{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:44:26Z","timestamp":1792449866395,"version":"4.5.0"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.bioorg.2021.104709","type":"journal-article","created":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T09:40:45Z","timestamp":1612863645000},"page":"104709","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Antioxidant and anti-sickling activity of glucal-based triazoles compounds \u2013 An in vitro and in silico study"],"prefix":"10.1016","volume":"109","author":[{"given":"Rodinei","family":"Vieira Veloso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anwar","family":"Shamim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yann","family":"Lamarrey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9lio A.","family":"Stefani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Mozer Sciani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2021.104709_b0005","doi-asserted-by":"crossref","first-page":"976","DOI":"10.3389\/fphys.2019.00976","article-title":"The effect of antioxidants on the properties of red blood cells from patients with sickle cell anemia","volume":"10","author":"Al Balushi","year":"2019","journal-title":"Front Physiol."},{"key":"10.1016\/j.bioorg.2021.104709_b0010","doi-asserted-by":"crossref","unstructured":"A.C.S. Alves, T. Munhoz, F.G.N. Soares, L. Rockenbach, B. Gauer; D.F. Kawano, G.L.V. Poser, S.C. Garcia, V.L.E. Lima, Synthesis and in vitro evaluation of 1,2,3-triazole-4-chloromethylcoumarins with antioxidant activity, Lett. Drug Design Discov., v. 15, n. 7, 2018.","DOI":"10.2174\/1570180814666171011165051"},{"key":"10.1016\/j.bioorg.2021.104709_b0015","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.mcna.2016.09.009","article-title":"Sickle cell disease - a brief update","volume":"101","author":"Azar","year":"2017","journal-title":"Med. Clin. N. Am."},{"issue":"3","key":"10.1016\/j.bioorg.2021.104709_b0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0009744","article-title":"Discovery of fragment molecules that bind the human peroxiredoxin 5 active site","volume":"5","author":"Barelier","year":"2010","journal-title":"PLoS One."},{"key":"10.1016\/j.bioorg.2021.104709_b0025","doi-asserted-by":"crossref","unstructured":"E. Bonandi, M.S. Christodoulou, G. Fumagalli, D. Perdicchia, G. Rastelli, D. Passarella, The 1,2,3-triazole ring as a bioisostere in medicinal chemistry. Drug Disc. Today, v. 22, n. 10, 2017.","DOI":"10.1016\/j.drudis.2017.05.014"},{"issue":"6","key":"10.1016\/j.bioorg.2021.104709_b0030","doi-asserted-by":"crossref","first-page":"120","DOI":"10.7324\/JAPS.2015.50620","article-title":"Evaluation as antioxidant agents of 1,2,4-triazole derivatives: effects of essential functional groups","volume":"5","author":"Cetin","year":"2015","journal-title":"J. App. Pharm. Sci."},{"issue":"12","key":"10.1016\/j.bioorg.2021.104709_b0035","doi-asserted-by":"crossref","first-page":"3284","DOI":"10.1021\/ci500467k","article-title":"iLOGP: a simple, robust, and efficient description of n-octanol\/water partition coefficient for drug design using the GB\/SA approach","volume":"54","author":"Daina","year":"2014","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.bioorg.2021.104709_b0040","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1002\/cmdc.201600182","article-title":"A BOILED-Egg to predict gastrointestinal absorption and brain penetration of small molecules","volume":"11","author":"Daina","year":"2016","journal-title":"Chem. Med. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2021.104709_b0045","first-page":"61","article-title":"Radicais livres: conceitos, doen\u00e7as relacionadas, sistema de defesa e estresse oxidativo","volume":"43","author":"Ferreira","year":"1997","journal-title":"Rev. Assoc. M\u00e9d. Bras."