{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T18:50:45Z","timestamp":1772909445650,"version":"3.50.1"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.bioorg.2021.105215","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T22:04:46Z","timestamp":1627509886000},"page":"105215","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Potent antiplasmodial alkaloids from the rhizobacterium Pantoea agglomerans as hemozoin modulators"],"prefix":"10.1016","volume":"115","author":[{"given":"Bathini","family":"Thissera","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Hallyburton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Che Julius","family":"Ngwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hafsa","family":"Cherif-Silini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed S.I.","family":"Hassane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorna A.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Mutter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manal","family":"Eshelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Usama R.","family":"Abdelmohsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Yaseen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Pradel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lassaad","family":"Belbahri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahaa","family":"Elgendy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lamees","family":"Hegazy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mostafa E.","family":"Rateb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2021.105215_b0005","doi-asserted-by":"crossref","first-page":"112187","DOI":"10.1016\/j.jep.2019.112187","article-title":"Forest Fevers: traditional treatment of malaria in the southern lowlands of Laos","volume":"249","author":"Elliott","year":"2020","journal-title":"J. Ethnopharmacol."},{"issue":"24","key":"10.1016\/j.bioorg.2021.105215_b0010","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1056\/NEJMc0805011","article-title":"Evidence of artemisinin-resistant malaria in western Cambodia","volume":"359","author":"Noedl","year":"2008","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"10.1016\/j.bioorg.2021.105215_b0015","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1056\/NEJMoa0808859","article-title":"Artemisinin resistance in Plasmodium falciparum malaria","volume":"361","author":"Dondorp","year":"2009","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.bioorg.2021.105215_b0020","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s12936-019-2701-6","article-title":"K13-propeller gene polymorphisms in Plasmodium falciparum parasite population in malaria affected countries: a systematic review of prevalence and risk factors","volume":"18","author":"Ocan","year":"2019","journal-title":"Malar. J."},{"key":"10.1016\/j.bioorg.2021.105215_b0025","doi-asserted-by":"crossref","first-page":"14216","DOI":"10.1073\/pnas.0804628105","article-title":"Benefits of using multiple first-line therapies against malaria","volume":"105","author":"Boni","year":"2008","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"3","key":"10.1016\/j.bioorg.2021.105215_b0030","doi-asserted-by":"crossref","DOI":"10.1128\/microbiolspec.EI10-0013-2016","article-title":"Artemisinin-resistant Plasmodium falciparum malaria","volume":"4","author":"Fairhurst","year":"2016","journal-title":"Microbiol. Spectrum."},{"issue":"3","key":"10.1016\/j.bioorg.2021.105215_b0035","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1021\/acs.jnatprod.9b01285","article-title":"Natural products as sources of new drugs over the nearly four decades from 01\/1981 to 09\/2019","volume":"83","author":"Newman","year":"2020","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bioorg.2021.105215_b0040","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1021\/acs.jnatprod.5b01055","article-title":"Natural products as sources of new drugs from 1981 to 2014","volume":"79","author":"Newman","year":"2016","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bioorg.2021.105215_b0045","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ijmm.2013.08.011","article-title":"Antibiotics from neglected bacterial sources","volume":"304","author":"Pidot","year":"2014","journal-title":"Int. J. Med. Microbiol."},{"key":"10.1016\/j.bioorg.2021.105215_b0050","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.3390\/ijms20163989","article-title":"Durum Wheat Stress Tolerance Induced by Endophyte Pantoea agglomerans with Genes Contributing to Plant Functions and Secondary Metabolite Arsenal","volume":"20","author":"Cherif-Silini","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"24","key":"10.1016\/j.bioorg.2021.105215_b0055","doi-asserted-by":"crossref","first-page":"6486","DOI":"10.1128\/JB.01122-10","article-title":"Genome sequence of the biocontrol agent Pantoea agglomerans strain C9\u20131","volume":"192","author":"Smits","year":"2010","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.bioorg.2021.105215_b0060","doi-asserted-by":"crossref","first-page":"4047","DOI":"10.2147\/IDR.S279433","article-title":"Antimalarial drug resistance and novel targets for antimalarial drug discovery","volume":"13","author":"Shibeshi","year":"2020","journal-title":"Infect. Drug Resistance"},{"key":"10.1016\/j.bioorg.2021.105215_b0065","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.phytol.2016.07.007","article-title":"Antimicrobial and anti-oxidant activities of quinoline alkaloids from Pseudomonas aeruginosa BCC76810","volume":"17","author":"Supong","year":"2016","journal-title":"Phytochem. Lett."