-one derivatives as potent anticonvulsants","volume":"5","author":"Rashid","year":"2010","journal-title":"Chem. Sci. J."},{"key":"10.1016\/j.bioorg.2020.104350_b0315","doi-asserted-by":"crossref","first-page":"285","DOI":"10.2174\/157019312804070390","article-title":"Review on synthesis of biologically active diazepam derivatives","volume":"9","author":"Sathish Kumar","year":"2012","journal-title":"Mini-Rev. Org. Chem."},{"key":"10.1016\/j.bioorg.2020.104350_b0320","unstructured":"F.A. Carey, R.J. Sundberg, Advanced Organic Chemistry, Part A: Structure and Mechanisms, Chapter 9. Aromatic Substitution, 5th ed., 2007."},{"issue":"4","key":"10.1016\/j.bioorg.2020.104350_b0325","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/jlcr.2580130401","article-title":"Synthesis of 7-chloro-1,3-dihydro-5-(2-fluorophenyl)-1-methyl-2H-1,4-benzodiazepin-2-one-5-14C (fludiazepam-14C)","volume":"13","author":"Nakatsuka","year":"1977","journal-title":"J. Label Compd. Radiopharm."},{"key":"10.1016\/j.bioorg.2020.104350_b0330","series-title":"Organic Chemistry","first-page":"801","author":"Ouellette","year":"2018"},{"issue":"16","key":"10.1016\/j.bioorg.2020.104350_b0335","doi-asserted-by":"crossref","first-page":"3767","DOI":"10.1002\/ejoc.200600335","article-title":"Ionic liquid as catalyst and reaction medium \u2013 a simple, efficient and green procedure for knoevenagel condensation of aliphatic and aromatic carbonyl compounds using a task-specific basic ionic liquid","volume":"2006","author":"Ranu","year":"2006","journal-title":"Eur. J. Org. Chem."},{"key":"10.1016\/j.bioorg.2020.104350_b0340","doi-asserted-by":"crossref","unstructured":"I. Elghamry, M. Abdelsalam, Expedient phosgene-free synthesis of symmetrical diarylureas from carbamates, Arkivoc, 2019, part vi, 83\u201392.","DOI":"10.24820\/ark.5550190.p010.997"},{"issue":"3","key":"10.1016\/j.bioorg.2020.104350_b0345","first-page":"173","article-title":"Synthesis and biological evaluation of new sulfonamide derivatives","volume":"15","author":"Askar","year":"2017","journal-title":"Int. J. Chem. Sc."},{"key":"10.1016\/j.bioorg.2020.104350_b0350","doi-asserted-by":"crossref","unstructured":"K.G. Bedane, G.S. Singh, Reactivity and diverse synthetic applications of acyl isothiocyanates, ARKIVOC 2015 (vi) 206\u2013245.","DOI":"10.3998\/ark.5550190.p009.052"},{"issue":"7","key":"10.1016\/j.bioorg.2020.104350_b0355","first-page":"1154","article-title":"Design, synthesis and in vitro antitumor activity of novel phthalazin-1, 4-dione\/chalcone hybrids and phthalazin-1, 4-dione\/pyrazoline hybrids","volume":"7","author":"El-Feky","year":"2015","journal-title":"J. Chem. Pharmac. Res."},{"issue":"8","key":"10.1016\/j.bioorg.2020.104350_b0360","doi-asserted-by":"crossref","first-page":"3727","DOI":"10.1128\/AEM.65.8.3727-3729.1999","article-title":"The MTT [3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide] assay is a fast and reliable method for colorimetric determination of fungal cell densities","volume":"65","author":"Freimoser","year":"1999","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.bioorg.2020.104350_b0365","article-title":"5-(4-Methoxybenzylidene)thiazolidine-2,4-dione-derived VEGFR-2 inhibitors: design, synthesis, molecular docking, and anticancer evaluations","author":"El-Adl","year":"2020","journal-title":"Arch Pharm."},{"key":"10.1016\/j.bioorg.2020.104350_b0370","article-title":"Design, synthesis, molecular docking, and anticancer evaluations of 1-benzylquinazoline-2,4(1H,3H)-dione bearing different moieties as VEGFR-2 inhibitors","author":"El-Adl","year":"2020","journal-title":"Arch Pharm."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206820316485?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206820316485?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T15:43:01Z","timestamp":1763566981000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206820316485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":74,"alternative-id":["S0045206820316485"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2020.104350","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, green synthesis, molecular docking and anticancer evaluations of diazepam bearing sulfonamide moieties as VEGFR-2 inhibitors","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2020.104350","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104350"}}