},{"issue":"6","key":"10.1016\/j.bioorg.2021.104709_b0050","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1021\/jm901265h","article-title":"Synthesis, biological activity, and molecular modeling studies of 1H\u20131,2,3-Triazole derivatives of carbohydrates as \u03b1-glucosidases inhibitors","volume":"53","author":"Ferreira","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2021.104709_b0055","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1016\/j.ijbiomac.2016.09.073","article-title":"Sickle cell disease: Its molecular mechanism and the one drug that treats it","volume":"93","author":"Ferrone","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"issue":"63","key":"10.1016\/j.bioorg.2021.104709_b0060","doi-asserted-by":"crossref","first-page":"8765","DOI":"10.1021\/acs.jafc.5b03839","article-title":"Use and abuse of the DPPH(\u2022) radical","volume":"14","author":"Foti","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bioorg.2021.104709_b0065","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.freeradbiomed.2003.11.032","article-title":"The biochemistry of nitric oxide, nitrite and hemoglobin: role in blood flow regulation","volume":"15","author":"Gladwin","year":"2004","journal-title":"Free Radic. Biol. Med."},{"issue":"8","key":"10.1016\/j.bioorg.2021.104709_b0070","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.lfs.2005.05.103","article-title":"Antioxidant and antiradical activities of L-carnitine","volume":"78","author":"G\u00fcl\u00e7in","year":"2006","journal-title":"Life Sci."},{"issue":"3","key":"10.1016\/j.bioorg.2021.104709_b0075","doi-asserted-by":"crossref","first-page":"105","DOI":"10.18596\/jotcsa.23635","article-title":"Synthesis characterization, and antioxidant activities of novel 1-(morpholine-4-yl-methyl)-3-alkyl(aryl)-4-[4-(dimethylamino)-benzylidenamino]-4,5-dihydro-1H-1,2,4-triazol-5-ones","volume":"3","author":"G\u00fcrsoy-Kol","year":"2016","journal-title":"J. Turkish Chem. Soc., Section A Chem."},{"issue":"5","key":"10.1016\/j.bioorg.2021.104709_b0080","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1590\/S0103-50532012000500010","article-title":"Synthesis, urease inhibition, antioxidant and antibacterial studies of some 4-amino-5-aryl-3h-1,2,4-triazole-3-thiones and their 3,6-disubstituted 1,2,4-triazolo[3,4-b]1,3,4-thiadiazole derivatives","volume":"23","author":"Hanif","year":"2012","journal-title":"J. Braz. Chem. Soc."},{"key":"10.1016\/j.bioorg.2021.104709_b0085","series-title":"Comprehensive Medicinal Chemistry II","first-page":"43","article-title":"Computer-assisted drug design: quantitative structure\u2013activity relationship \u2013 a historical perspective and the future","author":"Hansch","year":"2007"},{"key":"10.1016\/j.bioorg.2021.104709_b0090","doi-asserted-by":"crossref","first-page":"52","DOI":"10.5581\/1516-8484.20130015","article-title":"Protective effect of flavonoids against reactive oxygen species production in sickle cell anemia patients treated with hydroxyurea","volume":"35","author":"Henneberg","year":"2013","journal-title":"Rev. Bras. Hematol. Hemoter."},{"key":"10.1016\/j.bioorg.2021.104709_b0095","doi-asserted-by":"crossref","unstructured":"B. Hofmann, H.J. Hecht, L. Flohe, Peroxiredoxins, Biol. Chem., v. 383, p. 347\u2013364, 2002.","DOI":"10.1515\/BC.2002.040"},{"key":"10.1016\/j.bioorg.2021.104709_b0100","doi-asserted-by":"crossref","first-page":"4894","DOI":"10.1074\/jbc.M609955200","article-title":"Structural basis of peroxide-mediated changes in human hemoglobin: a novel oxidative pathway","volume":"282","author":"Jia","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bioorg.2021.104709_b0105","doi-asserted-by":"crossref","unstructured":"A. Kashyap, O. Silakari, Triazoles: Multidimensional 5-Membered Nucleus for Designing Multitargeting Agents. In: Key Heterocycle Cores for Designing Multitargeting Molecules. Ed. Om Silakari., p. 323-342, 2018.","DOI":"10.1016\/B978-0-08-102083-8.00009-1"},{"issue":"9","key":"10.1016\/j.bioorg.2021.104709_b0110","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1039\/C7MT00104E","article-title":"Targeting \u03b2Cys93 in hemoglobin S with an antisickling agent possessing dual allosteric and antioxidant effects","volume":"9","author":"Kassa","year":"2017","journal-title":"Metallomics."