},{"issue":"2","key":"10.1016\/j.bioorg.2021.105215_b0070","doi-asserted-by":"crossref","first-page":"268","DOI":"10.3390\/biom10020268","article-title":"Induction of cryptic antifungal pulicatin derivatives from Pantoea agglomerans by microbial co-culture","volume":"10","author":"Thissera","year":"2020","journal-title":"Biomolecules"},{"issue":"7556","key":"10.1016\/j.bioorg.2021.105215_b0075","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/nature14451","article-title":"A novel multiple-stage antimalarial agent that inhibits protein synthesis","volume":"522","author":"Baraga\u00f1a","year":"2015","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.bioorg.2021.105215_b0080","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1128\/AAC.48.5.1807-1810.2004","article-title":"Novel, rapid, and inexpensive cell-based quantification of antimalarial drug efficacy","volume":"48","author":"Bennett","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bioorg.2021.105215_b0085","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.7164\/antibiotics.39.1160","article-title":"KF8940 (2-n-Heptyl-4-hydroxyquinoline-N-oxide), a potent and selective inhibitor of 5-lipoxygenase, produced by Pseudomonas methanica","volume":"39","author":"Kitamura","year":"1986","journal-title":"J. Antibiot."},{"key":"10.1016\/j.bioorg.2021.105215_b0090","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1039\/C0OB00652A","article-title":"Microwave and flow syntheses of Pseudomonas quinolone signal (PQS) and analogues","volume":"9","author":"Hodgkinson","year":"2011","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.bioorg.2021.105215_b0095","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0165-7208(97)80038-4","article-title":"Chapter 17-Quinolines","volume":"25","author":"Sharma","year":"1997","journal-title":"Pharmacochem. Library"},{"key":"10.1016\/j.bioorg.2021.105215_b0100","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.jinorgbio.2019.01.021","article-title":"What is pure hemozoin? A close look at the surface of the malaria pigment","volume":"194","author":"Guerra","year":"2019","journal-title":"J. Inorg. Biochem."},{"issue":"12","key":"10.1016\/j.bioorg.2021.105215_b0105","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.4155\/fmc.13.113","article-title":"Hemozoin and antimalarial drug discovery","volume":"5","author":"Fong","year":"2013","journal-title":"Future Med. Chem."},{"issue":"15398","key":"10.1016\/j.bioorg.2021.105215_b0110","article-title":"Antimalarial Quinoline Drugs inhibit \u03b2-Hematin and increase free Hemin catalysing peroxidative Reactions and inhibition of cysteine proteases","volume":"9","author":"Herraiz","year":"2019","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.bioorg.2021.105215_b0115","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0166-6851(03)00163-4","article-title":"The shape and size of hemozoin crystals distinguishes diverse Plasmodium species","volume":"130","author":"Noland","year":"2003","journal-title":"Molecul. Biochem. Parasitol."},{"issue":"27","key":"10.1016\/j.bioorg.2021.105215_b0120","doi-asserted-by":"crossref","first-page":"6010","DOI":"10.1016\/j.febslet.2005.09.035","article-title":"Structural and morphological characterisation of hemozoin produced by Schistosoma mansoni and Rhodnius prolixus","volume":"579","author":"Oliveira","year":"2005","journal-title":"Febs letters"},{"issue":"1","key":"10.1016\/j.bioorg.2021.105215_b0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0166-6851(00)00365-0","article-title":"Haemoproteus and Schistosoma synthesise heme polymers similar to Plasmodium hemozoin and \u03b2-hematin","volume":"113","author":"Chen","year":"2001","journal-title":"Mol. Biochem. Parasitol."},{"issue":"9","key":"10.1016\/j.bioorg.2021.105215_b0130","doi-asserted-by":"crossref","first-page":"e12694","DOI":"10.1371\/journal.pone.0012694","article-title":"Increase on the initial soluble heme levels in acidic conditions is an important mechanism for spontaneous heme crystallisation in vitro","volume":"5","author":"Stiebler","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.bioorg.2021.105215_b0135","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0021-9258(17)43657-X","article-title":"Hemin-mediated oxidative degradation of proteins","volume":"259","author":"Aft","year":"1984","journal-title":"J. Biol. Chem."},{"issue":"19","key":"10.1016\/j.bioorg.2021.105215_b0140","doi-asserted-by":"crossref","first-page":"12069","DOI":"10.1016\/S0021-9258(17)44341-9","article-title":"Hemin-mediated DNA strand scission","volume":"258","author":"Aft","year":"1983","journal-title":"J. Biol. Chem."},{"issue":"13","key":"10.1016\/j.bioorg.2021.105215_b0145","doi-asserted-by":"crossref","first-page":"6512","DOI":"10.1021\/acs.jmedchem.6b00719","article-title":"Identification and SAR Evaluation of Hemozoin-Inhibiting Benzamides Active against Plasmodium falciparum","volume":"59","author":"Wicht","year":"2016","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2021.105215_b0150","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1039\/C6OB02110G","article-title":"Shining new light on ancient drugs: preparation and subcellular localisation of novel fluorescent analogues of Cinchona alkaloids in intraerythrocytic Plasmodium falciparum","volume":"15","author":"Woodland","year":"2017","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.bioorg.2021.105215_b0155","article-title":"Privileged scaffolds in medicinal chemistry: design, synthesis, evaluation","author":"Jakubczyk","year":"2015","journal-title":"Roy. Soc. Chem."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206821005927?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206821005927?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T08:26:47Z","timestamp":1758616007000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206821005927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":31,"alternative-id":["S0045206821005927"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2021.105215","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Potent antiplasmodial alkaloids from the rhizobacterium Pantoea agglomerans as hemozoin modulators","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2021.105215","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105215"}}