{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:39:20Z","timestamp":1791841160696,"version":"4.3.4"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.bioorg.2021.105118","type":"journal-article","created":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T06:15:25Z","timestamp":1624515325000},"page":"105118","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Synthesis and comparison of in vitro dual anti-infective activities of novel naphthoquinone hybrids and atovaquone"],"prefix":"10.1016","volume":"114","author":[{"given":"Chan\u00e9","family":"Erasmus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janine","family":"Aucamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frans J.","family":"Smit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronnett","family":"Seldon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Jordaan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Digby F.","family":"Warner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2327-0551","authenticated-orcid":false,"given":"David D.","family":"N'Da","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2021.105118_b0005","unstructured":"WHO 2020a, Global Tuberculosis Report 2020; https:\/\/www.who.int\/publications\/i\/item\/9789240013131 [Date of access: 03 May 2021]."},{"key":"10.1016\/j.bioorg.2021.105118_b0010","article-title":"Mycobacterium tuberculosis H37Rv: in silico drug targets identification by metabolic pathways analysis","volume":"2014","author":"Amir","year":"2014","journal-title":"J. Evol. Biol."},{"key":"10.1016\/j.bioorg.2021.105118_b0015","unstructured":"WHO 2020b, Global Health Observatory (GHO) data: Leishmaniasis; https:\/\/www.who.int\/gho\/neglected_diseases\/leishmaniasis\/en\/ . [Date of access: 4 June 2020]."},{"key":"10.1016\/j.bioorg.2021.105118_b0020","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.genrep.2017.09.003","article-title":"Recent advancement and treatment of leishmaniasis based on pharmacoinformatics approach: Current and future outlook","volume":"9","author":"Ansari","year":"2017","journal-title":"Gene Rep."},{"key":"10.1016\/j.bioorg.2021.105118_b0025","doi-asserted-by":"crossref","first-page":"750","DOI":"10.12688\/f1000research.11120.1","article-title":"Leishmaniasis: a review","volume":"6","author":"Torres-Guerrero","year":"2017","journal-title":"F1000Res."},{"issue":"12","key":"10.1016\/j.bioorg.2021.105118_b0030","doi-asserted-by":"crossref","first-page":"e0006052","DOI":"10.1371\/journal.pntd.0006052","article-title":"Drug resistance and treatment failure in leishmaniasis: A 21st century challenge","volume":"11","author":"Ponte-Sucre","year":"2017","journal-title":"PloS Negl. Trop. Dis."},{"issue":"6","key":"10.1016\/j.bioorg.2021.105118_b0035","doi-asserted-by":"crossref","first-page":"e0005641","DOI":"10.1371\/journal.pntd.0005641","article-title":"Increased miltefosine tolerance in clinical isolates of Leishmania donovani is associated with reduced drug accumulation, increased infectivity and resistance to oxidative stress","volume":"11","author":"Deep","year":"2017","journal-title":"PloS Negl. Trop. Dis."},{"issue":"9","key":"10.1016\/j.bioorg.2021.105118_b0040","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.tim.2015.05.002","article-title":"The potential impact of coinfection on antimicrobial chemotherapy and drug resistance","volume":"23","author":"Birger","year":"2015","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.bioorg.2021.105118_b0045","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/1756-3305-6-79","article-title":"Co-infection of tuberculosis and parasitic diseases in humans: a systematic review","volume":"6","author":"Li","year":"2013","journal-title":"Parasit Vectors"},{"key":"10.1016\/j.bioorg.2021.105118_b0050","doi-asserted-by":"crossref","first-page":"3917","DOI":"10.3390\/molecules24213917","article-title":"Synthesis and Antiplasmodial Activity of 1,2,3-Triazole-Naphthoquinone Conjugates","volume":"24","author":"Oramas-Royo","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.bioorg.2021.105118_b0055","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2019.01995","article-title":"Microtiter Screening Reveals Oxygen-Dependent Antimicrobial Activity of Natural Products Against Mastitis-Causing Bacteria","volume":"10","author":"Ferguson","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.bioorg.2021.105118_b0060","doi-asserted-by":"crossref","first-page":"680","DOI":"10.3390\/pr7100680","article-title":"Antifungal Activity of Euclea divinorum Root and Study