{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T20:49:40Z","timestamp":1778273380508,"version":"3.51.4"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T00:00:00Z","timestamp":1662681600000},"content-version":"am","delay-in-days":312,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM121061"],"award-info":[{"award-number":["GM121061"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM131821"],"award-info":[{"award-number":["GM131821"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R15CA213185"],"award-info":[{"award-number":["R15CA213185"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R15GM120712"],"award-info":[{"award-number":["R15GM120712"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["Z01 ES043010"],"award-info":[{"award-number":["Z01 ES043010"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.bioorg.2021.105297","type":"journal-article","created":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T10:52:23Z","timestamp":1630320743000},"page":"105297","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["A new class of cytotoxic agents targets tubulin and disrupts microtubule dynamics"],"prefix":"10.1016","volume":"116","author":[{"given":"Ayad A.","family":"Al-Hamashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radhika","family":"Koranne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samkeliso","family":"Dlamini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulateef","family":"Alqahtani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Endri","family":"Karaj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maisha S.","family":"Rashid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph R.","family":"Knoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Dunworth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Kay H.","family":"Pflum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Robert A.","family":"Casero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lalith","family":"Perera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William R.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.M. Viranga","family":"Tillekeratne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2021.105297_b0005","first-page":"(n.d.)","year":"2021","journal-title":"(Accessed Feb 16"},{"issue":"2","key":"10.1016\/j.bioorg.2021.105297_b0010","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.currproblcancer.2009.03.001","article-title":"Targeted therapy for advanced non-small cell lung cancers: historical perspective, current practices, and future development","volume":"33","author":"Mahalingam","year":"2009","journal-title":"Curr Probl Cancer."},{"issue":"6","key":"10.1016\/j.bioorg.2021.105297_b0015","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1172\/JCI43424","article-title":"Early Tumor Dissemination, But Late Metastasis: Insights Into Tumor Dormancy","volume":"120","author":"R\u00f6cken","year":"2010","journal-title":"J. Clin. Invest."},{"issue":"8","key":"10.1016\/j.bioorg.2021.105297_b0020","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/S0960-9822(95)00180-1","article-title":"How Does Taxol Stabilize Microtubules?","volume":"5","author":"Arnal","year":"1995","journal-title":"Curr. Biol."},{"issue":"6","key":"10.1016\/j.bioorg.2021.105297_b0025","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/ncb2513","article-title":"Cdt1 Throws Kinetochore-Microtubule Attachments for a Loop","volume":"14","author":"Matson","year":"2012","journal-title":"Nat. Cell Biol."},{"issue":"6","key":"10.1016\/j.bioorg.2021.105297_b0030","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.ceb.2013.07.003","article-title":"Mitosis and Apoptosis: How is The Balance Set?","volume":"25","author":"Topham","year":"2013","journal-title":"Curr. Opin. Cell Biol."},{"issue":"6","key":"10.1016\/j.bioorg.2021.105297_b0035","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1158\/1535-7163.MCT-08-1084","article-title":"Length of Mitotic Arrest Induced by Microtubule-Stabilizing Drugs Determines Cell Death After Mitotic Exit","volume":"8","author":"Bekier","year":"2009","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.bioorg.2021.105297_b0040","first-page":"1","article-title":"A cell biological perspective on past, present and future investigations of the spindle assembly checkpoint","volume":"5","author":"Joglekar","year":"2016","journal-title":"Biology (Basel)."},{"issue":"1","key":"10.1016\/j.bioorg.2021.105297_b0045","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/nrm3494","article-title":"Microtubule Attachment and Spindle Assembly Checkpoint Signalling at The Kinetochore","volume":"14","author":"Foley","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bioorg.2021.105297_b0050","unstructured":"J. Almaliti, A.A. Al-Hamashi, A.T. Negmeldin, C.L. Hanigan, L. Perera, M. Kay, H. Pflum, R.A. \u22a5 Casero, L.M. Viranga Tillekeratne, Largazole Analogues Embodying Radical Changes in the Depsipeptide Ring: Development of a More Selective and Highly Potent Analogue, (n.d.)."},{"issue":"17","key":"10.1016\/j.bioorg.2021.105297_b0055","doi-asserted-by":"crossref","first-page":"3923","DOI":"10.1200\/JCO.2005.14.167","article-title":"Phase I Study of an Oral Histone Deacetylase Inhibitor, Suberoylanilide Hydroxamic Acid, in Patients With Advanced Cancer","volume":"23","author":"Kelly","year":"2005","journal-title":"J. Clin. Oncol."