{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T18:24:23Z","timestamp":1790274263766,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.bioorg.2021.104630","type":"journal-article","created":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T12:54:03Z","timestamp":1610110443000},"page":"104630","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":90,"special_numbering":"C","title":["Design and synthesis of methoxyphenyl- and coumarin-based chalcone derivatives as anti-inflammatory agents by inhibition of NO production and down-regulation of NF-\u03baB in LPS-induced RAW264.7 macrophage cells"],"prefix":"10.1016","volume":"107","author":[{"given":"Soha H.","family":"Emam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr","family":"Sonousi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman O.","family":"Osman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dukhyun","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gun-Do","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasha A.","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7203","key":"10.1016\/j.bioorg.2021.104630_b0005","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nature07205","article-title":"Cancer-related inflammation","volume":"454","author":"Mantovani","year":"2008","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.bioorg.2021.104630_b0010","first-page":"17","article-title":"Role of inducible cyclooxygenase (COX-2) in inflammation","volume":"4","author":"Seibert","year":"1994","journal-title":"Receptor"},{"issue":"2","key":"10.1016\/j.bioorg.2021.104630_b0015","doi-asserted-by":"crossref","first-page":"81s","DOI":"10.18433\/J3T886","article-title":"Evolution of nonsteroidal anti-inflammatory drugs (NSAIDs): cyclooxygenase (COX) inhibition and beyond","volume":"11","author":"Rao","year":"2008","journal-title":"J. Pharm. Pharm. Sci."},{"key":"10.1016\/j.bioorg.2021.104630_b0020","doi-asserted-by":"crossref","first-page":"103015","DOI":"10.1016\/j.bioorg.2019.103015","article-title":"Radical scavenging and anti-inflammatory activities of (hetero)arylethenesulfonyl fluorides: Synthesis and structure-activity relationship (SAR) and QSAR studies","volume":"89","author":"Jiang","year":"2019","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2021.104630_b0025","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.ijbiomac.2017.12.045","article-title":"Synthesis of novel benzodioxane midst piperazine moiety decorated chitosan silver nanoparticle against biohazard pathogens and as potential anti-inflammatory candidate: A molecular docking studies","volume":"108","author":"Karthik","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"issue":"6","key":"10.1016\/j.bioorg.2021.104630_b0030","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1039\/C7MD00111H","article-title":"Synthesis of benzo [d] thiazole-hydrazone analogues: molecular docking and SAR studies of potential H+\/K+ ATPase inhibitors and anti-inflammatory agents","volume":"8","author":"Wang","year":"2017","journal-title":"MedChemComm"},{"issue":"8","key":"10.1016\/j.bioorg.2021.104630_b0035","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1039\/C7MD00209B","article-title":"Synthesis and molecular docking studies of xanthone attached amino acids as potential antimicrobial and anti-inflammatory agents","volume":"8","author":"Chen","year":"2017","journal-title":"MedChemComm"},{"key":"10.1016\/j.bioorg.2021.104630_b0040","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.bioorg.2018.08.024","article-title":"Multi-targeted dihydrazones as potent biotherapeutics","volume":"81","author":"Li","year":"2018","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2021.104630_b0045","doi-asserted-by":"crossref","first-page":"17023","DOI":"10.1038\/sigtrans.2017.23","article-title":"NF-\u03baB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct Target Ther"},{"issue":"6","key":"10.1016\/j.bioorg.2021.104630_b0050","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/s10787-007-0013-x","article-title":"Role of nitric oxide in inflammatory diseases","volume":"15","author":"Sharma","year":"2007","journal-title":"Inflammopharmacology"},{"issue":"1","key":"10.1016\/j.bioorg.2021.104630_b0055","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s11101-014-9387-8","article-title":"Naturally occurring chalcones and their biological activities","volume":"15","author":"Rozmer","year":"2016","journal-title":"Phytochem. Rev."