of its Ethnobotany and Phytopharmacology","volume":"7","author":"Al-Fatimi","year":"2019","journal-title":"Processes"},{"key":"10.1016\/j.bioorg.2021.105118_b0065","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.3390\/ijms20071788","article-title":"Effects of Naphthazarin (DHNQ) Combined with Lawsone (NQ-2-OH) or 1,4-Naphthoquinone (NQ) on the Auxin-Induced Growth of Zea mays L. Coleoptile Segments","volume":"20","author":"Rudnicka","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2021.105118_b0070","article-title":"Synthesis and Screening of Anti-HSV-1 Activity of Thioglucoside Derivatives of Natural Polyhydroxy-1,4-Naphthoquinones","volume":"14","author":"Polonik","year":"2019","journal-title":"Nat. Prod. Commun."},{"issue":"6","key":"10.1016\/j.bioorg.2021.105118_b0075","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1021\/acs.jnatprod.6b01186","article-title":"Naphthoquinones of Sinningia reitzii and Anti-inflammatory\/Antinociceptive Activities of 8-Hydroxydehydrodunnione","volume":"80","author":"Soares","year":"2017","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bioorg.2021.105118_b0080","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/s41419-019-2041-z","article-title":"The natural compound gracillin exerts potent antitumor activity by targeting mitochondrial complex II","volume":"10","author":"Min","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bioorg.2021.105118_b0085","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s40816-019-0111-5","article-title":"Evaluation of anti-ROS and anticancer properties of Tabebuia pallida L. Leaves","volume":"5","author":"Rahman","year":"2019","journal-title":"Clin. Phytosci."},{"key":"10.1016\/j.bioorg.2021.105118_b0090","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.biopha.2018.10.143","article-title":"In vivo antileishmanial efficacy of a naphthoquinone derivate incorporated into a Pluronic\u00ae F127-based polymeric micelle system against Leishmania amazonensis infection","volume":"109","author":"Mendon\u00e7a","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.bioorg.2021.105118_b0095","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1515\/chem-2019-0030","article-title":"Synthesis and antiproliferative evaluation of some 1,4-naphthoquinone derivatives against human cervical cancer cells","volume":"17","author":"Kacmaz","year":"2019","journal-title":"Open Chem."},{"issue":"15","key":"10.1016\/j.bioorg.2021.105118_b0100","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1039\/b802649c","article-title":"The aza-analogues of 1,4-naphthoquinones are potent substrates and inhibitors of plasmodial thioredoxin and glutathione reductases and of human erythrocyte glutathione reductase","volume":"6","author":"Morin","year":"2008","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.bioorg.2021.105118_b0105","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/s12935-019-0925-8","article-title":"The diverse mechanisms and anticancer potential of naphthoquinones","volume":"19","author":"Pereyra","year":"2019","journal-title":"Cancer Cell Int."},{"issue":"3","key":"10.1016\/j.bioorg.2021.105118_b0110","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1039\/C8MD00582F","article-title":"Amide linked redox-active naphthoquinones for the treatment of mitochondrial dysfunction","volume":"10","author":"Woolley","year":"2019","journal-title":"MedChemComm."},{"key":"10.1016\/j.bioorg.2021.105118_b0115","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1007\/s10495-016-1259-9","article-title":"Plumbagin, a plant-derived naphthoquinone metabolite induces mitochondria mediated apoptosis-like cell death in Leishmania donovani: an ultrastructural and physiological study","volume":"21","author":"Awasthi","year":"2016","journal-title":"Apoptosis."},{"key":"10.1016\/j.bioorg.2021.105118_b0120","doi-asserted-by":"crossref","unstructured":"R. Kurtyka, W. Pokora, Z. Tukaj, W. Karcz, Effects of juglone and lawsone on oxidative stress in maize coleoptile cells treated with IAA, AoB Plants 8 (2016) plw073.","DOI":"10.1093\/aobpla\/plw073"},{"issue":"7","key":"10.1016\/j.bioorg.2021.105118_b0125","doi-asserted-by":"crossref","first-page":"5149","DOI":"10.1074\/jbc.M112.419069","article-title":"The naphthoquinone diospyrin is an inhibitor of DNA gyrase with a novel mechanism of action","volume":"288","author":"Karkare","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bioorg.2021.105118_b0130","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1111\/cbdd.13534","article-title":"Design, synthesis, and antimycobacterial activity of novel ciprofloxacin derivatives","volume":"94","author":"Cilliers","year":"2019","journal-title":"Chem. Biol. Drug Des."