{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T20:48:29Z","timestamp":1772657309231,"version":"3.50.1"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.bioorg.2021.104747","type":"journal-article","created":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T12:46:13Z","timestamp":1614948373000},"page":"104747","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Trehalose diamide glycolipids augment antigen-specific antibody responses in a Mincle-dependent manner"],"prefix":"10.1016","volume":"110","author":[{"given":"Amy T.","family":"Lynch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chihiro","family":"Motozono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy J.","family":"Foster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristel","family":"Kodar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma M.","family":"Dangerfield","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sho","family":"Yamasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. Neil","family":"Wedlock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mattie S.M.","family":"Timmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bridget L.","family":"Stocker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2021.104747_b0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pervac.2011.05.001","volume":"1","author":"Bonanni","year":"2011","journal-title":"Persp. Vaccinol."},{"key":"10.1016\/j.bioorg.2021.104747_b0010","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.pervac.2011.05.002","volume":"1","author":"Leo","year":"2011","journal-title":"Persp. Vaccinol."},{"key":"10.1016\/j.bioorg.2021.104747_b0015","doi-asserted-by":"crossref","first-page":"252","DOI":"10.3390\/vaccines2020252","volume":"2","author":"Bergmann-Leitner","year":"2014","journal-title":"Vaccines"},{"key":"10.1016\/j.bioorg.2021.104747_b0020","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1177\/2051013613480144","volume":"1","author":"Fox","year":"2013","journal-title":"Ther. Adv. Vaccines"},{"key":"10.1016\/j.bioorg.2021.104747_b0025","doi-asserted-by":"crossref","first-page":"5039","DOI":"10.4049\/jimmunol.163.9.5039","volume":"163","author":"Matsumoto","year":"1999","journal-title":"J Immunol."},{"key":"10.1016\/j.bioorg.2021.104747_b0030","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1038\/ni.1651","volume":"9","author":"Yamasaki","year":"2008","journal-title":"Nat Immunol."},{"key":"10.1016\/j.bioorg.2021.104747_b0035","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.3389\/fimmu.2017.01940","volume":"8","author":"Braganza","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bioorg.2021.104747_b0040","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1084\/jem.20091750","volume":"206","author":"Ishikawa","year":"2009","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bioorg.2021.104747_b0045","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.4049\/jimmunol.0904013","volume":"184","author":"Schoenen","year":"2010","journal-title":"J Immunol."},{"key":"10.1016\/j.bioorg.2021.104747_b0050","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1084\/jem.20081445","volume":"206","author":"Werninghaus","year":"2009","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bioorg.2021.104747_b0055","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.smim.2018.10.003","volume":"39","author":"Pedersen","year":"2018","journal-title":"Seminars Immunol."},{"key":"10.1016\/j.bioorg.2021.104747_b0060","doi-asserted-by":"crossref","first-page":"7067","DOI":"10.1016\/j.vaccine.2011.07.025","volume":"29","author":"Fomsgaard","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.bioorg.2021.104747_b0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0006950","volume":"4","author":"Gram","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.bioorg.2021.104747_b0070","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.4161\/hv.6.12.13143","volume":"6","author":"Ottenhoff","year":"2010","journal-title":"Hum. Vaccines"},{"key":"10.1016\/j.bioorg.2021.104747_b0075","first-page":"7","volume":"5","author":"Nguyen","year":"2020","journal-title":"Vaccines"},{"key":"10.1016\/j.bioorg.2021.104747_b0080","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1128\/IAI.73.1.250-257.2005","volume":"73","author":"Hovav","year":"2005","journal-title":"Infect Immun"},{"key":"10.1016\/j.bioorg.2021.104747_b0085","doi-asserted-by":"crossref","first-page":"5100","DOI":"10.1039\/C5CC00085H","volume":"51","author":"van der Peet","year":"2015","journal-title":"Chem Commun"},{"key":"10.1016\/j.bioorg.2021.104747_h0090","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1039\/C9OB02397F","volume":"18","author":"Foster","year":"2020","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.bioorg.2021.104747_h0095","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1021\/acs.jmedchem.9b01598","volume":"63","author":"Ryter","year":"2020","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2021.104747_h0100","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3389\/fimmu.2019.00338","volume":"10","author":"Smith","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bioorg.2021.104747_b0095","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1021\/acs.jmedchem.7b01468","volume":"61","author":"Foster","year":"2018","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2021.104747_b0100","doi-asserted-by":"crossref","unstructured":"A. A. Khan, S. H. Chee, R. J. McLaughlin, R. J.; J. L. Harper, F. Kamena, M. S. M. Timmer, B. L. Stocker, ChemBioChem, 12 (2011) 2572-2576.","DOI":"10.1002\/cbic.201100451"},{"key":"10.1016\/j.bioorg.2021.104747_b0105","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.tet.2017.11.076","volume":"12","author":"Khan","year":"2018","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bioorg.2021.104747_b0110","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/cbic.201300674","volume":"15","author":"Stocker","year":"2014","journal-title":"ChemBioChem"},{"key":"10.1016\/j.bioorg.2021.104747_b0115","doi-asserted-by":"crossref","first-page":"7593","DOI":"10.1021\/acs.joc.7b03269","volume":"15","author":"Bird","year":"2018","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bioorg.2021.104747_b0120","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1177\/1753425916651132","volume":"6","author":"Huber","year":"2016","journal-title":"Innate Immun."