},{"issue":"22","key":"10.1016\/j.bioorg.2021.104630_b0060","doi-asserted-by":"crossref","first-page":"7228","DOI":"10.1021\/jm901278z","article-title":"Structure-activity relationship studies of chalcone leading to 3-hydroxy-4,3',4',5'-tetramethoxychalcone and its analogues as potent nuclear factor kappaB inhibitors and their anticancer activities","volume":"52","author":"Srinivasan","year":"2009","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2021.104630_b0065","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ejmech.2015.05.004","article-title":"Anti-cancer chalcones: Structural and molecular target perspectives","volume":"98","author":"Mahapatra","year":"2015","journal-title":"Eur. J. Med. Chem."},{"issue":"23","key":"10.1016\/j.bioorg.2021.104630_b0070","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1080\/00397911.2018.1539178","article-title":"Antihyperglycemic activity of chalcone based novel 1-{3-[3-(substituted phenyl) prop-2-enoyl] phenyl} thioureas","volume":"48","author":"Acharjee","year":"2018","journal-title":"Synth. Commun."},{"key":"10.1016\/j.bioorg.2021.104630_b0075","doi-asserted-by":"crossref","first-page":"103133","DOI":"10.1016\/j.bioorg.2019.103133","article-title":"Chalcone derivatives and their antibacterial activities: Current development","volume":"91","author":"Xu","year":"2019","journal-title":"Bioorg. Chem."},{"issue":"23","key":"10.1016\/j.bioorg.2021.104630_b0080","doi-asserted-by":"crossref","first-page":"8110","DOI":"10.1021\/jm200946h","article-title":"Evaluation and discovery of novel synthetic chalcone derivatives as anti-inflammatory agents","volume":"54","author":"Wu","year":"2011","journal-title":"J. Med. Chem."},{"issue":"6","key":"10.1016\/j.bioorg.2021.104630_b0085","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1016\/j.ejmech.2010.01.060","article-title":"Synthesis, cytotoxicity, anti-oxidative and anti-inflammatory activity of chalcones and influence of A-ring modifications on the pharmacological effect","volume":"45","author":"Vogel","year":"2010","journal-title":"Eur. J. Med. Chem."},{"issue":"2","key":"10.1016\/j.bioorg.2021.104630_b0090","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ejmech.2006.09.019","article-title":"A review of anti-infective and anti-inflammatory chalcones","volume":"42","author":"Nowakowska","year":"2007","journal-title":"Eur. J. Med. Chem."},{"issue":"17","key":"10.1016\/j.bioorg.2021.104630_b0095","doi-asserted-by":"crossref","first-page":"5431","DOI":"10.1021\/jm800285f","article-title":"Inhibition of I\u03baB kinase-\u03b2 and anticancer activities of novel chalcone adamantyl arotinoids","volume":"51","author":"Lorenzo","year":"2008","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2021.104630_b0100","doi-asserted-by":"crossref","first-page":"112216","DOI":"10.1016\/j.ejmech.2020.112216","article-title":"Development of a novel nitric oxide (NO) production inhibitor with potential therapeutic effect on chronic inflammation","volume":"193","author":"Yang","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2021.104630_b0105","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.2147\/DDDT.S133172","article-title":"Design, synthesis, and biological evaluation of novel EF24 and EF31 analogs as potential I\u03baB kinase \u03b2 inhibitors for the treatment of pancreatic cancer","volume":"11","author":"Xie","year":"2017","journal-title":"Drug Des. Devel. Ther."},{"issue":"1","key":"10.1016\/j.bioorg.2021.104630_b0110","doi-asserted-by":"crossref","first-page":"25130","DOI":"10.1038\/srep25130","article-title":"Discovery of new MD2 inhibitor from chalcone derivatives with anti-inflammatory effects in LPS-induced acute lung injury","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioorg.2021.104630_b0115","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.bioorg.2019.03.033","article-title":"Promising anti-inflammatory effects of chalcones via inhibition of cyclooxygenase, prostaglandin E2, inducible NO synthase and nuclear factor \u03bab activities","volume":"87","author":"ur Rashid","year":"2019","journal-title":"Bioorg. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2021.104630_b0120","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1089\/107555303321223035","article-title":"Safety and anti-inflammatory activity of curcumin: A component of tumeric (curcuma longa)","volume":"9","author":"Chainani-Wu","year":"2003","journal-title":"J. Alternat. Complement. Med."},{"issue":"4","key":"10.1016\/j.bioorg.2021.104630_b0125","doi-asserted-by":"crossref","first-page":"293","DOI":"10.2174\/187152307783219989","article-title":"The anti-inflammatory effect of coumarin and its derivatives","volume":"6","author":"Hadjipavlou-Litina","year":"2007","journal-title":"Antiinflamm. Antiallergy Agents Med. Chem."