},{"issue":"36","key":"10.1016\/j.bioorg.2021.105118_b0135","doi-asserted-by":"crossref","first-page":"10220","DOI":"10.1002\/slct.201802002","article-title":"Potential Antileishmanial Activity of a Triazole-Based Hybrid Peptide against Leishmania major","volume":"3","author":"Maji","year":"2018","journal-title":"ChemistrySelect"},{"key":"10.1016\/j.bioorg.2021.105118_b0140","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.ejmech.2017.06.051","article-title":"Triazole derivatives and their anti-tubercular activity","volume":"138","author":"Zhang","year":"2017","journal-title":"Eur. J. Med. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2021.105118_b0145","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1039\/D0MD00291G","article-title":"Exploring the chemical space of 1,2,3-triazolyl triclosan analogs for discovery of new antileishmanial chemotherapeutic agents","volume":"12","author":"Fern\u00e1ndez de Luco","year":"2021","journal-title":"RSC Med. Chem."},{"key":"10.1016\/j.bioorg.2021.105118_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2019.102967","article-title":"Click chemistry-assisted synthesis of novel aminonaphthoquinone-1,2,3-triazole hybrids and investigation of their cytotoxicity and cancer cell cycle alterations","volume":"88","author":"Gholampour","year":"2019","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2021.105118_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.104122","article-title":"Synthesis, trypanocidal and anti-leishmania activity of new triazole-lapachol and nor-lapachol hybrids","volume":"103","author":"Pertino","year":"2020","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2021.105118_b0160","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.ejmech.2014.08.009","article-title":"Sequential synthesis of amino-1,4-naphthoquinone-appended triazoles and triazole-chromene hybrids and their antimycobacterial evaluation","volume":"85","author":"Devi Bala","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2021.105118_b0165","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1021\/jo9614708","article-title":"Efficient Synthesis of Aminonaphthoquinones and Azidobenzohydroquinones: Mechanistic Considerations of the Reaction of Hydrazoic Acid with Quinones. An Overview","volume":"62","author":"Couladouros","year":"1997","journal-title":"J. Org. Chem."},{"issue":"8","key":"10.1016\/j.bioorg.2021.105118_b0170","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.1021\/jo3000095","article-title":"Copper-Catalyzed Azide-Alkyne Cycloaddition Reaction in Water Using Cyclodextrin as a Phase Transfer Catalyst","volume":"77","author":"Shin","year":"2012","journal-title":"J. Org. Chem."},{"issue":"25","key":"10.1016\/j.bioorg.2021.105118_b0175","doi-asserted-by":"crossref","first-page":"5079","DOI":"10.1016\/j.tet.2013.04.091","article-title":"An unexpected copper catalyzed 'reduction' of an arylazide to amine through the formation of a nitrene intermediate","volume":"69","author":"Peng","year":"2013","journal-title":"Tetrahedron"},{"issue":"3","key":"10.1016\/j.bioorg.2021.105118_b0180","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.tetlet.2010.11.080","article-title":"Stereoselective anti-SN2\u2032 Mitsunobu reaction of \u03b1-hydroxy-\u03b1-alkenylsilanes","volume":"52","author":"Higashino","year":"2011","journal-title":"Tetrahedron Lett."},{"issue":"3","key":"10.1016\/j.bioorg.2021.105118_b0185","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1021\/jm049661n","article-title":"In silico prediction of membrane permeability from calculated molecular parameters","volume":"48","author":"Refsgaard","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2021.105118_b0190","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1002\/med.10041","article-title":"Selection criteria for drug-like compounds","volume":"23","author":"Muegge","year":"2003","journal-title":"Med. Res. Rev."},{"issue":"2","key":"10.1016\/j.bioorg.2021.105118_b0195","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0022-1759(86)90368-6","article-title":"Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability","volume":"89","author":"Denizot","year":"1986","journal-title":"J. Immunol. Meth."},{"key":"10.1016\/j.bioorg.2021.105118_b0200","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1023\/A:1015040217741","article-title":"Polar molecular surface as a dominating determinant for oral absorption and brain penetration of drugs","volume":"16","author":"Kelder","year":"1999","journal-title":"Pharm. Res."