},{"key":"10.1016\/j.bioorg.2021.104747_b0125","doi-asserted-by":"crossref","first-page":"17438","DOI":"10.1073\/pnas.1312649110","volume":"110","author":"Furukawa","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bioorg.2021.104747_b0130","doi-asserted-by":"crossref","first-page":"28457","DOI":"10.1074\/jbc.M113.497149","volume":"288","author":"Feinberg","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bioorg.2021.104747_b0135","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1073\/pnas.1612421114","volume":"114","author":"Decout","year":"2017","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bioorg.2021.104747_b0140","first-page":"5374","volume":"8","author":"S\u00f6ldner","year":"2018","journal-title":"Sci. Reports"},{"key":"10.1016\/j.bioorg.2021.104747_b0145","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1002\/cbic.201402506","volume":"16","author":"Kodar","year":"2015","journal-title":"ChemBioChem"},{"key":"10.1016\/j.bioorg.2021.104747_b0150","doi-asserted-by":"crossref","first-page":"2990","DOI":"10.1021\/acschembio.7b00797","volume":"12","author":"Zheng","year":"2017","journal-title":"ACS Chem Biol"},{"key":"10.1016\/j.bioorg.2021.104747_b0155","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1081\/PDT-120003494","volume":"7","author":"Waterman","year":"2002","journal-title":"Pharm. Dev. Technol."},{"key":"10.1016\/j.bioorg.2021.104747_b0160","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1002\/cbdv.200790169","volume":"4","author":"Testa","year":"2007","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.bioorg.2021.104747_b0165","doi-asserted-by":"crossref","unstructured":". R. Barret, \u2018Pharmacophore\u2019 in Medicinal Chemistry Fundamentals, Elesevier Ltd. (2018) chpt 8, 119-133.","DOI":"10.1016\/B978-1-78548-288-5.50008-1"},{"key":"10.1016\/j.bioorg.2021.104747_b0170","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1007\/s12272-017-0969-z","volume":"40","author":"Bastola","year":"2017","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.bioorg.2021.104747_b0175","doi-asserted-by":"crossref","first-page":"3464","DOI":"10.1016\/j.vaccine.2020.02.086","volume":"38","author":"Wilson-Welder","year":"2020","journal-title":"Vaccine"},{"key":"10.1016\/j.bioorg.2021.104747_b0180","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.vetmic.2015.02.019","volume":"177","author":"Zheng","year":"2015","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.bioorg.2021.104747_b0185","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.1002\/ece3.6146","volume":"10","author":"Garwood","year":"2020","journal-title":"Ecol. Evol."},{"key":"10.1016\/j.bioorg.2021.104747_b0190","volume":"9","author":"Ziegler","year":"2014","journal-title":"PLOS ONE"},{"key":"10.1016\/j.bioorg.2021.104747_b0195","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0008-6215(94)00312-4","volume":"268","author":"Garc\u00eda Fern\u00e1ndez","year":"1995","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.bioorg.2021.104747_b0200","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0008-6215(92)84254-P","volume":"237","author":"Johnson","year":"1992","journal-title":"Carbohydr. Res"},{"key":"10.1016\/j.bioorg.2021.104747_b0205","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1021\/jo302231v","volume":"78","author":"Paul","year":"2013","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bioorg.2021.104747_b0210","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1021\/ar00129a001","volume":"19","author":"Porter","year":"1986","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.bioorg.2021.104747_b0215","unstructured":"Schr\u00f6dinger Release 2020-4: Core Hopping, Schr\u00f6dinger, LLC, New York, NY, 2020."},{"key":"10.1016\/j.bioorg.2021.104747_b0220","doi-asserted-by":"crossref","first-page":"21222","DOI":"10.1074\/jbc.M116.749515","volume":"291","author":"Feinberg","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bioorg.2021.104747_b0225","doi-asserted-by":"crossref","first-page":"10902","DOI":"10.1039\/C6CC05631H","volume":"52","author":"Shah","year":"2016","journal-title":"S. J. Williams Chem Commun"},{"key":"10.1016\/j.bioorg.2021.104747_b0230","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1046\/j.1365-2567.2001.01337.x","volume":"104","author":"Nakae","year":"2001","journal-title":"Y. Iwakura Y. Immunol."},{"key":"10.1016\/j.bioorg.2021.104747_b0235","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10719-018-09857-9","volume":"36","author":"Stocker","year":"2019","journal-title":"Glycoconjugate J."},{"key":"10.1016\/j.bioorg.2021.104747_b0240","doi-asserted-by":"crossref","first-page":"6670","DOI":"10.3390\/molecules20046670","volume":"20","author":"Rambaruth","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.bioorg.2021.104747_b0245","doi-asserted-by":"crossref","unstructured":". D. L. Lindenwald, J. T. Monteiro, S. Rautenschlein, J. Meens, K. Jung, S. C. Becker SC, Lepenies B. 18 (2020)110047.","DOI":"10.1016\/j.vetimm.2020.110047"},{"key":"10.1016\/j.bioorg.2021.104747_b0250","doi-asserted-by":"crossref","first-page":"4232","DOI":"10.1039\/c0ob00226g","volume":"8","author":"Patel","year":"2010","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.bioorg.2021.104747_b0255","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/iid3.186","article-title":"Immunity","volume":"5","author":"Kodar","year":"2017","journal-title":"Inflamm. Dis."},{"key":"10.1016\/j.bioorg.2021.104747_b0260","first-page":"e01375","volume":"9","author":"Bridgeman","year":"2020","journal-title":"Recour. Announc."},{"key":"10.1016\/j.bioorg.2021.104747_b0265","first-page":"2163","volume":"29","author":"Frey","year":"1968","journal-title":"Am. J. Vet. Res."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206821001243?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206821001243?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T08:20:01Z","timestamp":1758615601000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206821001243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":55,"alternative-id":["S0045206821001243"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2021.104747","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Trehalose diamide glycolipids augment antigen-specific antibody responses in a Mincle-dependent manner","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2021.104747","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"104747"}}