},{"issue":"8","key":"10.1016\/j.bioorg.2021.105297_b0060","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/ja.2011.35","article-title":"Romidepsin (Istodax, NSC 630176, FR901228, FK228, depsipeptide): a natural product recently approved for cutaneous T-cell lymphoma","volume":"64","author":"VanderMolen","year":"2011","journal-title":"J. Antibiot. (Tokyo)"},{"issue":"2","key":"10.1016\/j.bioorg.2021.105297_b0065","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1177\/1078155216634178","article-title":"Belinostat for the treatment of relapsed or refractory peripheral T-cell lymphoma","volume":"23","author":"Campbell","year":"2017","journal-title":"J. Oncol. Pharm. Pract."},{"issue":"6","key":"10.1016\/j.bioorg.2021.105297_b0070","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/s40265-015-0388-8","article-title":"Panobinostat: First Global Approval","volume":"75","author":"Garnock-Jones","year":"2015","journal-title":"Drugs."},{"issue":"4","key":"10.1016\/j.bioorg.2021.105297_b0075","doi-asserted-by":"crossref","first-page":"505","DOI":"10.4155\/fmc.12.3","article-title":"Targeted cancer therapy: giving histone deacetylase inhibitors all they need to succeed","volume":"4","author":"Gryder","year":"2012","journal-title":"Futur. Med Chem."},{"issue":"8","key":"10.1016\/j.bioorg.2021.105297_b0080","doi-asserted-by":"crossref","first-page":"4592","DOI":"10.1073\/pnas.96.8.4592","article-title":"A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors","volume":"96","author":"Saito","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.bioorg.2021.105297_b0085","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1007\/s00280-011-1766-x","article-title":"Chidamide (CS055\/HBI-8000): a new histone deacetylase inhibitor of the benzamide class with antitumor activity and the ability to enhance immune cell-mediated tumor cell cytotoxicity","volume":"69","author":"Ning","year":"2012","journal-title":"Cancer Chemother Pharmacol."},{"issue":"22","key":"10.1016\/j.bioorg.2021.105297_b0090","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1016\/j.bmcl.2003.09.007","article-title":"Heterocyclic ketones as inhibitors of histone deacetylase","volume":"13","author":"Vasudevan","year":"2003","journal-title":"Bioorganic Med. Chem. Lett."},{"issue":"12","key":"10.1016\/j.bioorg.2021.105297_b0095","doi-asserted-by":"crossref","first-page":"7762","DOI":"10.1021\/acs.chemrev.7b00020","article-title":"Chalcone: A Privileged Structure in Medicinal Chemistry","volume":"117","author":"Zhuang","year":"2017","journal-title":"Chem. Rev."},{"issue":"7","key":"10.1016\/j.bioorg.2021.105297_b0100","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1021\/jm00169a021","article-title":"Chalcones: A New Class of Antimitotic Agents","volume":"33","author":"Edwards","year":"1990","journal-title":"J. Med. Chem."},{"issue":"9","key":"10.1016\/j.bioorg.2021.105297_b0105","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/S0960-894X(98)00162-0","article-title":"Potent antimitotic and cell growth inhibitory properties of substituted chalcones","volume":"8","author":"Ducki","year":"1998","journal-title":"Bioorganic Med. Chem. Lett."},{"issue":"22","key":"10.1016\/j.bioorg.2021.105297_b0110","doi-asserted-by":"crossref","first-page":"5844","DOI":"10.1016\/j.bmcl.2006.08.065","article-title":"Effects of \u03b1-substitutions on structure and biological activity of anticancer chalcones","volume":"16","author":"Lawrence","year":"2006","journal-title":"Bioorganic Med. Chem. Lett."},{"issue":"55","key":"10.1016\/j.bioorg.2021.105297_b0115","doi-asserted-by":"crossref","first-page":"8604","DOI":"10.1039\/C6CC03540J","article-title":"Expanding Biohybrid-\u00adMediated Asymmetric Catalysis into the Realm of RNA","volume":"52","author":"Duchemin","year":"2016","journal-title":"Chem. Commun."},{"issue":"7","key":"10.1016\/j.bioorg.2021.105297_b0120","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.tips.2015.04.013","article-title":"HDAC8: A multifaceted target for therapeutic interventions","volume":"36","author":"Chakrabarti","year":"2015","journal-title":"Trends Pharmacol. Sci."},{"issue":"7415","key":"10.1016\/j.bioorg.2021.105297_b0125","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nature11316","article-title":"HDAC8 Mutations in Cornelia de Lange Syndrome Affect The Cohesin Acetylation Cycle","volume":"489","author":"Deardorff","year":"2012","journal-title":"Nature."},{"issue":"10","key":"10.1016\/j.bioorg.2021.105297_b0130","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/nrc1951","article-title":"The NCI60 human tumour cell line anticancer drug screen","volume":"6","author":"Shoemaker","year":"2006","journal-title":"Nat Rev Cancer."},{"issue":"10","key":"10.1016\/j.bioorg.2021.105297_b0135","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1038\/sj.onc.1210779","article-title":"Histone deacetylase inhibitors induce mitotic slippage","volume":"27","author":"Stevens","year":"2008","journal-title":"Oncogene."