},{"key":"10.1016\/j.bioorg.2021.105118_b0205","doi-asserted-by":"crossref","first-page":"42717","DOI":"10.1038\/srep42717","article-title":"SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules","volume":"7","author":"Daina","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioorg.2021.105118_b0210","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1021\/ci034243x","article-title":"ESOL: estimating aqueous solubility directly from molecular structure","volume":"44","author":"Delaney","year":"2004","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"10.1016\/j.bioorg.2021.105118_b0215","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1021\/ci200387c","article-title":"Revisiting the general solubility equation: in silico prediction of aqueous solubility incorporating the effect of topographical polar surface area","volume":"52","author":"Ali","year":"2012","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.bioorg.2021.105118_b0220","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(00)00129-0","article-title":"Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings","volume":"46","author":"Lipinski","year":"2001","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"11","key":"10.1016\/j.bioorg.2021.105118_b0225","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/nrd4683","article-title":"Hit and lead criteria in drug discovery for infectious diseases of the developing world","volume":"14","author":"Katsuno","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"issue":"11","key":"10.1016\/j.bioorg.2021.105118_b0230","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1002\/cmdc.201402233","article-title":"Are 1,4- and 1,5-disubstituted 1,2,3-triazoles good pharmacophoric groups?","volume":"9","author":"Massarotti","year":"2014","journal-title":"ChemMedChem."},{"issue":"5","key":"10.1016\/j.bioorg.2021.105118_b0235","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1093\/jac\/dks504","article-title":"Antimalarial pharmacology and therapeutics of atovaquone","volume":"68","author":"Nixon","year":"2013","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.bioorg.2021.105118_b0240","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3762\/bjoc.4.13","article-title":"Trifluoromethyl ethers\u2013synthesis and properties of an unusual substituent","volume":"4","author":"Leroux","year":"2008","journal-title":"Beilstein J. Org. Chem."},{"issue":"6","key":"10.1016\/j.bioorg.2021.105118_b0245","doi-asserted-by":"crossref","first-page":"e1671","DOI":"10.1371\/journal.pntd.0001671","article-title":"An Image-Based High-Content Screening Assay for Compounds Targeting Intracellular Leishmania donovani Amastigotes in Human Macrophages","volume":"6","author":"Siqueira-Neto","year":"2012","journal-title":"PLOS Negl. Trop. Dis."},{"key":"10.1016\/j.bioorg.2021.105118_b0250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/854015","article-title":"Interactions between CYP3A4 and Dietary Polyphenols","volume":"2015","author":"Basheer","year":"2015","journal-title":"Oxid. Med. Cell Longev."},{"issue":"1","key":"10.1016\/j.bioorg.2021.105118_b0255","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s43188-020-00056-z","article-title":"A history of the roles of cytochrome P450 enzymes in the toxicity of drugs","volume":"37","author":"Guengerich","year":"2021","journal-title":"Toxicol. Res."},{"issue":"8","key":"10.1016\/j.bioorg.2021.105118_b0260","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.tips.2020.05.007","article-title":"Can CYP Inhibition Overcome Chemotherapy Resistance?","volume":"41","author":"Ingelman-Sundberg","year":"2020","journal-title":"Trends Pharmacol. Sci."},{"issue":"9","key":"10.1016\/j.bioorg.2021.105118_b0265","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1124\/dmd.115.065326","article-title":"Determination of a Degradation Constant for CYP3A4 by Direct Suppression of mRNA in a Novel Human Hepatocyte Model, HepatoPac","volume":"43","author":"Ramsden","year":"2015","journal-title":"Drug. Metab. Dispos."