},{"key":"10.1016\/j.bioorg.2021.104709_b0115","doi-asserted-by":"crossref","first-page":"931","DOI":"10.3389\/fphys.2019.00931","article-title":"Antisickling drugs targeting \u03b2Cys93 reduce iron oxidation and oxidative changes in sickle cell hemoglobin","volume":"10","author":"Kassa","year":"2019","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bioorg.2021.104709_b0120","doi-asserted-by":"crossref","first-page":"30451","DOI":"10.1074\/jbc.274.43.30451","article-title":"Cloning and characterization of AOEB166, a novel mammalian antioxidant enzyme of the peroxiredoxin family","volume":"274","author":"Knoops","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.bioorg.2021.104709_b0125","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1089\/ars.2010.3584","article-title":"Peroxiredoxin 5: structure, mechanism, and function of the mammalian atypical 2-Cys peroxiredoxin","volume":"15","author":"Knoops","year":"2011","journal-title":"Antioxid Redox Signal."},{"issue":"10","key":"10.1016\/j.bioorg.2021.104709_b0130","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s11094-011-0509-y","article-title":"Synthesis and antioxidant activity of new 1,2,4-triazole derivatives","volume":"44","author":"Kochikyan","year":"2011","journal-title":"Pharm. Chem. J."},{"key":"10.1016\/j.bioorg.2021.104709_b0135","doi-asserted-by":"crossref","unstructured":"R.I. Krutilina, A.V. Kropotov, C. Leutenegger, V.B. Serikov, Migrating leukocytes are the source of peroxiredoxin V during inflammation in the airways, J Inflamm., v. 3, n. 13, 2006.","DOI":"10.1186\/1476-9255-3-13"},{"key":"10.1016\/j.bioorg.2021.104709_b0140","doi-asserted-by":"crossref","unstructured":"S.S. Kumar, H.P. Kavitha, Synthesis and biological applications of triazole derivatives \u2013 A review, Mini-Rev. Org. Chem. v.10, 2013.","DOI":"10.2174\/1570193X11310010004"},{"issue":"18","key":"10.1016\/j.bioorg.2021.104709_b0145","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.2165\/11596540-000000000-00000","article-title":"Triazole antifungal agents in invasive fungal infections: a comparative review","volume":"71","author":"Lass-Fl\u00f6rl","year":"2011","journal-title":"Drugs"},{"issue":"46","key":"10.1016\/j.bioorg.2021.104709_b0150","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(00)00129-0","article-title":"Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings","volume":"1","author":"Lipinski","year":"2001","journal-title":"Adv. Drug. Deliv. Rev."},{"key":"10.1016\/j.bioorg.2021.104709_b0155","doi-asserted-by":"crossref","unstructured":"Z. Liu, T. Zhou, A.C. Ziegler, P. Dimitrion, L. Zuo, Oxidative stress in neurodegenerative diseases: from molecular mechanisms to clinical applications., v. 2017 p.11, 2017.","DOI":"10.1155\/2017\/2525967"},{"issue":"6","key":"10.1016\/j.bioorg.2021.104709_b0160","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.5936\/csbj.201302011","article-title":"Current progress in structure-based rational drug design marks a new mindset in drug discovery","volume":"5","author":"Lounnas","year":"2013","journal-title":"Comput. Struct. Biotechnol. J."},{"issue":"2","key":"10.1016\/j.bioorg.2021.104709_b0165","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1021\/acscentsci.8b00718","article-title":"Drug-membrane permeability across chemical space","volume":"5","author":"Menichetti","year":"2019","journal-title":"ACS Cent Sci."},{"issue":"1","key":"10.1016\/j.bioorg.2021.104709_b0170","doi-asserted-by":"crossref","first-page":"31","DOI":"10.12816\/0025348","article-title":"Methods for determining the antioxidant activity: a review","volume":"11","author":"Moharram","year":"2014","journal-title":"Alexandria J. Food Sci. Tech."