},{"issue":"25","key":"10.1016\/j.bioorg.2021.105297_b0140","doi-asserted-by":"crossref","first-page":"3853","DOI":"10.1038\/sj.onc.1206502","article-title":"Inhibition of histone deacetylase activity increases chromosomal instability by the aberrant regulation of mitotic checkpoint activation","volume":"22","author":"Shin","year":"2003","journal-title":"Oncogene."},{"issue":"13","key":"10.1016\/j.bioorg.2021.105297_b0145","doi-asserted-by":"crossref","first-page":"6360","DOI":"10.1158\/0008-5472.CAN-06-3012","article-title":"Histone Deacetylase Inhibitors Induce Premature Sister Chromatid Separation and Override the Mitotic Spindle Assembly Checkpoint","volume":"67","author":"Magnaghi-Jaulin","year":"2007","journal-title":"Cancer Res."},{"issue":"10","key":"10.1016\/j.bioorg.2021.105297_b0150","doi-asserted-by":"crossref","first-page":"e1435","DOI":"10.1038\/cddis.2014.412","article-title":"Histone deacetylase inhibitors promote glioma cell death by G2 checkpoint abrogation leading to mitotic catastrophe","volume":"5","author":"Cornago","year":"2014","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.bioorg.2021.105297_b0155","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms1319","article-title":"Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis","volume":"2","author":"Saurin","year":"2011","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.bioorg.2021.105297_b0160","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S1534-5807(04)00025-5","article-title":"Aurora B Regulates MCAK at the Mitotic Centromere","volume":"6","author":"Andrews","year":"2004","journal-title":"Dev. Cell."},{"key":"10.1016\/j.bioorg.2021.105297_b0165","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1083\/jcb.102.6.2023","article-title":"Dynamics of microtubule depolymerization in monocytes","volume":"102","author":"Cassimeris","year":"1986","journal-title":"J. Cell Biol."},{"issue":"3","key":"10.1016\/j.bioorg.2021.105297_b0170","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1073\/pnas.77.3.1561","article-title":"Taxol Stabilizes Microtubules in Mouse Fibroblast Cells","volume":"77","author":"Schiff","year":"1980","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6979","key":"10.1016\/j.bioorg.2021.105297_b0175","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/nature02393","article-title":"Insight Into Tubulin Regulation From A Complex With Colchicine and A Stathmin-Like Domain","volume":"428","author":"Ravelli","year":"2004","journal-title":"Nature."},{"issue":"11","key":"10.1016\/j.bioorg.2021.105297_b0180","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1007\/s11095-012-0828-z","article-title":"An Overview of Tubulin Inhibitors That Interact With The Colchicine Binding Site","volume":"29","author":"Lu","year":"2012","journal-title":"Pharm. Res."},{"issue":"1","key":"10.1016\/j.bioorg.2021.105297_b0185","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.ccell.2019.05.014","article-title":"Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss","volume":"36","author":"Fedoriw","year":"2019","journal-title":"Cancer Cell."},{"key":"10.1016\/j.bioorg.2021.105297_b0190","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.ejmech.2018.10.066","article-title":"1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase","volume":"162","author":"Lai","year":"2019","journal-title":"Eur. J. Med. Chem."},{"issue":"12","key":"10.1016\/j.bioorg.2021.105297_b0195","doi-asserted-by":"crossref","first-page":"8447","DOI":"10.1021\/acs.jmedchem.1c00413","article-title":"Efficient Synthesis and Bioevaluation of Novel Dual Tubulin\/Histone Deacetylase 3 Inhibitors as Potential Anticancer Agents","volume":"64","author":"Peng","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2021.105297_b0200","first-page":"1","article-title":"A novel dual HDAC6 and tubulin inhibitor, MPT0B451, displays anti-tumor ability in human cancer cells in vitro and in vivo","volume":"9","author":"Wu","year":"2018","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.bioorg.2021.105297_b0205","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1080\/14756366.2017.1417274","article-title":"Zinc binding groups for histone deacetylase inhibitors","volume":"33","author":"Zhang","year":"2018","journal-title":"J. Enzyme Inhib. Med. Chem."},{"issue":"52","key":"10.1016\/j.bioorg.2021.105297_b0210","doi-asserted-by":"crossref","first-page":"15090","DOI":"10.1073\/pnas.1610270114","article-title":"CRISPR screen identifies the NCOR \/ HDAC3 complex as a major suppressor of differentiation in rhabdomyosarcoma","volume":"113","author":"Phelps","year":"2016","journal-title":"PNAS."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004520682100674X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004520682100674X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T08:25:55Z","timestamp":1758615955000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004520682100674X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":42,"alternative-id":["S004520682100674X"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2021.105297","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A new class of cytotoxic agents targets tubulin and disrupts microtubule dynamics","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2021.105297","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105297"}}