},{"key":"10.1016\/j.bioorg.2021.105118_b0270","doi-asserted-by":"crossref","first-page":"202","DOI":"10.3389\/fphar.2017.00202","article-title":"Exploring the Role of CYP3A4 Mediated Drug Metabolism in the Pharmacological Modulation of Nitric Oxide Production","volume":"8","author":"P\u00e9rez-del Palacio","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bioorg.2021.105118_b0275","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1186\/1475-2875-13-214","article-title":"Auto-induction of phase I and phase II metabolism of artemisinin in healthy Chinese subjects after oral administration of a new artemisinin-piperaquine fixed combination","volume":"13","author":"Zang","year":"2014","journal-title":"Malar. J."},{"issue":"10","key":"10.1016\/j.bioorg.2021.105118_b0280","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1124\/dmd.116.070839","article-title":"Cytochrome P450 3A4 and CYP3A5-Catalyzed Bioactivation of Lapatinib","volume":"44","author":"Towles","year":"2016","journal-title":"Drug. Metab. Dispos."},{"issue":"1","key":"10.1016\/j.bioorg.2021.105118_b0285","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s00228-002-0424-y","article-title":"Inhibition by atovaquone of CYP2C9-mediated sulphamethoxazole hydroxylamine formation","volume":"58","author":"Miller","year":"2002","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.bioorg.2021.105118_b0290","doi-asserted-by":"crossref","first-page":"28482","DOI":"10.1038\/srep28482","article-title":"Evaluation of the inhibition potential of plumbagin against cytochrome P450 using LC-MS\/MS and cocktail approach","volume":"6","author":"Chen","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioorg.2021.105118_b0295","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.toxlet.2017.09.014","article-title":"Assessment of the inhibition risk of shikonin on cytochrome P450 via cocktail inhibition assay","volume":"281","author":"Tang","year":"2017","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.bioorg.2021.105118_b0300","doi-asserted-by":"crossref","unstructured":"Zhou Y, Hua A, Zhou Q, Geng P, Chen F, Yan L, Wang S, W. C, Inhibitory Effect of Lygodium Root on the Cytochrome P450 3A Enzyme in vitro and in vivo., Drug Des. Devel. Ther. 14 (2020) 1909-1919.","DOI":"10.2147\/DDDT.S249308"},{"issue":"9","key":"10.1016\/j.bioorg.2021.105118_b0305","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1124\/dmd.118.082032","article-title":"Comparison of Antifungal Azole Interactions with Adult Cytochrome P450 3A4 versus Neonatal Cytochrome P450 3A7","volume":"46","author":"Godamudunage","year":"2018","journal-title":"Drug. Metab. Dispos."},{"key":"10.1016\/j.bioorg.2021.105118_b0310","doi-asserted-by":"crossref","first-page":"6441","DOI":"10.1021\/bi300744z","article-title":"1,2,3-Triazole-heme interactions in cytochrome P450: functionally competent triazole-water-heme complexes","volume":"51","author":"Conner","year":"2012","journal-title":"Biochemistry"},{"issue":"11","key":"10.1016\/j.bioorg.2021.105118_b0315","doi-asserted-by":"crossref","first-page":"6748","DOI":"10.1128\/AAC.01178-16","article-title":"Bioluminescent Reporters for Rapid Mechanism of Action Assessment in Tuberculosis Drug Discovery","volume":"60","author":"Naran","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bioorg.2021.105118_b0320","doi-asserted-by":"crossref","first-page":"10118","DOI":"10.1021\/acs.jmedchem.7b01347","article-title":"Novel Antitubercular 6-Dialkylaminopyrimidine Carboxamides from Phenotypic Whole-Cell High Throughput Screening of a SoftFocus Library: Structure-Activity Relationship and Target Identification Studies","volume":"60","author":"Wilson","year":"2017","journal-title":"J. Med. Chem."},{"issue":"2","key":"10.1016\/j.bioorg.2021.105118_b0325","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1007\/s00436-012-3212-3","article-title":"Validation of a simple resazurin-based promastigote assay for the routine monitoring of miltefosine susceptibility in clinical isolates of Leishmania donovani","volume":"112","author":"Kulshrestha","year":"2013","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.bioorg.2021.105118_b0330","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206821004958?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206821004958?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T08:27:39Z","timestamp":1758616059000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206821004958"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":66,"alternative-id":["S0045206821004958"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2021.105118","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and comparison of in vitro dual anti-infective activities of novel naphthoquinone hybrids and atovaquone","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2021.105118","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105118"}}