},{"key":"10.1016\/j.bioorg.2021.104709_b0175","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0891-5849(02)01241-8","article-title":"Dietary flavonoid iron complexes as cytoprotective superoxide radical scavengers","volume":"34","author":"Moridani","year":"2003","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bioorg.2021.104709_b0180","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1021\/acs.molpharmaceut.8b00108","article-title":"A triazole disulfide compound increases the affinity of hemoglobina for oxygen and reduces the sickling of human sickle cells","volume":"15","author":"Nakagawa","year":"2018","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.bioorg.2021.104709_b0185","unstructured":"NATIONAL TOXICOLOGY PROGRAM. Chemical Information Review Document for Hydroxyurea [CAS No. 127-07-1], 2011."},{"issue":"1","key":"10.1016\/j.bioorg.2021.104709_b0190","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/00000441-198607000-00001","article-title":"Antioxidants in sickle cell disease: the in vitro effects of ascorbic acid","volume":"292","author":"Alachant","year":"1986","journal-title":"Am. J. Med. Sci."},{"key":"10.1016\/j.bioorg.2021.104709_b0195","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0022-2143(97)90062-7","article-title":"Increased red cell glutamine availability in sickle cell anemia: demonstration of increased active transport, affinity, and increased glutamate level in intact red cells","volume":"130","author":"Niihara","year":"1997","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.bioorg.2021.104709_b0200","unstructured":"OECD GUIDELINE FOR TESTING OF CHEMICALS. Test No. 423: Acute Oral toxicity - Acute Toxic Class Method, 2001."},{"issue":"2","key":"10.1016\/j.bioorg.2021.104709_b0205","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1590\/2177-9465-ean-2019-0194","article-title":"Fatores de risco para mortalidade em pacientes com doen\u00e7a falciforme: uma revis\u00e3o integrativa","volume":"24","author":"Pompeo","year":"2020","journal-title":"Esc. Anna. Nery."},{"key":"10.1016\/j.bioorg.2021.104709_b0210","doi-asserted-by":"crossref","first-page":"3","DOI":"10.5581\/1516-8484.20130008","article-title":"Oxidative stress in sickle cell disease","volume":"35","author":"Queiroz","year":"2013","journal-title":"Rev. Bras. Hematol. Hemoter."},{"key":"10.1016\/j.bioorg.2021.104709_b0215","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1016\/S0140-6736(10)61029-X","article-title":"Sickle-cell disease","volume":"376","author":"Rees","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.bioorg.2021.104709_b0220","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1182\/blood.V78.10.2753.2753","article-title":"Hydroxyl radical formation by sickle erythrocyte membranes: role of pathologic iron deposits and cytoplasmic reducing agents","volume":"78","author":"Repka","year":"1991","journal-title":"Blood."},{"key":"10.1016\/j.bioorg.2021.104709_b0225","first-page":"39","article-title":"Oxygen toxicity, free radicals and antioxidants in human disease: Biochemical implications in atherosclerosis and the problems of premature neonates","volume":"29","author":"Rice-Evans","year":"1995","journal-title":"Essays Biochem."},{"key":"10.1016\/j.bioorg.2021.104709_b0230","first-page":"5653","article-title":"Synthesis of stannyl-substituted D-glucal derivatives via palladium-catalyzed regioselective hydrostannation and their synthetic applications","volume":"1","author":"Shamim","year":"2016","journal-title":"Chem. Select"},{"key":"10.1016\/j.bioorg.2021.104709_b0235","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s11030-014-9564-0","article-title":"Synthesis of C-glycosyl-bis-1,2,3-triazole derivatives from 3,4,6-tri-O-acetyl-D-glucal","volume":"19","author":"Shamim","year":"2015","journal-title":"Mol. Divers."