},{"issue":"49","key":"10.1016\/j.bioorg.2021.104630_b0130","doi-asserted-by":"crossref","first-page":"38892","DOI":"10.1039\/C5RA05643H","article-title":"Coumarins as privileged scaffold for anti-inflammatory drug development","volume":"5","author":"Grover","year":"2015","journal-title":"RSC Adv."},{"key":"10.1016\/j.bioorg.2021.104630_b0135","doi-asserted-by":"crossref","first-page":"112832","DOI":"10.1016\/j.ejmech.2020.112832","article-title":"Antibacterial activities with the structure-activity relationship of coumarin derivatives","volume":"207","author":"Qin","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2021.104630_b0140","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.bioorg.2017.02.001","article-title":"Coumarins scaffolds as COX inhibitors","volume":"71","author":"Revankar","year":"2017","journal-title":"Bioorg. Chem."},{"issue":"3","key":"10.1016\/j.bioorg.2021.104630_b0145","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/(SICI)1099-1573(199705)11:3<211::AID-PTR72>3.0.CO;2-W","article-title":"Analgesic and antiinflammatory activities of Justicia pectoralis Jacq and its main constituents: coumarin and umbelliferone","volume":"11","author":"Lino","year":"1997","journal-title":"Phytother. Res."},{"issue":"10","key":"10.1016\/j.bioorg.2021.104630_b0150","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1134\/S1070363213100113","article-title":"Synthesis, structure and chemical transformations of 4-aminobenzaldehyde","volume":"83","author":"Nurkenov","year":"2013","journal-title":"Russ. J. Gen. Chem."},{"issue":"6","key":"10.1016\/j.bioorg.2021.104630_b0155","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1007\/s13738-016-0828-8","article-title":"Synthesis and cytotoxicity of novel chromenone derivatives bearing 4-nitrophenoxy phenyl acryloyl moiety","volume":"13","author":"Mahdavi","year":"2016","journal-title":"J. Iran. Chem. Soc."},{"issue":"2","key":"10.1016\/j.bioorg.2021.104630_b0160","doi-asserted-by":"crossref","first-page":"59","DOI":"10.52763\/PJSIR.PHYS.SCI.54.2011.59.67","article-title":"Facile synthesis and characterization of substituted pyrimidin-2 (1H)-ones and their chalcone precursors","volume":"54","author":"Ajani","year":"2011","journal-title":"Pakistan J. Sci. Ind. Res. Series A: Phys. Sci."},{"issue":"1","key":"10.1016\/j.bioorg.2021.104630_b0165","doi-asserted-by":"crossref","first-page":"102","DOI":"10.22146\/ijc.26864","article-title":"Synthesis of chalcone derivatives and their in vitro anticancer test against breast (T47D) and colon (WiDr) cancer cell line","volume":"18","author":"Anwar","year":"2018","journal-title":"Indones. J. Chem."},{"issue":"3","key":"10.1016\/j.bioorg.2021.104630_b0170","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3923\/jas.2016.77.87","article-title":"Comparative study of microwave-assisted and conventional synthesis of 3-[1-(s-phenylimino) ethyl]-2H-chromen-2-ones and selected hydrazone derivatives","volume":"16","author":"Ajani","year":"2016","journal-title":"J. Appl. Sci."},{"issue":"4","key":"10.1016\/j.bioorg.2021.104630_b0175","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1155\/2006\/395386","article-title":"Synthesis and antimicrobial activity of some novel chalcones of 2-hydroxy-1-acetonapthone and 3-acetyl coumarin","volume":"3","author":"Prasad","year":"2006","journal-title":"J. Chem."},{"issue":"2","key":"10.1016\/j.bioorg.2021.104630_b0180","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1073\/pnas.1517642113","article-title":"Systematic study of constitutive cyclooxygenase-2 expression: Role of NF-\u03baB and NFAT transcriptional pathways","volume":"113","author":"Kirkby","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"43","key":"10.1016\/j.bioorg.2021.104630_b0185","doi-asserted-by":"crossref","first-page":"17597","DOI":"10.1073\/pnas.1209192109","article-title":"Cyclooxygenase-1, not cyclooxygenase-2, is responsible for physiological production of prostacyclin in the cardiovascular system","volume":"109","author":"Kirkby","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"issue":"4","key":"10.1016\/j.bioorg.2021.104630_b0190","doi-asserted-by":"crossref","first-page":"471","DOI":"10.2174\/1568010054526359","article-title":"Nitric oxide production and signaling in inflammation","volume":"4","author":"Korhonen","year":"2005","journal-title":"Curr. Drug Targets Inflamm. Allergy"},{"issue":"3","key":"10.1016\/j.bioorg.2021.104630_b0195","doi-asserted-by":"crossref","DOI":"10.1186\/ar3045","article-title":"Central role of nitric oxide in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus","volume":"12","author":"Nagy","year":"2010","journal-title":"Arthritis Res. Ther."