},{"key":"10.1016\/j.bioorg.2021.104709_b0240","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.tetlet.2017.01.059","article-title":"Synthesis of a library of glucal-derived triazoles via copper-catalyzed azide\u2013alkyne cyclization","volume":"58","author":"Shamim","year":"2017","journal-title":"Tetrah. Let."},{"key":"10.1016\/j.bioorg.2021.104709_b0245","doi-asserted-by":"crossref","first-page":"5836","DOI":"10.1016\/j.tetlet.2015.08.052","volume":"56","author":"Shamim","year":"2015","journal-title":"Tetrahedron Letters."},{"key":"10.1016\/j.bioorg.2021.104709_b0250","doi-asserted-by":"crossref","first-page":"5183","DOI":"10.1055\/s-0036-1589090","article-title":"Synthesis of glycosyl azides and their applications using CuAAC Click chemistry to generate bis- and tris(triazolyl)glycosyl derivatives","volume":"49","author":"Shamim","year":"2017","journal-title":"Synthesis"},{"key":"10.1016\/j.bioorg.2021.104709_b0255","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1016\/j.tetlet.2012.01.102","article-title":"Synthesis of 1,2,3-triazolylpyranosides through click chemistry reaction","volume":"53","author":"Stefani","year":"2012","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.bioorg.2021.104709_b0260","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.bcmd.2015.11.007","article-title":"The investigation of resveratrol","volume":"58","author":"Theodorou","year":"2016","journal-title":"Blood Cells, Mol. Dis."},{"key":"10.1016\/j.bioorg.2021.104709_b0265","unstructured":"UNITED STATES ENVIRONMENTAL PROTECTION AGENCY. Health Effects Test Guidelines OPPTS 870.1000 Acute Toxicity Testing\u2014Background; 2002."},{"issue":"6","key":"10.1016\/j.bioorg.2021.104709_b0270","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1093\/bioinformatics\/bty707","article-title":"AdmetSAR 2.0: web-service for prediction and optimization of chemical ADMET properties","volume":"35","author":"Yang","year":"2018","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bioorg.2021.104709_b0275","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1074\/jbc.C400496200","article-title":"Reduction of cysteine sulfinic acid by sulfiredoxin is specific to 2-cys peroxiredoxins","volume":"280","author":"Woo","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.bioorg.2021.104709_b0280","first-page":"53","article-title":"Antioxidant intake in sickle cell disease","volume":"2","author":"Wright","year":"2014","journal-title":"Int. J. Clin. Nutr."},{"issue":"12","key":"10.1016\/j.bioorg.2021.104709_b0285","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1021\/tx900189p","article-title":"Quantitative structure-activity relationship modeling of rat acute toxicity by oral exposure","volume":"22","author":"Zhu","year":"2009","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.bioorg.2021.104709_b0290","first-page":"o53","volume":"E71","author":"Zukerman-Schpector","year":"2015","journal-title":"Acta Crystallogr."},{"issue":"9","key":"10.1016\/j.bioorg.2021.104709_b9000","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1002\/2211-5463.12103","article-title":"Differential heme release from various hemoglobin redox states and the upregulation of cellular heme oxygenase-1","volume":"6","author":"Kassa","year":"2016","journal-title":"FEBS Open Bio."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206821000857?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206821000857?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T08:15:51Z","timestamp":1758615351000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206821000857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":59,"alternative-id":["S0045206821000857"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2021.104709","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antioxidant and anti-sickling activity of glucal-based triazoles compounds \u2013 An in vitro and in silico study","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2021.104709","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104709"}}