},{"issue":"5","key":"10.1016\/j.bioorg.2021.104630_b0200","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.freeradbiomed.2007.04.026","article-title":"Methods to detect nitric oxide and its metabolites in biological samples","volume":"43","author":"Bryan","year":"2007","journal-title":"Free Radic. Biol. Med."},{"issue":"3","key":"10.1016\/j.bioorg.2021.104630_b0205","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.acthis.2018.02.005","article-title":"Tetrazolium salts and formazan products in Cell Biology: Viability assessment, fluorescence imaging, and labeling perspectives","volume":"120","author":"Stockert","year":"2018","journal-title":"Acta Histochem."},{"issue":"7","key":"10.1016\/j.bioorg.2021.104630_b0210","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0192-0561(99)00024-7","article-title":"Quercetin inhibits LPS-induced nitric oxide and tumor necrosis factor-alpha production in murine macrophages","volume":"21","author":"Manjeet","year":"1999","journal-title":"Int. J. Immunopharmacol"},{"issue":"11","key":"10.1016\/j.bioorg.2021.104630_b0215","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1248\/cpb.52.1326","article-title":"Antiallergic agents from natural sources 9. Inhibition of nitric oxide production by novel chalcone derivatives from mallotus philippinensis (euphorbiaceae)","volume":"52","author":"Daikonya","year":"2004","journal-title":"Chem. Pharm. Bull."},{"issue":"9","key":"10.1016\/j.bioorg.2021.104630_b0220","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1111\/jphp.12421","article-title":"Toluhydroquinone from Aspergillus sp. suppress inflammatory mediators via nuclear factor-\u03baB and mitogen-activated protein kinases pathways in lipopolysaccharide-induced RAW264.7 cells","volume":"67","author":"Hwang","year":"2015","journal-title":"J. Pharm. Pharmacol."},{"issue":"1","key":"10.1016\/j.bioorg.2021.104630_b0225","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1172\/JCI11830","article-title":"NF-\u03baB: a key role in inflammatory diseases","volume":"107","author":"Tak","year":"2001","journal-title":"J. Clin. Investig."},{"issue":"11","key":"10.1016\/j.bioorg.2021.104630_b0230","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.molmed.2007.09.002","article-title":"Signaling to NF-kappaB by Toll-like receptors","volume":"13","author":"Kawai","year":"2007","journal-title":"Trends Mol. Med."},{"issue":"31","key":"10.1016\/j.bioorg.2021.104630_b0235","doi-asserted-by":"crossref","first-page":"22758","DOI":"10.1074\/jbc.M113.482596","article-title":"Crystal structure of a human I\u03baB kinase \u03b2 asymmetric dimer","volume":"288","author":"Liu","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bioorg.2021.104630_b0240","first-page":"1869","article-title":"Synthesis and biological evaluation of novel indole-2-one and 7-aza-2-oxindole derivatives as anti-inflammatory agents","volume":"8","author":"Chen","year":"2014","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.bioorg.2021.104630_b0245","doi-asserted-by":"crossref","first-page":"103034","DOI":"10.1016\/j.bioorg.2019.103034","article-title":"Ultrasound-assisted synthesis of novel chalcone, heterochalcone and bis-chalcone derivatives and the evaluation of their antioxidant properties and as acetylcholinesterase inhibitors","volume":"90","author":"Polo","year":"2019","journal-title":"Bioorg. Chem."},{"issue":"7","key":"10.1016\/j.bioorg.2021.104630_b0250","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/ardp.201500434","article-title":"Characterization of the fluorescence properties of 4-dialkylaminochalcones and investigation of the cytotoxic mechanism of chalcones","volume":"349","author":"Zhou","year":"2016","journal-title":"Arch. Pharm."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206821000067?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206821000067?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T08:16:06Z","timestamp":1758615366000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206821000067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":50,"alternative-id":["S0045206821000067"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2021.104630","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design and synthesis of methoxyphenyl- and coumarin-based chalcone derivatives as anti-inflammatory agents by inhibition of NO production and down-regulation of NF-\u03baB in LPS-induced RAW264.7 macrophage cells","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2021.104630","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104630"}}